Dr Erin Shanahan

University of Sydney a Beckett Fellow
School of Life and Environmental Sciences

D17 - Charles Perkins Centre
The University of Sydney

Telephone +61 2 8627 7113

Biographical details

Erin is a microbiologist and University of Sydney a'Beckett Fellow, based in the School of Life and Environmental Sciences. Her research focuses on the role of the microbiota in gut health and colorectal cancer.

Erin completed a BSc (Hons) at The University of Sydney majoring in microbiology and immunology. She undertook her honours at the Centenary Institute, working on vaccine antigen identification inMycobacterium tuberculosis,for which she was awarded a University Medal. This was followed by a PhD in the same lab, in which Erin continued with her work on vaccine development as well as characterisation ofM. tuberculosiscell wall enzymes as potential antibiotic targets.

Following her PhD, Erin commenced a post-doctoral position at the Princess Alexandra Hospital Brisbane and The University of Queensland. She was based at the Translational Research Institute, with a focus on microbes in the upper gastrointestinal tract and their role in functional gut disorders, chronic liver disease and obesity. This work resulted in the commencement of a clinical trial assessing a novel treatment regime for upper GI functional gut symptoms.

In 2018 Erin returned to The University of Sydney to commence her research, supported by the a'Beckett Cancer Research Trust, to develop a research program investigating how host and microbial factors interact to influence bowel cancer development.

Research interests

Erin's research centres around host-microbe interactions relevant to human health.

With a background in molecular microbiology, immunology and bacterial pathogenesis, she aims to understand the mechanisms by which gut microbes may promote health or drive disease.

The gut microbiota is essential for health, however disruption to this microbial community is implicated in a variety of disease states, including chronic gastrointestinal disorders and colorectal cancer. Diet is a key factor driving host-gut microbiota interactions, and we aim to understand how specific nutrients influence the functional properties of the microbiota, as well as how microbial products influence gut health and colorectal cancer risk.

Current research students

Project title Research student
Investigating the roles of immune cells, microbes and metabolites in colorectal cancer recurrence Miguel CASTANEDA

Associations

Member of the Australian Society for Microbiology.

Member of the Microbiology Australia editorial board.

Themes

Microbiology; Biochemistry and metabolism; Human health

Honours project opportunities

  • The functional microbiota: understanding how microbes contribute to tumour development in the gut
  • Host-microbiome interactions in the intestinal microenvironment

Selected publications

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Journals

  • So, D., Whelan, K., Rossi, M., Morrison, M., Holtmann, G., Kelly, J., Shanahan, E., Staudacher, H., Campbell, K. (2018). Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis. American Journal of Clinical Nutrition, 107(6), 965-983. [More Information]
  • Shanahan, E., Shah, A., Koloski, N., Walker, M., Talley, N., Morrison, M., Holtmann, G. (2018). Influence of cigarette smoking on the human duodenal mucosa-associated microbiota. Microbiome, 6(1), 1-12. [More Information]
  • Zhong, L., Shanahan, E., Raj, A., Koloski, N., Fletcher, L., Morrison, M., Walker, M., Talley, N., Holtmann, G. (2017). Dyspepsia and the microbiome: Time to focus on the small intestine. Gut, 66(6), 1168-1169. [More Information]
  • Shanahan, E., Holtmann, G., Morrison, M. (2017). Life in the small intestine: the forgotten microbiome? (forthcoming). Microbiology Australia, 38(3), 116-121. [More Information]
  • Shah, A., Shanahan, E., Macdonald, G., Fletcher, L., Ghasemi, P., Morrison, M., Jones, M., Holtmann, G. (2017). Systematic Review and Meta-Analysis: Prevalence of Small Intestinal Bacterial Overgrowth in Chronic Liver Disease. Seminars in Liver Disease, 37(4), 388-400. [More Information]
  • Shanahan, E., Zhong, L., Talley, N., Morrison, M., Holtmann, G. (2016). Characterisation of the gastrointestinal mucosa-associated microbiota: A novel technique to prevent cross-contamination during endoscopic procedures. Alimentary Pharmacology and Therapeutics, 43(11), 1186-1196. [More Information]
  • Shanahan, E., Zhong, L., Talley, N., Morrison, M., Holtmann, G. (2016). Letter: investigating the intestinal mucosa-associated microbiota � relevance and potential pitfalls. Authors� reply. Alimentary Pharmacology and Therapeutics, 44(6), 648-649. [More Information]
  • Cuiv, P., Smith, W., Pottenger, S., Burman, S., Shanahan, E., Morrison, M. (2015). Isolation of genetically tractable most-wanted bacteria by metaparental mating. Scientific Reports, 5. [More Information]
  • Pinto, R., Leotta, L., Shanahan, E., West, N., Leyh, T., Britton, W., Triccas, J. (2013). Host cell-induced components of the sulfate assimilation pathway are major protective antigens of Mycobacterium tuberculosis. The Journal of Infectious Diseases, 207(5), 778-785. [More Information]
  • Tyne, A., Chan, J., Shanahan, E., Atmosukarto, I., Chan, H., Britton, W., West, N. (2013). TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines. Vaccine, 31(40), 4322-4329. [More Information]
  • Shanahan, E., Pinto (Pinto-Nadanachandran), R., Triccas, J., Britton, W., West, N. (2010). Cutinase-like protein-6 of Mycobacterium tuberculosis is recognised in tuberculosis patients and protects mice against pulmonary infection as a single and fusion protein vaccine. Vaccine, 28(5), 1341-1346. [More Information]

2018

  • So, D., Whelan, K., Rossi, M., Morrison, M., Holtmann, G., Kelly, J., Shanahan, E., Staudacher, H., Campbell, K. (2018). Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis. American Journal of Clinical Nutrition, 107(6), 965-983. [More Information]
  • Shanahan, E., Shah, A., Koloski, N., Walker, M., Talley, N., Morrison, M., Holtmann, G. (2018). Influence of cigarette smoking on the human duodenal mucosa-associated microbiota. Microbiome, 6(1), 1-12. [More Information]

2017

  • Zhong, L., Shanahan, E., Raj, A., Koloski, N., Fletcher, L., Morrison, M., Walker, M., Talley, N., Holtmann, G. (2017). Dyspepsia and the microbiome: Time to focus on the small intestine. Gut, 66(6), 1168-1169. [More Information]
  • Shanahan, E., Holtmann, G., Morrison, M. (2017). Life in the small intestine: the forgotten microbiome? (forthcoming). Microbiology Australia, 38(3), 116-121. [More Information]
  • Shah, A., Shanahan, E., Macdonald, G., Fletcher, L., Ghasemi, P., Morrison, M., Jones, M., Holtmann, G. (2017). Systematic Review and Meta-Analysis: Prevalence of Small Intestinal Bacterial Overgrowth in Chronic Liver Disease. Seminars in Liver Disease, 37(4), 388-400. [More Information]

2016

  • Shanahan, E., Zhong, L., Talley, N., Morrison, M., Holtmann, G. (2016). Characterisation of the gastrointestinal mucosa-associated microbiota: A novel technique to prevent cross-contamination during endoscopic procedures. Alimentary Pharmacology and Therapeutics, 43(11), 1186-1196. [More Information]
  • Shanahan, E., Zhong, L., Talley, N., Morrison, M., Holtmann, G. (2016). Letter: investigating the intestinal mucosa-associated microbiota � relevance and potential pitfalls. Authors� reply. Alimentary Pharmacology and Therapeutics, 44(6), 648-649. [More Information]

2015

  • Cuiv, P., Smith, W., Pottenger, S., Burman, S., Shanahan, E., Morrison, M. (2015). Isolation of genetically tractable most-wanted bacteria by metaparental mating. Scientific Reports, 5. [More Information]

2013

  • Pinto, R., Leotta, L., Shanahan, E., West, N., Leyh, T., Britton, W., Triccas, J. (2013). Host cell-induced components of the sulfate assimilation pathway are major protective antigens of Mycobacterium tuberculosis. The Journal of Infectious Diseases, 207(5), 778-785. [More Information]
  • Tyne, A., Chan, J., Shanahan, E., Atmosukarto, I., Chan, H., Britton, W., West, N. (2013). TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines. Vaccine, 31(40), 4322-4329. [More Information]

2010

  • Shanahan, E., Pinto (Pinto-Nadanachandran), R., Triccas, J., Britton, W., West, N. (2010). Cutinase-like protein-6 of Mycobacterium tuberculosis is recognised in tuberculosis patients and protects mice against pulmonary infection as a single and fusion protein vaccine. Vaccine, 28(5), 1341-1346. [More Information]

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