Outline

Overview

Viruses are some of the simplest biological machinery known yet they are also the etiological agents for some of the most important human diseases. New technologies that have revolutionised the discovery of viruses are also revealing a hitherto unappreciated abundance and diversity in the ecosphere, and a wider role in human health and disease. Developing new gene technologies have enabled the use of viruses as therapeutic agents, in novel vaccine approaches, gene delivery and in the treatment of cancer. This unit of study is designed to introduce students who have a basic understanding of molecular biology to the rapidly evolving field of virology. Viral infection in plant and animal cells and bacteria is covered by an examination of virus structure, genomes, gene expression and replication. Building upon these foundations, this unit progresses to examine host-virus interactions, pathogenesis, cell injury, the immune response and the prevention and control of infection and outbreaks. The structure and replication of sub-viral agents: viroids and prions, and their role in disease are also covered. The practical component provides hands-on experience in current diagnostic and research techniques such as molecular biology, cell culture, serological techniques, immunofluorescence and immunoblot analyses and is designed to enhance the students' practical skills and complement the lecture series. In these practical sessions experience will be gained handling live, potentially pathogenic microbes. Tutorials cover a range of topical issues and provide a forum for students to develop their communication and critical thinking skills. The unit will be taught by the Discipline of Microbiology within the School of Life and Environmental Sciences with the involvement of the Discipline of Infectious Diseases and Immunology within the Sydney Medical School.

Unit details and rules

Academic unit	Life and Environmental Sciences Academic Operations
Credit points	6
Prerequisites ?	6 cp from (MIMI2X02 or MEDS2004 or MICR2X22 or BMED2404)
Corequisites ?	None
Prohibitions ?	VIRO3901
Assumed knowledge ?	Fundamental concepts of microorganisms, biomolecules and ecosystems
Available to study abroad and exchange students	Yes

Teaching staff

Coordinator	Timothy Newsome, timothy.newsome@sydney.edu.au
Lecturer(s)	Edward Holmes, edward.holmes@sydney.edu.au
	Michael Kertesz, michael.kertesz@sydney.edu.au
	Allison Abendroth, allison.abendroth@sydney.edu.au
	Gary Muscatello, gary.muscatello@sydney.edu.au
	Markus Hofer, markus.hofer@sydney.edu.au
	Barry Slobedman, barry.slobedman@sydney.edu.au
	Christopher Denes, christopher.denes@sydney.edu.au

Type	Description	Weight	Due	Length
Supervised exam ?	Main exam Written exam under supervised conditions	50%	Formal exam period	2 hours
Outcomes assessed:
Small continuous assessment	Practical assessment Five 3% assessments	15%	Multiple weeks	Submitted at the end of practical class
Outcomes assessed:
Presentation	Presentation Short presentation (12%), peer assessment (3%).	15%	Multiple weeks	12 minutes
Outcomes assessed:
Tutorial quiz	Preparation quiz Preparation quiz for practicals, five 1% assessments.	5%	Multiple weeks	30 minutes
Outcomes assessed:
Small test	Theory of practice exam Multiple choice questions, calculations and short answer questions.	15%	Week 12	1.5 hours
Outcomes assessed:
= hurdle task ? = group assignment ?

Assessment summary

Theory of practical exam: Assess achievement of unit learning outcomes of the Unit of Study, explicity focused on the learning outcomes covered in the Practical classes.
Preparation quiz: Preceding Practical classes 2-6 students are required to complete a brief very short answer/MCQ assessment
covering safety aspects of the upcoming class and familiarity with the procedural and theoretical aspects experiments to be undertaken. Completion of the pre-class assessment is a requirement for attendance and students will receive feedback based upon their performance.
Practical assessment: This assessment tests the students’ comprehension of the background material, the results obtained and their interpretation and assimilation of the results. There is a continuous assessment for Practical classes 2-6 and they must be handed in by the end of class and students will receive feedback on their performance.
Presentation: This is a group activity (3-4 students) and concerns the presentation of a primary piece of literature including
the analysis experimental techniques used in current virological research, linking the theory covered in the core lecture stream with the techniques studied in the Practical classes. Failure to submit a draft presentation by the draft deadline incurs a penalty of 10% of the final mark of the assessment. This also includes a peer assessment task that involves student groups peer assessing the draft presentation of another group and providing feedback.
Final exam: Assess achievement of unit learning outcomes of the Unit of Study, explicitly focused on the learning outcomes covered in the Lecture material. This assessment comprises short answer questions. This assessment is compulsory and failure to attend, attempt, or submit will result in the award of an AF grade. If a second replacement exam is required, this exam may be delivered via an alternative assessment method, such as a viva voce (oral exam). The alternative assessment will meet the same learning outcomes as the original exam. The format of the alternative assessment will be determined by the unit coordinator.

Detailed information for each assessment and late penalties can be found on Canvas.

Assessment criteria

The University awards common result grades, set out in the Coursework Policy 2014 (Schedule 1).

As a general guide, a high distinction indicates work of an exceptional standard, a distinction a very high standard, a credit a good standard, and a pass an acceptable standard.

Result name	Mark range	Description
High distinction	85 - 100	At HD level, a student demonstrates a flair for the subject as well as a detailed and comprehensive understanding of the unit material. A ‘High Distinction’ reflects exceptional achievement and is awarded to a student who demonstrates the ability to apply their subject knowledge and understanding to produce original solutions for novel or highly complex problems and/or comprehensive critical discussions of theoretical concepts.
Distinction	75 - 84	At DI level, a student demonstrates an aptitude for the subject and a well-developed understanding of the unit material. A ‘Distinction’ reflects excellent achievement and is awarded to a student who demonstrates an ability to apply their subject knowledge and understanding of the subject to produce good solutions for challenging problems and/or a reasonably well-developed critical analysis of theoretical concepts.
Credit	65 - 74	At CR level, a student demonstrates a good command and knowledge of the unit material. A ‘Credit’ reflects solid achievement and is awarded to a student who has a broad general understanding of the unit material and can solve routine problems and/or identify and superficially discuss theoretical concepts.
Pass	50 - 64	At PS level, a student demonstrates proficiency in the unit material. A ‘Pass’ reflects satisfactory achievement and is awarded to a student who has threshold knowledge.
Fail	0 - 49	When you don’t meet the learning outcomes of the unit to a satisfactory standard.

For more information see guide to grades.

Late submission

In accordance with University policy, these penalties apply when written work is submitted after 11:59pm on the due date:

Deduction of 5% of the maximum mark for each calendar day after the due date.
After ten calendar days late, a mark of zero will be awarded.

Academic integrity

The Current Student website provides information on academic integrity and the resources available to all students. The University expects students and staff to act ethically and honestly and will treat all allegations of academic integrity breaches seriously.

We use similarity detection software to detect potential instances of plagiarism or other forms of academic integrity breach. If such matches indicate evidence of plagiarism or other forms of academic integrity breaches, your teacher is required to report your work for further investigation.

Use of generative artificial intelligence (AI) and automated writing tools

You may only use generative AI and automated writing tools in assessment tasks if you are permitted to by your unit coordinator. If you do use these tools, you must acknowledge this in your work, either in a footnote or an acknowledgement section. The assessment instructions or unit outline will give guidance of the types of tools that are permitted and how the tools should be used.

Your final submitted work must be your own, original work. You must acknowledge any use of generative AI tools that have been used in the assessment, and any material that forms part of your submission must be appropriately referenced. For guidance on how to acknowledge the use of AI, please refer to the AI in Education Canvas site.

The unapproved use of these tools or unacknowledged use will be considered a breach of the Academic Integrity Policy and penalties may apply.

Studiosity is permitted unless otherwise indicated by the unit coordinator. The use of this service must be acknowledged in your submission as detailed on the Learning Hub’s Canvas page.

Outside assessment tasks, generative AI tools may be used to support your learning. The AI in Education Canvas site contains a number of productive ways that students are using AI to improve their learning.

Learning support

Simple extensions

If you encounter a problem submitting your work on time, you may be able to apply for an extension of five calendar days through a simple extension.  The application process will be different depending on the type of assessment and extensions cannot be granted for some assessment types like exams.

Special consideration

If exceptional circumstances mean you can’t complete an assessment, you need consideration for a longer period of time, or if you have essential commitments which impact your performance in an assessment, you may be eligible for special consideration or special arrangements.

Special consideration applications will not be affected by a simple extension application.

Using AI responsibly

Co-created with students, AI in Education includes lots of helpful examples of how students use generative AI tools to support their learning. It explains how generative AI works, the different tools available and how to use them responsibly and productively.

Weekly schedule

WK	Topic	Learning activity
Multiple weeks	Fundamental concepts in virology including replication, classification and structure.	Lecture (5 hr)
	Host-pathogen interactions during viral infection including bacteriophage, plant viruses, the immune response to viruses, virus evolution and ONE Health	Lecture (9 hr)
	Key examples of human viral pathogens	Lecture (11 hr)
	Experimental design, critical thinking and practical skill used in experimental virology.	Practical (26 hr)
	Critical evaluation of virology research	Presentation (2 hr)

Attendance and class requirements

According to Faculty of Science Resolutions "Unless otherwise stated in a separate local provision, students are expected to attend a minimum of 80% of timetabled activities for a unit of study, unless granted exemption by the Associate Dean." Failure to meet this minimum requirement will result in a maximum returned mark of 49 FA for this unit of study.

sydney.edu.au/handbooks/science/coursework/faculty_resolutions.shtml

All core assessments must be completed to pass this unit. Failure to complete the assessment will result in a maximum returned mark of 49 FA for this unit of study.

A minimum of 3 of the 5 Practical assessments must be completed to pass this unit. Failure to complete the minimum Practical assessments will result in a maximum returned mark of 49 FA for this unit of study.

Study commitment

Typically, there is a minimum expectation of 1.5-2 hours of student effort per week per credit point for units of study offered over a full semester. For a 6 credit point unit, this equates to roughly 120-150 hours of student effort in total.

Required readings

All readings for this unit can be accessed through the Library eReserve, available on Canvas.

Knipe and Howley. Fields Virology. 6th edition 2013. Available freely as an electronic resource from the University of Sydney library.

Learning outcomes

Learning outcomes are what students know, understand and are able to do on completion of a unit of study. They are aligned with the University's graduate qualities and are assessed as part of the curriculum.

Outcomes
Graduate qualities

At the completion of this unit, you should be able to:

LO1. Define the key characteristics of viruses that distinguish them from other agents of disease such as bacteria, sub-viral particles and prions. Describe the role of viruses as agents of disease, their function in the ecosphere, abundance and diversity.
LO2. Explain how different classes of viruses replicate, and the impact of genome type on replication and virus structure.
LO3. Explain how the immune system is able to combat viral infections and confer immunity, and the various ways viruses have evolved to circumvent this control mechanism. Explain how viral diseases emerge and the threat posed to public health. Explain how anti-viral drugs and vaccination act to limit virus replication.
LO4. Perform basic cell culture, fluorescence microscopy, diagnostic and molecular techniques used in a modern virology laboratory, and explain the scientific principles behind these techniques
LO5. Critically evaluate experimental approaches used in virology to formulate and test hypotheses.

Graduate qualities

The graduate qualities are the qualities and skills that all University of Sydney graduates must demonstrate on successful completion of an award course. As a future Sydney graduate, the set of qualities have been designed to equip you for the contemporary world.

GQ1	Depth of disciplinary expertise Deep disciplinary expertise is the ability to integrate and rigorously apply knowledge, understanding and skills of a recognised discipline defined by scholarly activity, as well as familiarity with evolving practice of the discipline.
GQ2	Critical thinking and problem solving Critical thinking and problem solving are the questioning of ideas, evidence and assumptions in order to propose and evaluate hypotheses or alternative arguments before formulating a conclusion or a solution to an identified problem.
GQ3	Oral and written communication Effective communication, in both oral and written form, is the clear exchange of meaning in a manner that is appropriate to audience and context.
GQ4	Information and digital literacy Information and digital literacy is the ability to locate, interpret, evaluate, manage, adapt, integrate, create and convey information using appropriate resources, tools and strategies.
GQ5	Inventiveness Generating novel ideas and solutions.
GQ6	Cultural competence Cultural Competence is the ability to actively, ethically, respectfully, and successfully engage across and between cultures. In the Australian context, this includes and celebrates Aboriginal and Torres Strait Islander cultures, knowledge systems, and a mature understanding of contemporary issues.
GQ7	Interdisciplinary effectiveness Interdisciplinary effectiveness is the integration and synthesis of multiple viewpoints and practices, working effectively across disciplinary boundaries.
GQ8	Integrated professional, ethical, and personal identity An integrated professional, ethical and personal identity is understanding the interaction between one’s personal and professional selves in an ethical context.
GQ9	Influence Engaging others in a process, idea or vision.

Outcome map

Learning outcomes	Graduate qualities
Learning outcomes

Responding to student feedback

This section outlines changes made to this unit following staff and student reviews.

Sessional change

Additional information

Immunocompetence: In this unit you will gain experience handling potentially pathogenic microbes. You are strongly advised to contact the unit coordinator if you have any predisposing condition or issue that might be relevant to your participation in these practical sessions.

Work, health and safety

We are governed by the Work Health and Safety Act 2011, Work Health and Safety Regulation 2011 and Codes of Practice. Penalties for non-compliance have increased. Everyone has a responsibility for health and safety at work. The University’s Work Health and Safety policy explains the responsibilities and expectations of workers and others, and the procedures for managing WHS risks associated with University activities.

General Laboratory Safety Rules

No eating or drinking is allowed in any laboratory under any circumstances
A laboratory coat and closed-toe shoes are mandatory
Follow safety instructions in your manual and posted in laboratories
In case of fire, follow instructions posted outside the laboratory door
First aid kits, eye wash and fire extinguishers are located in or immediately outside each laboratory
As a precautionary measure, it is recommended that you have a current tetanus immunisation. This can be obtained from University Health Service: unihealth.usyd.edu.au/

Disclaimer

The University reserves the right to amend units of study or no longer offer certain units, including where there are low enrolment numbers.

To help you understand common terms that we use at the University, we offer an online glossary.

Current students

Overview

Overview

Unit details and rules

Teaching staff

Assessment

Assessment

Assessment summary

Assessment criteria

Late submission

Academic integrity

Learning support

Learning support

Simple extensions

Special consideration

Using AI responsibly

Weekly schedule

Weekly schedule

Attendance and class requirements

Study commitment

Required readings

Learning outcomes

Learning outcomes

Graduate qualities

Outcome map

Responding to student feedback

Responding to student feedback

Additional information

Additional information

Work, health and safety

Disclaimer

On this page

Useful links

Media

Student links

About us

Connect

Current students

VIRO3001: Virology

Semester 1, 2023 [Normal day] - Camperdown/Darlington, Sydney

Overview

Overview

Unit details and rules

Teaching staff

Assessment

Assessment

Assessment summary

Assessment criteria

Late submission

Academic integrity

Learning support

Learning support

Simple extensions

Special consideration

Using AI responsibly

Weekly schedule

Weekly schedule

Attendance and class requirements

Study commitment

Required readings

Learning outcomes

Learning outcomes

Graduate qualities

Outcome map

Responding to student feedback

Responding to student feedback

Additional information

Additional information

Work, health and safety

Disclaimer

On this page

Useful links

Media

Student links

About us

Connect