Mr Christopher Harmer

PhD
Postdoctoral Research Associate

G08 - Biochemistry and Microbiology Building
The University of Sydney


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Biographical details

My work focuses on the small mobile genetic elements and plasmids that are responsible for the spread of antibiotic resistance genes in Gram negative bacteria. Over the past six years we have shown that IS26, the most common insertion sequence in Gram negative bacteria, uses a novel mechanism to move resistance genes within and between bacteria.

Current projects

How insertion sequences mobilise antibiotic resistance genes, NHMRC Project Grant 2018-2021

Associations

Member of the Australian Society for Microbiology

Treasurer, NSW-ACT State Branch, Australian Society for Microbiology

Themes

Microbiology

Selected grants

2018

  • How insertion sequences mobilize antibiotic resistance genes; Hall R, Harmer C; National Health and Medical Research Council (NHMRC)/Project Grants.

2015

  • A new mechanism for transposition of antibiotic resistance genes; Hall R, Harmer C; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Ambrose, S., Harmer, C., Hall, R. (2018). Compatibility and entry exclusion of IncA and IncC plasmids revisited: IncA and IncC plasmids are compatible. Plasmid, 96-97, 7-12. [More Information]
  • Ambrose, S., Harmer, C., Hall, R. (2018). Evolution and typing of IncC plasmids contributing to antibiotic resistance in Gram-negative bacteria. Plasmid, 99, 40-55. [More Information]
  • Harmer, C., Hall, R. (2017). Evolution in situ of ARI-A in pB2-1, a type 1 IncC plasmid recovered from Klebsiella pneumoniae, and stability of Tn4352B. Plasmid, 94, 7-14. [More Information]
  • Harmer, C., Hamidian, M., Hall, R. (2017). pIP40a, a type 1 IncC plasmid from 1969 carries the integrative element GIsul2 and a novel class II mercury resistance transposon. Plasmid, 92, 17-25. [More Information]
  • Harmer, C., Hall, R. (2017). Targeted conservative formation of cointegrates between two DNA molecules containing IS26 occurs via strand exchange at either IS end. Molecular Microbiology, 106(3), 409-418. [More Information]
  • Dentice, R., Elkins, M., Middleton, P., Bishop, J., Wark, P., Dorahy, D., Harmer, C., Hu, H., Bye, P. (2016). A randomised trial of hypertonic saline during hospitalisation for exacerbation of cystic fibrosis. Thorax, 71(2), 141-147. [More Information]
  • Harmer, C., Hamidian, M., Ambrose, S., Hall, R. (2016). Destabilization of IncA and IncC plasmids by SGI1 and SGI2 type Salmonella genomic islands. Plasmid, 87-88, 51-57. [More Information]
  • Harmer, C., Hall, R. (2016). PCR-based typing of IncC plasmids. Plasmid, 87-88, 37-42. [More Information]
  • Harmer, C., Partridge, S., Hall, R. (2016). pDGO100, a type 1 IncC plasmid from 1981 carrying ARI-A and a Tn1696-like transposon in a novel integrating element. Plasmid, 86, 38-45. [More Information]
  • Harmer, C., Holt, K., Hall, R. (2015). A type 2 A/C2 plasmid carrying the aacC4 apramycin resistance gene and the erm(42) erythromycin resistance gene recovered from two Salmonella enterica serovars. The Journal of Antimicrobial Chemotherapy, 70, 1021-1025. [More Information]
  • Harmer, C., Wynn, M., Pinto, R., Cordwell, S., Rose, B., Harbour, C., Triccas, J., Manos, J. (2015). Homogentisate 1-2-Dioxygenase Downregulation in the Chronic Persistence of Pseudomonas aeruginosa Australian Epidemic Strain-1 in the CF Lung. PloS One, 10(8), 1-13. [More Information]
  • Harmer, C., Hall, R. (2015). IS26-Mediated Precise Excision of the IS26-aphA1a Translocatable Unit. mBio, 6(6), 1-9. [More Information]
  • Anantham, S., Harmer, C., Hall, R. (2015). p39R861-4, A Type 2A/C2 Plasmid Carrying a Segment from the A/C1 Plasmid RA1. Microbial Drug Resistance: Mechanisms Epidemiology And Disease, 21(6), 571-576. [More Information]
  • Harmer, C., Hall, R. (2015). The A to Z of A/C plasmids. Plasmid, 80, 63-82. [More Information]
  • Harmer, C., Moran, R., Hall, R. (2014). Movement of IS26-Associated Antibiotic Resistance Genes Occurs via a Translocatable Unit That Includes a Single IS26 and Preferentially Inserts Adjacent to Another IS26. mBio, 5(5), 1-10. [More Information]
  • Harmer, C., Hall, R. (2014). pRMH760, a Precursor of A/C2 Plasmids Carrying blaCMY and blaNDM Genes. Microbial Drug Resistance: Mechanisms Epidemiology And Disease, 20(5), 416-423. [More Information]
  • Harmer, C., Alnassafi, K., Hu, H., Elkins, M., Bye, P., Rose, B., Cordwell, S., Triccas, J., Harbour, C., Manos, J. (2013). Modulation of gene expression by Pseudomonas aeruginosa during chronic infection in the adult cystic fibrosis lung. Microbiology, 159(11), 2354-2363. [More Information]
  • Hu, H., Harmer, C., Anuj, S., Wainwright, C., Manos, J., Cheney, J., Harbour, C., Zablotska, I., Turnbull, L., Whitchurch, C., Rose, B., et al (2013). Type 3 secretion system effector genotype and secretion phenotype of longitudinally collected Pseudomonas aeruginosa isolates from young children diagnosed with cystic fibrosis following newborn screening. Clinical Microbiology and Infection, 19(3), 266-272. [More Information]
  • Manos, J., Hu, H., Rose, B., Wainwright, C., Zablotska, I., Cheney, J., Turnbull, L., Whitchurch, C., Grimwood, K., Harmer, C., Harbour, C., et al (2013). Virulence factor expression patterns in Pseudomonas aeruginosa strains from infants with cystic fibrosis. European Journal of Clinical Microbiology and Infectious Diseases, 32(12), 1583-1592. [More Information]
  • Hare, N., Solis, N., Harmer, C., Marzook, N., Rose, B., Harbour, C., Crossett, B., Manos, J., Cordwell, S. (2012). Proteomic profiling of Pseudomonas aeruginosa AES-1R, PAO1 and PA14 reveals potential virulence determinants associated with a transmissible cystic fibrosis-associated strain. BMC Microbiology, 12(January 2012), 1-14. [More Information]
  • Harmer, C., Triccas, J., Hu, H., Rose, B., Bye, P., Elkins, M., Manos, J. (2012). Pseudomonas aeruginosa strains from the chronically infected cystic fibrosis lung display increased invasiveness of A549 epithelial cells over time. Microbial Pathogenesis, 53(1), 37-43. [More Information]
  • Fung, C., Naughton, S., Turnbull, L., Tingpej, P., Rose, B., Arthur, J., Hu, H., Harmer, C., Harbour, C., Hassett, D., Manos, J., et al (2010). Gene expression of Pseudomonas aeruginosa in a mucin-containing synthetic growth medium mimicking CF lung sputum. Journal of Medical Microbiology, 59(Pt9), 1089-1100. [More Information]

2018

  • Ambrose, S., Harmer, C., Hall, R. (2018). Compatibility and entry exclusion of IncA and IncC plasmids revisited: IncA and IncC plasmids are compatible. Plasmid, 96-97, 7-12. [More Information]
  • Ambrose, S., Harmer, C., Hall, R. (2018). Evolution and typing of IncC plasmids contributing to antibiotic resistance in Gram-negative bacteria. Plasmid, 99, 40-55. [More Information]

2017

  • Harmer, C., Hall, R. (2017). Evolution in situ of ARI-A in pB2-1, a type 1 IncC plasmid recovered from Klebsiella pneumoniae, and stability of Tn4352B. Plasmid, 94, 7-14. [More Information]
  • Harmer, C., Hamidian, M., Hall, R. (2017). pIP40a, a type 1 IncC plasmid from 1969 carries the integrative element GIsul2 and a novel class II mercury resistance transposon. Plasmid, 92, 17-25. [More Information]
  • Harmer, C., Hall, R. (2017). Targeted conservative formation of cointegrates between two DNA molecules containing IS26 occurs via strand exchange at either IS end. Molecular Microbiology, 106(3), 409-418. [More Information]

2016

  • Dentice, R., Elkins, M., Middleton, P., Bishop, J., Wark, P., Dorahy, D., Harmer, C., Hu, H., Bye, P. (2016). A randomised trial of hypertonic saline during hospitalisation for exacerbation of cystic fibrosis. Thorax, 71(2), 141-147. [More Information]
  • Harmer, C., Hamidian, M., Ambrose, S., Hall, R. (2016). Destabilization of IncA and IncC plasmids by SGI1 and SGI2 type Salmonella genomic islands. Plasmid, 87-88, 51-57. [More Information]
  • Harmer, C., Hall, R. (2016). PCR-based typing of IncC plasmids. Plasmid, 87-88, 37-42. [More Information]
  • Harmer, C., Partridge, S., Hall, R. (2016). pDGO100, a type 1 IncC plasmid from 1981 carrying ARI-A and a Tn1696-like transposon in a novel integrating element. Plasmid, 86, 38-45. [More Information]

2015

  • Harmer, C., Holt, K., Hall, R. (2015). A type 2 A/C2 plasmid carrying the aacC4 apramycin resistance gene and the erm(42) erythromycin resistance gene recovered from two Salmonella enterica serovars. The Journal of Antimicrobial Chemotherapy, 70, 1021-1025. [More Information]
  • Harmer, C., Wynn, M., Pinto, R., Cordwell, S., Rose, B., Harbour, C., Triccas, J., Manos, J. (2015). Homogentisate 1-2-Dioxygenase Downregulation in the Chronic Persistence of Pseudomonas aeruginosa Australian Epidemic Strain-1 in the CF Lung. PloS One, 10(8), 1-13. [More Information]
  • Harmer, C., Hall, R. (2015). IS26-Mediated Precise Excision of the IS26-aphA1a Translocatable Unit. mBio, 6(6), 1-9. [More Information]
  • Anantham, S., Harmer, C., Hall, R. (2015). p39R861-4, A Type 2A/C2 Plasmid Carrying a Segment from the A/C1 Plasmid RA1. Microbial Drug Resistance: Mechanisms Epidemiology And Disease, 21(6), 571-576. [More Information]
  • Harmer, C., Hall, R. (2015). The A to Z of A/C plasmids. Plasmid, 80, 63-82. [More Information]

2014

  • Harmer, C., Moran, R., Hall, R. (2014). Movement of IS26-Associated Antibiotic Resistance Genes Occurs via a Translocatable Unit That Includes a Single IS26 and Preferentially Inserts Adjacent to Another IS26. mBio, 5(5), 1-10. [More Information]
  • Harmer, C., Hall, R. (2014). pRMH760, a Precursor of A/C2 Plasmids Carrying blaCMY and blaNDM Genes. Microbial Drug Resistance: Mechanisms Epidemiology And Disease, 20(5), 416-423. [More Information]

2013

  • Harmer, C., Alnassafi, K., Hu, H., Elkins, M., Bye, P., Rose, B., Cordwell, S., Triccas, J., Harbour, C., Manos, J. (2013). Modulation of gene expression by Pseudomonas aeruginosa during chronic infection in the adult cystic fibrosis lung. Microbiology, 159(11), 2354-2363. [More Information]
  • Hu, H., Harmer, C., Anuj, S., Wainwright, C., Manos, J., Cheney, J., Harbour, C., Zablotska, I., Turnbull, L., Whitchurch, C., Rose, B., et al (2013). Type 3 secretion system effector genotype and secretion phenotype of longitudinally collected Pseudomonas aeruginosa isolates from young children diagnosed with cystic fibrosis following newborn screening. Clinical Microbiology and Infection, 19(3), 266-272. [More Information]
  • Manos, J., Hu, H., Rose, B., Wainwright, C., Zablotska, I., Cheney, J., Turnbull, L., Whitchurch, C., Grimwood, K., Harmer, C., Harbour, C., et al (2013). Virulence factor expression patterns in Pseudomonas aeruginosa strains from infants with cystic fibrosis. European Journal of Clinical Microbiology and Infectious Diseases, 32(12), 1583-1592. [More Information]

2012

  • Hare, N., Solis, N., Harmer, C., Marzook, N., Rose, B., Harbour, C., Crossett, B., Manos, J., Cordwell, S. (2012). Proteomic profiling of Pseudomonas aeruginosa AES-1R, PAO1 and PA14 reveals potential virulence determinants associated with a transmissible cystic fibrosis-associated strain. BMC Microbiology, 12(January 2012), 1-14. [More Information]
  • Harmer, C., Triccas, J., Hu, H., Rose, B., Bye, P., Elkins, M., Manos, J. (2012). Pseudomonas aeruginosa strains from the chronically infected cystic fibrosis lung display increased invasiveness of A549 epithelial cells over time. Microbial Pathogenesis, 53(1), 37-43. [More Information]

2010

  • Fung, C., Naughton, S., Turnbull, L., Tingpej, P., Rose, B., Arthur, J., Hu, H., Harmer, C., Harbour, C., Hassett, D., Manos, J., et al (2010). Gene expression of Pseudomonas aeruginosa in a mucin-containing synthetic growth medium mimicking CF lung sputum. Journal of Medical Microbiology, 59(Pt9), 1089-1100. [More Information]

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