Hemodynamics and fMRI

We have developed quantitative, physiologically-based, mathematical models of neural activity and hemodynamics (flow of blood and oxygen) in the brain, both in response to stimuli and in the resting state. We have shown that that these models successfully reproduce a wide range of phenomena, including the recent prediction and experimental confirmation of cortical hemodynamic waves that propagate across the brain after a stimulus.

Numerous areas exist for PhD, MSc, or Honors projects, which could include theoretical, computational, experimental, and/or clinically-related components in cooperation with our collaborators locally and at other universities.

Schematic Vessel Diagram

Spatiotemporal Hemodynamic Modeling

KEY PUBLICATIONS

  1. Aquino K.M, Robinson P.A., Drysdale P.M. (2014) 'Spatiotemporal hemodynamic response functions derived from physiology' - Journal of Theoretical Biology, accepted (2014) doi: http://dx.doi.org/10.1016/j.jtbi.2013.12.027
  2. Aquino K.M., Schira M.M., Robinson P.A., Drysdale P.M., Breakspear M. (2012) ‘Hemodynamic traveling waves in Human Visual Cortex’, PLoS - Computational Biology, DOI: 10.1371/journal.pcbi.1002435.
  3. Drysdale P.M., Huber J.P., Robinson P.A., Aquino K.M, (2010) ‘Spatiotemporal BOLD hemodynamics from a poroelastic hemodynamic model’, The journal of Theoretical Biology 265, 523-534.
  4. Breakspear, M., Bullmore, E. T., Aquino, K., Das, P., & Williams, L. M. (2006). The multiscale character of evoked cortical activity. NeuroImage, 30(4), 1230-1242.
  5. Robinson, P. A., Drysdale, P. M., Van der Merwe, H., Kyriakou, E., Rigozzi, M. K., Germanoska, B., & Rennie, C. J. (2006). Bold responses to stimuli: dependence on frequency, stimulus form, amplitude, and repetition rate. Neuroimage, 31(2), 585-599.