Dr Thang Khuong

Postdoctoral Research Associate
School of Life and Environmental Sciences

Member of the Charles Perkins Centre

D17 - Charles Perkins Centre
The University of Sydney


Biographical details

Thang Khuong did his doctoral studies in BioMedical Sciences with a major in developmental molecular neuroscience at the renowned University of Leuven (KU Leuven) in Belgium. His postdoctoral training was conducted at the Garvan Institute of Medical Research and current research is currently situated at the University of Sydney.

Research interests

His ambition is to succeed in world-leading research in the field of neuroscience to make a world-changing contribution to improvement of health in patients with neurological diseases. He has a strong interest in doing research for the development of mechanism-based therapies by integrating methodology from both basic biology and clinical drug development. His unique expertise in using a multidisciplinary approach and combining techniques in molecular genetics, molecular imaging, electrophysiology and pharmacology has led him to make several breakthroughs in not only in chronic pain, but also in venom toxicology, metabolism, neurodegeneration, and basic synaptic biology. He has published original research papers in multiple high-profile journals, including Neuron, PNAS, Cell Metabolism, Journal of Clinical Investigation, Nature Communications, and Science Advances.

Teaching and supervision

He has been supervising both undergraduates and graduate students to undertake their research thesis works in the areas of neuroscience. Under his supervision, one undergraduate student achieved the UNSW university medal for Neuroscience in 2013.

Current projects

Molecular mechanism of sleep regulation after nerve injury

Novel genetic mechanisms ofneuropathic pain

Genome-wide study to identify new genes that regulate motor functions

Themes

Molecular biology and biotechnology; Genetics and genomics; Food and nutrition

Selected grants

2017

  • Functional genomic dissection of motor neuron disease; Neely G, Khuong T, Lin Y; Motor Neurone Disease Research Institute of Australia/Grants in aid.

Selected publications

Download citations: PDF RTF Endnote

Journals

  • Lau, M., Manion, J., Littleboy, J., Oyston, L., Khuong, T., Wang, Q., Nguyen, D., Hesselson, D., Seymour, J., Neely, G. (2019). Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote. Nature Communications, 10(1). [More Information]
  • Khuong, T., Wang, Q., Manion, J., Oyston, L., Lau, M., Towler, H., Lin, Y., Neely, G. (2019). Nerve injury drives a heightened state of vigilance and neuropathic sensitization in Drosophila. Science Advances, 5(7), 1-12. [More Information]
  • Hamoudi, Z., Khuong, T., Cole, T., Neely, G. (2018). A fruit fly model for studying paclitaxel-induced pain. F1000Research, 7, 1-12. [More Information]
  • Lau, M., Lin, Y., Kisling, S., Cotterell, J., Wilson, Y., Wang, K., Khuong, T., Bakhshi, N., Cole, T., Oyston, L., Cole, A., Neely, G. (2017). A simple high throughput assay to evaluate water consumption in the fruit fly. Scientific Reports, 7(1), 1-10. [More Information]
  • Martin, L., Smith, S., Khoutorsky, A., Magnussen, C., Samoshkin, A., Sorge, R., Cho, C., Yosefpour, N., Sivaselvachandran, S., Cole, T., Khuong, T., Neely, G., et al (2017). Epiregulin and EGFR interactions are involved in pain processing. Journal of Clinical Investigation, 127(9), 3353-3366. [More Information]
  • Wang, Q., Lin, Y., Zhang, L., Wilson, Y., Oyston, L., Cotterell, J., Qi, Y., Khuong, T., Bakhshi, N., Planchenault, Y., Lau, M., Cole, T., Wong, A., Simpson, S., Neely, G., et al (2016). Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response. Cell Metabolism, 24(1), 75-90. [More Information]
  • Nagy, V., Cole, T., Van Campenhout, C., Khuong, T., Leung, C., Vermeiren, S., Novatchkova, M., Wenzel, D., Cikes, D., Polyansky, A., Neely, G., et al (2015). The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception. Cell Cycle, 14(12), 1799-1808. [More Information]
  • Khuong, T., Neely, G. (2013). Conserved systems and functional genomic assessment of nociception. FEBS Journal, 280(21), 5298-5306. [More Information]
  • Leung, C., Wilson, Y., Khuong, T., Neely, G. (2013). Fruit flies as a powerful model to drive or validate pain genomics efforts. Pharmacogenomics, 14(15), 1879-1887. [More Information]
  • Khuong, T., Habets, R., Kuenen, S., Witkowska, A., Kasprowicz, J., Swerts, J., Jahn, R., van den Bogaart, G., Verstreken, P. (2013). Synaptic PI(3,4,5)P3 Is Required for Syntaxin1A Clustering and Neurotransmitter Release. Neuron, 77(6), 1097-1108. [More Information]
  • Slabbaert, J., Khuong, T., Verstreken, P. (2012). Phosphoinositides at the Neuromuscular Junction of Drosophila melanogaster: A Genetic Approach. Methods in Cell Biology, 108, 227-247. [More Information]
  • Khuong, T., Habets, R., Slabbaert, J., Verstreken, P. (2010). WASP is activated by phosphatidylinositol-4,5-bisphosphate to restrict synapse growth in a pathway parallel to bone morphogenetic protein signaling. Proceedings of the National Academy of Sciences of the United States of America, 107(40), 17379-17384. [More Information]

2019

  • Lau, M., Manion, J., Littleboy, J., Oyston, L., Khuong, T., Wang, Q., Nguyen, D., Hesselson, D., Seymour, J., Neely, G. (2019). Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote. Nature Communications, 10(1). [More Information]
  • Khuong, T., Wang, Q., Manion, J., Oyston, L., Lau, M., Towler, H., Lin, Y., Neely, G. (2019). Nerve injury drives a heightened state of vigilance and neuropathic sensitization in Drosophila. Science Advances, 5(7), 1-12. [More Information]

2018

  • Hamoudi, Z., Khuong, T., Cole, T., Neely, G. (2018). A fruit fly model for studying paclitaxel-induced pain. F1000Research, 7, 1-12. [More Information]

2017

  • Lau, M., Lin, Y., Kisling, S., Cotterell, J., Wilson, Y., Wang, K., Khuong, T., Bakhshi, N., Cole, T., Oyston, L., Cole, A., Neely, G. (2017). A simple high throughput assay to evaluate water consumption in the fruit fly. Scientific Reports, 7(1), 1-10. [More Information]
  • Martin, L., Smith, S., Khoutorsky, A., Magnussen, C., Samoshkin, A., Sorge, R., Cho, C., Yosefpour, N., Sivaselvachandran, S., Cole, T., Khuong, T., Neely, G., et al (2017). Epiregulin and EGFR interactions are involved in pain processing. Journal of Clinical Investigation, 127(9), 3353-3366. [More Information]

2016

  • Wang, Q., Lin, Y., Zhang, L., Wilson, Y., Oyston, L., Cotterell, J., Qi, Y., Khuong, T., Bakhshi, N., Planchenault, Y., Lau, M., Cole, T., Wong, A., Simpson, S., Neely, G., et al (2016). Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response. Cell Metabolism, 24(1), 75-90. [More Information]

2015

  • Nagy, V., Cole, T., Van Campenhout, C., Khuong, T., Leung, C., Vermeiren, S., Novatchkova, M., Wenzel, D., Cikes, D., Polyansky, A., Neely, G., et al (2015). The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception. Cell Cycle, 14(12), 1799-1808. [More Information]

2013

  • Khuong, T., Neely, G. (2013). Conserved systems and functional genomic assessment of nociception. FEBS Journal, 280(21), 5298-5306. [More Information]
  • Leung, C., Wilson, Y., Khuong, T., Neely, G. (2013). Fruit flies as a powerful model to drive or validate pain genomics efforts. Pharmacogenomics, 14(15), 1879-1887. [More Information]
  • Khuong, T., Habets, R., Kuenen, S., Witkowska, A., Kasprowicz, J., Swerts, J., Jahn, R., van den Bogaart, G., Verstreken, P. (2013). Synaptic PI(3,4,5)P3 Is Required for Syntaxin1A Clustering and Neurotransmitter Release. Neuron, 77(6), 1097-1108. [More Information]

2012

  • Slabbaert, J., Khuong, T., Verstreken, P. (2012). Phosphoinositides at the Neuromuscular Junction of Drosophila melanogaster: A Genetic Approach. Methods in Cell Biology, 108, 227-247. [More Information]

2010

  • Khuong, T., Habets, R., Slabbaert, J., Verstreken, P. (2010). WASP is activated by phosphatidylinositol-4,5-bisphosphate to restrict synapse growth in a pathway parallel to bone morphogenetic protein signaling. Proceedings of the National Academy of Sciences of the United States of America, 107(40), 17379-17384. [More Information]

To update your profile click here. For support on your academic profile contact .