Dr Lipin Loo

Research Fellow
School of Life and Environmental Sciences

Member of the Charles Perkins Centre

D17 - Charles Perkins Centre
The University of Sydney


Biographical details

Dr Lipin Loo joined University of Sydney as Dr John and Anne Chong Genome Editing and Stem Cell Research Fellow and hisprimary interest is studying the complex process of neuronal differentiation.Lipin received his PhD in Pharmacology from University of Iowa in 2013. He received postdoctoral training in the Zylka lab at the Neuroscience Center of University of North Carolina from 2014 to 2017.

Research interests

Utilizing genetic screens and single-cell transcriptomics,Lipin aims to identify and map transcriptional changes underlying different cellular trajectories during development and also under pathophysiological conditions such as chronic pain and neuropathy. Elucidating these orchestrated transcriptional changes will have a far-ranging impact on our understanding of disease-causing developmental aberrations, our capacity to restore normal function in damaged or diseased neurons, and our capability to generate substitute neurons from stem cells.

Teaching and supervision

Single-Cell Genomics under BIOL3X18 Gene Technology and Genomics

Current research students

Project title Research student
Functional genomics to find new ways to extend lifespan and preserve neurological function with age. Sayan MITRA

Associations

  • International Association for the Study on Pain (IASP)
  • Society for Neuroscience

Awards and honours

  • 2018-2021 – Dr John And Anne Chong Genome Editing and Stem Cell Research Fellowship
  • 2017 – Office of Postdoctoral Affairs Travel Award
  • 2012 – Telphy Travel Award
  • 2011 – Telphy Travel Award
  • 2004-2008 –Starr Foundation Scholar

Selected publications

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Journals

  • Loo, L., Zylka, M. (2017). Conditional deletion of Pip5k1c in sensory ganglia and effects on nociception and inflammatory sensitization. Molecular Pain, 13, 1-8. [More Information]
  • Mickle, A., Shepherd, A., Loo, L., Mohapatra, D. (2015). Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking. Pain, 156(9), 1620-1636. [More Information]
  • Loo, L., Wright, B., Zylka, M. (2015). Lipid kinases as therapeutic targets for chronic pain. Pain, 156(Suppl 1), S2-S10. [More Information]
  • Wright, B., Loo, L., Street, S., Ma, A., Taylor-Blake, B., Stashko, M., Jin, J., Janzen, W., Frye, S., Zylka, M. (2014). The Lipid Kinase PIP5K1C Regulates Pain Signaling and Sensitization. Neuron, 82(4), 836-847. [More Information]
  • Shepherd, A., Loo, L., Mohapatra, D. (2013). Chemokine Co-Receptor CCR5/CXCR4-Dependent Modulation of Kv2.1 Channel Confers Acute Neuroprotection to HIV-1 Glycoprotein gp120 Exposure. PloS One, 8(9). [More Information]
  • Sowers, L., Loo, L., Wu, Y., Campbell, E., Ulrich, J., Wu, S., Paemka, L., Wassink, T., Meyer, K., et al (2013). Disruption of the non-canonical Wnt gene PRICKLE2 leads to autism-like behaviors with evidence for hippocampal synaptic dysfunction. Molecular Psychiatry, 18(10), 1077-1089. [More Information]
  • Shepherd, A., Loo, L., Gupte, R., Mickle, A., Mohapatra, D. (2012). Distinct modifications in Kv2.1 channel via chemokine receptor CXCR4 regulate neuronal survival-death dynamics. Journal of Neuroscience, 32(49), 17725-17739. [More Information]
  • Maity, B., Stewart, A., Yang, J., Loo, L., Sheff, D., Shepherd, A., Mohapatra, D., Fisher, R. (2012). Regulator of G protein signaling 6 (RGS6) protein ensures coordination of motor movement by modulating GABA B receptor signaling. Journal of Biological Chemistry, 287(7), 4972-4981. [More Information]
  • Loo, L., Shepherd, A., Mickle, A., Lorca, R., Shutov, L., Usachev, Y., Mohapatra, D. (2012). The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical G-beta-gamma-dependent modulation of TRPV1 channel. Journal of Neuroscience, 32(35), 11942-11955. [More Information]
  • Walder, R., Radhakrishnan, R., Loo, L., Rasmussen, L., Mohapatra, D., Wilson, S., Sluka, K. (2012). TRPV1 is important for mechanical and heat sensitivity in uninjured animals and development of heat hypersensitivity after muscle inflammation. Pain, 153(8), 1664-1672. [More Information]

2017

  • Loo, L., Zylka, M. (2017). Conditional deletion of Pip5k1c in sensory ganglia and effects on nociception and inflammatory sensitization. Molecular Pain, 13, 1-8. [More Information]

2015

  • Mickle, A., Shepherd, A., Loo, L., Mohapatra, D. (2015). Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking. Pain, 156(9), 1620-1636. [More Information]
  • Loo, L., Wright, B., Zylka, M. (2015). Lipid kinases as therapeutic targets for chronic pain. Pain, 156(Suppl 1), S2-S10. [More Information]

2014

  • Wright, B., Loo, L., Street, S., Ma, A., Taylor-Blake, B., Stashko, M., Jin, J., Janzen, W., Frye, S., Zylka, M. (2014). The Lipid Kinase PIP5K1C Regulates Pain Signaling and Sensitization. Neuron, 82(4), 836-847. [More Information]

2013

  • Shepherd, A., Loo, L., Mohapatra, D. (2013). Chemokine Co-Receptor CCR5/CXCR4-Dependent Modulation of Kv2.1 Channel Confers Acute Neuroprotection to HIV-1 Glycoprotein gp120 Exposure. PloS One, 8(9). [More Information]
  • Sowers, L., Loo, L., Wu, Y., Campbell, E., Ulrich, J., Wu, S., Paemka, L., Wassink, T., Meyer, K., et al (2013). Disruption of the non-canonical Wnt gene PRICKLE2 leads to autism-like behaviors with evidence for hippocampal synaptic dysfunction. Molecular Psychiatry, 18(10), 1077-1089. [More Information]

2012

  • Shepherd, A., Loo, L., Gupte, R., Mickle, A., Mohapatra, D. (2012). Distinct modifications in Kv2.1 channel via chemokine receptor CXCR4 regulate neuronal survival-death dynamics. Journal of Neuroscience, 32(49), 17725-17739. [More Information]
  • Maity, B., Stewart, A., Yang, J., Loo, L., Sheff, D., Shepherd, A., Mohapatra, D., Fisher, R. (2012). Regulator of G protein signaling 6 (RGS6) protein ensures coordination of motor movement by modulating GABA B receptor signaling. Journal of Biological Chemistry, 287(7), 4972-4981. [More Information]
  • Loo, L., Shepherd, A., Mickle, A., Lorca, R., Shutov, L., Usachev, Y., Mohapatra, D. (2012). The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical G-beta-gamma-dependent modulation of TRPV1 channel. Journal of Neuroscience, 32(35), 11942-11955. [More Information]
  • Walder, R., Radhakrishnan, R., Loo, L., Rasmussen, L., Mohapatra, D., Wilson, S., Sluka, K. (2012). TRPV1 is important for mechanical and heat sensitivity in uninjured animals and development of heat hypersensitivity after muscle inflammation. Pain, 153(8), 1664-1672. [More Information]

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