Dr Ingrid Macindoe

Postdoctoral Research Associate
School of Life and Environmental Sciences

G08 - Biochemistry and Microbiology Building
The University of Sydney


Biographical details

Ingrid completed a PhD in biochemistry at the University of Sydney in 2010 under the supervision of Dr Margie Sunde. She has been working in Prof Joel Mackay’s laboratory as a postdoctoral research associate since 2014.

Research interests

Ingrid began her career as a structural biologist, studying the self-assembly of a fungal protein during her PhD, then using X-ray crystallography to solve the structure of a protein involved in chromatin looping as a new postdoc.

More recently, Ingrid’s research has been moving further into the field of cell biology where she has been using techniques such as CRISPR/Cas9 genome editing, RT-qPCR and ChIP to study epigenetic regulation of gene expression. Her recent research projects include:

  • studying imprinting of the Ube3a gene in Angelman Syndrome via an antisense transcript
  • targeting epigenetic modifiers to specific locations in the genome to modulate gene expression in a directed way
  • investigating the interaction of BET proteins with chromatin remodellers

Teaching and supervision

Ingrid co-supervises PhD, Honours, and TSP students, as well as visiting international students in Prof Joel Mackay’s lab. She also has experience demonstrating for 1st, 2nd and 3rd year undergraduates.

Selected publications

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Journals

  • Mohanty, B., Hanson-Manful, P., Finn, T., Chambers, C., McKellar, J., Macindoe, I., Helder, S., Setiyaputra, S., Zhong, Y., Mackay, J., et al (2019). The uncharacterized bacterial protein YejG has the same architecture as domain III of elongation factor G. Proteins: Structure, Function, and Bioinformatics, 87(8), 699-705. [More Information]
  • Macindoe, I., Kwan, A., Ren, Q., Morris, V., Yang, W., Mackay, J., Sunde, M. (2012). Self-assembly of functional, amphipathic amyloid monolayers by the fungal hydrophobin EAS. Proceedings of the National Academy of Sciences of the United States of America, 109(14), E804-E811. [More Information]
  • Morris, V., Ren, Q., Macindoe, I., Kwan, A., Byrne, N., Sunde, M. (2011). Recruitment of Class I Hydrophobins to the Air: Water Interface Initiates a Multi-step Process of Functional Amyloid Formation. Journal of Biological Chemistry, 286(18), 15955-15963. [More Information]
  • Macindoe, I., Glockner, L., Vukasin, P., Stennard, F., Costa, M., Harvey, R., Mackay, J., Sunde, M. (2009). Conformational stability and DNA binding specificity of the cardiac T-box transcription factor Tbx20. Journal of Molecular Biology, 389(3), 606-618. [More Information]
  • Kwan, A., Macindoe, I., Vukasin, P., Morris, V., Kass, I., Gupte, R., Mark, A., Templeton, M., Mackay, J., Sunde, M. (2008). The Cys3-Cys4 Loop of the Hydrophobin EAS Is Not Required for Rodlet Formation and Surface Activity. Journal of Molecular Biology, 382, 708-720. [More Information]

2019

  • Mohanty, B., Hanson-Manful, P., Finn, T., Chambers, C., McKellar, J., Macindoe, I., Helder, S., Setiyaputra, S., Zhong, Y., Mackay, J., et al (2019). The uncharacterized bacterial protein YejG has the same architecture as domain III of elongation factor G. Proteins: Structure, Function, and Bioinformatics, 87(8), 699-705. [More Information]

2012

  • Macindoe, I., Kwan, A., Ren, Q., Morris, V., Yang, W., Mackay, J., Sunde, M. (2012). Self-assembly of functional, amphipathic amyloid monolayers by the fungal hydrophobin EAS. Proceedings of the National Academy of Sciences of the United States of America, 109(14), E804-E811. [More Information]

2011

  • Morris, V., Ren, Q., Macindoe, I., Kwan, A., Byrne, N., Sunde, M. (2011). Recruitment of Class I Hydrophobins to the Air: Water Interface Initiates a Multi-step Process of Functional Amyloid Formation. Journal of Biological Chemistry, 286(18), 15955-15963. [More Information]

2009

  • Macindoe, I., Glockner, L., Vukasin, P., Stennard, F., Costa, M., Harvey, R., Mackay, J., Sunde, M. (2009). Conformational stability and DNA binding specificity of the cardiac T-box transcription factor Tbx20. Journal of Molecular Biology, 389(3), 606-618. [More Information]

2008

  • Kwan, A., Macindoe, I., Vukasin, P., Morris, V., Kass, I., Gupte, R., Mark, A., Templeton, M., Mackay, J., Sunde, M. (2008). The Cys3-Cys4 Loop of the Hydrophobin EAS Is Not Required for Rodlet Formation and Surface Activity. Journal of Molecular Biology, 382, 708-720. [More Information]

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