Ms Adrianne Jenner

Telephone 9114 1262

Curriculum vitae Curriculum vitae

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Biographical details

My research focuses on using a range of mathematical modelling techniques, (including differential equations, cellular automaton, dynamical systems, optimisation methods) to understand problems in medicine. My current research areas include:

  • Oncolytic Virotherapy
  • Immunotherapy
  • Pancreatic Chemotherapy Implants

Each of these areas is explained in more detail below:

Oncolytic Virotherapy

Cancer virotherapy is emerging as a promising cancer treatment that involves genetically-engineering viruses to attack tumours cells. In collaboration with a genetic engineering laboratory at Hanyang University, Seoul, Korea, we have developed models of viral infection of tumour growth to help understand what improvements can be made to the viruses and also the optimal dosage protocl.

Immunotherapy

Immunotherapy is a new and promising approach to cancer treatment. It involves helping the body's immune defences defeat tumours. By combining oncolytic viruses with immunostimulatory viruses, an antitumour immue reponse can be instigated. This allows for the bodies own immune system to work towards eradicating tumour cells. Using mathematical modelling, we have investigated the sensitivity of immune stimulation and how this alters the treatment outcome.

Pancreatic Chemotherapy Implants

Developing an effective treatment for pancreatic cancer presents a unique challenge for two reasons: (1) intravenous drug delivery results in limited concentration at the tumour site and (2) pancreatic tumours form dense impenetrable heterogeneous masses that inhibit drug diffusion. Chemotherapy-loaded implants are a promising experimental treatment that could overcome these challenges. The implants allow localised sustained delivery of chemotherapy and, by carefully selecting the implant injection site, can bypass the dense tumour structure. Using a hybrid Voronoi Cellular Automaton (VCA) and PDE modelling approach, we optimize two attributes of this therapy: the drug release profile and implant configuration. The implants can be made with different levels of polymer concentrations which affect the drug release profile. From the model, we have determined the optimal release profile as a function of polymer concentration. We have also quantified the dependency of treatment outcome on implant location and configuration. Our model presents a unique visualisation tool for our collaborators and allows the mathematical optimisation of the implants to be communicated effectively. The model and techniques we present could easily be translated to a range of medical applications.

Teaching and supervision

Location:Carslaw 807

Timetable

AL_Jenner

Academic page

Current projects

Publications:

Jenner, Adrianne, Adelle CF Coster, Peter Kim and Federico Frascoli. "Treating cancerous cells with viruses: insights from a minimal model for oncolytic virotherapy".Letters in Biomathematics

Jenner, Adrianne, C.O. Yun, A. Yoon, Adelle CF Coster, and Peter Kim. "Modelling combined virotherapy and immunotherapy: strengthening the antitumour immune response mediated by IL-12 and GM-CSF".Letters in Biomathematics.

Jenner, Adrianne, Adelle CF Coster, and Peter Kim. "Mathematical modelling of oncolytic virotherapy: The effects of a PEG-modified adenovirus conjugated with herceptin."The Australian Mathematical Society: 297.

Email:a.jenner@maths.usyd.edu.au,

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