This study is to investigate the link between innate and adaptive immunity in kidney ischemia reperfusion injury and allograft rejection with a view to identifying new therapeutic targets.
Professor Steve Chadban, Associate Professor Huiling Wu.
Camperdown - School of Medical Sciences - Bosch Institute
Masters/PHD
Allograft rejection is the major cause of premature kidney transplant failure after transplantation. Allograft rejection occurs because of an adaptive alloimmune response mediated by antigen specific T cells. Our previous results suggest that innate immune mechanisms dependent on macrophages and Toll like receptors play important roles in kidney ischemia reperfusion injury and transplantation. The aim of this study is to examine the link between innate and adaptive immunity in ischemia reperfusion injury, acute and chronic kidney rejection with a view to identifying new therapeutic targets in our animal models of kidney ischemia reperfusion injury and allograft rejection. In particular, projects focus on:
Investigation may include in vivo and in vitro studies in animal models of kidney ischemia reperfusion injury, acute and chronic rejection. The techniques to be used include immunohistochemistry, molecular biology (RNA isolation, cDNA synthesis, real time PCR), flow cytometry (FACS), ELISA analysis and cell culture.
The opportunity ID for this research opportunity is 248