Dr Hamutal Mazrier

BSc (Magna Cum Laude), DVM, PhD
Lecturer in Developmental Biology, Paediatrics and Reproduction

B01 - J.D. Stewart Building
The University of Sydney

Telephone +61 2 9351 6881

Biographical details

Throughout my academic career, I have used comparative approach and been publishing research on spontaneous canine and feline animal models of inherited diseases. I established my own Lab group on 2015. My current research focuses on inherited developmental abnormalities and on immunogenomics and breed phenotypes of complex inherited diseases, using comparative gene array studies and functional genomics. Previously, I have been researching animal models for human Mendelian metabolic diseases. I have graduated with a Doctor of Veterinary Medicine (DVM) degree, completed a residency program in Small Animal Medical Genetics (UPenn) and graduated with PhD (Genomics; USyd). I offer extensive clinical and research experience on veterinary genetics, paediatrics, reproduction and developmental / comparative anatomy, delivered to veterinary students and vets worldwide.

Research interests

  • Animal Genetics and Genomics, Reproduction, Paediatrics
  • Animal models for inherited Human diseases
  • Animal Developmental anomalies

Teaching and supervision

  • Developmental veterinary anatomy, Comparative anatomy,
  • Reproduction and neonatal care
  • Veterinary Genetics

Current projects

Gene variants associated with canine Cryptorchidism

Gene variants associated with Neural TubeDefects in dogs

Genevariants in coding regions of the canine interleukin 7 and interleukin 7 receptor (IL7/IL7R) pathway

Associations

Australasian Society for Immunology (ASI)

Early- and Mid-Career Researcher forum, The Australian Academy of Science

Awards and honours

2018-2019 TJ Robinson Travelling Fellow, University of Sydney, Faculty of Science, Sydney School of Veterinary Science

2017 The Inagural Australasian Society for Immunology (ASI) Women's Initiative Award

2017 Finalist - Excellence in teaching award, University of Sydney, Faculty of Science, Sydney School of Veterinary Science (DVM program)

2015-2016 Sir Zelman Cowen Universities Fund Academic Exchange Fellow

2016 Finalist - Excellence in teaching award, University of Sydney, Faculty of Veterinary Science, School of Life and Environmental Sciences (BVSc & DVM programs)

2010 Fianlist - BD Science Communication Prize, 40th Annual ASI Conference

2009 - 2012 Endeavour International Postgraduate Research Scholar (EIPRS), Australian Government

2009 - 2012 International Postgraduate Award (IPA) Scholar, University of Sydney

Selected grants

2017

  • Travel Grant - 46th Australasian Society for Immunology Annual Meeting, Nov 27- Dec 1, Brisbane; Mazrier H; Australasian Society for Immunology Inc./Travel Grant.

2016

  • Searching for gene variances involved in canine atopic dermatitis: A comparison between Israeli and Australian dogs from high risk breeds; Zur G, Mazrier H; Hebrew University of Jerusalem The Koret School of Veterinary Medicine/Clinical Research Grant.

2015

  • Targeting genes from primary immune system cells in a chicken embryo model of neural crest development and migration; Mazrier H; Sir Zelman Cowen Universities Fund/Academic Exchange Fellowship.
  • A 3-Dimensional application for an integrated learning of Veterinary Anatomy; Mazrier H, Burland G; DVC Education/Small Educational Innovation Grant.

Selected publications

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Journals

  • Wang, P., Mazrier, H., Caverly Rae, J., Raj, K., Giger, U. (2018). A GNPTAB nonsense variant is associated with feline mucolipidosis II (I-Cell disease). BMC Veterinary Research, 14(416), 1-8. [More Information]
  • Mazrier, H., Vogelnest, L., Thomson, P., Taylor, R., Williamson, P. (2016). Canine atopic dermatitis: breed risk in Australia and evidence for a susceptible clade. Veterinary Dermatology, 27(42), 167-e42. [More Information]
  • Waud, B., Mazrier, H., Wade, C. (2016). Digging for known genetic mutations underlying inherited bone and cartilage characteristics and disorders in the dog and cat. Veterinary and Comparative Orthopaedics and Traumatology, 29(4), 269-276. [More Information]
  • Mazrier, H., Vogelnest, L., Kohl, A., Taylor, R., Sela-Donenfeld, D., Wei, J., Williamson, P. (2016). Exploring the IL7-IL7R pathway: a comparative approach confirms reduced gene expression in atopic dogs and a function in prenatal immune system development of chicks. European Journal of Immunology, 46(Suppl. 1), 1055-1055.
  • Mazrier, H., Bargai, U. (2016). The cost of lameness of dairy cows in the era of intense husbandry. Israel Journal of Veterinary Medicine, 71(1).
  • Mortlock, S., Booth, R., Mazrier, H., Khatkar, M., Williamson, P. (2016). Visualization of Genome Diversity in German Shepherd Dogs. Bioinformatics and Biology Insights, 9(2), 37-42. [More Information]
  • Mazrier, H., Thomson, P., Hollinshead, F., Dawson, M., Williamson, P. (2015). Heritability of graduation from a Guide Dog training program. Journal of Veterinary Behavior, 10(5), 447-447. [More Information]
  • Mazrier, H., Tal, S., Aizinbud, E., Bargai, U. (2006). A field investigation of the use of the pedometer for the early detection of lameness in cattle. Canadian Veterinary Journal, 47, 883-886.
  • Bargai, U., Mazrier, H. (2003). Epidemiological Aspects of Sequelae of Subclinical Laminitis. Israel Journal of Veterinary Medicine, 58(4), 97-99.
  • Mazrier, H., Van Hoeven, M., Wang, P., Knox, V., Aguirre, G., Holt, E., Weimelt, S., Sleeper, M., Hubler, M., Haskins, M., et al (2003). Inheritance, Biochemical Abnormalities, and Clinical Features of Feline Mucolipidosis II: The First Animal Model of Human I-Cell Disease. Journal of Heredity, 94(4), 363-373.
  • Haskins, M., Casal, M., Ellinwood, N., Melniczek, J., Mazrier, H., Giger, U. (2002). Animal models for mucopolysaccharidoses and their clinical relevance. Acta Paediatrica, 439, 88-97.
  • Parker Ponder, K., Melniczek, J., Xu, L., Weil, M., O'Malley, T., O'Donnell, P., Knox, V., Aguirre, G., Mazrier, H., Ellinwood, N., et al (2002). Therapeutic neonatal hepatic gene therapy in mucopolysaccharidosis VII dogs. Proceedings of the National Academy of Sciences of the United States of America, 99(20). [More Information]
  • Xu, L., Haskins, M., Melniczek, J., Gao, C., Weil, M., O'Malley, T., O'Donnell, P., Mazrier, H., Ellinwood, N., Zweigle, J., et al (2002). Transduction of Hepatocytes after Neonatal Delivery of a Moloney Murine Leukemia Virus Based Retroviral Vector Results in Long-Term Expression of B-Glucuronidase in Mucopolysaccharidosis VII Dogs. Molecular Therapy, 5(2), 141-153.

Conferences

  • Shanmugam, S., Blackband, J., Child, G., McDonald, B., Mazrier, H. (2018). Diseases not traditionally associated with the reproductive system: Should we neglect gender bias & neutering risk? 5th NSW Reproduction Forum, Australia.
  • Tran, Q., Wade, C., Mazrier, H. (2018). From head to tail: Racing towards understanding of inherited diseases in Greyhounds. Sydney School of Veterinary Science 2018 Research Conference, Australia.
  • Greenfield, A., Clancy, W., Williamson, P., Mazrier, H. (2018). Investigating gene variants of IL7R in canine atopic dermatitis. 10th Annual NSW-ACT ASI Branch meeting, Australia.
  • Clancy, W., Williamson, P., Wade, C., Mazrier, H. (2017). Gene variants of interleukin receptors and their involvement in inherited canine inflammatory diseases: Serendipity or designation? 46th Annual ASI conference, Australia.
  • Mazrier, H., Haase, B., Moore, E., Reppas, G., Malik, R., Wade, C. (2016). Investigating the genomics of serum hypertriglyceridemia in the miniature Schnauzer dog. Faculty of Veterinary Science 2016 Research Conference, Australia.
  • Giger, U., Raj, K., Murrow, C., Traas, A., Erat, A., Van Hoeven, M., Mazrier, H., Haskins, M. (2015). Congenital Hypothyroidism with Goiter in Cats due to a TPO Mutation. 24th ECVIM-CA Conference, N/A: N/A.
  • Mazrier, H., Vogelnest, L., Taylor, R., Williamson, P. (2014). Expression of the microRNA, miR-31, is reduced in leukocytes of dogs with atopic dermatitis. Genetics Society of AustralAsia, n/a: N/A.
  • Mazrier, H., Vogelnest, L., Taylor, R., Williamson, P. (2013). Identification of a clade of dog breeds susceptible to atopic dermatitis with a unique immunophenotypic profile. Genetics Society of AustralAsia Inc Annual Conference Sydney - Genetics in the Harbour City, Sydney: Genetics Society of AustralAsia, Inc.
  • Mazrier, H., Vogelnest, L., Wei, J., Taylor, R., Williamson, P. (2012). An Integrated analysis of atopic dermatitis: Differentially expressed immunoregulatory pathways. The 8th International Conference on Advances in Canine and Feline Genomics and Inherited Disease, N/A: N/A.
  • Mazrier, H., Vogelnest, L., Taylor, R., Williamson, P. (2012). Comparative analysis of atopic dermatitis dogs identifies a clade of susceptible breeds. The seventh World Congress of Veterinary Dermatology, n/a: N/A.
  • Mazrier, H., Vogelnest, L., Taylor, R., Williamson, P. (2010). Analysis of cytokines/chemokines in canine atopic dermatitis. 40th Annual ASI conference, Australia: Australasian Society for Immunology.

2018

  • Wang, P., Mazrier, H., Caverly Rae, J., Raj, K., Giger, U. (2018). A GNPTAB nonsense variant is associated with feline mucolipidosis II (I-Cell disease). BMC Veterinary Research, 14(416), 1-8. [More Information]
  • Shanmugam, S., Blackband, J., Child, G., McDonald, B., Mazrier, H. (2018). Diseases not traditionally associated with the reproductive system: Should we neglect gender bias & neutering risk? 5th NSW Reproduction Forum, Australia.
  • Tran, Q., Wade, C., Mazrier, H. (2018). From head to tail: Racing towards understanding of inherited diseases in Greyhounds. Sydney School of Veterinary Science 2018 Research Conference, Australia.
  • Greenfield, A., Clancy, W., Williamson, P., Mazrier, H. (2018). Investigating gene variants of IL7R in canine atopic dermatitis. 10th Annual NSW-ACT ASI Branch meeting, Australia.

2017

  • Clancy, W., Williamson, P., Wade, C., Mazrier, H. (2017). Gene variants of interleukin receptors and their involvement in inherited canine inflammatory diseases: Serendipity or designation? 46th Annual ASI conference, Australia.

2016

  • Mazrier, H., Vogelnest, L., Thomson, P., Taylor, R., Williamson, P. (2016). Canine atopic dermatitis: breed risk in Australia and evidence for a susceptible clade. Veterinary Dermatology, 27(42), 167-e42. [More Information]
  • Waud, B., Mazrier, H., Wade, C. (2016). Digging for known genetic mutations underlying inherited bone and cartilage characteristics and disorders in the dog and cat. Veterinary and Comparative Orthopaedics and Traumatology, 29(4), 269-276. [More Information]
  • Mazrier, H., Vogelnest, L., Kohl, A., Taylor, R., Sela-Donenfeld, D., Wei, J., Williamson, P. (2016). Exploring the IL7-IL7R pathway: a comparative approach confirms reduced gene expression in atopic dogs and a function in prenatal immune system development of chicks. European Journal of Immunology, 46(Suppl. 1), 1055-1055.
  • Mazrier, H., Haase, B., Moore, E., Reppas, G., Malik, R., Wade, C. (2016). Investigating the genomics of serum hypertriglyceridemia in the miniature Schnauzer dog. Faculty of Veterinary Science 2016 Research Conference, Australia.
  • Mazrier, H., Bargai, U. (2016). The cost of lameness of dairy cows in the era of intense husbandry. Israel Journal of Veterinary Medicine, 71(1).
  • Mortlock, S., Booth, R., Mazrier, H., Khatkar, M., Williamson, P. (2016). Visualization of Genome Diversity in German Shepherd Dogs. Bioinformatics and Biology Insights, 9(2), 37-42. [More Information]

2015

  • Giger, U., Raj, K., Murrow, C., Traas, A., Erat, A., Van Hoeven, M., Mazrier, H., Haskins, M. (2015). Congenital Hypothyroidism with Goiter in Cats due to a TPO Mutation. 24th ECVIM-CA Conference, N/A: N/A.
  • Mazrier, H., Thomson, P., Hollinshead, F., Dawson, M., Williamson, P. (2015). Heritability of graduation from a Guide Dog training program. Journal of Veterinary Behavior, 10(5), 447-447. [More Information]

2014

  • Mazrier, H., Vogelnest, L., Taylor, R., Williamson, P. (2014). Expression of the microRNA, miR-31, is reduced in leukocytes of dogs with atopic dermatitis. Genetics Society of AustralAsia, n/a: N/A.

2013

  • Mazrier, H., Vogelnest, L., Taylor, R., Williamson, P. (2013). Identification of a clade of dog breeds susceptible to atopic dermatitis with a unique immunophenotypic profile. Genetics Society of AustralAsia Inc Annual Conference Sydney - Genetics in the Harbour City, Sydney: Genetics Society of AustralAsia, Inc.

2012

  • Mazrier, H., Vogelnest, L., Wei, J., Taylor, R., Williamson, P. (2012). An Integrated analysis of atopic dermatitis: Differentially expressed immunoregulatory pathways. The 8th International Conference on Advances in Canine and Feline Genomics and Inherited Disease, N/A: N/A.
  • Mazrier, H., Vogelnest, L., Taylor, R., Williamson, P. (2012). Comparative analysis of atopic dermatitis dogs identifies a clade of susceptible breeds. The seventh World Congress of Veterinary Dermatology, n/a: N/A.

2010

  • Mazrier, H., Vogelnest, L., Taylor, R., Williamson, P. (2010). Analysis of cytokines/chemokines in canine atopic dermatitis. 40th Annual ASI conference, Australia: Australasian Society for Immunology.

2006

  • Mazrier, H., Tal, S., Aizinbud, E., Bargai, U. (2006). A field investigation of the use of the pedometer for the early detection of lameness in cattle. Canadian Veterinary Journal, 47, 883-886.

2003

  • Bargai, U., Mazrier, H. (2003). Epidemiological Aspects of Sequelae of Subclinical Laminitis. Israel Journal of Veterinary Medicine, 58(4), 97-99.
  • Mazrier, H., Van Hoeven, M., Wang, P., Knox, V., Aguirre, G., Holt, E., Weimelt, S., Sleeper, M., Hubler, M., Haskins, M., et al (2003). Inheritance, Biochemical Abnormalities, and Clinical Features of Feline Mucolipidosis II: The First Animal Model of Human I-Cell Disease. Journal of Heredity, 94(4), 363-373.

2002

  • Haskins, M., Casal, M., Ellinwood, N., Melniczek, J., Mazrier, H., Giger, U. (2002). Animal models for mucopolysaccharidoses and their clinical relevance. Acta Paediatrica, 439, 88-97.
  • Parker Ponder, K., Melniczek, J., Xu, L., Weil, M., O'Malley, T., O'Donnell, P., Knox, V., Aguirre, G., Mazrier, H., Ellinwood, N., et al (2002). Therapeutic neonatal hepatic gene therapy in mucopolysaccharidosis VII dogs. Proceedings of the National Academy of Sciences of the United States of America, 99(20). [More Information]
  • Xu, L., Haskins, M., Melniczek, J., Gao, C., Weil, M., O'Malley, T., O'Donnell, P., Mazrier, H., Ellinwood, N., Zweigle, J., et al (2002). Transduction of Hepatocytes after Neonatal Delivery of a Moloney Murine Leukemia Virus Based Retroviral Vector Results in Long-Term Expression of B-Glucuronidase in Mucopolysaccharidosis VII Dogs. Molecular Therapy, 5(2), 141-153.

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