2024

• Diaz Vegas, A., Cooke, K., Cutler, H., Yau, B., Masson, S., Harney, D., Fuller, O., Potter, M., Madsen, S., Craw, N., Zhang, Y., Moreno, C., Kebede, M., Neely, G., Stoeckli, J., Burchfield, J., James, D. (2024). Deletion of miPEP in adipocytes protects against obesity and insulin resistance by boosting muscle metabolism. Molecular Metabolism, 86. [More Information]
• Cutler, H., Madsen, S., Masson, S., Cooke, K., Potter, M., Burchfield, J., Stoeckli, J., Nelson, M., Cooney, G., James, D. (2024). Dual Tracer Test to Measure Tissue-Specific Insulin Action in Individual Mice Identifies In Vivo Insulin Resistance Without Fasting Hyperinsulinemia. Diabetes, 73(3), 359-373. [More Information]
• Yau, B., Madsen, S., Nelson, M., Cooke, K., Fritzen, A., Thorius, I., Stoeckli, J., James, D., Kebede, M. (2024). Genetics and diet shape the relationship between islet function and whole body metabolism. American Journal of Physiology - Endocrinology and Metabolism, 326(5), E663-E672. [More Information]
• Van Gerwen, J., Masson, S., Cutler, H., Diaz Vegas, A., Potter, M., Stoeckli, J., Madsen, S., Nelson, M., Humphrey, S., James, D. (2024). The genetic and dietary landscape of the muscle insulin signalling network. eLife, 12. [More Information]
• Thillainadesan, S., Jiang, B., Kebede, M., Morahan, G., James, D., Madsen, S., Hocking, S., Lambert, A., Cooke, K., Stoeckli, J., Yau, B., Masson, S., Howell, A., Potter, M., Fuller, O. (2024). The metabolic consequences of ‘yo-yo’ dieting are markedly influenced by genetic diversity. International Journal of Obesity, 48(8), 1170-1179. [More Information]

2023

• Diaz Vegas, A., Norris, D., Jall-Rogg, S., Cooke, K., Conway, O., Shun-Shion, A., Duan, X., Potter, M., Van Gerwen, J., Baird, H., Humphrey, S., James, D., Burchfield, J., et al (2023). A high-content endogenous GLUT4 trafficking assay reveals new aspects of adipocyte biology. Life Science Alliance, 6(1), 1-19. [More Information]
• Madsen, S., Nelson, M., Deshpande, V., Humphrey, S., Cooke, K., Howell, A., Diaz Vegas, A., Burchfield, J., Stoeckli, J., James, D. (2023). Deep Proteome Profiling of White Adipose Tissue Reveals Marked Conservation and Distinct Features Between Different Anatomical Depots. Molecular and Cellular Proteomics, 22(3), 100508. [More Information]
• Krishnan, K., El Hachem, E., Keller, M., Patel, S., Carroll, L., Diaz Vegas, A., Gyuricza, I., Light, C., Cao, Y., Pan, C., James, D., et al (2023). Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy. eLife, 12. [More Information]
• Krishnan, K., El Hachem, E., Keller, M., Patel, S., carroll, L., Diaz Vegas, A., Gyuricza, I., Light, C., Cao, Y., Pan, C., James, D., et al (2023). Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy. eLife. [More Information]
• Nguyen, T., Lau, A., Bier, J., Cooke, K., Lenthall, H., Ruiz-Diaz, S., Avery, D., Brigden, H., Zahra, D., Sewell, W., Williams, A., Wong, M., James, D., et al (2023). Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2. The Journal of Experimental Medicine, 220(6). [More Information]
• Masson, S., Madsen, S., Cooke, K., Potter, M., Diaz Vegas, A., Carroll, L., Thillainadesan, S., Cutler, H., Walder, K., Cooney, G., Stoeckli, J., James, D., et al (2023). Leveraging genetic diversity to identify small molecules that reverse mouse skeletal muscle insulin resistance. eLife, 12. [More Information]
• Diaz Vegas, A., Madsen, S., Cooke, K., Carroll, L., Khor, J., Turner, N., Lim, X., Astore, M., Morris, J., Don, A., James, D., Burchfield, J., et al (2023). Mitochondrial electron transport chain, ceramide, and coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle. eLife, 12. [More Information]
• Fazakerley, D., Van Gerwen, J., Cooke, K., Duan, X., Needham, E., Diaz-Vegas, A., Madsen, S., Norris, D., Shun-Shion, A., Krycer, J., Burchfield, J., Yang, P., James, D., Humphrey, S., et al (2023). Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance. Nature Communications, 14(1), 1-20. [More Information]
• Fazakerley, D., Van Gerwen, J., Cooke, K., Duan, X., Needham, E., Díaz-Vegas, A., Madsen, S., Norris, D., Shun-Shion, A., Krycer, J., Burchfield, J., Yang, P., James, D., Humphrey, S., et al (2023). Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance. Nature Communications, 14(1), 923.
• Allayee, H., Farber, C., Seldin, M., Williams, E., James, D., Lusis, A. (2023). Systems genetics approaches for understanding complex traits with relevance for human disease. eLife, 12. [More Information]

2022

• Tapsell, L., Cooney, G., Baur, L., Oscarsson, J., James, D., Simpson, S., Huang, X., Caterson, I. (2022). A Reflection on the Life of Len Storlien. Nutrition Today, 57(6), 367-368. [More Information]
• Needham, E., Hingst, J., Parker, B., Morrison, K., Yang, G., Onslev, J., Kristensen, J., Hojlund, K., Ling, N., Oakhill, J., James, D., Humphrey, S., et al (2022). Personalized phosphoproteomics identifies functional signaling. Nature Biotechnology, 40, 576-584. [More Information]
• Molendijk, J., Blazev, R., Mills, R., Ng, Y., Watt, K., Chau, D., Gregorevic, P., Crouch, P., Hilton, J., Lisowski, L., James, D., et al (2022). Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function. eLife, 11, 1-32. [More Information]
• Marzec, K., Rogers, S., McCloy, R., Parker, B., James, D., Watkins, D., Burgess, A. (2022). SILAC kinase screen identifies potential MASTL substrates. Scientific Reports, 12(1). [More Information]
• Zheng, Y., Ding, L., Meng, X., Potter, M., Kearney, A., Zhang, J., Sun, J., James, D., Yang, G., Zhou, C. (2022). Structural insights into Ras regulation by SIN1. Proceedings of the National Academy of Sciences of the United States of America, 119(19), 1-10. [More Information]
• Nelson, M., Madsen, S., Cooke, K., Fritzen, A., Thorius, I., Masson, S., carroll, L., Weiss, F., Seldin, M., Potter, M., Hocking, S., Fazakerley, D., Brandon, A., Thillainadesan, S., Senior, A., Cooney, G., Stoeckli, J., James, D. (2022). Systems-level analysis of insulin action in mouse strains provides insight into tissue- and pathway-specific interactions that drive insulin resistance. Cell Metabolism, 34(2), 227-239.e6. [More Information]
• Thillainadesan, S., Madsen, S., James, D., Hocking, S. (2022). The impact of weight cycling on health outcomes in animal models: A systematic review and meta-analysis. Obesity Reviews, 23(5), e13416-1-e13416-10. [More Information]
• Ayer, A., Fazakerley, D., James, D., Stocker, R. (2022). The role of mitochondrial reactive oxygen species in insulin resistance. Free Radical Biology and Medicine, 179, 339-362. [More Information]
• Duan, X., Norris, D., Humphrey, S., Yang, P., Cooke, K., Bultitude, W., Parker, B., Conway, O., Burchfield, J., Krycer, J., James, D., Fazakerley, D., et al (2022). Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate. Biochemical Journal, 479(11), 1237-1256. [More Information]

2021

• Burchfield, J., James, D. (2021). A co-receptor that represses beta-cell insulin action. Nature Metabolism, 3(2), 126-127. [More Information]
• Kim, T., Tang, O., Vernon, S., Kott, K., Koay, Y., Park, J., James, D., Grieve, S., Speed, T., Yang, P., Figtree, G., John, O., Yang, J. (2021). A hierarchical approach to removal of unwanted variation for large-scale metabolomics data. Nature Communications, 12(1), 4992-1-4992-10. [More Information]
• Kearney, A., Norris, D., Ghomlaghi, M., Wong, M., Humphrey, S., Carroll, L., Yang, G., Cooke, K., Yang, P., Geddes, T., James, D., Burchfield, J., et al (2021). Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis. eLife, 10, 1-32. [More Information]
• Chen, W., Tumanov, S., Fazarkeley, D., Cantley, J., James, D., Dunn, L., Shaik, T., Suarna, C., Stocker, R. (2021). Bilirubin deficiency renders mice susceptible to hepatic steatosis in the absence of insulin resistance. Redox Biology, 47, 102152. [More Information]
• Farmer, T., Xie, S., Naslavsky, N., Stoeckli, J., James, D., Caplan, S. (2021). Defining the protein and lipid constituents of tubular recycling endosomes. Journal of Biological Chemistry, 296, 100190. [More Information]
• Yang, G., Francis, D., Krycer, J., Larance, M., Zhang, Z., Novotny, C., Diaz Vegas, A., Shokat, K., James, D. (2021). Dissecting the biology of mTORC1 beyond rapamycin. Science Signaling, 14(701), eabe0161. [More Information]
• Ghomlaghi, M., Yang, G., Shin, S., James, D., Nguyen, L. (2021). Dynamic modelling of the PI3K/MTOR signalling network uncovers biphasic dependence of mTORC1 activity on the mTORC2 subunit SIN1. PLoS Computational Biology, 17(9), e1008513. [More Information]
• Ayer, A., Fazakerley, D., Suarna, C., Maghzal, G., Sheipouri, D., Lee, K., Bradley, M., Fernández-del-Rio, L., Tumanov, S., Kong, S., James, D., Stocker, R., et al (2021). Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q. Redox Biology, 46, 102127. [More Information]
• Francis, D., Ghazanfar, S., Havula, E., Krycer, J., Strbenac, D., Senior, A., Minard, A., Geddes, T., Nelson, M., Weiss, F., Stoeckli, J., Yang, J., James, D. (2021). Genome-wide analysis in Drosophila reveals diet-by-gene interactions and uncovers diet-responsive genes. G3: Genes, Genomes, Genetics, 11(10), jkab171. [More Information]
• Recasens, A., Humphrey, S., Ellis, M., Hoque, M., Abbassi, R., Chen, B., Longworth, M., Needham, E., James, D., Johns, T., Kassiou, M., Yang, P., Munoz, L., et al (2021). Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells. Cell Death Discovery, 7(1), 81. [More Information]
• James, D., Thorens, B. (2021). Mike Mueckler (1953–2021): The father of the mammalian SLC2 Glucose transporter family. American Journal of Physiology - Endocrinology and Metabolism, 321(4), E490-E492. [More Information]
• Le Couteur, D., Solon-Biet, S., Parker, B., Pulpitel, T., Brandon, A., Hunt, N., Wali, J., Gokarn, R., Senior, A., Cooney, G., Raubenheimer, D., James, D., Simpson, S., et al (2021). Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol, and rapamycin. Cell Metabolism, 33(12), 2367-2379.e4. [More Information]
• Kim, H., Kim, T., Hoffman, N., Xiao, D., James, D., Humphrey, S., Yang, P. (2021). PhosR enables processing and functional analysis of phosphoproteomic data. Cell Reports, 34(8), 108771-1-108771-23. [More Information]
• Bishay, R., Tonks, K., George, J., Samocha-Bonet, D., Meyerowitz-Katz, G., Chisholm, D., James, D., Greenfield, J. (2021). Plasma Bile Acids More Closely Align With Insulin Resistance, Visceral and Hepatic Adiposity Than Total Adiposity. Journal of Clinical Endocrinology and Metabolism, 106(3), e1131-e1139. [More Information]
• Yau, B., Naghiloo, S., Diaz Vegas, A., Carr, A., Van Gerwen, J., Needham, E., Jevon, D., Chen, S., Hoehn, K., Brandon, A., Macia, L., Cooney, G., Thorn, P., Larance, M., James, D., Humphrey, S., Kebede, M., et al (2021). Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet. iScience, 24(10), 103099. [More Information]
• Harney, D., Cielesh, M., Chu, R., Cooke, K., James, D., Stoeckli, J., Larance, M. (2021). Proteomics analysis of adipose depots after intermittent fasting reveals visceral fat preservation mechanisms. Cell Reports, 34(9), 108804. [More Information]
• Norris, D., Yang, P., Shin, S., Kearney, A., Kim, H., Geddes, T., Senior, A., Fazakerley, D., Nguyen, L., James, D., Burchfield, J. (2021). Signaling Heterogeneity is Defined by Pathway Architecture and Intercellular Variability in Protein Expression. iScience, 24(2), 102118. [More Information]
• James, D., Stoeckli, J., Birnbaum, M. (2021). The aetiology and molecular landscape of insulin resistance. Nature Reviews Molecular Cell Biology, 22(11), 751-771. [More Information]

2020

• Zhang, Z., Li, W., Yang, G., Lu, X., Qi, X., Wang, S., Cao, C., Zhang, P., Ren, J., Zhao, J., Burchfield, J., James, D., et al (2020). CASK modulates the assembly and function of the Mint1/Munc18-1 complex to regulate insulin secretion. Cell Discovery, 6(1), 1-17. [More Information]
• Li, M., Parker, B., Pearson, E., Hunter, B., Cao, J., Koay, Y., Guneratne, O., James, D., Yang, J., Lal, S., O'Sullivan, J. (2020). Core functional nodes and sex-specific pathways in human ischaemic and dilated cardiomyopathy. Nature Communications, 11(1), 2843. [More Information]
• Quek, L., Krycer, J., Ohno, S., Yugi, K., Fazakerley, D., Scalzo, R., Elkington, S., Dai, Z., Hirayama, A., Ikeda, S., James, D., et al (2020). Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin. iScience, 23(2), 1-20. [More Information]
• Knudsen, J., Fritzen, A., James, D., Jensen, T., Kleinert, M., Richter, E. (2020). Growth Factor-Dependent and -Independent Activation of mTORC2. Trends in Endocrinology and Metabolism, 31(1), 13-24. [More Information]
• Krycer, J., Quek, L., Francis, D., Zadoorian, A., Weiss, F., Cooke, K., Nelson, M., Diaz Vegas, A., Humphrey, S., Scalzo, R., Varney, B., Nagarajan, S., Hoy, A., Cooney, G., Fazakerley, D., James, D., et al (2020). Insulin signaling requires glucose to promote lipid anabolism in adipocytes. Journal of Biological Chemistry, 295(38), 13250-13266. [More Information]
• Ohno, S., Quek, L., Krycer, J., Yugi, K., Hirayama, A., Ikeda, S., Shoji, F., Suzuki, K., Soga, T., James, D., et al (2020). Kinetic Trans-omic Analysis Reveals Key Regulatory Mechanisms for Insulin-Regulated Glucose Metabolism in Adipocytes. iScience, 23(9), 1-45. [More Information]
• Krycer, J., Quek, L., Francis, D., Fazakerley, D., Elkington, S., Diaz Vegas, A., Cooke, K., Weiss, F., Duan, X., Kurdyukov, S., Cooney, G., James, D., et al (2020). Lactate production is a prioritized feature of adipocyte metabolism. Journal of Biological Chemistry, 295(1), 83-98. [More Information]
• Krycer, J., Elkington, S., Diaz Vegas, A., Cooke, K., Burchfield, J., Fisher-Wellman, K., Cooney, G., Fazakerley, D., James, D. (2020). Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes. Journal of Biological Chemistry, 295(1), 99-110. [More Information]
• Wang, K., Lin, Y., Lai, M., Su, Z., Oyston, L., Clark, T., Park, S., Khuong, T., Lau, M., Shenton, V., James, D., Simpson, S., Neely, G., et al (2020). PGC1-alpha Controls Sucrose Taste Sensitization in Drosophila. Cell Reports, 31(1), 1-15. [More Information]
• Parker, B., Kiens, B., Wojtaszewski, J., Richter, E., James, D. (2020). Quantification of exercise-regulated ubiquitin signaling in human skeletal muscle identifies protein modification cross talk via NEDDylation. The FASEB Journal, 34(4), 5906-5916. [More Information]

2019

• Francis, D., Krycer, J., Cooney, G., James, D. (2019). A modified gas-trapping method for high-throughput metabolic experiments in Drosophila melanogaster. BioTechniques, 67(3), 123-125. [More Information]
• Stoeckli, J., Zadoorian, A., Cooke, K., Deshpande, V., Yau, B., Kebede, M., Humphrey, S., James, D. (2019). ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation. Molecular Metabolism, 25, 83-94. [More Information]
• Parker, B., Calkin, A., Seldin, M., Keating, M., Tarling, E., Yang, P., Moody, S., Liu, Y., Zerenturk, E., Needham, E., James, D., et al (2019). An integrative systems genetic analysis of mammalian lipid metabolism. Nature, 567(7747), 187-193. [More Information]
• Mills, R., Parker, B., Monnot, P., Needham, E., Vivien, C., Ferguson, C., Parton, R., James, D., Porrello, E., Hudson, J. (2019). Development of a human skeletal micro muscle platform with pacing capabilities. Biomaterials, 198, 217-227. [More Information]
• Cantley, J., Davenport, A., Vetterli, L., Nemes, N., Whitworth, P., Boslem, E., Thai, L., Mellett, N., Meikle, P., James, D., et al (2019). Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass. Diabetologia, 62(1), 99-111. [More Information]
• Mills, R., Parker, B., Quaife-Ryan, G., Voges, H., Needham, E., Bornot, A., Ding, M., Andersson, H., Polla, M., Elliott, D., James, D., et al (2019). Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway. Cell Stem Cell, 24(6), 895-907. [More Information]
• Su, Z., Burchfield, J., Yang, P., Humphrey, S., Yang, G., Francis, D., Yasmin, S., Shin, S., Norris, D., Kearney, A., Astore, M., Scavuzzo, J., Wang, Q., Parker, B., Neely, G., Vafaee, F., Chiu, J., Yeo, R., Hogg, P., Fazakerley, D., Kuyucak, S., James, D., et al (2019). Global redox proteome and phosphoproteome analysis reveals redox switch in Akt. Nature Communications, 10(1), 1-18. [More Information]
• Needham, E., Parker, B., Burykin, T., James, D., Humphrey, S. (2019). Illuminating the dark phosphoproteome. Science Signaling, 12(565), 1-18. [More Information]
• Fazakerley, D., Fritzen, A., Nelson, M., Thorius, I., Cooke, K., Humphrey, S., Cooney, G., James, D. (2019). Insulin Tolerance Test under Anaesthesia to Measure Tissue-specific Insulin-stimulated Glucose Disposal. Bio-protocol, 9(2), 1-13. [More Information]
• Yang, P., Humphrey, S., Cinghu, S., Pathania, R., Oldfield, A., Kumar, D., Perera, D., Yang, J., James, D., Mann, M., et al (2019). Multi-omic profiling reveals dynamics of the phased progression of pluripotency. Cell Systems. [More Information]
• Fazakerley, D., Krycer, J., Kearney, A., Hocking, S., James, D. (2019). Muscle and adipose tissue insulin resistance: malady without mechanism? Journal of Lipid Research, 60(10), 1720-1732. [More Information]
• Needham, E., Humphrey, S., Cooke, K., Fazakerley, D., Duan, X., Parker, B., James, D. (2019). Phosphoproteomics of Acute Cell Stressors Targeting Exercise Signaling Networks Reveal Drug Interactions Regulating Protein Secretion. Cell Reports, 29(6), 1524-1538.e6. [More Information]
• Nelson, M., Parker, B., Burchfield, J., Hoffman, N., Needham, E., Cooke, K., Naim, T., Sylow, L., Ling, N., Francis, D., Norris, D., Chaudhuri, R., Stoeckli, J., James, D., et al (2019). Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry. EMBO Journal, 38(24), 1-20. [More Information]
• Brandon, A., Liao, B., Diakanastasis, B., Parker, B., Kaddatz, K., McManus, S., O'Reilly, L., Kimber, E., van der Kraan, A., Hancock, D., Cooney, G., James, D., et al (2019). Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance. Cell Metabolism, 29(1), 183-191. [More Information]
• Harney, D., Hutchison, A., Hatchwell, L., Humphrey, S., James, D., Hocking, S., Heilbronn, L., Larance, M. (2019). Proteomic Analysis of Human Plasma during Intermittent Fasting. Journal of Proteome Research, 18(5), 2228-2240. [More Information]
• Yang, G., Humphrey, S., Murashige, D., Francis, D., Wang, Q., Cooke, K., Neely, G., James, D. (2019). RagC phosphorylation autoregulates mTOR complex 1. EMBO Journal, 38(3), 1-10. [More Information]
• Yugi, K., Ohno, S., Krycer, J., James, D., Kuroda, S. (2019). Rate-oriented trans-omics: integration of multiple omic data on the basis of reaction kinetics. Current Opinion in Systems Biology, 15, 109-120. [More Information]
• Small, L., Brandon, A., Parker, B., Deshpande, V., Samsudeen, A., Kowalski, G., Reznick, J., Wilks, D., Preston, E., Bruce, C., James, D., Cooney, G., et al (2019). Reduced insulin action in muscle of high fat diet rats over the diurnal cycle is not associated with defective insulin signaling. Molecular Metabolism, 25, 107-118. [More Information]
• Kearney, A., Cooke, K., Norris, D., Zadoorian, A., Krycer, J., Fazakerley, D., Burchfield, J., James, D. (2019). Serine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytes. Journal of Biological Chemistry, 294(45), 16729-16739. [More Information]
• Harney, D., Hutchison, A., Su, Z., Hatchwell, L., Heilbronn, L., Hocking, S., James, D., Larance, M. (2019). Small-protein enrichment assay enables the rapid, unbiased analysis of over 100 low abundance factors from human plasma. Molecular and Cellular Proteomics, 18(9), 1899-1915. [More Information]
• Jiménez de Oya, N., Esler, W., Huard, K., El-Kattan, A., Karamanlidis, G., Blázquez, A., Ramos-Ibeas, P., Escribano-Romero, E., Louloudes-Lázaro, A., Casas, J., James, D., et al (2019). Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models. Emerging Microbes and Infections, 8(1), 624-636. [More Information]
• Klip, A., McGraw, T., James, D. (2019). Thirty sweet years of GLUT4. Journal of Biological Chemistry, 294(30), 11369-11381. [More Information]

2018

• Krycer, J., Diskin, C., Nelson, M., Zeng, X., Fazakerley, D., James, D. (2018). A gas trapping method for high-throughput metabolic experiments. BioTechniques, 64(1), 27-29. [More Information]
• Small, L., Brandon, A., Quek, L., Krycer, J., James, D., Turner, N., Cooney, G. (2018). Acute activation of pyruvate dehydrogenase increases glucose oxidation in muscle without changing glucose uptake. American Journal of Physiology - Endocrinology and Metabolism, 315(2), E258-E266. [More Information]
• Hingst, J., Bruhn, L., Hansen, M., Rosschou, M., Birk, J., Fentz, J., Foretz, M., Viollet, B., Sakamoto, K., Faergeman, N., Parker, B., James, D., et al (2018). Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle. Molecular Metabolism, 16, 24-34. [More Information]
• Whitham, M., Parker, B., Friedrichsen, M., Hingst, J., Hjorth, M., Hughes, W., Egan, C., Cron, L., Watt, K., Kuchel, R., James, D., et al (2018). Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise. Cell Metabolism, 27(1), 237-251. [More Information]
• Norris, D., Geddes, T., James, D., Fazakerley, D., Burchfield, J. (2018). Glucose transport: Methods for interrogating GLUT4 trafficking in adipocytes. Methods in Molecular Biology, 1713, 193-215. [More Information]
• Burchfield, J., Kebede, M., Meoli, C., Stoeckli, J., Whitworth, P., Wright, A., Hoffman, N., Minard, A., Ma, X., Krycer, J., Nelson, M., Yau, B., Cooke, K., Cooney, G., James, D., Fazakerley, D., et al (2018). High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice. Journal of Biological Chemistry, 293(15), 5731-5745. [More Information]
• Humphrey, S., Karayel, O., James, D., Mann, M. (2018). High-throughput and high-sensitivity phosphoproteomics with the EasyPhos platform. Nature Protocols, 13(9), 1897-1916. [More Information]
• Rogers, S., McCloy, R., Parker, B., Gallego-Ortega, D., Law, A., Chin, V., Conway, J., Fey, D., Millar, E., O'Toole, S., Cesare, A., James, D., Burgess, A., et al (2018). MASTL overexpression promotes chromosome instability and metastasis in breast cancer. Oncogene, 37(33), 4518-4533. [More Information]
• Duan, X., Krycer, J., Cooke, K., Yang, G., James, D., Fazakerley, D. (2018). Membrane Topology of Trafficking Regulator of GLUT4 1 (TRARG1). Biochemistry, 57(26), 3606-3615. [More Information]
• Fazakerley, D., Chaudhuri, R., Yang, P., Maghazal, G., Cooke, K., Krycer, J., Humphrey, S., Parker, B., Fisher-Wellman, K., Meoli, C., Hoffman, N., Diskin, C., Burchfield, J., Yang, J., James, D., et al (2018). Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance. eLife, 7(Article number e32111), 1-38. [More Information]
• Fazakerley, D., Minard, A., Krycer, J., Cooke, K., Stoeckli, J., Harney, D., Burchfield, J., Maghzal, G., Caldwell, S., Hartley, R., James, D., et al (2018). Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation. Journal of Biological Chemistry, 293(19), 7315-7328. [More Information]
• Kleinert, M., Parker, B., Jensen, T., Raun, S., Pham, P., Han, X., James, D., Richter, E., Sylow, L. (2018). Quantitative proteomic characterization of cellular pathways associated with altered insulin sensitivity in skeletal muscle following high-fat diet feeding and exercise training. Scientific Reports, 8(1), 1-11. [More Information]
• Su, Z., Deshpande, V., James, D., Stoeckli, J. (2018). Tankyrase modulates insulin sensitivity in skeletal muscle cells by regulating the stability of GLUT4 vesicle proteins. Journal of Biological Chemistry, 293(22), 8578-8587. [More Information]
• Chaudhuri, R., Krycer, J., Fazakerley, D., Fisher-Wellman, K., Su, Z., Hoehn, K., Yang, J., Kuncic, Z., Vafaee, F., James, D. (2018). The transcriptional response to oxidative stress is part of, but not sufcient for, insulin resistance in adipocytes. Scientific Reports, 8(1), 1-15. [More Information]

2017

• Norris, D., Yang, P., Krycer, J., Fazakerley, D., James, D., Burchfield, J. (2017). An improved Akt reporter reveals intra- and inter-cellular heterogeneity and oscillations in signal transduction. Journal of Cell Science, 130, 2757-2766. [More Information]
• Krycer, J., Fisher-Wellman, K., Fazakerley, D., Muoio, D., James, D. (2017). Bicarbonate alters cellular responses in respiration assays. Biochemical and Biophysical Research Communications, 489, 399-403. [More Information]
• Krycer, J., Yugi, K., Hirayama, A., Fazakerley, D., Quek, L., Scalzo, R., Ohno, S., Hodson, M., Ikeda, S., Shoji, F., Domanova, W., Parker, B., Nelson, M., Humphrey, S., Cooney, G., James, D., et al (2017). Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism. Cell Reports, 21(12), 3536-3547. [More Information]
• Mills, R., Titmarsh, D., Koenig, X., Parker, B., Ryall, J., Quaife-Ryan, G., Voges, H., Hodgson, M., Ferguson, C., Drowley, L., Needham, E., James, D., et al (2017). Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Proceedings of the National Academy of Sciences of the United States of America, 114(40), E8372-E8381. [More Information]
• Nelson, M., Lahiri, S., Chow, J., Byrne, F., Hargett, S., Breen, D., Olzomer, E., Wu, L., Cooney, G., Turner, N., James, D., et al (2017). Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival. Nature Communications, 8, 1-11. [More Information]
• Kleinert, M., Parker, B., Fritzen, A., Knudsen, J., Jensen, T., Kjøbsted, R., Sylow, L., Ruegg, M., James, D., Richter, E. (2017). Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice. Journal of Physiology, 595(14), 4845-4855. [More Information]
• Stoeckli, J., Fisher-Wellman, K., Chaudhuri, R., Zeng, X., Fazakerley, D., Meoli, C., Cooke, K., Hoffman, N., Mangiafico, S., Xirouchaki, C., Cooney, G., James, D., et al (2017). Metabolomic analysis of insulin resistance across different mouse strains and diets. Journal of Biological Chemistry, 292(47), 19135-19145. [More Information]
• Parker, B., Burchfield, J., Clayton, D., Geddes, T., Payne, R., Kiens, B., Wojtaszewski, J., Richter, E., James, D. (2017). Multiplexed temporal quantification of the exercise-regulated plasma peptidome. Molecular and Cellular Proteomics, 16(12), 2055-2068. [More Information]
• Krycer, J., Fazakerley, D., Cater, R., Cooke, K., Naghiloo, S., Burchfield, J., Humphrey, S., Vandenberg, R., Ryan, R., James, D. (2017). The amino acid transporter SLC1A3 is plasma membrane-localised in adipocytes and its activity is insensitive to insulin. FEBS Letters, 591(2), 322-330. [More Information]
• Simpson, S., Le Couteur, D., James, D., George, J., Gunton, J., Solon-Biet, S., Raubenheimer, D. (2017). The Geometric Framework for Nutrition as a tool in precision medicine. Nutrition and Healthy Aging, 4(3), 217-226. [More Information]

2016

• Schoenwaelder, S., Darbousset, R., Cranmer, S., Ramshaw, H., Orive, S., Sturgeon, S., Yuan, Y., Yao, Y., Krycer, J., Woodcock, J., Maclean, J., James, D., Jackson, S., et al (2016). 14-3-3z regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Nature Communications, 7, 1-15. [More Information]
• Li, Z., Schulze, R., Weller, S., Krueger, E., Schott, M., Zhang, X., Casey, C., Liu, J., Stoeckli, J., James, D., et al (2016). A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets. Science Advances, 2(12), 1-16. [More Information]
• Wu, L., Levina, A., Harris, H., Cai, Z., Lai, B., Vogt, S., James, D., Lay, P. (2016). Carcinogenic chromium(VI) compounds formed by intracellular oxidation of chromium(III) dietary supplements by adipocytes. Angewandte Chemie - International Edition, 55(5), 1742-1745. [More Information]
• Solon-Biet, S., Cogger, V., Pulpitel, T., Heblinski, M., Wahl, D., McMahon, A., Warren, A., Durrant-Whyte, J., Walters, K., Krycer, J., Ponton, F., Gokarn, R., Wali, J., Conigrave, A., James, D., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2016). Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework. Cell Metabolism, 24(4), 555-565. [More Information]
• Minard, A., Wong, M., Chaudhuri, R., Tan, S., Humphrey, S., Parker, B., Yang, J., Laybutt, D., Cooney, G., Coster, A., Stoeckli, J., James, D. (2016). Hyperactivation of the Insulin Signaling Pathway Improves Intracellular Proteostasis by Coordinately Up-regulating the Proteostatic Machinery in Adipocytes. Journal of Biological Chemistry, 291(49), 25629-25640. [More Information]
• Davey, J., Watt, K., Parker, B., Chaudhuri, R., Ryall, J., Cunningham, L., Qian, H., Sartorelli, V., Sandri, M., Chamberlain, J., James, D., et al (2016). Integrated expression analysis of muscle hypertrophy identifies Asb2 as a negative regulator of muscle mass. JCI Insight, 1(5), 1-15. [More Information]
• Yang, P., Patrick, E., Humphrey, S., Ghazanfar, S., James, D., Jothi, R., Yang, J. (2016). KinasePA: Phosphoproteomics data annotation using hypothesis driven kinase perturbation analysis. Proteomics, 16(13), 1868-1871. [More Information]
• Ohno,, S., Krycer, J., Yugi,, K., Quek, L., Hirayama,, A., Soga,, T., Kuroda,, S., James, D. (2016). Metabolic flux analysis in insulin-stimulated adipocytes form temporal patterns of intracellular metabolome data. Metabolic Engineering 11, : Institute of Electrical and Electronics Engineers Inc.
• Brandon, A., Stuart, E., Leslie, S., Hoehn, K., James, D., Kraegen, E., Turner, N., Cooney, G. (2016). Minimal impact of age and housing temperature on the metabolic phenotype of Acc2K/K mice. Journal of Endocrinology, 228(3), 127-134. [More Information]
• Minard, A., Tan, S., Yang, P., Fazakerley, D., Domanova, W., Parker, B., Humphrey, S., Jothi, R., Stoeckli, J., James, D. (2016). mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes. Cell Reports, 17(1), 29-36. [More Information]
• Kleinert, M., Parker, B., Chaudhuri, R., Fazakerley, D., Serup, A., Cooke, K., Krycer, J., Sylow Hansen, L., Fritzen, A., Hoffman, N., James, D., et al (2016). mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3. Molecular Metabolism, 5(8), 646-655. [More Information]
• Vafaee, F., Krycer, J., Ma, X., Burykin, T., James, D., Kuncic, Z. (2016). ORTI: An Open-Access Repository of Transcriptional Interactions for Interrogating Mammalian Gene Expression Data. PloS One, 11(10), 1-21. [More Information]
• Yang, P., Humphrey, S., James, D., Yang, J., Jothi, R. (2016). Positive-unlabeled ensemble learning for kinase substrate prediction from dynamic phosphoproteomics data. Bioinformatics, 32(2), 252-259. [More Information]
• Rogers, S., Fey, D., McCloy, R., Parker, B., Mitchell, N., Payne, R., Daly, R., James, D., Caldon, C., Watkins, D., et al (2016). PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells. Journal of Cell Science, 129(7), 1340-1354. [More Information]
• Stoeckli, J., Piper, R., James, D. (2016). Regulated versus Constitutive Secretion - A Major Form of Intercellular Communication. In Not known (Eds.), Encyclopedia of Cell Biology, (pp. 376-383). TBC. [More Information]
• Tonks, K., Coster, A., Christopher, M., Chaudhuri, R., Xu, A., Gagnon-Bartsch, J., Chisholm, D., James, D., Meikle, P., Greenfield, J., et al (2016). Skeletal Muscle and Plasma Lipidomic Signatures of Insulin Resistance and Overweight/Obesity in Humans. Obesity, 24(4), 908-916. [More Information]
• Parker, B., Thaysen-Andersen, M., Fazakerley, D., Holliday, M., Packer, N., James, D. (2016). Terminal Galactosylation and Sialylation Switching on Membrane Glycoproteins upon TNF-Alpha-Induced Insulin Resistance in Adipocytes. Molecular and Cellular Proteomics, 15(1), 141-153. [More Information]
• Domanova, W., Krycer, J., Chaudhuri, R., Yang, P., Vafaee, F., Fazakerley, D., Humphrey, S., James, D., Kuncic, Z. (2016). Unraveling Kinase Activation Dynamics Using Kinase-Substrate Relationships from Temporal Large-Scale Phosphoproteomics Studies. PloS One, 11(6), 1-14. [More Information]

2015

• Wong, M., Krycer, J., Burchfield, J., James, D., Kuncic, Z. (2015). A generalised enzyme kinetic model for predicting the behaviour of complex biochemical systems. FEBS Open Bio, 5, 226-239. [More Information]
• Yang, G., Murashige, D., Humphrey, S., James, D. (2015). A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation. Cell Reports, 12(6), 937-943. [More Information]
• Lee, J., Walsh, M., Hoehn, K., James, D., Wherry, E., Choi, Y. (2015). Acetyl CoA Carboxylase 2 Is Dispensable for CD8+ T Cell Responses. PloS One, 10(9), 1-9. [More Information]
• Kee, A., Yang, L., Lucas, C., Greenberg, M., Martel, N., Leong, G., Hughes, W., Cooney, G., James, D., Ostap, M., et al (2015). An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake. Traffic, 16(7), 691-711. [More Information]
• Ma, X., Lee, P., Chisholm, D., James, D. (2015). Control of adipocyte differentiation in different fat depots; Implications for pathophysiology or therapy. Frontiers in Endocrinology, 6, 1-8. [More Information]
• Chaudhuri, R., Khoo, P., Tonks, K., Junutula, J., Kolumam, G., Modrusan, Z., Samocha-Bonet, D., Meoli, C., Hocking, S., Fazakerley, D., Stoeckli, J., Yang, J., James, D., et al (2015). Cross-species gene expression analysis identifies a novel set of genes implicated in human insulin sensitivity. Npj Systems Biology And Applications, 1, 1-10. [More Information]
• Rogers, S., McCloy, R., Parker, B., Chaudhuri, R., Gayevskiy, V., Hoffman, N., Watkins, D., Daly, R., James, D., Burgess, A. (2015). Dataset from the global phosphoproteomic mapping of early mitotic exit in human cells. Data in Brief, 5, 45-52. [More Information]
• Hoffman, N., Parker, B., Chaudhuri, R., Fisher-Wellman, K., Kleinert, M., Humphrey, S., Yang, P., Holliday, M., Trefely, S., Fazakerley, D., Stoeckli, J., Burchfield, J., James, D., et al (2015). Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates. Cell Metabolism, 22(5), 922-935. [More Information]
• McCloy, R., Parker, B., Rogers, S., Chaudhuri, R., Gayevskiy, V., Hoffman, N., Ali, N., Watkins, N., Daly, R., James, D., et al (2015). Global Phosphoproteomic Mapping of Early Mitotic Exit in Human Cells Identifies Novel Substrate Dephosphorylation Motifs. Molecular and Cellular Proteomics, 14(8), 2194-2212. [More Information]
• Trefely, S., Khoo, P., Krycer, J., Chaudhuri, R., Fazakerley, D., Parker, B., Sultani, G., Lee, J., Stephan, J., Torres, E., James, D., Stoeckli, J., et al (2015). Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/IGF-1 Signalling Pathway. Journal of Biological Chemistry, 290(43), 25834-25846. [More Information]
• Phua, Y., Nguyen, A., Roden, D., Elsworth, B., Deng, N., Nikolic, I., Yang, J., McFarland, A., Russell, R., Kaplan, W., O'Toole, S., James, D., et al (2015). MicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor gene. Breast Cancer Research, 17(1), 1-18. [More Information]
• Chaudhuri, R., Sadrieh, A., Hoffman, N., Parker, B., Humphrey, S., Stoeckli, J., Hill, A., James, D., Yang, J. (2015). PhosphOrtholog: a web-based tool for cross-species mapping of orthologous protein post-translational modification. BMC Genomics, 16(1), 1-14. [More Information]
• Humphrey, S., James, D., Mann, M. (2015). Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation. Trends in Endocrinology and Metabolism, 26(12), 676-687. [More Information]
• Fazakerley, D., Naghiloo, S., Chaudhuri, R., Koumanov, F., Burchfield, J., Cooke, K., Krycer, J., Prior, M., Parker, B., Murrow, B., Stoeckli, J., Meoli, C., James, D., et al (2015). Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumour Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes. Journal of Biological Chemistry, 290(39), 23528-23542. [More Information]
• Tan, S., Fisher_Wellman, K., Fazakerley, D., Ng, Y., Pant, H., Li, J., Meoli, C., Coster, A., Stoeckli, J., James, D. (2015). Selective insulin resistance in adipocytes. Journal of Biological Chemistry, 290(18), 11337-11348. [More Information]
• Ma, D., Stolte, C., Krycer, J., James, D., O'Donoghue, S. (2015). SnapShot: Insulin/IGF1 Signaling. Cell, 161(4), 948-948. [More Information]
• Hocking, S., Stewart, R., Brandon, A., Suryana, E., Stuart, E., Baldwin, E., Kolumam, G., Modrusan, Z., Junutula, J., Gunton, J., James, D., et al (2015). Subcutaneous fat transplantation alleviates diet-induced glucose intolerance and inflammation in mice. Diabetologia, 58(7), 1587-1600. [More Information]
• Parker, B., Yang, G., Humphrey, S., Chaudhuri, R., Ma, X., Peterman, S., James, D. (2015). Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry. Science Signaling, 8(380), 1-8. [More Information]
• Stoeckli, J., Meoli, C., Hoffman, N., Fazakerley, D., Pant, H., Cleasby, M., Ma, X., Kleinert, M., Brandon, A., Lopez, J., James, D., et al (2015). The RabGAP TBC1D1 Plays a Central Role in Exercise-Regulated Glucose Metabolism in Skeletal Muscle. Diabetes, 64(6), 1914-1922. [More Information]

2014

• Kleinert, M., Sylow Hansen, L., Fazakerley, D., Krycer, J., Thomas, K., Oxbøll, A., Jordy, A., Jensen, T., Yang, G., Schjerling, P., James, D., et al (2014). Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo. Molecular Metabolism, 3(6), 630-641. [More Information]
• Yang, P., Patrick, E., Tan, S., Fazakerley, D., Burchfield, J., Gribben, C., Prior, M., James, D., Yang, J. (2014). Direction pathway analysis of large-scale proteomics data reveals novel features of the insulin action pathway. Bioinformatics, 30(6), 808-814. [More Information]
• Li, J., Cantley, J., Burchfield, J., Meoli, C., Stockli, J., Whitworth, P., Pant, H., Chaudhuri, R., Groffen, A., Verhage, M., James, D. (2014). DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake. Diabetologia, 57(10), 2173-2182. [More Information]
• Chow, J., Lawrence, R., Healy, M., Dominy, J., Liao, J., Breen, D., Byrne, F., Kenwood, B., Lackner, C., James, D., et al (2014). Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation. Molecular Metabolism, 3(4), 419-431. [More Information]
• Wu, L., Samocha-Bonet, D., Whitworth, P., Fazakerley, D., Turner, N., Biden, T., James, D., Cantley, J. (2014). Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity. Molecular Metabolism, 3(4), 465-473. [More Information]
• Ma, X., Yang, P., Kaplan, W., Lee, B., Wu, L., Yang, J., Yasunaga, M., Sato, K., Chisholm, D., James, D. (2014). ISL1 Regulates Peroxisome Proliferator-Activated Receptor gamma Activation and Early Adipogenesis via Bone Morphogenetic Protein 4-Dependent and -Independent Mechanisms. Molecular and Cellular Biology, 34(19), 3607-3617. [More Information]
• Taddeo, E., Laker, R., Breen, D., Akhtar, Y., Kenwood, B., Liao, J., Zhang, M., Fazakerley, D., Tomsig, J., Harris, T., James, D., et al (2014). Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle. Molecular Metabolism, 3(2), 124-134. [More Information]
• Lee, J., Walsh, M., Hoehn, K., James, D., Wherry, E., Choi, Y. (2014). Regulator of Fatty Acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity. Journal of Immunology, 192(7), 3190-3199. [More Information]
• Parker, B., Shepherd, N., Trefely, S., Hoffman, N., White, M., Engholm-Keller, K., Hambly, B., Larsen, M., James, D., Cordwell, S. (2014). Structural Basis for Phosphorylation and Lysine Acetylation Cross-talk in a Kinase Motif Associated with Myocardial Ischemia and Cardioprotection. Journal of Biological Chemistry, 289(37), 25890-25906. [More Information]
• Wu, L., Meoli, C., Mangiafico, S., Fazakerley, D., Cogger, V., Mohamad, M., Pant, H., Kang, M., Powter, E., Burchfield, J., Gamble, J., Le Couteur, D., James, D., et al (2014). Systemic VEGF-A Neutralization Ameliorates Diet-Induced Metabolic Dysfunction. Diabetes, 63(8), 2656-2667. [More Information]
• Fletcher, R., Gribben, C., Ma, X., Burchfield, J., Thomas, K., Krycer, J., James, D., Fazakerley, D. (2014). The Role of the Niemann-Pick Disease, Type C1 Protein in Adipocyte Insulin Action. PloS One, 9(4), 1-10. [More Information]

2013

• Iseli, T., Turner, N., Zeng, X., Cooney, G., Kraegen, E., Yao, S., Ye, Y., James, D., Ye, J. (2013). Activation of AMPK by Bitter Melon Triterpenoids Involves CaMKKbeta. PloS One, 8(4), 1-9. [More Information]
• Yu, H., Rathore, S., Lopez, J., Davis, E., James, D., Martin, J., Shen, J. (2013). Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins. Proceedings of the National Academy of Sciences of the United States of America, 110(35), E3271-E3280. [More Information]
• Humphrey, S., Yang, G., Yang, P., Fazakerley, D., Stockli, J., Yang, J., James, D. (2013). Dynamic adipocyte phosphoproteome reveals that akt directly regulates mTORC2. Cell Metabolism, 17(6), 1009-1020. [More Information]
• Shewan, A., McCann, R., Lamb, C., Stirrat, L., Kioumourtzoglou, D., Adamson, I., Verma, S., James, D., Bryant, N. (2013). Endosomal sorting of GLUT4 and Gap1 is conserved between yeast and insulin-sensitive cells. Journal of Cell Science, 126(7), 1576-1582. [More Information]
• Tonks, K., Ng, Y., Miller, S., Coster, A., Samocha-Bonet, D., Iseli, T., Xu, A., Patrick, E., Yang, J., Junutula, J., et al (2013). Impaired Akt phosphorylation in insulin-resistant human muscle is accompanied by selective and heterogeneous downstream defects. Diabetologia, 56(4), 875-885. [More Information]
• Burchfield, J., Lu, J., Fazakerley, D., Tan, S., Ng, Y., Mele, K., Buckley, M., Han, W., Hughes, W., James, D. (2013). Novel systems for dynamically assessing insulin action in live cells reveals heterogeneity in the insulin response. Traffic, 14(3), 259-273. [More Information]
• Xie, L., Yang, Y., Liang, T., Dolai, S., Xie, H., Parsaud, L., Lopez, J., He, Y., Chidambaram, S., Lam, P., et al (2013). RalA GTPase Tethers Insulin Granules to L- and R-Type Calcium Channels Through Binding α2δ-1 Subunit. Traffic, 14(4), 428-439. [More Information]

2012

• Tan, S., Ng, Y., Meoli, C., Kumar, A., Khoo, P., Fazakerley, D., Junutula, J., Vali, S., James, D., Stockli, J. (2012). Amplification and demultiplexing in insulin-regulated Akt protein kinase pathway in adipocytes. Journal of Biological Chemistry, 287(9), 6128-6138. [More Information]
• Christie, M., Whitten, A., King, G., Hu, S., Jarrott, R., Chen, K., Duff, A., Callow, P., Collins, B., James, D., et al (2012). Low-resolution solution structures of Munc 18: Syntaxin protein complexes indicate an open binding mode driven by the Syntaxin N-peptide. Proceedings of the National Academy of Sciences of the United States of America, 109(25), 9816-9821. [More Information]
• King, G., Stockli, J., Hu, S., Winnen, B., Duprez, W., Meoli, C., Junutula, J., Jarrott, R., James, D., Whitten, A., et al (2012). Membrane-curvature protein exhibits interdomain flexibility and binds a small GTPase. Journal of Biological Chemistry, 287(49), 40996-41006. [More Information]
• Hoehn, K., Turner, N., Cooney, G., James, D. (2012). Phenotypic Discrepancies in Acetyl-CoA Carboxylase 2-deficient Mice. Journal of Biological Chemistry, 287(19), 1-1. [More Information]
• Yang, P., Humphrey, S., Fazakerley, D., Prior, M., Yang, G., James, D., Yang, J. (2012). Re-Fraction: A machine learning approach for deterministic identification of protein homologues and splice variants in large-scale MS-based proteomics. Journal of Proteome Research, 11(5), 3035-3045. [More Information]
• Davey, J., Humphrey, S., Junutula, J., Mishra, A., Lambright, D., James, D., Stockli, J. (2012). TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes. Traffic, 13(10), 1429-1441. [More Information]
• Tan, S., Ng, Y., Burchfield, J., Ramm, G., Lambright, D., Stockli, J., James, D. (2012). The RabGAP TBC1D4/AS160 contains an atypical PTB domain that interacts with plasma membrane phospholipids to facilitae GLUT4 trafficking in adipocytes. Molecular and Cellular Biology, 32(24), 4946-4959. [More Information]
• Hu, S., Whitten, A., King, G., Jones, A., Rowland, A., James, D., Martin, J. (2012). The weak complex between RhoGAP Protein ARHGAP22 and Signal Regulatory Protein 14-3-3 has 1:2 stoichiometry and a single peptide binding mode. PloS One, 7(8), 1-11. [More Information]
• Humphrey, S., James, D. (2012). Uncaging Akt. Science Signaling, 5(223). [More Information]

2011

• Stockli, J., Fazakerley, D., James, D. (2011). GLUT4 exocytosis. Journal of Cell Science, 124(24), 4147-4159. [More Information]
• Rowland, A., Larance, M., Hughes, W., James, D. (2011). Identification of RhoGAP22 as an Akt-Dependent Regulator of Cell Motility in Response to Insulin. Molecular and Cellular Biology, 31(23), 4789-4800. [More Information]
• Rowland, A., Fazakerley, D., James, D. (2011). Mapping Insulin/GLUT4 Circuitry. Traffic, 12(6), 672-681. [More Information]
• Tan, S., Ng, Y., James, D. (2011). Next-generation Akt inhibitors provide greater specificity: effects on glucose metabolism in adipocytes. Biochemical Journal, 435(2), 539-544. [More Information]
• Prior, M., Larance, M., Lawrence, R., Soul, J., Humphrey, S., Burchfield, J., Kistler, C., Davey, J., La-Borde, P., Buckley, M., James, D., et al (2011). Quantitative Proteomic Analysis of the Adipocyte Plasma Membrane. Journal of Proteome Research, 10(11), 4970-4982. [More Information]
• Bach, M., Larance, M., James, D., Ramm, G. (2011). The serine/threonine kinase ULK1 is a target of multiple phosphorylation events. Biochemical Journal, 440(2), 283-291. [More Information]

2010

• Hu, L., Ye, J., Li, J., James, D., Kraegen, E., Zhang, H., Cheng, Z., Li, J. (2010). 13, 13a-Dihydroberberine derivatives, their pharmaceutical compositions and uses. Patent No. 2007816496.
• Konstantopoulos, N., Foletta, V., Segal, D., Shields, K., Sanigorski, A., Windmill, K., Swinton, C., Connor, T., Wanyonyi, S., Dyer, T., et al (2010). A Gene Expression Signature for Insulin Resistance. Physiological Genomics, 43(3), 110-20. [More Information]
• Hoehn, K., Turner, N., Swarbrick, M., Wilks, D., Preston, E., Phua, Y., Hoy, A., James, D., Cooney, G., et al (2010). Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity. Cell Metabolism, 11(1), 70-76. [More Information]
• Tan, S., Ng, Y., James, D. (2010). Akt inhibitors reduce glucose uptake independently of their effects on Akt. Biochemical Journal, 432(1), 191-197. [More Information]
• Ng, Y., Ramm, G., Burchfield, J., Coster, A., Stockli, J., James, D. (2010). Cluster Analysis of Insulin Action in Adipocytes Reveals a Key Role for Akt at the Plasma Membrane. Journal of Biological Chemistry, 285(4), 2245-2257. [More Information]
• Ng, Y., Ramm, G., James, D. (2010). Dissecting the mechanism of insulin resistance using a novel heterodimerization strategy to activate Akt. Journal of Biological Chemistry, 285(8), 5232-5239. [More Information]
• Larance, M., Rowland, A., Hoehn, K., Humphreys, D., Preiss, T., Guilhaus, M., James, D. (2010). Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3. Molecular and Cellular Proteomics, 9(4), 682-694. [More Information]
• Lamb, C., McCann, R., Stockli, J., James, D., Bryant, N. (2010). Insulin-Regulated Trafficking of GLUT4 Requires Ubiquitination. Traffic (Malden), 11(11), 1445-1454. [More Information]
• Fazakerley, D., Holman, G., Marley, A., James, D., Stockli, J., Coster, A. (2010). Kinetic evidence for unique regulation of GLUT4 trafficking by insulin and AMP-activated protein kinase activators in L6 myotubes. Journal of Biological Chemistry, 285(3), 1653-1660. [More Information]
• Stockli, J., Fazakerley, D., Coster, A., Holman, G., James, D. (2010). Muscling in on GLUT4 kinetics. Communicative and Integrative Biology, 3(3), 260-262. [More Information]

2009

• Lopez, J., Burchfield, J., Blair, D., Mele, K., Ng, Y., Vallotton, P., James, D., Hughes, W. (2009). Identification of a Distal GLUT4 Trafficking Event Controlled by Actin Polymerisation. Molecular Biology of the Cell, 20(17), 3918-3929. [More Information]
• Stockli, J., James, D. (2009). Insulin Action under Arrestin. Cell Metabolism, 9(3), 213-214. [More Information]
• Hoehn, K., Salmon, A., Hohnen-Behrens, C., Turner, N., Hoy, A., Maghzal, G., Stocker, R., Van Remmen, H., Kraegen, E., Cooney, G., et al (2009). Insulin resistance is a cellular antioxidant defense mechanism. Proceedings of the National Academy of Sciences of the United States of America, 106(42), 17787-17792. [More Information]
• Sun, C., Vallotton, P., Wang, D., Lopez, J., Ng, Y., James, D. (2009). Membrane boundary extraction using circular multiple paths. Pattern Recognition, 42(4), 523-530. [More Information]
• Crowe, S., Wu, L., Economou, C., Turpin, S., Matzaris, M., Hoehn, K., Hevener, A., James, D., Duh, E., et al (2009). Pigment epithelium-derived factor contributes to insulin resistance in obesity. Cell Metabolism, 10(1), 40-47. [More Information]
• Mele, K., Vallotton, P., Burchfield, J., James, D., Hughes, W. (2009). Towards fully automated identification of Vesicle-Membrane Fusion Events in TIRF Microscopy. [More Information]
• Ke, C., James, D., Kraegen, E., Cooney, G., Ye, Y., Tan, M., Chen, T., Li, X., Ye, J. (2009). Use of compounds extracted from Momordica charantia L. in the manufacture of medicaments for prevention and treatment of diabetes and obesity. Patent No. 2009212026.
• Zhao, P., Yang, L., Lopez, J., Fan, J., Burchfield, J., Bai, L., Hong, W., Xu, T., James, D. (2009). Variations in the requirement for v-SNAREs in GLUT4 trafficking in adipocytes. Journal of Cell Science, 122(19), 3472-3480. [More Information]

2008

• Tan, M., Ye, J., Turner, N., Hohnen-Behrens, C., Ke, C., Tang, C., Chen, T., Weiss, H., Gesing, E., Rowland, A., et al (2008). Anti-diabetic activities of triterpenoids from bitter melon associated with activation of the AMPK pathway. Chemistry and Biology, 15(3), 263-273. [More Information]
• Turner, N., Li, J., Gosby, A., To, S., Cheng, Z., Miyoshi, H., Taketo, M., Cooney, G., Kraegen, E., James, D., et al (2008). Berberine and its more Biologically Availible Derivative Dihyroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMPK and Improve Insulin Action. Diabetes, 57(5), 1414-1418. [More Information]
• Yip, M., Ramm, G., Larance, M., Hoehn, K., Wagner, M., Guilhaus, M., James, D. (2008). CaMKII-Mediated Phosphorylation of the Myosin Motor Myo1c is required for Insulin-Stimulated GLUT4 Translocation in Adipocytes. Cell Metabolism, 8(5), 384-398. [More Information]
• Govers, R., James, D., Coster, A. (2008). High-Throughput Analysis of the Dynamics of Recycling Cell Surface Proteins. In Andrei I. Ivanov (Eds.), Exocytosis and Endocytosis, (pp. 129-146). New Jersey, United States of America: Humana Press.
• Hoehn, K., Hohnen-Behrens, C., Cederberg, A., Wu, L., Turner, N., Yuasa, T., Ebina, Y., James, D. (2008). IRS1-independent defects define major nodes of insulin resistance. Cell Metabolism, 7(5), 421-433. [More Information]
• Brummer, T., Larance, M., Abreu, M., Lyons, R., Timpson, P., Emmerich, C., Fleuren, E., Lehrbach, G., Schramek, D., Guilhaus, M., et al (2008). Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. EMBO Journal, 27(17), 2305-2316. [More Information]
• Ng, Y., Ramm, G., Lopez, J., James, D. (2008). Rapid Activation of Akt2 is Sufficient to Stimulate GLUT4 Translocation in 3T3-L1 Adipocytes. Cell Metabolism, 7(4), 348-356. [More Information]
• Stockli, J., Davey, J., Hohnen-Behrens, C., Xu, A., James, D., Ramm, G. (2008). Regulation of Glut4 Translocation by the RabGAP AS160/TBC1D4: Role of Phosphorylation and Membrane Association. Molecular Endocrinology, 22(12), 2703-2715. [More Information]
• Achuthan, A., Masendycz, P., Lopez, J., Nguyen, T., James, D., Sweet, M., Hamilton, J., Scholz, G. (2008). Regulation of the Endosomal SNARE Protein Syntaxin 7 by Colony-Stimulating Factor 1 in Macrophages. Molecular and Cellular Biology, 28(20), 6149-6159. [More Information]
• Bao, Y., Lopez, J., James, D., Hunziker, W. (2008). Snapin Interacts with the Exo70 subunit of the exocyst and modulates GLUT4 trafficking. Journal of Biological Chemistry, 283(1), 324-331. [More Information]
• Hocking, S., Chisholm, D., James, D. (2008). Studies of Regional adipose transplantation reveal a unique and beneficial interaction between subcutaneous adipose tissue and the intra-abdominal compartment. Diabetologia, 51(5), 900-902. [More Information]
• Larance, M., Ramm, G., James, D. (2008). The GLUT4 Code. Molecular Endocrinology, 22(2), 226-233. [More Information]
• Lopez, J., Kwan, E., Xie, L., He, Y., James, D., Gaisano, H. (2008). The RalA GTPase is a Central Regulator of Insulin Exocytosis for Pancreatic Islet Beta Cells. Journal of Biological Chemistry, 283(26), 17939-17945. [More Information]

2007

• Hoy, A., Bruce, C., Cederberg, A., Turner, N., James, D., Cooney, G., Kraegen, E. (2007). Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation. American Journal of Physiology - Endocrinology and Metabolism, 293(5), e1358-e1364. [More Information]

2006

• Thomas, E., Zhe, Y., Molero, J., Schmitz-Peiffer, C., Ramm, G., James, D., Whitehead, J. (2006). The subcellular fractionation properties and function of insulin receptor substrate-1 (IRS-1) are independent of cytoskeletal integrity. International Journal of Biochemistry and Cell Biology, 38(10), 1686-1699. [More Information]