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ASSESS THE GP GLYCOPROTEIN STRUCTURES OF EBOLA AND MARBURG VIRUS ENVELOPES, THEIR MUCIN-LIKE DOMAINS AND SITES FOR IMMUNE ATTACK

This project extends our published ebola (EBOV) gp's structures, and furthers our studies for immune targeting. Taking a holistic approach our studies aim to examine both the standa more...

Supervisor(s): Lynch, Garry (Dr)

EFFECTS OF TYPE I INTERFERONS IN CHRONIC VIRAL INFECTIONS

When type I interferon signalling is impaired, infection with lymphocytic choriomeningitis virus results in chronic infection and dysfunctional CD8+ T cell function. Investigate how more...

Supervisor(s): Hofer, Markus (Dr)

Display of Viral Surface Glycoprotein on Virus like particles (VPLS) for Structure and Immune Epitope Discovery

Unanchored recombinant soluble monomers are often the proteins used in many structure analyses and immunologic testing. But in reality viral surface glycoproteins are orientated, te more...

Supervisor(s): Lynch, Garry (Dr)

STUDIES OF VARIABLE OR CONSERVED SURFACE PROTEIN SITES OF NEISSERIA MENINGITIDIS AS EPITOPES FOR STRAIN-SPECIFIC VACCINES OR BROAD-STRAIN (UNIVERSAL) VACCINES

The gram-negative Neisseria Meningititis (NM) remains a significant microbial problem and particularly lethal for the very young. Serogroup B strains are particularly troublesome an more...

Supervisor(s): Lynch, Garry (Dr)