IMMU3202: Semester 2, 2022

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Units IMMU3202 Semester 2 2022 [Normal day]

Unit outline_

IMMU3202: Immunology in Human Disease

Semester 2, 2022 [Normal day] - Camperdown/Darlington, Sydney

Overview

This study unit builds on the series of lectures that outlined the general properties of the immune system, effector lymphocytes and their functions, delivered in the core courses , IMMU2101 - Introductory Immunology and BMED2404 - Microbes, Infection and Immunity (formerly IMMU2001 and BMED2807), IMMU2X11 Immunobiology and MIMI2X02/MEDS2004 Microbes, Infection and Immunity. We emphasise fundamental concepts to provide a scientific basis for studies in clinical immunology; dysfunctions of the immune system e.g. autoimmune disease, immunodeficiencies, and allergy, and immunity in terms of host - pathogen interactions. This unit has a strong focus on significant clinical problems in immunology and the scientific background to these problems. The unit includes lectures from research scientists and clinicians covering areas such as allergy, immunodeficiency, autoimmune disease and transplantation. This course provides challenging information from the forefront of clinical immunology and helps the student develop an understanding of immune responses in human health and disease. This unit directly complements the unit 'Molecular and Cellular Immunology IMMU3102' and students are very strongly advised to undertake these study units concurrently.

Unit details and rules

Academic unit	Department of Medical Sciences
Credit points	6
Prerequisites ?	IMMU2101 or BMED2404 or MEDS2004 or MIMI2X02 or IMMU2X11
Corequisites ?	None
Prohibitions ?	IMMU3903
Assumed knowledge ?	None
Available to study abroad and exchange students	Yes

Teaching staff

Coordinator	Allison Abendroth, allison.abendroth@sydney.edu.au
Lecturer(s)	Kylie Shaddock, kylie.shaddock@sydney.edu.au
	Carl Feng, carl.feng@sydney.edu.au
	Allison Abendroth, allison.abendroth@sydney.edu.au
	Alexandra Sharland, alexandra.sharland@sydney.edu.au
	Jamie Triccas, jamie.triccas@sydney.edu.au
	Mainthan Palendira, umaimainthan.palendira@sydney.edu.au
	Jessie Lee, jessie.lee@sydney.edu.au
	Georges Grau, georges.grau@sydney.edu.au
	Helen McGuire, helen.mcguire@sydney.edu.au
	James Yun, james.yun@sydney.edu.au
	Roger Garsia, r.garsia@sydney.edu.au
	Stephen Adelstein, stephen.adelstein@sydney.edu.au

Type	Description	Weight	Due	Length
Final exam (Record+)	Final exam Written exam	50%	Formal exam period	2 hours
Outcomes assessed:
Tutorial quiz	Practical class quizzes Quizzes	5%	Multiple weeks	10 minutes
Outcomes assessed:
Presentation	Workshop Oral Paper presentation Oral presentation	15%	Multiple weeks	12 minutes
Outcomes assessed:
Assignment	Practical assignment Practical assessment	15%	Week 09 Due date: 09 Oct 2022 at 23:59	1250 words
Outcomes assessed:
Presentation	Poster abstract and presentation Poster presentation	15%	Week 12 Due date: 30 Oct 2022 at 23:59	12 min talk and 250 word abstract
Outcomes assessed:
= Type B final exam ?

Assessment summary

Detailed information for each assessment can be found on Canvas.

Assessment criteria

The University awards common result grades, set out in the Coursework Policy 2014 (Schedule 1).

As a general guide, a high distinction indicates work of an exceptional standard, a distinction a very high standard, a credit a good standard, and a pass an acceptable standard.

Result name	Mark range	Description
High distinction	85 - 100
Distinction	75 - 84
Credit	65 - 74
Pass	50 - 64
Fail	0 - 49	When you don’t meet the learning outcomes of the unit to a satisfactory standard.

For more information see guide to grades.

Late submission

In accordance with University policy, these penalties apply when written work is submitted after 11:59pm on the due date:

Deduction of 5% of the maximum mark for each calendar day after the due date.
After ten calendar days late, a mark of zero will be awarded.

Academic integrity

The Current Student website provides information on academic integrity and the resources available to all students. The University expects students and staff to act ethically and honestly and will treat all allegations of academic integrity breaches seriously.

We use similarity detection software to detect potential instances of plagiarism or other forms of academic integrity breach. If such matches indicate evidence of plagiarism or other forms of academic integrity breaches, your teacher is required to report your work for further investigation.

Use of generative artificial intelligence (AI) and automated writing tools

You may only use generative AI and automated writing tools in assessment tasks if you are permitted to by your unit coordinator. If you do use these tools, you must acknowledge this in your work, either in a footnote or an acknowledgement section. The assessment instructions or unit outline will give guidance of the types of tools that are permitted and how the tools should be used.

Your final submitted work must be your own, original work. You must acknowledge any use of generative AI tools that have been used in the assessment, and any material that forms part of your submission must be appropriately referenced. For guidance on how to acknowledge the use of AI, please refer to the AI in Education Canvas site.

The unapproved use of these tools or unacknowledged use will be considered a breach of the Academic Integrity Policy and penalties may apply.

Studiosity is permitted unless otherwise indicated by the unit coordinator. The use of this service must be acknowledged in your submission as detailed on the Learning Hub’s Canvas page.

Outside assessment tasks, generative AI tools may be used to support your learning. The AI in Education Canvas site contains a number of productive ways that students are using AI to improve their learning.

Learning support

Simple extensions

If you encounter a problem submitting your work on time, you may be able to apply for an extension of five calendar days through a simple extension.  The application process will be different depending on the type of assessment and extensions cannot be granted for some assessment types like exams.

Special consideration

If exceptional circumstances mean you can’t complete an assessment, you need consideration for a longer period of time, or if you have essential commitments which impact your performance in an assessment, you may be eligible for special consideration or special arrangements.

Special consideration applications will not be affected by a simple extension application.

Using AI responsibly

Co-created with students, AI in Education includes lots of helpful examples of how students use generative AI tools to support their learning. It explains how generative AI works, the different tools available and how to use them responsibly and productively.

Weekly schedule

WK	Topic	Learning activity
Week 01	Introduction and course overview; Immunology of pregnancy	Lecture (2 hr)
Week 02	Workshop 1	Workshop (2 hr)
Week 02	Neonatal immunology	Lecture (1 hr)
Week 03	Practical 1. 1. Introduction to the IMMU3202 practical class; 2. Viral case studies: investigating infection, immunity, and diagnosis of varicella zoster virus infections (part 1)	Practical (4 hr)
Week 03	MHC/Genetics of Human Disease; Immunity to infectious pathogens 1: viruses and immune evasion	Lecture (2 hr)
Week 04	Workshop 2	Workshop (2 hr)
Week 04	Immunity to infectious pathogens 2: intracellular and extracellular bacteria	Lecture (1 hr)
Week 05	Practical 2. Viral case studies: investigating infection, immunity, and diagnosis of varicella zoster virus infections (part 2)	Practical (4 hr)
Week 05	Immunity to infectious pathogens 3: parasites; Immunodeficiency-Acquired immunodeficiency-HIV	Lecture (2 hr)
Week 06	Workshop 3. Oral journal paper presentation	Presentation (2 hr)
Week 06	Primary immunodeficiency: Molecular basis of primary immunodeficiences	Lecture (1 hr)
Week 07	Practical 3. Immunodeficiency case studies: acquired and congenital immunodeficiency cases	Practical (4 hr)
Week 07	Skin immunology; Neuroimmunology	Lecture (2 hr)
Week 08	Vaccination and novel vaccines approaches	Lecture (1 hr)
Week 09	Workshop 4. Oral journal paper presentation	Presentation (2 hr)
Week 09	Self-Tolerance and Autoimmunity; Autoimmune Diseases	Lecture (2 hr)
Week 10	Practical 4. Immune-mediated case studies: immune mediated haemolysis and autoimmune disorders	Practical (4 hr)
Week 10	Transplantation Immunology	Lecture (1 hr)
Week 11	Workshop 5	Workshop (2 hr)
Week 11	Tumor Immunology and therapy; Allergic Diseases and immunotherapy	Lecture (2 hr)
Week 12	Advances in Technology-Omics Era in Immunology of Human Disease	Lecture (1 hr)
Week 12	Poster presentation	Presentation (4 hr)
Week 13	Allergy/snake bite and immunotherapies	Practical (4 hr)
Week 13	Aging immune system and immunosenescence; Make up lecture slot/Revision	Lecture (2 hr)

Attendance and class requirements

Attendance: Satisfactory attendance at all workshops and practical classes is therefore a requirement to pass this course. For Immunology in Human Disease, satisfactory attendance is defined as ≥ 80% which means that if you miss more than 2 workshops or 2 practical classes without approved special consideration for illness or misadventure, or pre-approved Special arrangement, you will not be allowed to pass this unit of study. Students who arrive more than 30 minutes late to a tutorial or practical class will be recorded as being absent.

Study commitment

Typically, there is a minimum expectation of 1.5-2 hours of student effort per week per credit point for units of study offered over a full semester. For a 6 credit point unit, this equates to roughly 120-150 hours of student effort in total.

Required readings

All readings for this unit can be accessed through the Library eReserve, available on Canvas.

Cellular & Molecular Immunology, 9th Ed 2018, AK Abbas, AH Lichtman & Pillai, Elsevier.

Learning outcomes

Learning outcomes are what students know, understand and are able to do on completion of a unit of study. They are aligned with the University's graduate qualities and are assessed as part of the curriculum.

Outcomes
Graduate qualities

At the completion of this unit, you should be able to:

LO1. understand how principles of immunology are applied to the understanding and treatment of human diseases
LO2. demonstrate effective skills in retrieving, analysing, and interpreting scientific information from current literature sources
LO3. demonstrate advanced oral and written communication skills
LO4. demonstrate knowledge of and training in analysis and interpretation of laboratory based experiments

Graduate qualities

The graduate qualities are the qualities and skills that all University of Sydney graduates must demonstrate on successful completion of an award course. As a future Sydney graduate, the set of qualities have been designed to equip you for the contemporary world.

GQ1	Depth of disciplinary expertise Deep disciplinary expertise is the ability to integrate and rigorously apply knowledge, understanding and skills of a recognised discipline defined by scholarly activity, as well as familiarity with evolving practice of the discipline.
GQ2	Critical thinking and problem solving Critical thinking and problem solving are the questioning of ideas, evidence and assumptions in order to propose and evaluate hypotheses or alternative arguments before formulating a conclusion or a solution to an identified problem.
GQ3	Oral and written communication Effective communication, in both oral and written form, is the clear exchange of meaning in a manner that is appropriate to audience and context.
GQ4	Information and digital literacy Information and digital literacy is the ability to locate, interpret, evaluate, manage, adapt, integrate, create and convey information using appropriate resources, tools and strategies.
GQ5	Inventiveness Generating novel ideas and solutions.
GQ6	Cultural competence Cultural Competence is the ability to actively, ethically, respectfully, and successfully engage across and between cultures. In the Australian context, this includes and celebrates Aboriginal and Torres Strait Islander cultures, knowledge systems, and a mature understanding of contemporary issues.
GQ7	Interdisciplinary effectiveness Interdisciplinary effectiveness is the integration and synthesis of multiple viewpoints and practices, working effectively across disciplinary boundaries.
GQ8	Integrated professional, ethical, and personal identity An integrated professional, ethical and personal identity is understanding the interaction between one’s personal and professional selves in an ethical context.
GQ9	Influence Engaging others in a process, idea or vision.

Outcome map

Learning outcomes	Graduate qualities
Learning outcomes

Responding to student feedback

This section outlines changes made to this unit following staff and student reviews.

Poster presentations done on an individual basis rather than in pairs

Disclaimer

The University reserves the right to amend units of study or no longer offer certain units, including where there are low enrolment numbers.

To help you understand common terms that we use at the University, we offer an online glossary.

Current students

Overview

Overview

Unit details and rules

Teaching staff

Assessment

Assessment

Assessment summary

Assessment criteria

Late submission

Academic integrity

Learning support

Learning support

Simple extensions

Special consideration

Using AI responsibly

Weekly schedule

Weekly schedule

Attendance and class requirements

Study commitment

Required readings

Learning outcomes

Learning outcomes

Graduate qualities

Outcome map

Responding to student feedback

Responding to student feedback

Disclaimer

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