Sydney Seminars

7 September 2017

Professor Brian Dixon (all the way from Ontario!) who will be presenting his research on antigen presentation in fish.

Environmental influences on antigen presentation in fish"

Major Histocompatibility Complex (MHC) receptors are central to the initiation of immune responses through binding of peptide fragments of pathogens and presenting them to T cells (antigen presentation), which start immune responses to the specific pathogens. There are several accessory molecules required to perform this task, all of which are the same as those used in antigen presentation in mammals. The discovery and characterization of Major Histocompatibility Complex genes, and the genes encoding their accessory molecules, in teleost fish has revealed some startling differences in the regulation of the immune response between fish and mammals, as well as between the different orders of fish. The function of these molecules under normal conditions and at non-physiological temperatures will be discussed.

Biography: Professor Brian Dixon was born in Whitehaven Castle in northern England. His research focuses on fish immune systems and the impact of the environment in their function. He received his Bachelor's degree from Wilfrid Laurier University and his MSc from the University of Guelph. His PhD thesis examined immune responses to parasites of fish and seals and was carried out at Dalhousie University in Halifax, Nova Scotia. Dr. Dixon received a scholarship from the National Science and Engineering Research Council of Canada to be a postdoctoral fellow at Wageningen University in the Netherlands and another from the Medical Research Council of Canada to be a postdoctoral fellow at Stanford University in California, during which time took a course in ethics. Currently a professor of Biology at the University of Waterloo, Dr. Dixon was the recipient of a Premier's Research Excellence Award from the Province of Ontario, the Canada Research Chair in Fish and Environmental Immunology and was recently given an Natural Sciences and Engineering Research Council of Canada Synergy award for collaboration with the aquaculture industry.

Time: 1-2pm

Location: VSCC Webster LT

Cost: Free

Contact: Elspeth McLennan

Email: 13220e145b5663471131342a561c162b07314979520c234f1410