Immunisation and Hajj Research

Lab head: Robert Booy
Location: NCIRS, Kids Researach Institute, Children's Hospital at Westmead

Influenza Vaccination: Fever, antipyretics and immunogenicity

Primary supervisor: Robert Booy

Professor Robert Booy is head of Clinical Research at the National Centre for Immunisation Research and Surveillance.  He is involved in research on vaccine preventable diseases, be they in infants, children, adults or the elderly. His work on Mass Gathering Medicine is included in the Collaborating Centre workplan for international Mass Gathering Medicine Centre..

He is currently researching improvements to influenza vaccines wrt better protection, and improved safety by reviewing existing data at the individual level, never before done in clinical trials. There are also exciting projects on long-term protection against infection and cancer due to HPV.

Research opportunities exist also in relation to individual level data collected from very large clinical trials adressing important questions like safety, immunogenicity and effectiveness of new vaccines.

Recent work has found some very provocative findings in regard to the impact of influenza immunisation in young children - either having a fever or being given antipyretic (anti-fever) medicine, both have a substantial impact on immunogenicity and potential effectiveness.  There is scope to use existing data to better address this question across several other studies.  The student would be supervised by a recent PhD student and Prof Booy and a statistician.  The methodology is already known to work well and initial data has been submitted for publication - this follow-up work is highly publishable.

Discipline: Applied Medical Sciences, Westmead
Co-supervisors: Harunor Rashid, Jean Li-Kim-Moy
Keywords: Infection and immunity, Vaccination, Human papillomavirus