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A C-terminal domain of the chromatin remodeller CHD1

[ PDB file ] [ PubMed link ]

Our collaborator (and former PhD student in Jacqui's lab) Daniel Ryan identified a conserved region in CHD1 that hadn't previously been appreciated. It turned out to be nicely structured and Biswa and Ana together were able to work it up to solve its structure by NMR. Steph helped out by looking to see whether it was a DNA-binding domain - seems to have some DNA-binding activity that is non-specific - which might well be functionally relevant.

Complex formed between LMO4 and CtIP

[ PDB file ] [ PubMed link ]

Chu Wai knocked this structure off working together with Ann. The structure highlights how many partners can interact with these LMO proteins and how they do so through these very short sequence motifs (that aren't very well conserved). It makes you realize that these vast unstructured tracts found in most transcription factors could be full of function...

30-A negative stain EM model of the S12 subcomplex of NuRD

[ PDB file ] [ PubMed link ]

Our first foray into single-particle electron microscopy! This is a model, based on negative-stain EM data, of two molecules of RBBP4 bound to a C-terminal segment of MTA1. We think this structural unit is repeated twice in the intact NuRD complex - but exactly what its function is is still a little unclear!

Another three-way complex

Stay tuned for more information...

A long-sought structure - but it still isn't giving up all its secrets to us just yet!

Stay tuned for more information...

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Lastest update: "Lab members page", on 29th Nov 2019.


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