student profile: Ms Sherry Chen


Thesis work

Thesis title: Cerebellar contributions to cognitive changes in frontotemporal dementia

Supervisors: Olivier PIGUET , Muireann IRISH , Fiona KUMFOR , Ramon LANDIN-ROMERO

Thesis abstract:

Cerebellum is traditionally associated with motor coordination. Disorders in fine movement, equilibrium, posture and motor learning are the most common clinical manifestations in patients with cerebellar damage. Since the late 19th, however, overwhelming evidence has demonstrated the functional connectivity between the cerebellum and associated cerebral areas, as well as the cerebellar contribution in cognition. My project utilised different cognitive tasks in combination with structural magnetic resonance imaging technique to investigate cerebellar contribution to cognitive changes in dementia. Currently this research has found widespread cerebellar atrophy in frontotemporal dementia, and demonstrated that this cerebellar atrophy is associated with patients’ cognitive deficits. This study provides evidence for the cerebellar contribution in cognition, and will help us to increase our understanding of the underlying mechanism of frontotemporal dementia.

Note: This profile is for a student at the University of Sydney. Views presented here are not necessarily those of the University.