Clinical trials
Our clinical trials are conducted according to the strict guidelines of the ICH GCP (International Conference on the Harmonisation of Good Clinical Practice) and our staff are experienced and internationally certified in vision assessments and retinal imaging procedures.
Study staff maintain current certifications across multiple reading centres worldwide in all retinal imaging procedures including optical coherence tomography, fundus autofluorescence, retinal photography and visual electrophysiology .
Therapies are becoming available for inherited retinal diseases (IRD). IRD’s in general progress slowly over time often with declines in function followed by long periods of stability.
To be able to detect if potential therapies are effective there is a need for an understanding of the disease progress in individuals. The Eye genetics and Inherited retinal disease group have developed clinical protocols in collaboration with international and local centres to standardise these assessments.
Participation in the natural history studies assists in improving understanding the condition and importantly assist in identifying the most appropriate outcome measures which are critical for therapeutic intervention studies.
Trials
Nacuity Safety and Efficacy of NPI-001 Tablets versus Placebo for Treatment of Retinitis Pigmentosa Associated with Usher Syndrome.
This study is assessing the economic impact of living with an inherited retinal disease.
This study is assessing the clinical function in people with Stargardt disease utilising advanced multimodal imaging and visual functional studies.
This study is assessing the clinical function in people with cone-rod or cone dystrophy utilising advanced multimodal imaging and visual functional studies.
This study is assessing the clinical function in people with Achromatopsia utilising advanced multimodal imaging and visual functional studies.
This study is assessing the clinical function in people with Retinitis Pigmentosa utilising advanced multimodal imaging and visual functional studies.
Stargardt Disease study -Protocol Number: LBS-008-CT03
Title: Phase 3, Multicenter, Randomized, Double-Masked, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Tinlarebant in the Treatment of Stargardt Disease in Adolescent Subjects
The study objective is to determine whether VR mobility assessment tool parameters can serve as biomarkers of functional vision in participants with retinal disease
This study is assessing the clinical function in people with KCNV2 retinpathy utilising advanced multimodal imaging and visual functional studies.
This study is assessing the clinical function in people with macular dystrophy utilising advanced multimodal imaging and visual functional studies.
This study is assessing the clinical function in people with IMPDH1 associated retinopathy utilising advanced multimodal imaging and visual functional studies.
This study is assessing the clinical function in people with GUCY2D related cone dystrophy utilising advanced multimodal imaging and visual functional studies.
This study is assessing the clinical function in people with PRPH2 associated retinopathy utilising advanced multimodal imaging and visual functional studies.
This study is assessing the clinical function in people with MERTK associated retinopathy utilising advanced multimodal imaging and visual functional studies.
This study is assessing the clinical function in people with PRPF31 associated retinopathy utilising advanced multimodal imaging and visual functional studies.
This study is assessing the clinical function in people with Stargardt disease (ABCA4) utilising advanced multimodal imaging and visual functional studies.
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South Block, Sydney Eye Hospital 8 Macquarie Street Sydney NSW 2000