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How do molecules make memories? Understanding synaptic plasticity at the level of protein pathways and signalling.

This project aims to discover and validate new molecular mechanisms of how synaptic plasticity, which underlies learning and memory, is regulated by protein interactions and phospho more...

Supervisor(s): Graham, Mark (Dr)

Viral Commandeering of Cellular Oncogenic Signalling Pathways

Cell-to-cell spread of caccinia virus infection induces dramatic rearrangements to cell morphology and alterations to cell behaviour.  This project will study the role of host more...

Supervisor(s): Newsome, Timothy (Dr)

Define regulatory control pathways delivering NPF (nitrate) and AMT (ammonium) transport activities across root types and cell profiles

We have previously identified the tissue expression patterns of ZmNPF6;6 and ZmNPF6;4 in maize root tips (Wen, Z., et al., The Plant Cell, 2017) and used qPCR as well as custom arra more...

Supervisor(s): Kaiser, Brent (Professor)

Dissecting the architecture of the Insulin Signaling Pathway

The aim of this pathway is to understand how the insulin signalling pathway regulates metabolic homeostasis.The Lead Supervisor for this project is David James. This project will a more...

Supervisor(s): James, David (Professor)

Gene editing of stem cells or cancer to develop new stem cell therapies to treat human disease

This project involves the use of human stem cells and CRISPR genome editing to study basic signalling pathways controlling stem cell differentiation and/or cancer. A compliment more...

Supervisor(s): Neely, Greg (Professor)

Facilitating treatments for neurodegenerative Parkinson’s disease

Opportunities exist to join a leading group conducting research into Parkinson's disease. Our group combines the disciplines of biochemistry, immunology, molecular biology and cell more...

Supervisor(s): Dzamko, Nicolas (Dr)

The global analysis of liver protein complexes during the response to intermittent fasting

In animals, short periods of nutrient deprivation, such as intermittent fasting, have been shown to provide benefits with regard to cancer risk/treatment and ageing. Our aims are to more...

Supervisor(s): Larance, Mark (Dr)

Discovery and validation of new ceramide synthase inhibitors to treat metabolic disease

Ceramide synthase enzyme isoforms 1, 5, and 6, are heavily implicated as drivers of obesity, insulin resistance, and diabetes. Targeting these enzymes is expected to yield new thera more...

Supervisor(s): Don, Anthony (Associate Professor), Qi, Jacob (Dr)