Chemical Biology at the University of Sydney

Conference Program

8:50 Opening of Symposium: Prof. Trevor Hambley (Dean of Science)
9:00

Plenary presentation: Prof. Annette Beck-Sickinger (Universität Leipzig)

Semi-synthesis of proteins to expand biological function

9:40 Session 1 (studying macromolecules). Session chair: A/Prof. Richard Payne
Joel Mackay - Integrative structural analysis of a 1-MDa chromatin remodeling complex
Rob Thompson - Probing the effects of post-translational modifications on the activity of tick-derived      anticoagulants
Sandro Ataide - The Signal Recognition Particle RNA and its multi functions
Jacqui Matthews - Protein Engineering and Transcriptional Regulation
11:00 Morning tea
11:30 Session 2 (enabling technologies on campus). Session chair: Prof. Kate Jolliffe
Ann Kwan - SMB NMR Facility and chemical biology
Adrian Smith - The Advanced Cytometry Facility - enabling technologies for single cell analysis
Pam Young - Cellular Imaging Facility in the Charles Perkins Centre: A Node of Sydney Microscopy and Microanalysis
Ben Crossett - What is the MSCF?
12:00 3-Minute poster presentations. Session chair: Prof. Kate Jolliffe
12:50 Lunch and poster session
14:00 Session 3 (targeting and imaging). Session chair: A/Prof. Renae Ryan
Margie Sunde - Using amyloid to your advantage - functional fibrils from fungal hydrophobin proteins
Peter Rutledge - Visualising ion flux with small molecule probes, and nanoparticles
Andrew Katsifis - TBD
Phil Robinson - TBD
Liz New - Molecular imaging tools for intracellular redox state and biological metal ions
15:40 Afternoon tea and poster session
16:00 Session 4 (developing active small molecules). Session chair: Dr Benjamin Parker
Mary Collins - Multiple binding interfaces on nACh receptors allude to stoichiometric dependent actions of antagonists
Rachel Codd - New siderophore scaffolds from precursor-directed biosynthesis
Paul Witting - Pre-treatment with the synthetic antioxidant T-butyl bisphenol protects cerebral tissues from experimental ischemia reperfusion injury
Lenka Munoz - Development of allosteric MK2 inhibitors with blood-brain barrier permeability
17:20

Plenary presentation: Dr James Crawford (Genentech)

Potent and Selective Pyridone BTK Inhibitors With Activity Against Mutant Forms of BTK

18:00 Closing remarks
Drinks reception (Law Foyer)