The critically ill are the most vulnerable people in our health system and their care is highly resource intensive. Most admissions to intensive care units are precipitated or complicated by infection, which is the most common cause of preventable mortality and adds billions of dollars to the annual cost of health care.

We aim to improve health care systems, patient safety and management of critical infections, by integrating innovative clinical, scientific and biotechnological solutions for diagnosis, surveillance and management.

Our trainees and Fellows work in multidisciplinary infectious diseases research in the critically ill and in the effective translation of research into practice and policy. We are developing tools for real time diagnosis and tracking of specific pathogens, and next-generation informatics to tailor prescribing for individuals, improve hospital infection control and track outbreaks of highly transmissible or antibiotic resistant pathogens.

  • Pathogen and host indicators of disease risk, severity and outcome
  • Proactive risk modification by selective removal of colonizing high-risk pathogens such as highly antibiotic-resistant E. coli and Klebsiella clones
  • Proactive risk modification by selective eradication of antibiotic resistance genes from bacterial populations in vivo
  • Rapid molecular and other diagnostic modalities
  • Bacteriophage therapy for severe infections such as staphylococcal endocarditis

Our work is funded almost exclusively by the Australian National Health and Medical Research Council. Specific project areas and linked grants and researchers are detailed in this website. Translation of our findings into policy and practice will flow through our established networks and roles of the investigators on key committees of government and professional societies.