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Cannabinoid regulation of neuromuscular transmission

Cannabinoid drugs are under active consideration for treatment of a wide range of health conditions. This electrophysiology project will investigate the influence of specific endoca more...

Supervisor(s): Phillips, William (Bill) (Associate Professor), Protti, Dario (Dr)

Conopeptides as potential pain therapeutics

Dissecting mechanisms of chronic pain using patch clamp analyses of cellular and synaptic electrophysiology in spinal cord slices and behavioural correlations. more...

Supervisor(s): Christie, Macdonald (Professor)

ENGINEERED EXTRASYNAPTIC GABAA RECEPTORS: TOWARDS NOVEL ANALGESICS

Recently, there has been an increase of interest in α4δ-containing GABAA receptors as novel drug targets for the design of a new class of analgesics. However, to date th more...

Supervisor(s): Balle, Thomas (Associate Professor), Collins, Mary (Professor)

Cellular mechanisms of opioid tolerance and dependence

Tolerance and dependence that contribute to opioid addiction will be studied using patch clamp analyses of cellular and synaptic electrophysiology in brain slices and behavioural co more...

Supervisor(s): Christie, Macdonald (Professor)

Muscle specific kinase in synaptic adaptation

This project will investigate the role of postsynaptic Muscle specific Kinase (MuSK) in regulating presynaptic neurotransmitter release at the neuromuscular junction. more...

Supervisor(s): Phillips, William (Bill) (Associate Professor), Protti, Dario (Dr)

Molecular Dynamics of Glutamate Transporters

The aim of this project is to develop a molecular model for the mechanism of glutamate transport and through this we expect to identify novel means of pharmacologically manipulating more...

Supervisor(s): Ryan, Renae (Associate Professor)

Emotion, cognition and psychiatric disorders

The key goal of this project is to identify objective brain and behaviour markers of major mental illnesses and their treatment. In this research area, we integrate information whic more...

Supervisor(s): Williams, Lea (Professor)

Visual Development and Dynamics of Perception

This research area will apply and test quantitative physiologically-based models of the development and response properties of primary visual cortex, to better understand how visual more...

Supervisor(s): Robinson, Peter (Professor)

Pathways to therapies in blinding genetic retinal eye diseases

In this project, novel disease genes and variants are identified that cause blinding retinal eye diseases. Cellular, gene editing, proteomic and animal model approaches are taken to more...

Supervisor(s): Jamieson, Robyn (Associate Professor)

Whole genome CRISPR screening to define drug mechanism of action

This project will involve new whole genome CRISPR editing strategies, coupled with bioinformatics analysis, to identify the complete molecular mechanism of action for relevant human more...

Supervisor(s): Neely, Greg (Associate Professor)