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Project
Descriptions: Temperature
Effects on Structure |
Osteoporosis
Sue Corley (with Dr Rory
Clifton-Bligh, Kolling Institute Royal North Shore Hospital and A/Prof Arthur
Conigrave, MMB, Sydney) The Calcium Sensing
Receptor (CaSR) is involved in regulating calcium within the body and is a
target for drugs to treat osteoporosis, one of the major health issues facing
Australia. We have modelled the interaction of hydrated Ca2+, Mg2+ and Sr2+ ions with the amino acid residues implicated
in the CaSR . We have found acidic and very polar residues together with the
protein backbone group represent the most likely residues involved in binding.
We have used these models to describe the quantitative and qualitative
differences in observed in the binding of Ca2+ and Mg2+ ions. Our calculations have enabled us to identify a putative
binding site within the extracellular domain of the CaSR. |
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Selected Publications: |