Dr Markus Hofer

Lecturer
School of Life and Environmental Sciences

Member of the Charles Perkins Centre

G08 - Biochemistry and Microbiology Building
The University of Sydney

Telephone +61 2 9351 2233
Fax +61 2 9351 5858

Website Room 705 - G08 Molecular Bioscience Building

Biographical details

Dr Markus Hofer is a senior lecturer at the University of Sydney. He has more than 15 years of experience as a clinical neuropathologist.

He obtained his medical doctorate at the Albert-Ludwigs University in Freiburg, Germany and was a senior consultant and the deputy head for the Department of Neuropathology at the University Hospital Marburg, Germany.

Research interests

The brain is the most complex organ in the human body, containing over one hundred billion nerve cells. In contrast to other organs, the brain has a very limit capacity to regenerate and damage is often irreversible. One of the major ways the brain can become damaged is during inflammation. Inflammation is part of the process that the body uses to eliminate microbial infection but it also occurs during autoimmune disease and in response to external factors such as diet.

My research aims to understand the delicate balance of signalling factors that control inflammation in the brain and to explore the process of neurodegeneration. Part of my work focuses on how inflammation contributes to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. To do this, my laboratory uses both in vivo and in vitro models including cell culture, transgenic and knock-out mice, as well as experimental infection of mice with lymphocytic choriomeningitis virus (LCMV), a model for viral encephalitis.

In our lab, we offer research opportunities for undergraduate and postgraduate students. For more information, please visit www.hoferlab.com

Current research students

Project title Research student
Neurotoxic and/or neuroprotective: The role of microglia in neuroinflammation Alanna SPITERI

Current projects

Our research group is interested in a broad range of topics within the fields of neuropathology and immunobiology.

CYTOKINOPATHIES

Cytokinopathies are a group of debilitating diseases that are caused by inappropriate production of cytokines. Examples include Aicardi-Goutières syndrome, systemic lupus erythematosus and neuromyelitis optica (NMO). We aim to identify the molecular mechanisms and key cellular targets that underlie cytokinopathies.

INTERFERONS IN VIRUS DEFENCE

As their name suggests, interferons ‘interfere’ with viral replication, preventing an infection from spreading. However, interferons also play an important role in fine tuning the immune response.

Using models such as lymphocytic choriomeningitis virus and zika virus, we investigate how the immune system responds to virusesthrough interferon signalling.

COLLABORATIONS

From mental health to gut bacteria, the immune system of the brain can have far reaching consequences for the rest of the body.

We use our knowledge and experimental techniques to support a broad range of collaborations across many different aspects of biology.

For more information, please visit www.hoferlab.com

Themes

Molecular biology and biotechnology; Genetics and genomics; Human health

International links

Austria

(Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna) Prof. Mathias Mueller

Germany

(Deutsches Rheumaforschungszentrum Berlin) Prof. Max Loehning

Germany

(Institute for Medical Microbiology and Hospital Hygiene, Philipps University Marburg.) PD. Dr. Magdalena Huber

Selected grants

2019

  • Role of vasculopathy in cerebral Type I interferonopathies; Hofer M; Eli Lilly and Company/Research Agreement.

2016

  • The phosphoproteome of INN-a and IL-6 driven neurological diseases; Hofer M; Faculty of Science/Seed Funding.

2015

  • Investigating the impact of serine phosphorylation of the transcription factor STAT1 in multiple sclerosis; Hofer M; Multiple Sclerosis Research Australia/Incubator Grant.
  • Contribution of serine phosphorylation of STAT1 to interferon action in the CNS; Hofer M; DVC Research/Bridging Support Grant.

2014

  • Adaptive Learning Systems to facilitate Flipped Classes and build curriculum bridges; Denyer G, Hofer M, Hinton T, Cook J; DVC Education/Small Educational Innovation Grant.

Selected publications

Download citations: PDF RTF Endnote

Book Chapters

  • Hofer, M., Campbell, I. (2009). Central Nervous System Inflammation: Cytokines and JAK/STAT/SOCS Signal Transduction. In Binder MD, Hirokawa N, Windhorst U, Hirsch M. (Eds.), Encyclopedia of Neuroscience, (pp. 641-650). New York: Springer. [More Information]

Journals

  • Nitsch, L., Zimmermann, J., Krauthausen, M., Hofer, M., Saggu, R., Petzold, G., Heneka, M., Getts, D., Campbell, I., Muller, M. (2019). CNS-Specific Synthesis of Interleukin 23 Induces a Progressive Cerebellar Ataxia and the Accumulation of Both T and B Cells in the Brain: Characterization of a Novel Transgenic Mouse Model. Molecular Neurobiology, In Press, 1-17. [More Information]
  • Suprunenko, T., Hofer, M. (2019). Complexities of Type I Interferon Biology: Lessons from LCMV. Viruses, 11(2), 1-20. [More Information]
  • Jones, H., Sharma, S., Mohammad, S., Kothur, K., Patel, S., Brilot-Turville, F., Guastella, A., Dale, R., Hofer, M. (2019). Maternal thyroid autoimmunity associated with acute-onset neuropsychiatric disorders and global regression in offspring. Developmental Medicine and Child Neurology, 61(8), 984-988. [More Information]
  • West, P., Viengkhou, B., Campbell, I., Hofer, M. (2019). Microglia responses to interleukin-6 and type I interferons in neuroinflammatory disease. GLIA, 67(10), 1821-1841. [More Information]
  • Jung, S., Suprunenko, T., Ashhurst, T., King, N., Hofer, M. (2018). Collateral damage: What effect does anti-CD4 and anti-CD8alpha antibody-mediated depletion have on leukocyte populations? Journal of Immunology, 201(7), 2176-2186. [More Information]
  • Li, W., Viengkhou, B., Denyer, G., West, P., Campbell, I., Hofer, M. (2018). Microglia have a more extensive and divergent response to interferon-alpha compared with astrocytes. GLIA, 66(10), 2058-2078. [More Information]
  • Huber, M., Suprunenko, T., Ashhurst, T., Marbach, F., Raifer, H., Wolff, S., Strecker, T., Viengkhou, B., Jung, S., Obermann, H., King, N., Campbell, I., Hofer, M., et al (2017). IRF9 Prevents CD8+ T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection. Journal of Virology, 91(22), 1-15. [More Information]
  • Vachharajani, N., Joeris, T., Luu, M., Hartmann, S., Pautz, S., Jenike, E., Pantazis, G., Prinz, I., Hofer, M., Steinhoff, U., et al (2017). Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7. Oncotarget, 8(31), 50447-50459. [More Information]
  • Li, W., Hofer, M., Songkhunawej, P., Jung, S., Hancock, D., Denyer, G., Campbell, I. (2017). Type I interferon-regulated gene expression and signaling in murine mixed glial cells lacking signal transducers and activators of transcription 1 or 2 or interferon regulatory factor 9. Journal of Biological Chemistry, 292(14), 5845-5859. [More Information]
  • Mikaelyan, A., Thompson, C., Hofer, M., Brune, A. (2016). Deterministic Assembly of Complex Bacterial Communities in Guts of Germ-Free Cockroaches. Applied and Environmental Microbiology, 82(4), 1256-1263. [More Information]
  • Hofer, M., Campbell, I. (2016). Immunoinflammatory diseases of the central nervous system - The tale of two cytokines. British Journal of Pharmacology, 173(4), 716-728. [More Information]
  • Suprunenko, T., Hofer, M. (2016). The emerging role of interferon regulatory factor 9 in the antiviral host response and beyond. Cytokine & Growth Factor Reviews, 29, 35-43. [More Information]
  • Almolda, B., de Labra, C., Barrera, I., Gruart, A., Delgado-Garcia, J., Villacampa, N., Vilella, A., Hofer, M., Hidalgo, J., Campbell, I., et al (2015). Alterations in microglial phenotype and hippocampal neuronal function in transgenic mice with astrocyte-targeted production of interleukin-10. Brain, Behavior, and Immunity, 45, 80-97. [More Information]
  • Campbell, L., Simonin, A., Chen, C., Ferdous, J., Padula, M., Harry, E., Hofer, M., Campbell, I., Carter, D. (2015). Cryptococcus Strains with Different Pathogenic Potentials Have Diverse Protein Secretomes. Eukaryotic Cell (Online), 14(6), 554-563. [More Information]
  • Visekruna, A., Linnerz, T., Martinic, V., Vachharajani, N., Hartmann, S., Harb, H., Joeris, T., Pfefferle, P., Hofer, M., Steinhoff, U. (2015). Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis. Mucosal Immunology, 8(2), 307-315. [More Information]
  • Teymoortash, A., Zieger, L., Hoch, S., Pagenstecher, A., Hofer, M. (2014). Distinct microscopic features of perineural invasion in adenoid cystic carcinoma of the head and neck. Histopathology, 64(7), 1037-1039. [More Information]
  • Li, W., Hofer, M., Jung, S., Lim, S., Campbell, I. (2014). IRF7-Dependent Type I Interferon Production Induces Lethal Immune-Mediated Disease in STAT1 Knockout Mice Infected with Lymphocytic Choriomeningitis Virus. Journal of Virology, 88(13), 7578-7588. [More Information]
  • Nocon, A., Ip, J., Terry, R., Lim, S., Getts, D., Muller, M., Hofer, M., King, N., Campbell, I. (2014). The Bacteriostatic Protein Lipocalin 2 Is Induced in the Central Nervous System of Mice with West Nile Virus Encephalitis. Journal of Virology, 88(1), 679-689. [More Information]
  • Hofer, M., Rohlfs, J., Teymoortash, A., Pagenstecher, A. (2013). A 62-year-old female with an intranasal mass extending into the lamina cribrosa. Brain Pathology, 23, 105-108. [More Information]
  • Zimmermann, J., Krauthausen, M., Hofer, M., Heneka, M., Campbell, I., Muller, M. (2013). CNS-Targeted Production of IL-17A Induces Glial Activation, Microvascular Pathology and Enhances the Neuroinflammatory Response to Systemic Endotoxemia. PloS One, 8(2), 1-13. [More Information]
  • Siegfried, A., Berchtold, S., Manncke, B., Deuschle, E., Reber, J., Ott, T., Weber, M., Kalinke, U., Hofer, M., Hatesuer, B., et al (2013). IFIT2 is an effector protein of type I IFN-mediated amplification of lipopolysaccharide (LPS)-induced TNF-α secretion and LPS-induced endotoxin shock. Journal of Immunology, 191(7), 3913-3921. [More Information]
  • Li, W., Hofer, M., Nocon, A., Manders, P., Campbell, I. (2013). Interferon regulatory factor 7 (IRF7) is required for the optimal initial control but not subsequent clearance of lymphocytic choriomeningitis virus infection in mice. Virology, 439(2), 152-162. [More Information]
  • Bujan, B., Hofer, M., Oertel, W., Pagenstecher, A., Burk, K. (2013). Multiple system atrophy of the cerebellar type (MSA-C) with concomitant beta-amyloid and tau pathology. Clinical Neuropathology, 32, 286-290. [More Information]
  • Hofer, M., Campbell, I. (2013). Type I interferon in neurological disease-The devil from within. Cytokine and Growth Factor Reviews, 24(3), 257-267. [More Information]
  • Hofer, M., Riehmer, V., Kuhnt, D., Braun, V., Nimsky, C., Weber, R., Sommer, C., Pagenstecher, A. (2012). Genomic profiling to assess the clonal relationship between histologically distinct intracranial tumours. Neuropathology and Applied Neurobiology, 38(5), 500-504. [More Information]
  • Hofer, M., Li, W., Manders, P., Terry, R., Lim, S., King, N., Campbell, I. (2012). Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus. Journal of Virology, 86(12), 6932-6946. [More Information]
  • Ghandourah, S., Hofer, M., Kiessling, A., El-Zayat, B., Schofer, M. (2012). Painful muscle fibrosis following synthol injections in a bodybuilder: a case report. Journal of Medical Case Reports, 6, 1-4. [More Information]
  • Getts, D., Terry, R., Getts, M., Muller, M., Rana, S., Deffrasnes, C., Ashhurst, T., Radford, J., Hofer, M., Thomas, S., Campbell, I., King, N. (2012). Targeted blockade in lethal West Nile virus encephalitis indicates a crucial role for very late antigen (VLA)-4-dependent recruitment of nitric oxide-producing macrophages. Journal of Neuroinflammation, 9(1), 1-8. [More Information]
  • Ip, J., Nocon, A., Hofer, M., Lim, S., Müller, M., Campbell, I. (2011). Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration. Journal of Neuroinflammation, 8(124), 1-15. [More Information]
  • Thompson, C., Hofer, M., Campbell, I., Holmes, A. (2010). Community Dynamics in the Mouse Gut Microbiota: A Possible Role for IRF9-Regulated Genes in Community Homeostasis. PloS One, 5(4), e10335-1-e10335-9. [More Information]
  • Muller, M., Carter, S., Hofer, M., Campbell, I. (2010). Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity - a tale of conflict and conundrum. Neuropathology and Applied Neurobiology, 36(5), 368-387. [More Information]
  • Ellis, S., Gysbers, V., Manders, P., Li, W., Hofer, M., Muller, M., Campbell, I. (2010). The Cell-Specific Induction of CXC Chemokine Ligand 9 Mediated by IFN-{gamma} in Microglia of the Central Nervous System Is Determined by the Myeloid Transcription Factor PU.1. Journal of Immunology, 185(3), 1864-1877. [More Information]
  • Hofer, M., Li, W., Lim, S., Campbell, I. (2010). The type I interferon-alpha mediates a more severe neurological disease in the absence of the canonical signaling molecule interferon regulatory factor 9. Journal of Neuroscience, 30(3), 1149-1157. [More Information]
  • Campbell, I., Hofer, M., Pagenstecher, A. (2010). Transgenic models for cytokine-induced neurological disease. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1802 (10), 903-917. [More Information]
  • Vetter, M., Hofer, M., Roth, E., Pircher, H., Pagenstecher, A. (2009). Intracerebral interleukin 12 induces glioma rejection in the brain predominantly by CD8+ T cells and independently of interferon-gamma. Journal of Neuropathology and Experimental Neurology, 68(5), 525-534. [More Information]
  • Quintana, A., Muller, M., Frausto, R., Ramos, R., Getts, D., Sanz, E., Hofer, M., Krathausen, M., King, N., Hildago, J., Campbell, I. (2009). Site-Specific Production of IL-6 in the Central Nervous System Retargets and Enchances the Inflammatory Response in Experimental Autoimmune Encephalomyelitis. Journal of Immunology, 183(3), 2079-2088. [More Information]
  • Sanz, E., Hofer, M., Unzeta, M., Campbell, I. (2008). Minimal Role for STAT1 in Interleukin-6 Signaling and Actions in the Murine Brain. GLIA, 56(2), 190-199. [More Information]
  • Hofer, M., Carter, S., Muller, M., Campbell, I. (2008). Unaltered Neurological Disease and Mortality in CXCR3-Deficient Mice Infected Intracranially with Lymphocytic Choriomeningitis Virus-Armstrong. Viral Immunology, 21(4), 425-433. [More Information]
  • Muller, M., Carter, S., Hofer, M., Manders, P., Getts, D., Getts, M., Dreykluft, A., Lu, B., Gerard, C., King, N., Campbell, I. (2007). CXCR3 Signaling Reduces the Severity of Experimental Autoimmune Encephalomyelitis by Controlling the Parenchymal Distribution of Effector and Regulatory T Cells in the Central Nervous System. Journal of Immunology, 179(5), 2774-2786. [More Information]
  • Hofer, M., Schindler, A., Ehrensberger, F., Staeheli, P., Pagenstecher, A. (2006). Absence of Borna disease virus in the CNS of epilepsy patients. Journal Of Clinical Virology.
  • Hofer, M. (2006). Absence of Borna disease virus in the CNS of epilepsy patients. Journal Of Clinical Virology, 36(1), 84-85. [More Information]
  • Wacher, C., Muller, M., Hofer, M., Getts, D., Zabaras, R., Ousman, S., Terenzi, F., Sen, G., King, N., Campbell, I. (2006). Coordinated Regulation and Widespread Cellular Expression of Interferon-Stimulated Genes (ISG) ISG-49, ISG-54, and ISG-56 in the Central Nervous System after Infection with Distinct Viruses. Journal of Virology, 81(2), 860-871. [More Information]
  • Wacher, C., Muller, M., Hofer, M., Getts, D., Zabaras, R., Ousman, S., Terenzi, F., Sen, G., King, N., Campbell, I. (2006). Coordinated regulation and widespread cellular expression of the interferon-stimulated genes (ISG)-49, ISG-54 and ISG-56 in the central nervous system following infection with distinct viruses. Journal of Virology, 81(2), 860-871. [More Information]
  • Hofer, M., Weber, A., Haffner, K., Berlis, A., Klingel, K., Kruger, M., Kandolf, R., Volk, B. (2005). Acute hemorrhagic leukoencephalitis (Hurst’s disease) linked to Epstein-Barr virus infection. Acta Neuropathologica, 109(2), 226-230. [More Information]
  • Harloff, A., Rauer, S., Hofer, M., Klisch, J., Els, T. (2005). Fulminant acute disseminated encephalomyelitis mimicking acute bacterial meningoencephalitis. European Journal of Neurology, 12(1), 67-69. [More Information]
  • Hofer, M., Finger, C., Pagenstecher, A. (2005). Molecular genotyping of the murine H-2K MHC class I allele. Journal of Immunological Methods, 302(1-2), 168-171. [More Information]
  • Kuhne, M., Sidler, D., Hofer, S., Hofer, M., Ludwig, C. (2005). Zuviel Blut und eine erstaunliche Diagnose [Too much blood and an astonishing diagnosis]. Swiss Medical Forum, 5, 273-275. [More Information]
  • Friedl, G., Hofer, M., Auber, B., Sauder, C., Hausmann, J., Staeheli, P., Pagenstecher, A. (2004). Borna Disease Virus Multiplication in Mouse Organotypic Slice Cultures Is Site-Specifically Inhibited by Gamma Interferon but Not by Interleukin-12. Journal of Virology, 78(3), 1212-1218. [More Information]
  • Hofer, M., Hausmann, J., Staeheli, P., Pagenstecher, A. (2004). Cerebral Expression of Interleukin-12 Induces Neurological Disease via Differential Pathways and Recruits Antigen-Specific T Cells in Virus-Infected Mice. American Journal of Pathology, 165(3), 949-958. [More Information]
  • Freude, S., Hausmann, J., Hofer, M., Pham-Mitchell, N., Campbell, I., Staeheli, P., Pagenstecher, A. (2002). Borna disease virus accelerates inflammation and disease associated with transgenic expression of interleukin-12 in the central nervous system. Journal Of Clinical Virology, 76(23), 12223-122232.
  • Allmang, U., Hofer, M., Herzog, S., Bechter, K., Staeheli, P. (2001). Low avidity of human serum antibodies for Borna disease virus antigens questions their diagnostic value. Molecular Psychiatry, 6(3), 329-333.
  • Czygan, M., Hallensleben, W., Hofer, M., Pollak, S., Sauder, C., Bilzer, T., Blumcke, I., Riederer, P., Bogerts, B., et al (1999). Borna disease virus in human brains with a rare form of hippocampal degeneration but not in brains of patients with common neuropsychiatric disorders. The Journal of Infectious Diseases, 180(5), 1695-1699. [More Information]

Conferences

  • Hofer, M., Mueller, M., O'Sullivan, C., Manders, P., Campbell, I. (2007). Lethal lymphocytic choriomeningitis virus (LCMV) infection in STAT1 KO mice is associated with dysregulated PD-1/B7-H1 and a phenotypic switch in the T-cell response. International Society for Interferon and Cytokine Research, Interferon Anniversary Meeting (ISICR 2007), United Kingdom: Mary Ann Liebert Inc. Publishers.

2019

  • Nitsch, L., Zimmermann, J., Krauthausen, M., Hofer, M., Saggu, R., Petzold, G., Heneka, M., Getts, D., Campbell, I., Muller, M. (2019). CNS-Specific Synthesis of Interleukin 23 Induces a Progressive Cerebellar Ataxia and the Accumulation of Both T and B Cells in the Brain: Characterization of a Novel Transgenic Mouse Model. Molecular Neurobiology, In Press, 1-17. [More Information]
  • Suprunenko, T., Hofer, M. (2019). Complexities of Type I Interferon Biology: Lessons from LCMV. Viruses, 11(2), 1-20. [More Information]
  • Jones, H., Sharma, S., Mohammad, S., Kothur, K., Patel, S., Brilot-Turville, F., Guastella, A., Dale, R., Hofer, M. (2019). Maternal thyroid autoimmunity associated with acute-onset neuropsychiatric disorders and global regression in offspring. Developmental Medicine and Child Neurology, 61(8), 984-988. [More Information]
  • West, P., Viengkhou, B., Campbell, I., Hofer, M. (2019). Microglia responses to interleukin-6 and type I interferons in neuroinflammatory disease. GLIA, 67(10), 1821-1841. [More Information]

2018

  • Jung, S., Suprunenko, T., Ashhurst, T., King, N., Hofer, M. (2018). Collateral damage: What effect does anti-CD4 and anti-CD8alpha antibody-mediated depletion have on leukocyte populations? Journal of Immunology, 201(7), 2176-2186. [More Information]
  • Li, W., Viengkhou, B., Denyer, G., West, P., Campbell, I., Hofer, M. (2018). Microglia have a more extensive and divergent response to interferon-alpha compared with astrocytes. GLIA, 66(10), 2058-2078. [More Information]

2017

  • Huber, M., Suprunenko, T., Ashhurst, T., Marbach, F., Raifer, H., Wolff, S., Strecker, T., Viengkhou, B., Jung, S., Obermann, H., King, N., Campbell, I., Hofer, M., et al (2017). IRF9 Prevents CD8+ T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection. Journal of Virology, 91(22), 1-15. [More Information]
  • Vachharajani, N., Joeris, T., Luu, M., Hartmann, S., Pautz, S., Jenike, E., Pantazis, G., Prinz, I., Hofer, M., Steinhoff, U., et al (2017). Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7. Oncotarget, 8(31), 50447-50459. [More Information]
  • Li, W., Hofer, M., Songkhunawej, P., Jung, S., Hancock, D., Denyer, G., Campbell, I. (2017). Type I interferon-regulated gene expression and signaling in murine mixed glial cells lacking signal transducers and activators of transcription 1 or 2 or interferon regulatory factor 9. Journal of Biological Chemistry, 292(14), 5845-5859. [More Information]

2016

  • Mikaelyan, A., Thompson, C., Hofer, M., Brune, A. (2016). Deterministic Assembly of Complex Bacterial Communities in Guts of Germ-Free Cockroaches. Applied and Environmental Microbiology, 82(4), 1256-1263. [More Information]
  • Hofer, M., Campbell, I. (2016). Immunoinflammatory diseases of the central nervous system - The tale of two cytokines. British Journal of Pharmacology, 173(4), 716-728. [More Information]
  • Suprunenko, T., Hofer, M. (2016). The emerging role of interferon regulatory factor 9 in the antiviral host response and beyond. Cytokine & Growth Factor Reviews, 29, 35-43. [More Information]

2015

  • Almolda, B., de Labra, C., Barrera, I., Gruart, A., Delgado-Garcia, J., Villacampa, N., Vilella, A., Hofer, M., Hidalgo, J., Campbell, I., et al (2015). Alterations in microglial phenotype and hippocampal neuronal function in transgenic mice with astrocyte-targeted production of interleukin-10. Brain, Behavior, and Immunity, 45, 80-97. [More Information]
  • Campbell, L., Simonin, A., Chen, C., Ferdous, J., Padula, M., Harry, E., Hofer, M., Campbell, I., Carter, D. (2015). Cryptococcus Strains with Different Pathogenic Potentials Have Diverse Protein Secretomes. Eukaryotic Cell (Online), 14(6), 554-563. [More Information]
  • Visekruna, A., Linnerz, T., Martinic, V., Vachharajani, N., Hartmann, S., Harb, H., Joeris, T., Pfefferle, P., Hofer, M., Steinhoff, U. (2015). Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis. Mucosal Immunology, 8(2), 307-315. [More Information]

2014

  • Teymoortash, A., Zieger, L., Hoch, S., Pagenstecher, A., Hofer, M. (2014). Distinct microscopic features of perineural invasion in adenoid cystic carcinoma of the head and neck. Histopathology, 64(7), 1037-1039. [More Information]
  • Li, W., Hofer, M., Jung, S., Lim, S., Campbell, I. (2014). IRF7-Dependent Type I Interferon Production Induces Lethal Immune-Mediated Disease in STAT1 Knockout Mice Infected with Lymphocytic Choriomeningitis Virus. Journal of Virology, 88(13), 7578-7588. [More Information]
  • Nocon, A., Ip, J., Terry, R., Lim, S., Getts, D., Muller, M., Hofer, M., King, N., Campbell, I. (2014). The Bacteriostatic Protein Lipocalin 2 Is Induced in the Central Nervous System of Mice with West Nile Virus Encephalitis. Journal of Virology, 88(1), 679-689. [More Information]

2013

  • Hofer, M., Rohlfs, J., Teymoortash, A., Pagenstecher, A. (2013). A 62-year-old female with an intranasal mass extending into the lamina cribrosa. Brain Pathology, 23, 105-108. [More Information]
  • Zimmermann, J., Krauthausen, M., Hofer, M., Heneka, M., Campbell, I., Muller, M. (2013). CNS-Targeted Production of IL-17A Induces Glial Activation, Microvascular Pathology and Enhances the Neuroinflammatory Response to Systemic Endotoxemia. PloS One, 8(2), 1-13. [More Information]
  • Siegfried, A., Berchtold, S., Manncke, B., Deuschle, E., Reber, J., Ott, T., Weber, M., Kalinke, U., Hofer, M., Hatesuer, B., et al (2013). IFIT2 is an effector protein of type I IFN-mediated amplification of lipopolysaccharide (LPS)-induced TNF-α secretion and LPS-induced endotoxin shock. Journal of Immunology, 191(7), 3913-3921. [More Information]
  • Li, W., Hofer, M., Nocon, A., Manders, P., Campbell, I. (2013). Interferon regulatory factor 7 (IRF7) is required for the optimal initial control but not subsequent clearance of lymphocytic choriomeningitis virus infection in mice. Virology, 439(2), 152-162. [More Information]
  • Bujan, B., Hofer, M., Oertel, W., Pagenstecher, A., Burk, K. (2013). Multiple system atrophy of the cerebellar type (MSA-C) with concomitant beta-amyloid and tau pathology. Clinical Neuropathology, 32, 286-290. [More Information]
  • Hofer, M., Campbell, I. (2013). Type I interferon in neurological disease-The devil from within. Cytokine and Growth Factor Reviews, 24(3), 257-267. [More Information]

2012

  • Hofer, M., Riehmer, V., Kuhnt, D., Braun, V., Nimsky, C., Weber, R., Sommer, C., Pagenstecher, A. (2012). Genomic profiling to assess the clonal relationship between histologically distinct intracranial tumours. Neuropathology and Applied Neurobiology, 38(5), 500-504. [More Information]
  • Hofer, M., Li, W., Manders, P., Terry, R., Lim, S., King, N., Campbell, I. (2012). Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus. Journal of Virology, 86(12), 6932-6946. [More Information]
  • Ghandourah, S., Hofer, M., Kiessling, A., El-Zayat, B., Schofer, M. (2012). Painful muscle fibrosis following synthol injections in a bodybuilder: a case report. Journal of Medical Case Reports, 6, 1-4. [More Information]
  • Getts, D., Terry, R., Getts, M., Muller, M., Rana, S., Deffrasnes, C., Ashhurst, T., Radford, J., Hofer, M., Thomas, S., Campbell, I., King, N. (2012). Targeted blockade in lethal West Nile virus encephalitis indicates a crucial role for very late antigen (VLA)-4-dependent recruitment of nitric oxide-producing macrophages. Journal of Neuroinflammation, 9(1), 1-8. [More Information]

2011

  • Ip, J., Nocon, A., Hofer, M., Lim, S., Müller, M., Campbell, I. (2011). Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration. Journal of Neuroinflammation, 8(124), 1-15. [More Information]

2010

  • Thompson, C., Hofer, M., Campbell, I., Holmes, A. (2010). Community Dynamics in the Mouse Gut Microbiota: A Possible Role for IRF9-Regulated Genes in Community Homeostasis. PloS One, 5(4), e10335-1-e10335-9. [More Information]
  • Muller, M., Carter, S., Hofer, M., Campbell, I. (2010). Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity - a tale of conflict and conundrum. Neuropathology and Applied Neurobiology, 36(5), 368-387. [More Information]
  • Ellis, S., Gysbers, V., Manders, P., Li, W., Hofer, M., Muller, M., Campbell, I. (2010). The Cell-Specific Induction of CXC Chemokine Ligand 9 Mediated by IFN-{gamma} in Microglia of the Central Nervous System Is Determined by the Myeloid Transcription Factor PU.1. Journal of Immunology, 185(3), 1864-1877. [More Information]
  • Hofer, M., Li, W., Lim, S., Campbell, I. (2010). The type I interferon-alpha mediates a more severe neurological disease in the absence of the canonical signaling molecule interferon regulatory factor 9. Journal of Neuroscience, 30(3), 1149-1157. [More Information]
  • Campbell, I., Hofer, M., Pagenstecher, A. (2010). Transgenic models for cytokine-induced neurological disease. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1802 (10), 903-917. [More Information]

2009

  • Hofer, M., Campbell, I. (2009). Central Nervous System Inflammation: Cytokines and JAK/STAT/SOCS Signal Transduction. In Binder MD, Hirokawa N, Windhorst U, Hirsch M. (Eds.), Encyclopedia of Neuroscience, (pp. 641-650). New York: Springer. [More Information]
  • Vetter, M., Hofer, M., Roth, E., Pircher, H., Pagenstecher, A. (2009). Intracerebral interleukin 12 induces glioma rejection in the brain predominantly by CD8+ T cells and independently of interferon-gamma. Journal of Neuropathology and Experimental Neurology, 68(5), 525-534. [More Information]
  • Quintana, A., Muller, M., Frausto, R., Ramos, R., Getts, D., Sanz, E., Hofer, M., Krathausen, M., King, N., Hildago, J., Campbell, I. (2009). Site-Specific Production of IL-6 in the Central Nervous System Retargets and Enchances the Inflammatory Response in Experimental Autoimmune Encephalomyelitis. Journal of Immunology, 183(3), 2079-2088. [More Information]

2008

  • Sanz, E., Hofer, M., Unzeta, M., Campbell, I. (2008). Minimal Role for STAT1 in Interleukin-6 Signaling and Actions in the Murine Brain. GLIA, 56(2), 190-199. [More Information]
  • Hofer, M., Carter, S., Muller, M., Campbell, I. (2008). Unaltered Neurological Disease and Mortality in CXCR3-Deficient Mice Infected Intracranially with Lymphocytic Choriomeningitis Virus-Armstrong. Viral Immunology, 21(4), 425-433. [More Information]

2007

  • Muller, M., Carter, S., Hofer, M., Manders, P., Getts, D., Getts, M., Dreykluft, A., Lu, B., Gerard, C., King, N., Campbell, I. (2007). CXCR3 Signaling Reduces the Severity of Experimental Autoimmune Encephalomyelitis by Controlling the Parenchymal Distribution of Effector and Regulatory T Cells in the Central Nervous System. Journal of Immunology, 179(5), 2774-2786. [More Information]
  • Hofer, M., Mueller, M., O'Sullivan, C., Manders, P., Campbell, I. (2007). Lethal lymphocytic choriomeningitis virus (LCMV) infection in STAT1 KO mice is associated with dysregulated PD-1/B7-H1 and a phenotypic switch in the T-cell response. International Society for Interferon and Cytokine Research, Interferon Anniversary Meeting (ISICR 2007), United Kingdom: Mary Ann Liebert Inc. Publishers.

2006

  • Hofer, M., Schindler, A., Ehrensberger, F., Staeheli, P., Pagenstecher, A. (2006). Absence of Borna disease virus in the CNS of epilepsy patients. Journal Of Clinical Virology.
  • Hofer, M. (2006). Absence of Borna disease virus in the CNS of epilepsy patients. Journal Of Clinical Virology, 36(1), 84-85. [More Information]
  • Wacher, C., Muller, M., Hofer, M., Getts, D., Zabaras, R., Ousman, S., Terenzi, F., Sen, G., King, N., Campbell, I. (2006). Coordinated Regulation and Widespread Cellular Expression of Interferon-Stimulated Genes (ISG) ISG-49, ISG-54, and ISG-56 in the Central Nervous System after Infection with Distinct Viruses. Journal of Virology, 81(2), 860-871. [More Information]
  • Wacher, C., Muller, M., Hofer, M., Getts, D., Zabaras, R., Ousman, S., Terenzi, F., Sen, G., King, N., Campbell, I. (2006). Coordinated regulation and widespread cellular expression of the interferon-stimulated genes (ISG)-49, ISG-54 and ISG-56 in the central nervous system following infection with distinct viruses. Journal of Virology, 81(2), 860-871. [More Information]

2005

  • Hofer, M., Weber, A., Haffner, K., Berlis, A., Klingel, K., Kruger, M., Kandolf, R., Volk, B. (2005). Acute hemorrhagic leukoencephalitis (Hurst’s disease) linked to Epstein-Barr virus infection. Acta Neuropathologica, 109(2), 226-230. [More Information]
  • Harloff, A., Rauer, S., Hofer, M., Klisch, J., Els, T. (2005). Fulminant acute disseminated encephalomyelitis mimicking acute bacterial meningoencephalitis. European Journal of Neurology, 12(1), 67-69. [More Information]
  • Hofer, M., Finger, C., Pagenstecher, A. (2005). Molecular genotyping of the murine H-2K MHC class I allele. Journal of Immunological Methods, 302(1-2), 168-171. [More Information]
  • Kuhne, M., Sidler, D., Hofer, S., Hofer, M., Ludwig, C. (2005). Zuviel Blut und eine erstaunliche Diagnose [Too much blood and an astonishing diagnosis]. Swiss Medical Forum, 5, 273-275. [More Information]

2004

  • Friedl, G., Hofer, M., Auber, B., Sauder, C., Hausmann, J., Staeheli, P., Pagenstecher, A. (2004). Borna Disease Virus Multiplication in Mouse Organotypic Slice Cultures Is Site-Specifically Inhibited by Gamma Interferon but Not by Interleukin-12. Journal of Virology, 78(3), 1212-1218. [More Information]
  • Hofer, M., Hausmann, J., Staeheli, P., Pagenstecher, A. (2004). Cerebral Expression of Interleukin-12 Induces Neurological Disease via Differential Pathways and Recruits Antigen-Specific T Cells in Virus-Infected Mice. American Journal of Pathology, 165(3), 949-958. [More Information]

2002

  • Freude, S., Hausmann, J., Hofer, M., Pham-Mitchell, N., Campbell, I., Staeheli, P., Pagenstecher, A. (2002). Borna disease virus accelerates inflammation and disease associated with transgenic expression of interleukin-12 in the central nervous system. Journal Of Clinical Virology, 76(23), 12223-122232.

2001

  • Allmang, U., Hofer, M., Herzog, S., Bechter, K., Staeheli, P. (2001). Low avidity of human serum antibodies for Borna disease virus antigens questions their diagnostic value. Molecular Psychiatry, 6(3), 329-333.

1999

  • Czygan, M., Hallensleben, W., Hofer, M., Pollak, S., Sauder, C., Bilzer, T., Blumcke, I., Riederer, P., Bogerts, B., et al (1999). Borna disease virus in human brains with a rare form of hippocampal degeneration but not in brains of patients with common neuropsychiatric disorders. The Journal of Infectious Diseases, 180(5), 1695-1699. [More Information]

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