Sublingual atropine drops are used frequently in the treatment of clozapine-induced hypersalivation and drooling. To date, no studies have investigated the pharmacokinetics of sublingually administered atropine and if it is different from that of oral atropine.
Participants will be having a single dose of 0.6mg sublingual atropine drops on day 1. On day 2 at least 4 days after day 1 dose: a single 0.6mg dose of atropine tablet to be swallowed. On day 3 at least 4 days after day 2 dose: a single 1.2mg dose of sublingual atropine drops. Participation in all 3 days is ideal but not a must for participation.
Sequential venous blood will be collected over 10 hours at the Charles Perkins Centre-Camperdown, NSW.
A small compensation for travel expenses will be provided at the end of each study day.
Ethics committee approval number: HREC/18/RPAH/687
You may be eligible to participate in this study if:
If you are interested in assisting with this important and exciting area of research, please contact the study principal investigator and coordinator Omar Mubaslat on 9515 8145 or firstname.lastname@example.org