Post-translational modifications in bacterial proteins

Summary

This project will identify novel proteins that are post-translationally modified in bacterial pathogens and the role of such modification in virulence.

Supervisor(s)

Professor Stuart Cordwell

Research Location

School of Life and Environmental Sciences

Program Type

Masters/PHD

Synopsis

Post-translational modifications, such as phosphorylation and glycosylation, modify the structure and function of proteins. Furthermore, protein cleavage provides antigenic variation and may dictate novel functions. This project will examine both global protein modifications (e.g. phosphoproteomics) as well as characterize modifications in individual proteins such as the CadF adhesin of Campylobacter jejuni. Oxidative stress, caused by the release of toxic reactive oxygen species (ROS) from inflammatory immune cells, must be overcome by the majority of human pathogens. This project aims to identify how oxidative stress modifies protein expression, as well as determine whether disulfide bond formation is induced under such conditions.

Additional Information

HDR Inherent Requirements

In addition to the academic requirements set out in the Science Postgraduate Handbook, you may be required to satisfy a number of inherent requirements to complete this degree. Example of inherent requirement may include:

- Confidential disclosure and registration of a disability that may hinder your performance in your degree;
- Confidential disclosure of a pre-existing or current medical condition that may hinder your performance in your degree (e.g. heart disease, pace-maker, significant immune suppression, diabetes, vertigo, etc.);
- Ability to perform independently and/or with minimal supervision;
- Ability to undertake certain physical tasks (e.g. heavy lifting);
- Ability to undertake observatory, sensory and communication tasks;
- Ability to spend time at remote sites (e.g. One Tree Island, Narrabri and Camden);
- Ability to work in confined spaces or at heights;
- Ability to operate heavy machinery (e.g. farming equipment);
- Hold or acquire an Australian driver’s licence;
- Hold a current scuba diving license;
- Hold a current Working with Children Check;
- Meet initial and ongoing immunisation requirements (e.g. Q-Fever, Vaccinia virus, Hepatitis, etc.)

You must consult with your nominated supervisor regarding any identified inherent requirements before completing your application.

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Keywords

Cystic fibrosis, Gastrointestinal Disease, Guillain-Barre Syndrome, Antibiotic resistance, Proteomics, Phosphorylation, Glycosylation, oxidative stress, mass spectrometry, Infectious diseases, Cell biology, Infection & immunity

Opportunity ID

The opportunity ID for this research opportunity is: 65

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