Clinical outcomes analysis of patients who undergo resection for malignant Hepato-Biliary tumours

Summary

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Available projects
Clinical and molecular markers of early tumour recurrence in patients with malignant hepato-biliary tumours,
Clinical and molecular markers of metastatic potential in colorectal cancer,
Stromal biomarker patterns in colorectal liver metastases
These projects will be done in conjunction with Professor Mark Molloy in the Colorectal Cancer Genetics laboratory in the Kolling Institute at RNSH. Using frozen tumour tissue and sera collected and stored in the Upper GI tumour biobank, a range of biomarkers will be analysed using proteomic and genomic tools to help understand the risk of recurrence or early metastatic potential in patients with malignant hepatobiliary tumours. The large prospective clinical data base held in the Upper GI surgery department will also be a valuable resource for these projects.

Supervisor

Professor Thomas J Hugh.

Research location

Royal North Shore Hospital (RNSH)

Program type

Masters/PHD

Synopsis

• Clinical and molecular markers of early tumour recurrence in patients with malignant hepato-biliary tumours
• Clinical and molecular markers of metastatic potential in colorectal cancer
• Stromal biomarker patterns in colorectal liver metastases
This project will be done in conjunction with Professor Mark Molloy in the Colorectal Cancer Genetics laboratory in the Kolling Institute at RNSH. Using frozen tumour and sera collected and stored in the Upper GI tumour biobank, a range of biomarkers will be analysed using proteomic and genomic tools to help understand the risk of recurrence or early metastatic potential in patients with malignant hepatobiliary tumours
• Presentation and management of patients with neuroendocrine liver metastases
The HPB Unit at RNSH has treated many patients with neuroendocrine tumours and has a special interest in the management of patients with neuroendocrine liver metastases. The large prospective clinical database contains many patients with this condition and will involve examining the presenting features and investigation and treatment of these patients
• The economic cost of surgical treatment of colorectal liver metastases
This project will analyse the overall economic impact of the diagnoses and surgical treatment of patients with colorectal liver metastases. This will be done in conjunction with a current PhD student with in the Upper GI surgery unit

Additional information

For more information contact tom.hugh@sydney.edu.au

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Opportunity ID

The opportunity ID for this research opportunity is 2847