Miss Anastasia Suraev

BSc (Adv) (Hons) MPsych (Clinical Neuropsychology)

Telephone +61 2 9351 0746

Website Lambert Initiative for Cannabinoid Therapeutics

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Thesis work

Thesis title: Effects of cannabis-based therapy on sleep architecture, cognition, and daytime functioning in adults with insomnia disorder: a high-density electroencephalography (HdEEG) study

Supervisors: Camilla HOYOS , Ron GRUNSTEIN

Thesis abstract:

Anecdotally, Cannabis sativa is frequently reported by consumers to promote sleep. Indeed, a recent Australian survey found that sleep disorders were the fourth most indicated reason for using cannabis for medicinal reasons in a community sample of 1,700 users (Lintzeris et al., 2018). While improved sleep is one of the positive effects that cannabis users typically report, there is limited randomised, controlled trials using modern methods of electroencephalography (EEG) or polysomnography (PSG) assessing the effects of cannabis on sleep. Moreover, no study to date has examined the effects of cannabis-based therapies in people with clinician-diagnosed insomnia. The overall aims of this PhD project are two-fold: (1) to explore the effects of a commonly used cannabis-based therapy on sleep using high-quality objective measures, and (2) to identify the issues and concerns raised by the medical profession surrounding the use of medicinal cannabis in people with sleep disturbances given the steadily increasing prescribing rates for medicinal cannabis in Australia. In addition to a systematic review of the relevant literature on the effects of cannabis on sleep, a randomised, placebo-controlled, double-blinded, crossover pilot trial will be conducted using novel high-density EEG coupled with magnetic resonance imaging (MRI) to comprehensively examine and localise differences in sleep architecture and brain activation following a single dose of a cannabis-based therapy in patients with insomnia disorder. Next-day daytime cognitive function and driving ability will also be assessed. Further to this, a comprehensive survey of sleep specialists' knowledge and attitudes towards the use of medicinal cannabis for people with sleep disturbances will also be conducted. With increasing consumer interest and uptake of medicinal cannabis for a diverse range of conditions with comorbid sleep disturbances such as chronic pain and palliative care conditions in Australia, it is important that we better understand how cannabis-based therapies affect sleep and next-day function before it becomes routine clinical practice. This work will not only produce high-quality pilot data on the safety and efficacy of a commonly used cannabis-based therapy in insomnia disorder, but will also highlight key issues facing the medical profession in prescribing medicinal cannabis to patients with sleep disorders.

Awards and honours

The Brain and Mind Centre Research Excellence and Impact Award November 2018

Research Training Program (RTP) Scholarship 2018 - 2021

Vice Chancellor's Research Scholarship 2018 - 2021

Travel Award to 27th International Cannabinoid Research Society Conference, Montreal 2017

Themes

Neuroscience; Cognition; Clinical

Selected publications

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Journals

  • Clarke, D., Sarkissian, L., Todd, S., Suraev, A., Bahceci, D., Brzozowska, N., Arnold, J. (2019). Nrg1 deficiency modulates the behavioural effects of prenatal stress in mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 88, 86-95. [More Information]
  • Suraev, A., Lintzeris, N., Stuart, J., Kevin, R., Blackburn, R., Richards, E., Arnold, J., Ireland, C., Todd, L., Allsop, D., McGregor, I. (2018). Author Correction: Composition and Use of Cannabis Extracts for Childhood Epilepsy in the Australian Community. Scientific Reports, 8(1), 1-1. [More Information]
  • Suraev, A., Lintzeris, N., Stuart, J., Kevin, R., Blackburn, R., Richards, E., Arnold, J., Ireland, C., Todd, L., Allsop, D., McGregor, I. (2018). Composition and Use of Cannabis Extracts for Childhood Epilepsy in the Australian Community. Scientific Reports, 8(1), 28127. [More Information]
  • Russell, J., Maguire, S., Hunt, G., Kesby, A., Suraev, A., Stuart, J., Booth, J., McGregor, I. (2018). Intranasal oxytocin in the treatment of anorexia nervosa: Randomized controlled trial during re-feeding. Psychoneuroendocrinology, 87, 83-92. [More Information]
  • Karanges, E., Suraev, A., Elias, N., Manocha, R., McGregor, I. (2018). Knowledge and attitudes of Australian general practitioners towards medicinal cannabis: a cross-sectional survey. BMJ Open, 8(7), 1-9. [More Information]
  • Suraev, A., Todd, L., Bowen, M., Allsop, D., McGregor, I., Ireland, C., Lintzeris, N. (2017). An Australian nationwide survey on medicinal cannabis use for epilepsy: History of antiepileptic drug treatment predicts medicinal cannabis use. Epilepsy and Behavior, 70, 334-340. [More Information]
  • Hicks, C., Cornish, J., Baracz, S., Suraev, A., McGregor, I. (2016). Adolescent pre-treatment with oxytocin protects against adult methamphetamine-seeking behavior in female rats. Addiction Biology, 21(2), 304-315. [More Information]
  • Baracz, S., Parker, L., Suraev, A., Everett, N., Goodchild, A., McGregor, I., Cornish, J. (2016). Chronic Methamphetamine Self-Administration Dysregulates Oxytocin Plasma Levels and Oxytocin Receptor Fibre Density in the Nucleus Accumbens Core and Subthalamic Nucleus of the Rat. Journal of Neuroendocrinology, 28(4), 1-13. [More Information]
  • Karanges, E., Ramos, L., Dampney, B., Suraev, A., Li, K., McGregor, I., Hunt, G. (2016). Contrasting regional Fos expression in adolescent and young adult rats following acute administration of the antidepressant paroxetine. Brain Research Bulletin, 121, 246-254. [More Information]
  • Bowen, M., Hari Dass, S., Booth, J., Suraev, A., Vyas, A., McGregor, I. (2014). Active coping toward predatory stress is associated with lower corticosterone and progesterone plasma levels and decreased methylation in the medial amygdala vasopressin system. Hormones and Behavior, 66(3), 561-566. [More Information]
  • Suraev, A., Bowen, M., Ali, S., Hicks, C., Ramos, L., McGregor, I. (2014). Adolescent exposure to oxytocin, but not the selective oxytocin receptor agonist TGOT, increases social behavior and plasma oxytocin in adulthood. Hormones and Behavior, 65(5), 488-496. [More Information]
  • Johnston, J., Lintzeris, N., Allsop, D., Suraev, A., Booth, J., Carson, D., Helliwell, D., Winstock, A., McGregor, I. (2014). Lithium carbonate in the management of cannabis withdrawal: a randomized placebo-controlled trial in an inpatient setting. Psychopharmacology, 231(24), 4623-4636. [More Information]

2019

  • Clarke, D., Sarkissian, L., Todd, S., Suraev, A., Bahceci, D., Brzozowska, N., Arnold, J. (2019). Nrg1 deficiency modulates the behavioural effects of prenatal stress in mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 88, 86-95. [More Information]

2018

  • Suraev, A., Lintzeris, N., Stuart, J., Kevin, R., Blackburn, R., Richards, E., Arnold, J., Ireland, C., Todd, L., Allsop, D., McGregor, I. (2018). Author Correction: Composition and Use of Cannabis Extracts for Childhood Epilepsy in the Australian Community. Scientific Reports, 8(1), 1-1. [More Information]
  • Suraev, A., Lintzeris, N., Stuart, J., Kevin, R., Blackburn, R., Richards, E., Arnold, J., Ireland, C., Todd, L., Allsop, D., McGregor, I. (2018). Composition and Use of Cannabis Extracts for Childhood Epilepsy in the Australian Community. Scientific Reports, 8(1), 28127. [More Information]
  • Russell, J., Maguire, S., Hunt, G., Kesby, A., Suraev, A., Stuart, J., Booth, J., McGregor, I. (2018). Intranasal oxytocin in the treatment of anorexia nervosa: Randomized controlled trial during re-feeding. Psychoneuroendocrinology, 87, 83-92. [More Information]
  • Karanges, E., Suraev, A., Elias, N., Manocha, R., McGregor, I. (2018). Knowledge and attitudes of Australian general practitioners towards medicinal cannabis: a cross-sectional survey. BMJ Open, 8(7), 1-9. [More Information]

2017

  • Suraev, A., Todd, L., Bowen, M., Allsop, D., McGregor, I., Ireland, C., Lintzeris, N. (2017). An Australian nationwide survey on medicinal cannabis use for epilepsy: History of antiepileptic drug treatment predicts medicinal cannabis use. Epilepsy and Behavior, 70, 334-340. [More Information]

2016

  • Hicks, C., Cornish, J., Baracz, S., Suraev, A., McGregor, I. (2016). Adolescent pre-treatment with oxytocin protects against adult methamphetamine-seeking behavior in female rats. Addiction Biology, 21(2), 304-315. [More Information]
  • Baracz, S., Parker, L., Suraev, A., Everett, N., Goodchild, A., McGregor, I., Cornish, J. (2016). Chronic Methamphetamine Self-Administration Dysregulates Oxytocin Plasma Levels and Oxytocin Receptor Fibre Density in the Nucleus Accumbens Core and Subthalamic Nucleus of the Rat. Journal of Neuroendocrinology, 28(4), 1-13. [More Information]
  • Karanges, E., Ramos, L., Dampney, B., Suraev, A., Li, K., McGregor, I., Hunt, G. (2016). Contrasting regional Fos expression in adolescent and young adult rats following acute administration of the antidepressant paroxetine. Brain Research Bulletin, 121, 246-254. [More Information]

2014

  • Bowen, M., Hari Dass, S., Booth, J., Suraev, A., Vyas, A., McGregor, I. (2014). Active coping toward predatory stress is associated with lower corticosterone and progesterone plasma levels and decreased methylation in the medial amygdala vasopressin system. Hormones and Behavior, 66(3), 561-566. [More Information]
  • Suraev, A., Bowen, M., Ali, S., Hicks, C., Ramos, L., McGregor, I. (2014). Adolescent exposure to oxytocin, but not the selective oxytocin receptor agonist TGOT, increases social behavior and plasma oxytocin in adulthood. Hormones and Behavior, 65(5), 488-496. [More Information]
  • Johnston, J., Lintzeris, N., Allsop, D., Suraev, A., Booth, J., Carson, D., Helliwell, D., Winstock, A., McGregor, I. (2014). Lithium carbonate in the management of cannabis withdrawal: a randomized placebo-controlled trial in an inpatient setting. Psychopharmacology, 231(24), 4623-4636. [More Information]

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