Neural Imaging Laboratory

Lab head: Luke Henderson
Location: Anderson Stuart Building, Camperdown Campus

The major aim of the laboratory is to define the brain circuitry underlying the responses to pain originating in different structures. With particular interest in, defining which brain regions are responsible for the different perceptual qualities associated with pain of different origin; pain originating in skin is normally sharp and easy to localise, whereas pain of muscle origin is usually dull and diffuse. More specifically, this laboratory investigates pain processing by exploring brain activation patterns during skin and muscle pain, as well as examining the cardiovascular consequences of these manipulations in terms of sympathetic nerve activation. Furthermore, the superficial and deep pain processing circuits are being studied.

Lab members: L Henderson (head)

Brain changes associated with chronic pain in humans

Primary supervisor: Luke Henderson

The major aim of the laboratory is to define the brain circuitry underlying acute and chronic pain in humans. We are particularly interested in defining the anatomical and functional brain changes associated with chronic pain following spinal cord injury and peripheral nerve injury in humans. In collaboration with Professor Philip Siddall at the Pain Management Research Institute at RNSH we are using state-of-the-art human magnetic resonance imaging techniques to explore anatomical and functional changes that occur in patients with pain following spinal cord injury. In collaboration with Professors Greg Murray and Chris Peck at the Orofacial Pain clinic at Westmead hospital we are exploring long-term brain changes in patients with various forms of orofacial chronic pain. Finally, in collaboration with Professor Vaughan Macefield at UWS we are defining the brain circuitry responsible for acute skin and muscle pain in healthy individuals.

Discipline: Anatomy & Histology