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Develop single-cell mechanobiological methods for discovering molecular mechanisms of cardiovascular and neuronal mechanical force sensing

IF 39.74] https://sydney.edu.au/news-opinion/news/2019/04/02/research-unlocks-biomechanic-mystery-behind-deadly-blood-clots.html 2) Nature Communications (2018) – Ju L, McFadyen JD, ... Nature Commun 9(1): 1084. doi: 10.1038/s41467-018-03430-6 [IF 12.53
www.sydney.edu.au/research/opportunities/2785.html
Research opportunities_

Artificial Intelligence (AI) assisted single-cell biomechanical nanotools for cardiovascular mechanobiology

Traditional biochemical and biophysical techniques often falter in visualizing and characterizing their kinetic and signalling processes on singular living cells. ... The goal? To illuminate their role in cardiovascular diseases, especially in blood
www.sydney.edu.au/research/opportunities/3498.html

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Modulating coronary atherosclerosis through perivascular fat (PVAT)

Significance: Ultimately, this novel project will uncover biological processes observed in one tissue (e.g., PVAT) may influence processes observed in a different tissue (e.g., blood vessel). ... During the atherosclerotic plaque progression, endothelial
www.sydney.edu.au/research/opportunities/2913.html
Research opportunities_

Develop point-of-care microfluidic technologies for cardiovascular and cerebrovascular diseases

It will be extremely useful for patients with diabetes, obesity and metabolic syndromes with sticky blood clot phenotypes and cardiovascular risk factors. ... We have recently discovered a new ‘biomechanical’ prothrombotic mechanism that highlights
www.sydney.edu.au/research/opportunities/2781.html
Research opportunities_

Artificial Intelligence (AI) assisted novel design and molecular dynamics simulation of anti-thrombotic peptides and experimental validation by nanomedicine delivery

While the interplay of shear in blood flow and its effect on proteins like von Willebrand factor (VWF) and FVIII is evident, a comprehensive understanding of their structures remains elusive. ... Capability of independently output processing models and
www.sydney.edu.au/research/opportunities/3500.html