The Center for Children's Bone Health

Lab head: David Little, Aaron Schindeler, Craig Munns
Location: The Kids Research Institute at The Children's Hospital at Westmead

The Center for Children's Bone Health (CCBH) aims to advance orthopaedic care and bone health through an improved understanding of bone diseases, bone healing and pharmaceutical therapies. Its research approach is highly translational, bridging the gap from bench to bedside.

The CCBH encompasses an array of basic scientists, engineers, technicians and research assistants, postgraduate scholars, medical doctors and other clinical staff across the Sydney Children's Hospitals Network (SCHN).  Members of the CCBH have had significant academic and grant success and has a robust publication records, particularly in high impact bone, orthopaedic, and tissue engineering journals.

Website: http://www.kidsresearch.org.au/research/orthopaedic-biotechnology/index.php
Research approach equipment: Advanced genetically modified mouse models Culture of cell lines and primary bone & muscle cells from mice & humans Gene expression & protein analysis by qPCR and western blotting Tissue histology & histomorphometry XR, DEXA, QCT and microCT scanning Virus induced gene excision Surgical models in rodents(fracture models, BMP-induced bone, spine fusion) & drug administration Manufacturing of polymer scaffolds and other tissue engineering constructs

Studying the effects of genetic mutations on musculoskeletal tissue function

Primary supervisor: Aaron Schindeler

Our group studies a variety of genetic diseases that affect bone and muscle. To accomplish this, we have generated a variety of preclinical models of human disease that we have hypothesized reflect the situation in patients. 

To validate our hypotheses, we have obtained a large number of clinical muscle and bone tissue specimens. The Honours student will carry out histological analysis and examination by high-powered microscopy (confocal microscopy and/or electron microscopy). This will require advanced training in the latest-generation microscopes and analysis software at the Westmead Hub. The student's results will be published alongside existing preclinical data to determine the relevance of our model systems.

 

Contact Dr Aaron Schindeler (0404032645 or aaron.schindeler@sydney.edu.au) for further information.


Discipline: Applied Medical Sciences, Westmead
Co-supervisors: Andrew Biggin
Keywords: Bone health, Musculoskeletal diseases
Contact: