There are approximately 10 members of the Crossley Group at present and we undertake numerous research collaborations with both local and overseas universities.
Novel porphyrin-based chiral cavities are being investigated in studies of molecular recognition of amino acids and nucleic acids. Molecular recognition is used in important biological processes such as smell and enzymic reactions reactions and this study investigates the importance of flexibility/rigidity in host-guest interactions. This study also developed the concept of using very small entities, molecules, as a "molecular ruler".
Light capture is the first step of photosynthesis. Artificial porphyrin systems designed to mimic light capture in Nature are currently under investigation. New multi-porphyrin arrays assembled on dendrimer cores, are designed to mimic the LH1 and LH2 systems. Novel multi-chromophore wheels will be linked to examine the energy cascade seen in the bacterial light-harvesting antenna array. This research should shed extra light on the mechanism of photosynthesis and may also have application in solar energy devices.
The design and synthesis of new advanced materials based on metalloporphyrins is being undertaken. A novel approach to rigid extended aromatic systems has been developed to include the synthesis of novel polymers with the potential to behave as electrical conductors and semi-conductors. Synthesis of compounds that allow direct conjunction of the porphyrin pi-system with an external redox centre and use of these compounds to form thin films and as oxygenase models are also investigated. Studies in the areas of molecular switching devices, molecular shift-registers and non-linear optics are also under way.
This project seeks to control the outcome of poly-porphyrin synthesis to produce syn-stereoisomers by pre-organising the reactants to disfavour the kinetics of reactions that would lead to anti-stereoisomers. This will be achieved by use of a syn-template to make additional syn-templates. In a sense, this approach overcomes previous limitations of putative 'self-replication' systems that sought to achieve templated acceleration of an already favourable reaction. This project may provide the first unambiguous 'self-replicating' system based on simple unnatural molecules.
Work is underway on the synthesis of non-proteinogenic amino acids and dipeptides of biological interest. Target compounds included novel gamma-lactam antibiotics, the antibiotic and anti-tumour agents, anticapsin and bacilysin, the important metabolic intermediate, arogenate, and dipeptide inhibitors of the enzyme prolidase and of the HIV protease.
Recent advances in porphyrin synthesis discovered in Sydney are extended in this project. New concepts in porphyrin chemistry are being developed to yield very hydrophilic porphyrin-sugar hybrids and very lipophilic porphyrin-steroid hybrids and their properties of these novel systems are investigated.
For information about opportunities to work or collaborate with the Crossley Group, contact Professor Maxwell Crossley.