CRE Critical Infection
The critically ill are the most vulnerable people in our health system and their care is highly resource intensive. Most admissions to intensive care units are precipitated or complicated by infection, which is the most common cause of preventable mortality and adds billions of dollars to the annual cost of health care.
This CRE will improve health care systems, patient safety and management of critical infections, by integrating innovative microbiological, clinical, informatics and ethico-legal approaches to their diagnosis, surveillance and management. We will increase capacity in multidisciplinary infectious diseases research in the critically ill and in the effective translation of advances in biotechnology and informatics systems into practice and policy.
We will further develop tools for real time diagnosis and tracking of specific pathogens, and next-generation informatics to tailor prescribing for individuals, improve hospital infection control and track outbreaks of highly transmissible or antibiotic resistant pathogens.
- Pathogen and host indicators of disease risk, severity and outcome
- The role of co-infections
- The epidemiology of agents with highly variable gene pools eg influenza, antibiotic resistance genes
- Rapid molecular and other diagnostic modalities
- The social, cultural, ethical, professional and legal issues that shape understanding of infection risks and expectations of outcome (which affect compliance with prevention/treatment strategies).
We will build multi-disciplinary capacity in applied and clinical research. We will house a rich bank of accessible microbial strains and biological samples linked with clinical data. Translation of our findings into policy and practice will flow through our established networks and roles of the investigators on key committees of government and professional societies.