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Biomolecular studies of Parkinson’s disease

Opportunities exist to join a leading group conducting research into Parkinson's disease. Our group combines the disciplines of biochemistry, immunology, molecular biology and cell more...

Supervisor(s): Dzamko, Nicolas (Dr)

Molecular insights into a novel mammalian oxygen-sensing pathway

Oxygen (O2) is a vital biological resource most prominently known for its role as the final electron acceptor in aerobic respiration and, as such, adequate molecular mechanisms are more...

Supervisor(s): White, Mark (Dr), Mackay, Joel (Professor)

Control of complement cascade by labile disulphide bonds

The complement system is a key component of innate immunity that offers sophisticated protection against threats to the host organism. Complement is also an important component of t more...

Supervisor(s): Chiu, Joyce (Dr)

Control of immune cell activity via a redox switch in integrin

Our immune system protects us from invasion of pathogens and toxic materials. Immune cells such as monocytes and neutrophils circulate in the blood to monitor foreign materials and more...

Supervisor(s): Chiu, Joyce (Dr)

The Gene Environment Interaction

-Interrogating how different diets interact with genetics in different inbred mouse strains -Examining the genetic and environmental influence on tissue specific metabolomics -Exam more...

Supervisor(s): James, David (Professor)

Regulation of Lipid Turnover in the body

The project involves characterisation of a novel lipolysis regulator in adipocytes. more...

Supervisor(s): James, David (Professor)

The role of redox in signalling: assessing the requirement of reactive oxygen species in signal transduction

Define the role of ROS in insulin signal transduction and explore how loss of control of this process causes diseases such as diabetes and cancer more...

Supervisor(s): James, David (Professor)

Design of Novel Biosensors and Microfluidic Devices for Interrogating the Insulin Signalling Pathway

The aim of this project is to design, engineer and validate novel biosensors that can be used to interrogate the insulin signalling pathway in live cells. more...

Supervisor(s): James, David (Professor)

Utility of Cerebrospinal fluid proteomics to define molecular mechanisms in brain disease of childhood.

Brain diseases of childhood are very common and result in significant disability, and cost to the nation. Common diseases include epilepsy, cerebral palsy, autism and mental health more...

Supervisor(s): Dale, Russell (Professor)

Exploring the Sulfoproteome using Synthetic Sulfoproteins

More than 70% of all mammalian proteins are predicted to be functionalised with posttranslational modifications (PTMs). These modifications serve to expand the functional repertoire more...

Supervisor(s): Payne, Richard (Professor)