Adrian V George, Senior
School of Chemistry, Building F11
University of Sydney, NSW 2006, Australia
Email address: email@example.com
Telephone: +61 (2) 9351-4413
Fax: +61 (2) 9351-3329
- BSc (Hons) University of
Reading, UK 1981
- PhD University of Reading,
- Lecturer, University of
Reading, UK 1984 - 88
- Visiting Scientist, University
of California, Berkeley 1986
- University of Sydney 1988
- Fellow, Japan Society for
the Promotion of Science 1996
- University of Sydney Excellence
in Teaching Award 1999, 2007
- Graduate Certificate of
Education (Higher Education) 2000
- Royal Australian Chemical
Institute Nyholm Lecturer 2000
- Royal Australian Chemical
Institute Centenary of Federation Teaching Award 2001
- Australian College of Education
Teaching Award 2001
- Director of First Year
Studies, University of Sydney 2001 - 2006
- Associate Dean (Teaching and Learning), Faculty of Science 2002 - 2004
- Vice Chancellor's Award for Support of the Student Experience 2007
- Carrick Institute Award for Programs that Enhance Learning (Institutional Collaborations) 2007
- Vice Chancellor's Award for Support of the Student Experience 2011
Areas of Interest:
- Using High Pressures in
- Organometallic Chemistry
- Detection of steroid
abuse in athletes
- New Developments in Chemistry
The project aim is to use the porphyrinogen and calixpyrrole structure as a ligand for metals engaged in catalysis reactions. By providing a cavity for the metal we intend to extend the lifetime of the catalyst and have the ability to modify the reactivity of the metal through a variety of interactions with the calixpyrrole host. Large radii lanthanoid metals, such as samarium, have been coordinated in the cavity. Syntheses of a range of these cavity materials has been developed.
Detection of steroid use in sports
Dehydroepiandrosterone (DHEA), a naturally
produced androgen, may be administered by athletes with the aim of increasing
levels of the more active androgens such as testosterone (T) and
dihydrotestosterone (DHT). The International Olympic Committee (IOC) prohibits
DHEA administration in athletes, however its detection remains difficult due to
an incomplete understanding of DHEA metabolism as well as inter-individual variations.
In this study, Gas Chromatography-Mass
Spectrometry (GC-MS) demonstrated that a single oral administration of DHEA
(100 mg) to a subject altered the urinary steroid concentrations of
androsterone (A) and etiocholanolone (Et). The ratio of the concentration of A
to Et (A/Et) may provide a screening marker of DHEA administration. Values of
A/Et less than 0.5, measured following DHEA administration, were compared to a
reference distribution of A/Et values obtained from 858 urine samples. Only 3
of these had A/Et values less than 0.5.
The urine samples collected after DHEA
administration were also analysed by Gas Chromatography-Combustion-Isotope
Ratio Mass Spectrometry (GC-C-IRMS) to determine the Carbon Isotope Ratio (CIR,
d13C) of A and Et. This technique demonstrated that d13C A and d13C Et were reduced
following the single administration of DHEA. The difference between d13C Et and d13C A increased from
1.6 ‰ at the time of administration to a maximum value of 5.2 ‰, which
corresponded to a minimum A/Et value of 0.4.
Multiple oral administrations of 100 mg DHEA,
morning and night for seven days to a separate subject resulted in Et being 13C
depleted in relation to the DHEA that was administered. Also, an unknown
compound, detected in many of the GC-C-IRMS traces was shown to have d13C values similar to
those of Et. This compound, identified as 3a-5-cyclo-5a-androstan-6b-ol-17-one, may prove to be an effective indicator of DHEA
Education in Chemistry
Detailed analysis, both qualitative and quantitative, of examination scripts from some first year chemistry units has been undertaken. When combined with qualitative data from students about their experiences and perceptions, a number of interesting questions can be addressed. Firstly, the question of the extent to which the outcomes from our current assessment system are a reflection of students’ understanding can be examined. Analysis of students’ approaches to examination questions provides information about both misconceptions held and overall motivations and goals (performance orientation versus mastery orientation). Such information can be used not only to improve teaching in areas of student difficulty, but can also inform curriculum design more generally, with the ultimate goal of promoting deeper student understanding of the material under study. Secondly, the analysis provides data that supports the common belief that organic chemistry is an area that some students simply ‘don’t get’. The existence of barriers to deeper understanding of organic chemistry has been proven, and the nature of these barriers examined. Such information has obvious implications for improving teaching and learning in this fundamental area of chemistry, although more work in this area is needed.
& "The Essentials of Organic Chemistry"
George, A.V.; Field, L.D.; Hambley, T.W.; 1996 Prentice
- “Pressure and Viscosity Effects on Thermal Geometrical Isomerization of Oxacarbocyanine Cations” George, A.V.; Kim, J.C.; Ohga, Y.; Asano, T.; Weinberg, N.N., Bull. Chem. Soc. Jpn.,2001, 74, 103.
- “Small group learning in first year chemistry: Does it work?” George, A.V.; Muck, V., Aust. J. Ed. Chem., 2003, 62, 9.
- “Searching for new markers of endogenous steroid administration in athletes: ‘looking outside the metabolic box’” Cawley, A.T.; Hine, E.R.; Trout, G.J.; George, A.V.; Kazlauskas, R., Forensic Science International, 2004, 143, 103.
- “Isotopic Fractionation of Endogenous Anabolic Androgenic Steroids and its Relationship to Doping Control in Sports”, Cawley, A.T.; Kazlauskas, R.; Trout, G.J.; Rogerson, J.H.; George, A.V., Journal of Chromatographic Science, 2005, 43, 32-38.
- “Determination of urinary steroid sulfate metabolites using ion paired extraction”. Cawley, A.T.; Kazlauskas, R.; Trout, G.J.; George, A.V., Journal of Chromatography B, 2005, 825, 1-10.
- “From APCELL to ACELL and Beyond – Expanding a Multi-Institution Project from Larboatory-Based Teaching and Leaning” Jamie, I. M.; Read, J. R.; Barrie, S. C.; Bucat, R. B.; Buntine, M. A.; Crisp, G. T.; George, A. V.; Kable, S. H., Aust. J. Ed. Chem., 2006, 67, 7-13.
- “Buckling under Strain: Releif of Steric Pressure Occurs Differently for Samarium(III) Porphrynogen Complexes of the π-Bound Auxiliary Ligands Cyclopentadienyl and Cyclooctatetraenediyl” Frey, A. S. P.; Gardiner, M. G.; Stringer, D. N.; Yates, B. F.; George, A. V.; Jensen, P.; Turner, P., Organometallics 2007, 26(6), 1299-1302.
- “Advancing Chemistry by Enhancing Learning in the Laboratory (ACELL): a model for providing professional and personal development and facilitating improved student laboratory learning outcomes.” Buntine, M. A.; Read, J. R.; Barrie, S. C.; Bucat, R. B.; Crisp, G. T.; George, A. V.; Jamie, I. M.; Kable, S. H. Chem. Educ. Res. Pract., 2007, 8, 232 - 254.
“N-cyanomethyl-N-methyl-1-(3’,4’-methylenedioxphenyl)-2-propylamine: An MDMA manufacturing by-product”, Salouros, H.; Collins, M.; Tarrant, G.; George, A. V., J. Forensic Sci., 2008, 53(5) 1083-1091.
- “The detection of androstenedione abuse in sport: A mass spectrometry strategy to identify the 4-hydroxyandrostenedione metabolite. Cawley, A.T.; Trout, G.J.; Kazlauskas, R.; George, A.V. Rapid Commun. Mass Spectrom., 2008, 22, 4147-4157.
- “Carbon isotope ratio (d¹³C) values of urinary steroids for doping control in sport” Cawley, A.T.; Kazlauskas, R.; Trout, G.J.; Howe, C.; George, A.V. Steroids. 2009, 74(3), 379-392.
- “Development of criteria for the detection of adrenosterone administration by gas chromatography-mass spectrometry and gas chromatography-combustion-isotope ratio mass spectrometry for doping control” Brooker, L.; Parr, M. K.; Cawley, A.T.; Flenker, U.; Howe, C.; Kazlauskas, R.; Schanzer, W.; George, A.V. Drug Testing and Analysis, 2009Volume 1 Issue 11-12, Pages 587 - 595 Special Issue: Advances in sports drug testing Published Online: 27 Jan 2010
- “Using academic predictors to identify first year science students at risk of failing”. J.W. O’Byrne, J. W.; Britton, S.; George, A.; Franklin, S.; Frey, A. CAL-laborate International, 2009, 17(1), 15-25. ISBN: 1836-0858 (print version) ; 1836-0866 (on line version) http://science.uniserve.edu.au/tertiary_science_mathematics/publications/cal-laborate_international/current_issue
- “Isolation and Identification of Three By-products Found in Methylamphetamine Synthesised by the Emde Route” Salouros, H.; Collins, M.; George, A. V.; Davis, S., J. Forensic Sci., 2010 April 1-11, Vol 55(3) p 605-615.
lecture - Photons, Fireflies and a Feeling for Colour
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