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Patricia Tang

Academic (Research Only), Pharmaceutics.

Qualifications

PhD in Chemical Engineering, awarded 11/2002.
BE in Chemical Engineering, awarded 03/1998.

Contact Details

Phone: +61-2-9351 4450
Fax: +61-2-9351 4391
Email:

Research Interest

Dr Patricia Tang has been a research associate for 3.5 years in Aerosol Drug Delivery group, led by Professor Hak Kim Chan. During this time, she has been on projects involving solid state characterisation of mannitol, aerosol performance determination of various drugs compounds, development of an asthma diagnostic device for children, and production of aerosol suitable for inhalation using sonocrystallisation and spray drying techniques. Dr Tang has also more than 5 years combined experience with fractal concept in describing aggregates packing density and particle surface ruggedness.

She has successfully designed, constructed, and commissioned an optical particle size analyser during her PhD study. The equipment was specifically designed for measurement of settling velocities and size of aggregates and particulates with size ranges from 2 to 240 µm.

The particle imaging and settling rig was equipped with high magnification camera (1300 X), tight temperature control, and image analysis software to analyse the digital image captured. Moreover, the total cost of constructing the equipment was A$15,000. This low cost equipment, which is the first settling rig able to see particles as small as 2µm, is therefore cost effective.

Recently, Dr Tang has used Focused Ion Beam facility in Electron Microscope Unit to mill different drug particles, namely mannitol, bovine serum albumin, sodium chloride and sodium cromoglycate to see their inside structures.

Research Publications

Book Chapters

  • Tang, P., Chan, H.-K., Raper, J. A. Fractal geometry in pharmaceutical and biological applications-A review, Encyclopedia of Pharmaceutical Technology at www.dekker.com. (Third Edition).
  • Coates, M.S., Tang, P., Chan, H-K., Fletcher, D.F., and Raper, J.A. Characterisation of pharmaceutical aerosols for inhalation drug delivery, Particulate Systems in Nano and Biotechnologies, Sigmund, W., El-Shall, H., Moudgil, B., and Shah, D (Eds). Accepted .

Journal Articles

  • Syed Muhammad, S A F, Langrish, T A, Tang, P, Adi, H, Chan, H, Kazarian, S, Dehghani, F 2010, A novel method for the production of crystalline micronised particles, International Journal of Pharmaceutics, 388(1-2), 114-122
  • Tang, P., Chan, H., and Raper, J., 2009, Validation of computation method to predict aerodynamic diameter of particles with rough surface, Powder Technology, 192, 74-84
  • Tang, P., Chan, H., Chiou, H. C., Ogawa, K., Jones, M., Adi, H., Buckton, G., Prud'homme, R., and Raper, J., 2009, Characterisation and aerosolisation of mannitol particles produced via confined liquid impinging jets, International Journal of Pharmaceutics, 367, 51-57
  • Chew, N. Y. K., Tang, P., Chan, H-K., Raper, J.A. How much particle surface corrugation is sufficient to improve aerosol performance of powders? Pharm Res (2005), 22(1), 148-152.
  • Tang, P., Chan, H.-K., Raper, J. A. Prediction of aerodynamic diameter of particles with rough surfaces. Powder Technol (2004), 147(1-3), 64-78.
  • Tang, P., Chew, N. Y. K., Chan, H-K., Raper, J A. Limitation of determination of surface fractal dimension using N2 adsorption isotherms and modified Frenkel-Halsey-Hill theory. Langmuir (2003), 19(7), 2632-2638.
  • Nobbs, D., Tang, P., Raper, J. A. The design, construction and commissioning of a low-cost optical particle size analyser specifically for measurement of settling velocities and size of flocs. Meas Sci Technol (2002), 13(3), 297-302.
  • Tang, P., Raper, J. A. Modelling the settling behaviour of fractal aggregates - a review. Powder Technol (2002), 123(2-3), 114-125.
  • Tang, P., Greenwood, J., Raper, J. A. A model to describe the settling behaviour of fractal aggregates. J Colloid Interf Sci (2002), 247(1), 210-219.
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Conference Papers

  • Tang, P., Chan, H.-K., Raper, J. A. Validation of Computation Method to Predict Aerodynamic Diameter of Particles with Rough Surface. Accepted for Respiratory Drug Delivery X, Boca Raton, Florida, 23-27 April 2006.
  • Tang, P., Chan, H.-K., Raper, J. A, A method to calculate aerodynamic diameter of particles with fractal surface. Accepted for 5th World Congress Particle Technology, Orlando, Florida, 23-27 April 2006.
  • Purssell, I., Abbas, A., Romagnoli, J.A., Tang, P., and Chan, H-K. An investigation into the production of nanoparticles suitable for inhalation. 11th International Workshop on Industrial Crystallization, Gyeongju, Korea, 15-17 September 2004.
  • Chew, N. Y. K., Tang, P., Chan, H-K., Raper, J.A. Effect of surface roughness on the dispersion of aerosol particles with fractal characteristics. 7th World Biomaterial Congress, 17-21 May 2004.
  • Tang, P., Chan, H.-K., Raper, J. A. The use of a simple vacuum generator unit to disperse powders for aerosol particle size measurement. Respiratory Drug Delivery IX, Palm Desert, California, 25-29 April 2004.
  • Tang, P., Chan, H.-K., Raper, J. A. Computational method to predict aerodynamic diameters of particles with fractal surfaces. Australian Pharmaceutical Science Association., Sydney, Dec 2003.
  • Tang, P. Tam, E., de Gruyter, N., Chan, H-K. Method of precipitating and recovering sodium chloride particles. Australian Pharmaceutical Science Association, Melbourne, 8-13 Dec 2002.
  • Schneider, C., Tang, P., Chan, H-K., Impact of timing valve on the in vitro particle size distribution of the Bricanyl Turbuhaler®. Australian Pharmaceutical Science Association., Melbourne, 8-13 Dec 2002.
  • Chew, N.Y.K., Tang, P., Raper, J.A., Chan, H-K., Effect of surface roughness on powder aerosol performance. American Association of Pharmaceutical Scientists (AAPS), 10-14 November 2002, Toronto, Canada.
  • Tang, P., Greenwood, J., and Raper, J.A. A model to predict fractal dimension from sedimentation. The 4th World Congress Particle Technology, Sydney, Australia, 21-25 July 2002.
  • Greenwood, J., Tang, P., Cheung, W. H., Doherty, W. O. S., and Raper, J. A. The flocculation of calcium phosphate in sucrose solution: effect of key parameter on size and structure. The 6th World Congress of Chemical Engineering, Melbourne, Australia, 23-27 September 2001.
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