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Unit outline_

PHAR2823: Physical Pharmaceutics and Formulation B

Semester 2, 2020 [Normal day] - Camperdown/Darlington, Sydney

This unit of study builds on the material presented in Physical Pharmaceutics and Formulation A. The topics covered in this unit include: solid dose forms and particle science; dispersion dose forms including suspensions, colloidal dispersions, and emulsions; topical dose forms and semisolids; inhalation pharmaceutical aerosols; protein and peptide drugs and formulations; rectal products and novel drug delivery technologies; biomaterials; and material characterisation techniques. Aspects pertaining to the stability of dose forms are also presented in this unit. Practical activities relate to the preparation, quality control and quality assurance of a marketed solid (tablet) dosage form.

Unit details and rules

Academic unit Pharmacy
Credit points 6
Prerequisites
? 
(CHEM1611 or CHEM11X1 or CHEM19X1 or CHEM1903 or CHEM1612 or CHEM11X2 or CHEM19X2 or CHEM1904) and PHAR1812 and PHAR1822.
Corequisites
? 
None
Prohibitions
? 
None
Assumed knowledge
? 

None

Available to study abroad and exchange students

Yes

Teaching staff

Coordinator Wojciech Chrzanowski, wojciech.chrzanowski@sydney.edu.au
Lecturer(s) Kim Chan, kim.chan@sydney.edu.au
Philip Kwok, philip.kwok@sydney.edu.au
Tutor(s) Shiva Divakarla, kamini.divakarla@sydney.edu.au
Thanh Phan, thanh.phan@sydney.edu.au
Ramya Varanasi, ramya.varanasi@sydney.edu.au
Qingyu Lei, qingyu.lei@sydney.edu.au
Type Description Weight Due Length
Final exam (Record+) Type B final exam hurdle task Final examination
MCQ and short answer (MCQ 63.5% & SAQ 36.5% of the total exam mark)
65% Formal exam period 2 hours
Outcomes assessed: LO1 LO2 LO3 LO4 LO5 LO6
Online task Online quizzes
3 x MCQ quizzes
5% Multiple weeks 5 min
Outcomes assessed: LO1 LO6 LO5 LO4 LO3 LO2
Assignment Laboratory pre-work quiz - Practical 1a
MCQ
3% Multiple weeks 5 min
Outcomes assessed: LO1 LO2 LO3 LO4 LO5
Assignment group assignment Practical 1b
Report
20% Multiple weeks Prepared during the class (2x4h)
Outcomes assessed: LO1 LO2 LO3
Participation hurdle task Practical
Participation
2% Ongoing n/a
Outcomes assessed: LO1 LO6 LO5 LO4 LO2
Online task Mid-semester quiz
MCQ
5% Week 09 1 hour
Outcomes assessed: LO1 LO4 LO3 LO2
hurdle task = hurdle task ?
group assignment = group assignment ?
Type B final exam = Type B final exam ?

Assessment summary

  • Laboratory practicals: The practical exercises will be performed in small groups during the scheduled practical sessions. The objective of the practical exercises is to assess individual’s and group’s abilities to understand the underlying principles of the course through experimental investigation and critical analysis.  Students must obtain a grade of ‘Pass’ in this assessment to satisfy the requirements for this unit of study. If this assessment is not passed, the maximum final grade possible to obtain will be 45 F, regardless of the total raw mark obtained for the unit of study.
  • Mid-semester quiz: The mid semester quiz will consist of multiple choice questions.
  • Online quizzes: The online quizzes will consist of three separate online quizzes that consist of three multiple-choice questions.
  • Final examination: The final examination will consist of multiple choice questions and short answer questions.  Students must obtain a grade of ‘Pass’ in this assessment to satisfy the requirements for this unit of study. If this assessment is not passed, the maximum final grade possible to obtain will be 45 F, regardless of the total raw mark obtained for the unit of study. If you wish to sit your exam on-campus, a limited number of on-campus places will be available through an online booking system.
  • The replacement exam will be held in the formal Replacement Exam period (11/01/2021 to 14/01/2021).

Detailed information for each assessment can be found on Canvas.

Assessment criteria

The University awards common result grades, set out in the Coursework Policy 2014 (Schedule 1).

As a general guide, a high distinction indicates work of an exceptional standard, a distinction a very high standard, a credit a good standard, and a pass an acceptable standard.

Result name

Mark range

Description

High distinction

85 - 100

 

Distinction

75 - 84

 

Credit

65 - 74

 

Pass

50 - 64

 

Fail

0 - 49

When you don’t meet the learning outcomes of the unit to a satisfactory standard.

For more information see guide to grades.

Late submission

In accordance with University policy, these penalties apply when written work is submitted after 11:59pm on the due date:

  • Deduction of 5% of the maximum mark for each calendar day after the due date.
  • After ten calendar days late, a mark of zero will be awarded.

Academic integrity

The Current Student website provides information on academic integrity and the resources available to all students. The University expects students and staff to act ethically and honestly and will treat all allegations of academic integrity breaches seriously.

We use similarity detection software to detect potential instances of plagiarism or other forms of academic integrity breach. If such matches indicate evidence of plagiarism or other forms of academic integrity breaches, your teacher is required to report your work for further investigation.

Use of generative artificial intelligence (AI) and automated writing tools

You may only use generative AI and automated writing tools in assessment tasks if you are permitted to by your unit coordinator. If you do use these tools, you must acknowledge this in your work, either in a footnote or an acknowledgement section. The assessment instructions or unit outline will give guidance of the types of tools that are permitted and how the tools should be used.

Your final submitted work must be your own, original work. You must acknowledge any use of generative AI tools that have been used in the assessment, and any material that forms part of your submission must be appropriately referenced. For guidance on how to acknowledge the use of AI, please refer to the AI in Education Canvas site.

The unapproved use of these tools or unacknowledged use will be considered a breach of the Academic Integrity Policy and penalties may apply.

Studiosity is permitted unless otherwise indicated by the unit coordinator. The use of this service must be acknowledged in your submission as detailed on the Learning Hub’s Canvas page.

Outside assessment tasks, generative AI tools may be used to support your learning. The AI in Education Canvas site contains a number of productive ways that students are using AI to improve their learning.

Simple extensions

If you encounter a problem submitting your work on time, you may be able to apply for an extension of five calendar days through a simple extension.  The application process will be different depending on the type of assessment and extensions cannot be granted for some assessment types like exams.

Special consideration

If exceptional circumstances mean you can’t complete an assessment, you need consideration for a longer period of time, or if you have essential commitments which impact your performance in an assessment, you may be eligible for special consideration or special arrangements.

Special consideration applications will not be affected by a simple extension application.

Using AI responsibly

Co-created with students, AI in Education includes lots of helpful examples of how students use generative AI tools to support their learning. It explains how generative AI works, the different tools available and how to use them responsibly and productively.

WK Topic Learning activity Learning outcomes
- Protein formulations Lecture and tutorial (2 hr) LO1 LO5
Multiple weeks Characterisation of particulate systems Lecture and tutorial (3 hr) LO1 LO2 LO5
Solid oral dosage forms: tablets Lecture and tutorial (6 hr) LO1 LO2 LO5
Capsule technology Lecture and tutorial (3 hr) LO4 LO5
Solids advanced Lecture and tutorial (4 hr) LO2 LO5 LO6
Inhalation aerosols Lecture and tutorial (5 hr) LO1 LO3 LO5
Solids - Aerosols Lecture and tutorial (3 hr) LO1 LO5
Manufacturing, characterization and quality control of tablet Science laboratory (8 hr) LO1 LO2 LO3 LO4 LO5 LO6
Week 05 Introduction to the stability of pharmaceutical dose forms Lecture and tutorial (1 hr) LO5 LO6

Attendance and class requirements

  • Attendance: In regards to practical classes, both practical class sessions must be attended. A roll will be taken. 
  • Required materials: Email and Internet access is strongly recommended. Students will be required to access materials online via Canvas. While working within the dispensing laboratory, all students must wear a clean white lab coat and wear shoes which completely cover the feet (no sandals or thongs are permitted). When preparing products or working with ingredients, all students must wear rubber gloves (supplied in the laboratory) and safety glasses  which meet the requirements as displayed in the notice boards in the laboratory.

Study commitment

Typically, there is a minimum expectation of 1.5-2 hours of student effort per week per credit point for units of study offered over a full semester. For a 6 credit point unit, this equates to roughly 120-150 hours of student effort in total.

Required readings

All readings for this unit can be accessed through the Library eReserve, available on Canvas.

  • Aulton M.E. Pharmaceutics: The Science of Dosage Form Design (7th edn) Churchill Livingston

Learning outcomes are what students know, understand and are able to do on completion of a unit of study. They are aligned with the University's graduate qualities and are assessed as part of the curriculum.

At the completion of this unit, you should be able to:

  • LO1. understand principles involved in the formulation of medicaments that are composed of materials in the solid state
  • LO2. understand the physicochemical principles that underlie materials in the solid form
  • LO3. calculate the amounts of ingredients required in a formulation
  • LO4. discuss the manufacturing procedures and quality control procedures for these products
  • LO5. understand the design and formulation of novel drug delivery systems.
  • LO6. design methodology for quality control of pharmaceutical products.

Graduate qualities

The graduate qualities are the qualities and skills that all University of Sydney graduates must demonstrate on successful completion of an award course. As a future Sydney graduate, the set of qualities have been designed to equip you for the contemporary world.

GQ1 Depth of disciplinary expertise

Deep disciplinary expertise is the ability to integrate and rigorously apply knowledge, understanding and skills of a recognised discipline defined by scholarly activity, as well as familiarity with evolving practice of the discipline.

GQ2 Critical thinking and problem solving

Critical thinking and problem solving are the questioning of ideas, evidence and assumptions in order to propose and evaluate hypotheses or alternative arguments before formulating a conclusion or a solution to an identified problem.

GQ3 Oral and written communication

Effective communication, in both oral and written form, is the clear exchange of meaning in a manner that is appropriate to audience and context.

GQ4 Information and digital literacy

Information and digital literacy is the ability to locate, interpret, evaluate, manage, adapt, integrate, create and convey information using appropriate resources, tools and strategies.

GQ5 Inventiveness

Generating novel ideas and solutions.

GQ6 Cultural competence

Cultural Competence is the ability to actively, ethically, respectfully, and successfully engage across and between cultures. In the Australian context, this includes and celebrates Aboriginal and Torres Strait Islander cultures, knowledge systems, and a mature understanding of contemporary issues.

GQ7 Interdisciplinary effectiveness

Interdisciplinary effectiveness is the integration and synthesis of multiple viewpoints and practices, working effectively across disciplinary boundaries.

GQ8 Integrated professional, ethical, and personal identity

An integrated professional, ethical and personal identity is understanding the interaction between one’s personal and professional selves in an ethical context.

GQ9 Influence

Engaging others in a process, idea or vision.

Outcome map

Learning outcomes Graduate qualities
GQ1 GQ2 GQ3 GQ4 GQ5 GQ6 GQ7 GQ8 GQ9

This section outlines changes made to this unit following staff and student reviews.

Exam review sessions. Integration of the post-laboratory quiz with the report.

Work, health and safety

While working within the laboratory, all students must wear a clean white lab coat and wear shoes which completely cover the feet (no sandals or thongs are permitted).

Disclaimer

The University reserves the right to amend units of study or no longer offer certain units, including where there are low enrolment numbers.

To help you understand common terms that we use at the University, we offer an online glossary.