Amino acid sensing mechanisms in human biology.
Amino acid sensing mechanisms determine how dietary protein regulates appetite and satiety, how feeding influences endocrine responses and how nutrition can direct cell fate in breast and prostate cancers.
We are funded by the National Health and Medical Research Council to study the mechanisms by which amino acid sensing receptors control hormone secretion, appetite and satiety, and cell fate. This offers opportunities for PhD topics in the following areas: determining how protein regulates calcium metabolism, determining how protein regulates body weight via satiety hormones e.g., cholecystokinin, determining how amino acid sensing mechanisms can be used to control cancer.
Techniques used in the project: live cell imaging, BRET/FRET, alpha-screen assays of intracellular signaling; perifusion secretion assays, cell culture and transfection; RNAi; lenteviral infection; protein expression analysis, mutational analysis.
Want to find out more?
Amino acid sensing, Calcium metabolism, Hormone secretion, Appetite, satiety, Weight control and obesity, Cancer chemotherapy, Cell fate, Apoptosis, metastasis, Parathyroid hormone, Calcitonin, Cholecystokinin, Cancer & leukaemia, Liver & hormonal disorders, Cell biology, Health & lifestyle, Human body
The opportunity ID for this research opportunity is: 124