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Pain Phenotype Characterisation in Preclinical Models of Osteoarthritis

Osteoarthritis (OA) is the most common chronic joint disease, affecting 15% of the population and causing a significant socioeconomic burden. It is a debilitating condition characte more...

Supervisor(s): Zaki, Sanaa (Dr)

HOW DIFFERENT CELL TYPES OF THE BRAIN CONTRIBUTE TO CEREBRAL CYTOKINOPATHIES

The brain consists of a large number of different cell types, including neurons, astrocytes, oligodendrocytes, microglia and endothelial cells. Discover how these different cell typ more...

Supervisor(s): Hofer, Markus (Dr)

Genetics of Healthy Ageing

By exploiting the vast genetic landscape of an outbred mouse population we aim to explore the molecular cause of a range of diseases that limit healthy ageing in humans. This includ more...

Supervisor(s): James, David (Professor)

CHARACTERISATION OF ERUSIOLIN - A NEW PEPTIDE HORMONE

In this project we aim to characterise the function of a new gut-derived peptide we have discovered in human plasma, named erusiolin, which we hypothesise plays a role in appetite r more...

Supervisor(s): Larance, Mark (Dr)

THE PATHOGENIC AND PROTECTIVE EFFECTS OF MICROGLIA IN CEREBRAL CYTOKINOPATHIES

Microglia are the primary immune cells of the brain and have the potential to both protect and contribute to neurological disease. Explore the molecular mechanisms that microglia us more...

Supervisor(s): Hofer, Markus (Dr)

Modulating coronary atherosclerosis through perivascular fat (PVAT)

Background: Organ-to-organ communications are vital for living systems and play critical roles in cellular homeostasis. Various studies have demonstrated the existence and significa more...

Supervisor(s): Misra, Ashish (Dr)

A Novel Role in Stabilizing Vulnerable Atherosclerotic Plaque

Atherosclerosis is the leading cause of cardiovascular deaths, accounting for ~30% of all deaths in Australia in 2018. Atherosclerotic plaque rupture leads to heart failure and stro more...

Supervisor(s): Misra, Ashish (Dr)

Vascular dysfunction in mycobacterial pathogenesis

This project will investigate the importance of vascular remodelling and leakage in fuelling tuberculosis infection more...

Supervisor(s): Oehlers, Stefan (Dr), Britton, Warwick J (Professor)

GENE THERAPY FOR GENETIC BONE DISEASES

Gene therapy is becoming a practical approach to treat severe genetic conditions and in recent years conditions such as Spinal Muscular Atrophy (SMA) have been success stories. Our more...

Supervisor(s): Schindeler, Aaron (Associate Professor), Munns, Craig (Associate Professor)

Gene editing of stem cells or cancer to develop new stem cell therapies to treat human disease

This project involves the use of human stem cells and CRISPR genome editing to study basic signalling pathways controlling stem cell differentiation and/or cancer. A compliment more...

Supervisor(s): Neely, Greg (Professor)