Trevor Hambley Research Group

Publications

Pt(IV) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate. Zhang, J. Z.; Wexselblatt, E.; Hambley, T. W.; Gibson, D., Chemical Communications (Cambridge, United Kingdom), 2012, 48, 847-849.
Platinum-oxazoline complexes as anti-cancer agents: syntheses, characterisation and initial biological studies. Yadav, P. N.; Beveridge, R. E.; Blay, J.; Boyd, A. R.; Chojnacka, M. W.; Decken, A.; Deshpande, A. A.; Gardiner, M. G.; Hambley, T. W.; Hughes, M. J.; Jolly, L.; Lavangie, J. A.; MacInnis, T. D.; McFarland, S. A.; New, E. J.; Gossage, R. A., MedChemComm , 2011, 2, 274-277.
Visualising the hypoxia selectivity of cobalt(iii) prodrugs. Kim, B. J.; Hambley, T. W.; Bryce, N. S., Chem. Sci. , 2011, 2, 2135-2142.
Stabilization of Triam(m)inechloridoplatinum Complexes by Oxidation to PtIV. Daly, H. L.; Hall, M. D.; Failes, T. W.; Zhang, M.; Foran, G. J.; Hambley, T. W., Aust. J. Chem., 2011, 64, 273-278
The preparation and characterization of trans-platinum(iv) complexes with unusually high cytotoxicity. Cubo, L.; Hambley, T. W.; Sanz, M. P. J.; Carnero, A.; Navarro-Ranninger, C.; Quiroga, A. G., Dalton Trans., 2011, 40, 344-347
Growth of DLD-1 colon cancer cells on Variotis scaffolds of controlled porosity: a preliminary study. Ma, Y.; Bryce, N. S.; Whan, R. M.; Xiao, L.; Li, K.; Ruys, A. J.; Hambley, T. W.; Boughton, P., J. Biomimetics, Biomater., Tissue Eng. , 2010, 8, 79-89
Binding of [Pt(1C3)(dien)]2+ to the duplex DNA oligonucleotide 5'-d(TGGCCA)-3': the effect of an appended positive charge on the orientation and location of anthraquinone intercalation. Whan, R. M.; Messerle, B. A.; Hambley, T. W., Dalton Trans., 2009, 932-939
Fluorescent analogues of quinoline reveal amine ligand loss from cis and trans platinum(II) complexes in cancer cells. New, E. J.; Roche, C.; Madawala, R.; Zhang, J. Z.; Hambley, T. W., J. Inorg. Biochem. , 2009, 103, 1120-1125
Investigations using fluorescent ligands to monitor platinum(iv) reduction and platinum(ii) reactions in cancer cells. New, E. J.; Duan, R.; Zhang, J. Z.; Hambley, T. W., Dalton Trans., 2009, 3092-3101
Platinum Drug Distribution in Cancer Cells and Tumors. Klein, A. V.; Hambley, T. W., Chem. Rev. (Washington, DC, U. S.), 2009, 109, 4911-4920
Iron(III) complexes of fluorescent hydroxamate ligands: preparation, properties, and cellular processing. Clarke, A. J.; Yamamoto, N.; Jensen, P.; Hambley, T. W., Dalton Trans., 2009, 10787-10798
Accumulation of an anthraquinone and its platinum complexes in cancer cell spheroids: the effect of charge on drug distribution in solid tumour N. S. Bryce, J. Z. Zhang, R. M. Whan, N. Yamamoto and T. W. Hambley, Chem. Commun. (Cambridge, U. K.), 2009, 647-653
Radiolabelled probes for imaging multidrug resistance using single photon emission tomography (SPECT) and positron emission tomography (PET) K. J. Guenther, T. W. Hambley and M. Kassiou, Conference Proceedings, 2008, 291-320
Physiological Targeting to Improve Anticancer Drug Selectivity T. W. Hambley, Australian Journal of Chemistry, 2008, 61, 647-653
[¹H, ¹⁵N] Heteronuclear Single Quantum Coherence NMR Study of the Mechanism of Aquation of Platinum(IV) Ammine Complexes M. S. Davies; M. D. Hall; S. J. Berners-Price; T. W. Hambley, Inorganic Chemistry, 2008, 47, 7673-7680
Cellular uptake and distribution of cobalt complexes of fluorescent ligands N. Yamamoto; S. Danos; P. D. Bonnitcha; T. W. Failes; E. J. New; T. W. Hambley, Journal of Biological Inorganic Chemistry, 2008, 13, 861-871
Metal-Based Therapeutics T. W. Hambley, Science, 2007, 318, 1392-1393
Developing new metal-based therapeutics: challenges and opportunities T. W. Hambley, Dalton Transactions, 2007, 43, 4929-4937
Elemental Tomography of Cancer-Cell Spheroids Reveals Incomplete Uptake of Both Platinum(II) and Platinum(IV) Complexes R. A. Alderden; H. R. Mellor; S. Modok; M. D. Hall; S. R. Sutton; M. G. Newville; R. Callaghan; T. W. Hambley, Journal of the American Chemical Society, 2007, 129, 13400-13401
Bioreductive activation and drug chaperoning in cobalt pharmaceuticals M. D. Hall; T. W. Failes; N. Yamamoto; T. W. Hambley, Dalton Transactions, 2007, 36, 3983-3990
DFT Study of the Systematic Variations in Metal-Ligand Bond Lengths of Coordination Complexes: The Crucial Role of the Condensed Phase R. K. Hocking; R. J. Deeth; T. W. Hambley, Inorganic Chemistry, 2007, 46, 8238-8244
Transport kinetics of four- and six-coordinate platinum compounds in the multicell layer tumor model S. Modok; R. Scott; R. A. Alderden; M. D. Hall; H. R. Mellor; S. Bohic; T. Roose; T. W. Hambley; R. Callaghan, British Journal of Cancer, 2007, 97, 197-200
Basis for Design and Development of Platinum(IV) Anticancer Complexes M. D. Hall; H. R. Mellor; R. Callaghan; T. W. Hambley, Journal of Medicinal Chemistry, 2007, 50, 3403-3411
Database Analysis of Transition Metal Carbonyl Bond Lengths: Insight into the Periodicity of π Back-Bonding, σ Donation, and the Factors Affecting the Electronic Structure of the TM-CO Moiety R. K. Hocking; T. W. Hambley, Organometallics, 2007, 26, 2815-2823
Studies of a Co(III) complex of the MMP inhibitor marimastat: a potential hypoxia activated prodrug. T.W. Failes, C. Cullinane, C.I. Diakos, N. Yamamoto, J.G. Lyons, and T.W. Hambley, Chemistry, A European Journal, 2006, e-published
XANES determination of the Co oxidation state in solution and in cancer cells treated with Co(III) complexes. P.D. Bonnitcha, M.D. Hall, C.K. Underwood, G.J. Foran, M. Zhang, P.J. Beale, and T.W. Hambley, Journal of Inorganic Biochemistry, 2006, 100, 963-971
The Fate of Platinum(II) and Platinum(IV) Anti-Cancer Agents in Cancer Cells and Tumours. M.D. Hall, R.A. Alderden, M. Zhang, P. Beale, Z. Cai, B. Lai, A.P.J. Stampfl, and T.W. Hambley, Journal of Structural Biology, 2006, 155, 38-44
Models of hypoxia activated prodrugs: Co(III) complexes of hydroxamic acids. T.W. Failes and T.W. Hambley, Dalton Transactions, 2006, 1895-1901
Cytotoxic efficacy of an anthraquinone linked platinum anticancer drug. R.A. Alderden, H.R. Mellor, S. Modok, T.W. Hambley, and R. Callaghan, Biochemical Pharmacology, 2006, 71, 1136-1145
The influence of tumour microenvironmental factors on the efficacy of cisplatin and novel platinum(IV) complexes. H.R. Mellor, S. Snelling, M.D. Hall, S. Modok, M. Jaffar, T.W. Hambley and R. Callaghan, Biochemical Pharmacology, 2005, 70, 1137-1146
Comparative efficacy of novel platinum(IV) compounds with established chemotherapeutic drugs in solid tumour models. M.D. Hall, C. Martin, D.J.P. Ferguson, R.M. Phillips, T.W. Hambley, R. Callaghan, Biochemical Pharmacology, 2004, 67, 17-30
Platinum(IV) anticancer complexes. M.D. Hall, R.C. Dolman and T.W. Hambley, Metal Complexes in Tumor Diagnosis and as Anticancer Agents, Volume 42 of "Metal Ions in Biological Systems" A. Sigel and H. Sigel, editors., M. Dekker, New York & Basel, 2004, Ch. 9, 297-322
XANES determination of the platinum oxidation state distribution in cancer cells treated with platinum(IV) anticancer agents. M.D. Hall, G.J. Foran, M. Zhang, P.J. Beale, and T.W. Hambley, Journal of the American Chemical Society, 2003, 125, 7524-7525
The cellular distribution and oxidation state of platinum(II) and platinum(IV) antitumour complexes in cancer cells. M.D. Hall, C.T. Dillon, M. Zhang, P. Beale, Z. Cai, B. Lai, A.P.J. Stampfl, and T.W. Hambley, Journal of Biological Inorganic Chemistry, 2003, 8, 726-732
The interaction of metal ions and Marimastat with matrix metalloproteinase 9. C.K. Underwood, D. Min, J.G. Lyons and T.W. Hambley, Journal of Inorganic Biochemistry, 2003, 95, 165-170
The first examples of platinum amine hydroxamate complexes: structures and biological activity. T.W. Failes, M.D. Hall, and T.W. Hambley, Dalton Transactions, 2003, 1596-1600
Studies of the binding of a series of platinum(IV) complexes to plasma proteins. R.C. Dolman, G.B. Deacon and T.W. Hambley., Journal of Inorganic Biochemistry, 2002, 88, 260-267
Platinum(IV) antitumour compounds: their bioinorganic chemistry. M.D. Hall and T.W. Hambley, Coordination Chemistry Reviews, 2002, 232, 49-67
Platinum binding to DNA: structural controls and consequences. T.W. Hambley., Journal of the Chemical Society, Dalton Transactions, 2001, 2711-2718