Dr Sergey Kurdyukov

Research Fellow - Genome Editing Specialist
School of Life and Environmental Sciences

Member of the Charles Perkins Centre

D17 - Charles Perkins Centre
The University of Sydney

Telephone (02) 86277568

Biographical details

I have extensive experience in the fields of nucleic acids research, molecular biology and genetics.

I completed PhD in human genetics/molecular biology at the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (Moscow, Russia).

I applied and further developed my skills during postdoctoral studies at the Max-Planck Institute for Plant Breeding research (Germany) and at the University of Newcastle (Australia).

I participated in biomedical research at the Kolling Institute of Medical Research where I served as the manager of two core facilities; Genomics and Confocal Microscopy.

My research activities at the University of Arizona (USA) included studies of genetic and metabolic aspects of pulmonary arterial hypertension.

Research interests

My current research interests are mostly related to use of CRISPR genome editing technologies in order to answer a range of biological questions such as:

  • cancer-specific drivers of cell proliferation,
  • identification of molecular targets of cytotoxic compounds (venoms and toxins) extracted from Australian animals,
  • investigation of molecular mechanism of cellular senescence,
  • genetic components in longevity.

In my position of Genome Editing Specialist I am collaborating with a number of researcher helping them in precise genetic modifications and genome-wide CRISPR screening.

One of my interests is improving efficiency of the CRISPR genome editing technology and tools.

Current projects

Please contact me for Honours degree and PhD opportunities.

You research ideas will considered if they involve extensive genetic modifications or modulation of gene expression.

Themes

Molecular biology and biotechnology; Genetics and genomics

Selected grants

2012

  • Scanning for Mutations in Cancer Susceptibility Genes; Howell V, Kurdyukov S, Bullock M; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Genomics Core facilities Staff; Kurdyukov S; Northern Sydney Local Health District/Research Support.

Selected publications

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Journals

  • Kurdyukov, S., Eccles, C., Desai, A., Manuel, G., Yuan, J., Garcia, J., Rafikova, O., Rafikova, R. (2018). New cases of Glucose-6-Phosphate Dehydrogenase deficiency in Pulmonary Arterial Hypertension. PloS One, 13(8), 1-16. [More Information]
  • Kurdyukov, S., Bullock, M. (2016). DNA methylation analysis: Choosing the right method. Biology, 5(1), 1-21. [More Information]
  • Kurdyukov, S., Song, Y., Tiew, T., Wang, X., Nolan, K., Rose, R. (2015). Protocols for obtaining zygotic and somatic embryos for studying the regulation of early embryo development in the model legume Medicago truncatula. Journal of Visualized Experiments, 2015 (100). [More Information]
  • Kurdyukov, S., Mathesius, U., Nolan, K., Sheahan, M., Goffard, N., Carroll, B., Rose, R. (2014). The 2HA line of Medicago truncatula has characteristics of an epigenetic mutant that is weakly ethylene insensitive. BMC Plant Biology, 14(1). [More Information]
  • Kurdyukov, S., Song, Y., Sheahan, M., Rose, R. (2014). Transcriptional regulation of early embryo development in the model legume Medicago truncatula. Plant Cell Reports, 33(2), 349-362. [More Information]
  • Nolan, K., Kurdyukov, S., Rose, R. (2011). Characterisation of the legume SERK-NIK gene superfamily including splice variants: implications for development and defence. BMC Plant Biology, 11, 1-16. [More Information]
  • Brooks, R., Rose, R., Sheahan, M., Kurdyukov, S. (2011). Whole Genome Methylation Scanning Based on phi29 Polymerase Amplification. Biochemistry (Moscow), 76(9), 999-1002. [More Information]
  • Voisin, D., Nawrath, C., Kurdyukov, S., Franke, R., Reina-Pinto, J., Efremova, N., Will, I., Schreiber, L., Yephremov, A. (2009). Dissection of the Complex Phenotype in Cuticular Mutants of Arabidopsis Reveals a Role of SERRATE as a Mediator. PLoS Genetics, 5(10), 1-19. [More Information]
  • Nolan, K., Kurdyukov, S., Rose, R. (2009). Expression of the SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE1 (SERK1) gene is associated with developmental change in the life cycle of the model legume Medicago truncatula. Journal of Experimental Botany, 60(6), 1759-1771. [More Information]
  • Reina-Pinto, J., Voisin, D., Kurdyukov, S., Faust, A., Haslam, R., Michaelson, L., Efremova, N., Franke, B., Schreiber, L., et al (2009). Misexpression of FATTY ACID ELONGATION1 (FAE1) in the Arabidopsis epidermis induces cell death and suggests a critical role for phospholipase A2 in this process. The Plant Cell, 21(4), 1252-1272. [More Information]
  • Chen, S., Kurdyukov, S., Kereszt, A., Wang, X., Gresshoff, P., Rose, R. (2009). The association of homeobox gene expression with stem cell formation and morphogenesis in cultured Medicago truncatula. Planta, 230(4), 827-840. [More Information]
  • Mantiri, F., Kurdyukov, S., Chen, S., Rose, R. (2008). The transcription factor MtSERF1 may function as a nexus between stress and development in somatic embryogenesis in Medicago truncatula. Plant Signaling and Behavior, 3(7), 498-500.
  • Mantiri, F., Kurdyukov, S., Lohar, D., Sharopova, N., Saeed, N., Wang, X., VandenBosch, K., Rose, R. (2008). The transcription factor MtSERF1 of the ERF subfamily identified by transcriptional profiling is required for somatic embryogenesis induced by auxin plus cytokinin in Medicago truncatula. Plant Physiology, 146(4), 1622-1636. [More Information]
  • Kurdyukov, S., Faust, A., Trenkamp, S., Bar, S., Franke, R., Efremova, N., Tietjen, K., Schreiber, L., Saedler, H., et al (2006). Genetic and biochemical evidence for involvement of HOTHEAD in the biosynthesis of long-chain a-,x-dicarboxylic fatty acids and formation of extracellular matrix. Planta, 224, 325-329. [More Information]
  • Kurdyukov, S., Faust, A., Nawrath, C., Bar, S., Voisin, D., Efremova, N., Franke, R., Schreiber, L., Saedler, H., et al (2006). The epidermis-specific extracellular BODYGUARD controls cuticle development and morphogenesis in Arabidopsis. The Plant Cell, 18, 321-339. [More Information]
  • Kurdyukov, S., Lebedev, Y., Artamonova, I., Gorodentseva, T., Batrak, A., Mamedov, I., Azhikina, T., Legchilina, S., Efimenko, I., et al (2001). Full-sized HERV-K (HML-2) human endogenous retroviral LTR sequences on human chromosome 21: map locations and evolutionary history. Gene, 273(1), 51-61. [More Information]
  • Laman, A., Kurdyukov, S., Bulgakova, E., Anikeeva, N., Brovko, F. (2001). Subtractive hybridization of biotinylated DNA in phenol emulsion. Journal Of Biochemical and Biophysical Methods, 50(1), 43-52. [More Information]
  • Lebedev, Y., Belonovitch, O., Zybrova, N., Khil, P., Kurdyukov, S., Vinogradova, T., Hunsmann, G., Sverdlov, E. (2000). Differences in HERV-K LTR insertions in orthologous loci of humans and great apes. Gene, 247(1-2), 263-277. [More Information]

2018

  • Kurdyukov, S., Eccles, C., Desai, A., Manuel, G., Yuan, J., Garcia, J., Rafikova, O., Rafikova, R. (2018). New cases of Glucose-6-Phosphate Dehydrogenase deficiency in Pulmonary Arterial Hypertension. PloS One, 13(8), 1-16. [More Information]

2016

  • Kurdyukov, S., Bullock, M. (2016). DNA methylation analysis: Choosing the right method. Biology, 5(1), 1-21. [More Information]

2015

  • Kurdyukov, S., Song, Y., Tiew, T., Wang, X., Nolan, K., Rose, R. (2015). Protocols for obtaining zygotic and somatic embryos for studying the regulation of early embryo development in the model legume Medicago truncatula. Journal of Visualized Experiments, 2015 (100). [More Information]

2014

  • Kurdyukov, S., Mathesius, U., Nolan, K., Sheahan, M., Goffard, N., Carroll, B., Rose, R. (2014). The 2HA line of Medicago truncatula has characteristics of an epigenetic mutant that is weakly ethylene insensitive. BMC Plant Biology, 14(1). [More Information]
  • Kurdyukov, S., Song, Y., Sheahan, M., Rose, R. (2014). Transcriptional regulation of early embryo development in the model legume Medicago truncatula. Plant Cell Reports, 33(2), 349-362. [More Information]

2011

  • Nolan, K., Kurdyukov, S., Rose, R. (2011). Characterisation of the legume SERK-NIK gene superfamily including splice variants: implications for development and defence. BMC Plant Biology, 11, 1-16. [More Information]
  • Brooks, R., Rose, R., Sheahan, M., Kurdyukov, S. (2011). Whole Genome Methylation Scanning Based on phi29 Polymerase Amplification. Biochemistry (Moscow), 76(9), 999-1002. [More Information]

2009

  • Voisin, D., Nawrath, C., Kurdyukov, S., Franke, R., Reina-Pinto, J., Efremova, N., Will, I., Schreiber, L., Yephremov, A. (2009). Dissection of the Complex Phenotype in Cuticular Mutants of Arabidopsis Reveals a Role of SERRATE as a Mediator. PLoS Genetics, 5(10), 1-19. [More Information]
  • Nolan, K., Kurdyukov, S., Rose, R. (2009). Expression of the SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE1 (SERK1) gene is associated with developmental change in the life cycle of the model legume Medicago truncatula. Journal of Experimental Botany, 60(6), 1759-1771. [More Information]
  • Reina-Pinto, J., Voisin, D., Kurdyukov, S., Faust, A., Haslam, R., Michaelson, L., Efremova, N., Franke, B., Schreiber, L., et al (2009). Misexpression of FATTY ACID ELONGATION1 (FAE1) in the Arabidopsis epidermis induces cell death and suggests a critical role for phospholipase A2 in this process. The Plant Cell, 21(4), 1252-1272. [More Information]
  • Chen, S., Kurdyukov, S., Kereszt, A., Wang, X., Gresshoff, P., Rose, R. (2009). The association of homeobox gene expression with stem cell formation and morphogenesis in cultured Medicago truncatula. Planta, 230(4), 827-840. [More Information]

2008

  • Mantiri, F., Kurdyukov, S., Chen, S., Rose, R. (2008). The transcription factor MtSERF1 may function as a nexus between stress and development in somatic embryogenesis in Medicago truncatula. Plant Signaling and Behavior, 3(7), 498-500.
  • Mantiri, F., Kurdyukov, S., Lohar, D., Sharopova, N., Saeed, N., Wang, X., VandenBosch, K., Rose, R. (2008). The transcription factor MtSERF1 of the ERF subfamily identified by transcriptional profiling is required for somatic embryogenesis induced by auxin plus cytokinin in Medicago truncatula. Plant Physiology, 146(4), 1622-1636. [More Information]

2006

  • Kurdyukov, S., Faust, A., Trenkamp, S., Bar, S., Franke, R., Efremova, N., Tietjen, K., Schreiber, L., Saedler, H., et al (2006). Genetic and biochemical evidence for involvement of HOTHEAD in the biosynthesis of long-chain a-,x-dicarboxylic fatty acids and formation of extracellular matrix. Planta, 224, 325-329. [More Information]
  • Kurdyukov, S., Faust, A., Nawrath, C., Bar, S., Voisin, D., Efremova, N., Franke, R., Schreiber, L., Saedler, H., et al (2006). The epidermis-specific extracellular BODYGUARD controls cuticle development and morphogenesis in Arabidopsis. The Plant Cell, 18, 321-339. [More Information]

2001

  • Kurdyukov, S., Lebedev, Y., Artamonova, I., Gorodentseva, T., Batrak, A., Mamedov, I., Azhikina, T., Legchilina, S., Efimenko, I., et al (2001). Full-sized HERV-K (HML-2) human endogenous retroviral LTR sequences on human chromosome 21: map locations and evolutionary history. Gene, 273(1), 51-61. [More Information]
  • Laman, A., Kurdyukov, S., Bulgakova, E., Anikeeva, N., Brovko, F. (2001). Subtractive hybridization of biotinylated DNA in phenol emulsion. Journal Of Biochemical and Biophysical Methods, 50(1), 43-52. [More Information]

2000

  • Lebedev, Y., Belonovitch, O., Zybrova, N., Khil, P., Kurdyukov, S., Vinogradova, T., Hunsmann, G., Sverdlov, E. (2000). Differences in HERV-K LTR insertions in orthologous loci of humans and great apes. Gene, 247(1-2), 263-277. [More Information]

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