Chronic Disease-Diabetes
Background
There is a substantive research program by health economists within the Sydney School of Public Health on the economic aspects of the prevention and management of type 2 diabetes. This research has been conducted in collaboration with a range of national and international groups, including researchers from: the University of Oxford involved in the United Kingdom Prospective Diabetes Study (UKPDS); NHMRC Clinical Trials Centre involved in the Fenofribrate Intervention and Event Lowering in Diabetes (FIELD) study; the George Institute for International Health undertaking the Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation (ADVANCE) Study.
Past research has included costing of the progression of diabetes and its complications (including two recent Australian based studies), the impact of complications on utility and other measures of health related quality of life, the cost of scaling up intensive blood pressure and blood glucose control, the extrapolation of health outcomes and economic evaluation of interventions to better manage diabetes.
The main focus of current research is to develop a new version of the United Kingdom Prospective Diabetes (UKPDS) Outcomes Model: a computer simulation model for forecasting quality adjusted life expectancy and other outcomes of people with type 2 diabetes. Simulation models in diabetes are a valuable tool for evaluation of interventions as outcomes can take years and sometimes decades to eventuate (e.g. progression to renal failure).
Support
This research is currently supported by NHMRC project grant and grants from Diabetes Australia
Researchers involved
Selected Publications
Clarke PM, Gray AM, Briggs A, Farmer A, Fenn P, Stevens R, Matthews D, Stratton IM, Holman R. A model to estimate the lifetime health outcomes of patients with Type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 68) Outcomes Model, Diabetologia Vol. 47 pp.1747–1759, 2004.
Clarke P, Kelman C. Colagiuri S. Factors influencing the cost of hospital care for people with diabetes in Australia. Journal of Diabetes and Its Complications, 20, 2006, 349– 355.
Hayes AJ, Clarke PM, Glasziou PG, Simes RJ, Drury PL Keech AC. "Can self-rated health be used for risk prediction in patients with type 2 diabetes?" Diabetes Care 2008 31: 795-797. (2006 Impact Factor: 7.92)