Dr Alice Kane

NHMRC Early Career Fellow
School of Life and Environmental Sciences
Harvard Medical School

D17 - Charles Perkins Centre
The University of Sydney

Telephone +1 617 676 5849

Research interests

Biology of aging, animal models of frailty and aging, cardiovascular aging, sex differences in aging and frailty

Themes

Genetics and genomics; Biochemistry and metabolism; Human health

Selected grants

2018

  • Investigation of the Molecular Basis of Frailty and Development of Frailty Biomarkers in a Novel Mouse Ageing Model; Kane A; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.

2013

  • Insights from ageing and calorie restriction for the prevention and treatment of paracetamol hepatotoxicity; Hilmer S, Kane A, Le Couteur D, Cogger V; Australian Association of Gerontology/RM Gibson Research Grants.

Selected publications

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Book Chapters

  • Kane, A., Howlett, S. (2018). Approaches to the Assessment of Frailty in Animal Models. In Jeffrey L. Ram, P. Michael Conn (Eds.), Conn's Handbook of Models for Human Aging - Second Edition, (pp. 551-561). London: Academic Press. [More Information]
  • Kane, A., Howlett, S. (2018). Differences in Cardiovascular Aging in Men and Women. In Peter L. M. Kerkhof, Virginia M. Miller (Eds.), Sex-Specific Analysis of Cardiovascular Function, (pp. 389-411). Cham: Springer, Cham. [More Information]
  • Kane, A., Sinclair, D. (2018). Pharmacological Approaches for Modulating Sirtuins. In Leonard Guarente, Raul Mostoslavsky, Aleksey Kazantsev (Eds.), Introductory Review on Sirtuins in Biology, Aging, and Disease, (pp. 71-81). London: Academic Press. [More Information]
  • Ghimire, A., Kane, A., Howlett, S. (2018). Sex Differences in the Physiology and Pathology of the Aging Heart. In Ramachandran S. Vasan, Douglas B. Sawyer (Eds.), Encyclopedia of Cardiovascular Research and Medicine, (pp. 368-376). United States: Elsevier Inc. [More Information]

Journals

  • Kane, A., Keller, K., Heinz-Milne, S., Grandy, S., Howlett, S. (2018). A Murine Frailty Index Based on Clinical and Laboratory Measurements: Links Between Frailty and Pro-inflammatory Cytokines Differ in a Sex-Specific Manner. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 74(3), 275-282. [More Information]
  • Keller, K., Kane, A., Heinz-Milne, S., Grandy, S., Howlett, S. (2018). Chronic Treatment With the ACE Inhibitor Enalapril Attenuates the Development of Frailty and Differentially Modifies Pro- and Anti-inflammatory Cytokines in Aging Male and Female C57BL/6 Mice. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, In Press, 1-9. [More Information]
  • Kane, A., Shin, S., Wong, A., Fertan, E., Faustova, N., Howlett, S., Brown, R. (2018). Sex Differences in Healthspan Predict Lifespan in the 3xTg-AD Mouse Model of Alzheimer's Disease. Frontiers in Aging Neuroscience, 10, 1-10. [More Information]
  • Kane, A., Sinclair, D., Mitchell, J., Mitchell, S. (2018). Sex differences in the response to dietary restriction in rodents. Current Opinion in Physiology, 6, 28-34. [More Information]
  • Kane, A., Sinclair, D. (2018). Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases. Circulation Research, 123(7), 868-885. [More Information]
  • Kane, A., Huizer-Pajkos, A., Mach, J., Mitchell, S., de Cabo, R., Le Couteur, D., Howlett, S., Hilmer, S. (2017). A Comparison of Two Mouse Frailty Assessment Tools. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 72(7), 904-910. [More Information]
  • Kane, A., Howlett, S. (2017). Advances in Preclinical Models of Frailty. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 72(7), 867-869. [More Information]
  • Yorke, A., Kane, A., Hancock Friesen, C., Howlett, S., O'Blenes, S. (2017). Development of a Rat Clinical Frailty Index. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 72(7), 897-903. [More Information]
  • Kane, A., Ayaz, O., Ghimire, A., Feridooni, H., Howlett, S. (2017). Implementation of the mouse frailty index. Canadian Journal of Physiology and Pharmacology, 95(10), 1149-1155. [More Information]
  • Kane, A., Gregson, E., Theou, O., Rockwood, K., Howlett, S. (2017). The association between frailty, the metabolic syndrome, and mortality over the lifespan. GeroScience, 39(2), 221-229. [More Information]
  • Feridooni, H., Kane, A., Ayaz, O., Boroumandi, A., Polidovitch, N., Tsushima, R., Rose, R., Howlett, S. (2017). The impact of age and frailty on ventricular structure and function in C57BL/6J mice. Journal of Physiology, 595(12), 3721-3742. [More Information]
  • Kane, A., Mitchell, S., Mach, J., Huizer-Pajkos, A., McKenzie, C., Jones, B., Cogger, V., Le Couteur, D., de Cabo, R., Hilmer, S. (2016). Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type. Experimental Gerontology, 73, 95-106. [More Information]
  • Huizer-Pajkos, A., Kane, A., Howlett, S., Mach, J., Mitchell, S., De Cabo, R., Le Couteur, D., Hilmer, S. (2016). Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 71(5), 571-577. [More Information]
  • Kane, A., Hilmer, S., Mach, J., Mitchell, S., De Cabo, R., Howlett, S. (2016). Animal models of frailty: current applications in clinical research. Clinical Interventions in Aging, 11, 1519-1529. [More Information]
  • Kane, A., Hilmer, S., Boyer, D., Gavin, K., Nines, D., Howlett, S., De Cabo, R., Mitchell, S. (2016). Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 71(3), 333-339. [More Information]
  • Kane, A., Huizer-Pajkos, A., Mach, J., McKenzie, C., Mitchell, S., De Cabo, R., Jones, B., Cogger, V., Le Couteur, D., Hilmer, S. (2016). N-Acetyl Cysteine does not prevent liver toxicity from chronic low-dose plus subacute high-dose paracetamol exposure in young or old mice. Fundamental and Clinical Pharmacology, 30(3), 263-275. [More Information]
  • Kane, A., Howlett, S. (2016). Novel cardioprotection strategies for the aged heart: evidence from pre-clinical studies. Clinical and Experimental Pharmacology and Physiology, 43(12), 1251-1260. [More Information]
  • Mach, J., Huizer-Pajkos, A., Mitchell, S., McKenzie, C., Phillips, L., Kane, A., Jones, B., de Cabo, R., Cogger, V., Le Couteur, D., Hilmer, S. (2016). The effect of aging on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats. Fundamental and Clinical Pharmacology, 30(1), 23-34. [More Information]
  • Kane, A., Hilmer, S., Huizer-Pajkos, A., Mach, J., Nines, D., Boyer, D., Gavin, K., Mitchell, S., De Cabo, R. (2015). Factors that Impact on Interrater Reliability of the Mouse Clinical Frailty Index. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 70(6), 694-695. [More Information]
  • Mach, J., Huizer-Pajkos, A., Kane, A., Jones, B., McKenzie, C., Mitchell, S., de Cabo, R., Cogger, V., Le Couteur, D., Hilmer, S. (2015). The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats. Experimental Gerontology, 67, 54-61. [More Information]
  • Kane, A., Mitchell, S., Carroll, P., Matthews, S., Hilmer, S. (2012). Characteristics of older and younger patients with suspected paracetamol toxicity. Australasian Journal on Ageing, 31(3), 190-193. [More Information]
  • Mitchell, S., Kane, A., Hilmer, S. (2011). Age-related changes in the hepatic pharmacology and toxicology of paracetamol. Current Gerontology and Geriatrics Research, 2011, 1-14. [More Information]

2018

  • Kane, A., Keller, K., Heinz-Milne, S., Grandy, S., Howlett, S. (2018). A Murine Frailty Index Based on Clinical and Laboratory Measurements: Links Between Frailty and Pro-inflammatory Cytokines Differ in a Sex-Specific Manner. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 74(3), 275-282. [More Information]
  • Kane, A., Howlett, S. (2018). Approaches to the Assessment of Frailty in Animal Models. In Jeffrey L. Ram, P. Michael Conn (Eds.), Conn's Handbook of Models for Human Aging - Second Edition, (pp. 551-561). London: Academic Press. [More Information]
  • Keller, K., Kane, A., Heinz-Milne, S., Grandy, S., Howlett, S. (2018). Chronic Treatment With the ACE Inhibitor Enalapril Attenuates the Development of Frailty and Differentially Modifies Pro- and Anti-inflammatory Cytokines in Aging Male and Female C57BL/6 Mice. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, In Press, 1-9. [More Information]
  • Kane, A., Howlett, S. (2018). Differences in Cardiovascular Aging in Men and Women. In Peter L. M. Kerkhof, Virginia M. Miller (Eds.), Sex-Specific Analysis of Cardiovascular Function, (pp. 389-411). Cham: Springer, Cham. [More Information]
  • Kane, A., Sinclair, D. (2018). Pharmacological Approaches for Modulating Sirtuins. In Leonard Guarente, Raul Mostoslavsky, Aleksey Kazantsev (Eds.), Introductory Review on Sirtuins in Biology, Aging, and Disease, (pp. 71-81). London: Academic Press. [More Information]
  • Kane, A., Shin, S., Wong, A., Fertan, E., Faustova, N., Howlett, S., Brown, R. (2018). Sex Differences in Healthspan Predict Lifespan in the 3xTg-AD Mouse Model of Alzheimer's Disease. Frontiers in Aging Neuroscience, 10, 1-10. [More Information]
  • Ghimire, A., Kane, A., Howlett, S. (2018). Sex Differences in the Physiology and Pathology of the Aging Heart. In Ramachandran S. Vasan, Douglas B. Sawyer (Eds.), Encyclopedia of Cardiovascular Research and Medicine, (pp. 368-376). United States: Elsevier Inc. [More Information]
  • Kane, A., Sinclair, D., Mitchell, J., Mitchell, S. (2018). Sex differences in the response to dietary restriction in rodents. Current Opinion in Physiology, 6, 28-34. [More Information]
  • Kane, A., Sinclair, D. (2018). Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases. Circulation Research, 123(7), 868-885. [More Information]

2017

  • Kane, A., Huizer-Pajkos, A., Mach, J., Mitchell, S., de Cabo, R., Le Couteur, D., Howlett, S., Hilmer, S. (2017). A Comparison of Two Mouse Frailty Assessment Tools. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 72(7), 904-910. [More Information]
  • Kane, A., Howlett, S. (2017). Advances in Preclinical Models of Frailty. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 72(7), 867-869. [More Information]
  • Yorke, A., Kane, A., Hancock Friesen, C., Howlett, S., O'Blenes, S. (2017). Development of a Rat Clinical Frailty Index. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 72(7), 897-903. [More Information]
  • Kane, A., Ayaz, O., Ghimire, A., Feridooni, H., Howlett, S. (2017). Implementation of the mouse frailty index. Canadian Journal of Physiology and Pharmacology, 95(10), 1149-1155. [More Information]
  • Kane, A., Gregson, E., Theou, O., Rockwood, K., Howlett, S. (2017). The association between frailty, the metabolic syndrome, and mortality over the lifespan. GeroScience, 39(2), 221-229. [More Information]
  • Feridooni, H., Kane, A., Ayaz, O., Boroumandi, A., Polidovitch, N., Tsushima, R., Rose, R., Howlett, S. (2017). The impact of age and frailty on ventricular structure and function in C57BL/6J mice. Journal of Physiology, 595(12), 3721-3742. [More Information]

2016

  • Kane, A., Mitchell, S., Mach, J., Huizer-Pajkos, A., McKenzie, C., Jones, B., Cogger, V., Le Couteur, D., de Cabo, R., Hilmer, S. (2016). Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type. Experimental Gerontology, 73, 95-106. [More Information]
  • Huizer-Pajkos, A., Kane, A., Howlett, S., Mach, J., Mitchell, S., De Cabo, R., Le Couteur, D., Hilmer, S. (2016). Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 71(5), 571-577. [More Information]
  • Kane, A., Hilmer, S., Mach, J., Mitchell, S., De Cabo, R., Howlett, S. (2016). Animal models of frailty: current applications in clinical research. Clinical Interventions in Aging, 11, 1519-1529. [More Information]
  • Kane, A., Hilmer, S., Boyer, D., Gavin, K., Nines, D., Howlett, S., De Cabo, R., Mitchell, S. (2016). Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 71(3), 333-339. [More Information]
  • Kane, A., Huizer-Pajkos, A., Mach, J., McKenzie, C., Mitchell, S., De Cabo, R., Jones, B., Cogger, V., Le Couteur, D., Hilmer, S. (2016). N-Acetyl Cysteine does not prevent liver toxicity from chronic low-dose plus subacute high-dose paracetamol exposure in young or old mice. Fundamental and Clinical Pharmacology, 30(3), 263-275. [More Information]
  • Kane, A., Howlett, S. (2016). Novel cardioprotection strategies for the aged heart: evidence from pre-clinical studies. Clinical and Experimental Pharmacology and Physiology, 43(12), 1251-1260. [More Information]
  • Mach, J., Huizer-Pajkos, A., Mitchell, S., McKenzie, C., Phillips, L., Kane, A., Jones, B., de Cabo, R., Cogger, V., Le Couteur, D., Hilmer, S. (2016). The effect of aging on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats. Fundamental and Clinical Pharmacology, 30(1), 23-34. [More Information]

2015

  • Kane, A., Hilmer, S., Huizer-Pajkos, A., Mach, J., Nines, D., Boyer, D., Gavin, K., Mitchell, S., De Cabo, R. (2015). Factors that Impact on Interrater Reliability of the Mouse Clinical Frailty Index. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 70(6), 694-695. [More Information]
  • Mach, J., Huizer-Pajkos, A., Kane, A., Jones, B., McKenzie, C., Mitchell, S., de Cabo, R., Cogger, V., Le Couteur, D., Hilmer, S. (2015). The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats. Experimental Gerontology, 67, 54-61. [More Information]

2012

  • Kane, A., Mitchell, S., Carroll, P., Matthews, S., Hilmer, S. (2012). Characteristics of older and younger patients with suspected paracetamol toxicity. Australasian Journal on Ageing, 31(3), 190-193. [More Information]

2011

  • Mitchell, S., Kane, A., Hilmer, S. (2011). Age-related changes in the hepatic pharmacology and toxicology of paracetamol. Current Gerontology and Geriatrics Research, 2011, 1-14. [More Information]

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