University of Sydney Handbooks - 2016 Archive

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Biochemistry

Biochemistry

BCHM2071 Protein Biochemistry

Credit points: 6 Teacher/Coordinator: Dr Sandro F Ataide Session: Semester 2 Classes: Two 1-hour lectures per week, five 1-2 hour tutorials and six 3-4-hour practical sessions per semester Prerequisites: (MBLG1001 or MBLG1901 or MBLG1991) and (12 credit points of CHEM1XXX) Prohibitions: BCHM2011 or BCHM2971 Assessment: One 2.5-hour theory and theory of practical exam (55%), two one hour in-semester quizzes (15%), practical assignments and laboratory book reports (30%) Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Recommended concurrent units of study: MBLG2071 and BCHM2072 for progression to Senior Biochemistry.
This unit of study introduces biochemistry by describing the physical and chemical activities of proteins and their functions in cells. The details of protein interactions with other cellular components are presented and the relationship of protein structure and function is discussed. Techniques in protein chemistry and analysis, including proteomics are introduced together with key experiments which reveal the physical basis of the functioning of proteins. This course builds on the protein science presented in MBLG1001 and is ideally suited to students studying intermediate Chemistry, Pharmacology, Cell Biology, Immunology or Physiology together with Biochemistry. The practical course will nurture technical skills in biochemistry and will include protein preparation, the analysis of protein structure and enzymatic assays.
Textbooks
Lehninger Principles of Biochemistry, 6th edition, by Nelson and Cox Resources Manual for Biochemistry 2 Practical Sessions, Sem 2.
BCHM2971 Protein Biochemistry (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Sandro F Ataide Session: Semester 2 Classes: Two 1-hour lectures per week, five 1-2 hour tutorials and six 3-4-hour practical sessions per semester Prerequisites: (12 credit points of CHEM1XXX) and a mark of 75 in (MBLG1001 or MBLG1901 or MBLG1991) Prohibitions: BCHM2071 Assessment: One 2.5-hour theory and theory of practical exam (55%), two one hour in-semester quizzes (15%), practical assignments and laboratory book reports (30%) Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Recommended concurrent units of study: (MBLG2071 or MBLG2971) and (BCHM2072 or BCHM2972) for progression to Senior Biochemistry.
This advanced unit of study introduces biochemistry by describing the physical and chemical activities of proteins and their functions in cells. The details of protein interactions with other cellular components are presented and the relationship of protein structure and function is discussed. Techniques in protein chemistry and analysis, including proteomics are discussed together with key experiments which reveal the physical basis of the functioning of proteins. This course builds on the protein science presented in MBLG1X01 and is ideally suited to students studying Intermediate Chemistry, Pharmacology, Cell Biology, Immunology or Physiology together with Biochemistry. The advanced practical course will nurture technical skills in protein biochemistry and will include protein preparation, the interpretation of protein structure, enzymatic assays and biochemical analysis.
Textbooks
Lehninger Principles of Biochemistry, 6th edition, by Nelson and Cox Resources Manual for Biochemistry 2 Practical Sessions, Sem 2
BCHM2072 Human Biochemistry

Credit points: 6 Teacher/Coordinator: A/Prof Gareth Denyer Session: Semester 1 Classes: Two lectures per week, 8-10 optional tutorials, increasing in frequency towards the exams, and 2-3 hours per week of practical Prerequisites: (MBLG1001 or MBLG1901 or MBLG1991) and (12 credit points of CHEM1XXX) Prohibitions: BCHM2002 or BCHM2102 or BCHM2972 or BCHM2902 or BCHM2112 or BMED2401 or BMED2402 or BMED2403 or BMED2404 or BMED2405 or BMED2406 or BMED2801 or BMED2802 or BMED2803 or BMED2804 or BMED2805 or BMED2806 or BMED2807 or BMED2808 Assessment: One 3-hour exam (65%), practical work (25%), in semester assignments (10%). Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Recommended concurrent units of study: (MBLG2071 or MBLG2971) and BCHM2071 for progression to Senior Biochemistry.
This unit of study aims to describe how cells work at the molecular level, with a special emphasis on human biochemistry. The chemical reactions that occur inside cells are described in the first series of lectures, Cellular Metabolism. Aspects of the molecular architecture of cells that enable them to transduce messages and communicate with each other are described in the second half of the unit of study, Signal Transduction. At every stage there is emphasis on the 'whole body' consequences of reactions, pathways and processes. Cellular Metabolism describes how cells extract energy from fuel molecules like fatty acids and carbohydrates, how the body controls the rate of fuel utilisation and how the mix of fuels is regulated (especially under different physiological circumstances such as starvation and exercise). The metabolic inter-relationships of the muscle, brain, adipose tissue and liver and the role of hormones in coordinating tissue metabolic relationships is discussed. The unit also discusses how the body lays down and stores vital fuel reserves such as fat and glycogen, how hormones modulate fuel partitioning between tissues and the strategies involved in digestion and absorption and transport of nutrients. Signal Transduction covers how communication across membranes occurs (i.e. via surface receptors and signaling cascades). This allows detailed molecular discussion of the mechanism of hormone action and intracellular process targeting. The practical component complements the lectures by exposing students to experiments that investigate the measurement of glucose utilisation using radioactive tracers and the design of biochemical assay systems. During the unit of study, generic skills are nurtured by frequent use of analytical and problem solving activities. Opportunities are provided to redesign and repeat experiments so as to provide a genuine research experience. Student exposure to generic skills will be extended by the introduction of exercises designed to teach oral communication, instruction writing and planning skills.
BCHM2972 Human Biochemistry (Advanced)

Credit points: 6 Teacher/Coordinator: A/Prof Gareth Denyer Session: Semester 1 Classes: Two lectures per week, 8-10 optional tutorials increasing in frequency towards the exams, and 2-3 hours per week of practical. Prerequisites: (12 credit points of CHEM1XXX) and a mark of 75 in (MBLG1001 or MBLG1901 or MBLG1991) Prohibitions: BCHM2072 orBMED2401 or BMED2402 or BMED2403 or BMED2404 or BMED2405 or BMED2406 or BMED2801 or BMED2802 or BMED2803 or BMED2804 or BMED2805 or BMED2806 or BMED2807 or BMED2808 Assessment: One 3-hour exam (65%), practical work (25%), in semester assignments (10%). Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Recommended concurrent units of study: (MBLG2071 or MBLG2971) and (BCHM2071 or BCHM2971) for progression to Senior Biochemistry.
This advanced unit aims to describe how cells work at the molecular level, with a special emphasis on human biochemistry. The chemical reactions that occur inside cells are described in the first series of lectures, Cellular Metabolism. Aspects of the molecular architecture of cells that enable them to transduce messages and communicate with each other are described in the second half of the unit of study, Signal Transduction. At every stage there is emphasis on the 'whole body' consequences of reactions, pathways and processes. Cellular Metabolism describes how cells extract energy from fuel molecules like fatty acids and carbohydrates, how the body controls the rate of fuel utilization and how the mix of fuels is regulated (especially under different physiological circumstances such as starvation and exercise). The metabolic inter-relationships of the muscle, brain, adipose tissue and liver and the role of hormones in coordinating tissue metabolic relationships is discussed. The unit also discusses how the body lays down and stores vital fuel reserves such as fat and glycogen, how hormones modulate fuel partitioning between tissues and the strategies involved in digestion and absorption and transport of nutrients. Signal Transduction covers how communication across membranes occurs (i.e., via surface receptors and signaling cascades). This allows detailed molecular discussion of the mechanism of hormone action and intracellular process targeting. The practical component complements the lectures by exposing students to experiments that investigate the measurement of glucose utilisation using radioactive tracers and the design of biochemical assay systems. During the unit of study, generic skills are nurtured by frequent use of analytical and problem solving activities. Opportunities are provided to redesign and repeat experiments so as to provide a genuine research experience. Student exposure to generic skills will be extended by the introduction of exercise designed to teach oral communication, instruction writing and planning skills.
The differences between the advanced and regular versions of this Unit of Study is in the in-semester assignments and some of the practical sessions.
MBLG2071 Molecular Biology and Genomics

Credit points: 6 Teacher/Coordinator: Dr Markus Holfer Session: Semester 1 Classes: Two 1-hour lectures per week and one 4-hour practical per fortnight. Prerequisites: (MBLG1001 or MBLG1901 or MBLG1991) and 12 credit points of CHEM1XXX Prohibitions: BCHM2001 or MBLG2111 or MBLG2871 or BCHM2901 or AGCH2001 or MBLG2901 or BCHM2101 or MBLG2101 or MBLG2971 or MBLG2771 or MBLG2001 Assessment: One 2.5-hour exam, practical work, laboratory reports (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Recommended concurrent units of study: (BCHM2071 or BCHM2971) and (BCHM2072 or BCHM2972) for progression to Senior Biochemistry.
The flow of genetic information determines the characteristics and fate of every cell. In this course, we will explore how genetic information is regulated in eukaryotes, covering key processes such as replication, transcription and translation. We will investigate how these fundamental processes can be studied and manipulated in the laboratory. This course will introduce classical tools of molecular biology such as polymerase chain reaction, as well as more recent advances such as gene expression microarrays and novel sequencing technologies. We will discuss how model organisms, ranging from worms to transgenic mice, have changed our understanding of gene expression. In the practical component of the course, we will explore gene regulation and expression using model system as well as perform plasmid isolation and DNA fingerprinting. This unit of study extends the basic concepts introduced in MBLG1001/1901 and provides a firm foundation for students wishing to continue in molecular biology or apply molecular techniques to other fields.
MBLG2971 Molecular Biology and Genomics (Adv)

Credit points: 6 Teacher/Coordinator: Dr Markus Hofer Session: Semester 1 Classes: Two 1-hour lectures per week; one 4-hour practical per fortnight. Prerequisites: 12 credit points of CHEM1XXX and a mark of 75 in (MBLG1001 or MBLG1901 or MBLG1991) Prohibitions: MBLG2901 or MBLG2001 or BCHM2001 or AGCH2001 or MBLG2101 or MBLG2871 or MBLG2111 or MBLG2771 or BCHM2101 or MBLG2071 or BCHM2901 Assessment: One 2.5-hour exam, practical work, laboratory reports. Mode of delivery: Normal (lecture/lab/tutorial) day
The content is based on the standard unit MBLG2071 but certain aspects will be investigated in greater depth and at a more advanced level. The flow of genetic information determines the characteristics and fate of every cell. In this course, we will explore how genetic information is regulated in eukaryotes, covering key processes such as replication, transcription and translation. We will investigate how these fundamental processes can be studied and manipulated in the laboratory. This course will introduce classical tools of molecular biology such as polymerase chain reaction, as well as more recent advances such as gene expression microarrays and novel sequencing technologies. We will discuss how model organisms, ranging from worms to transgenic mice, have changed our understanding of gene expression. In the practical component of the course, we will explore gene regulation and expression using model system as well as perform plasmid isolation and DNA fingerprinting. This unit of study extends the basic concepts introduced in MBLG1001/1901 and provides a firm foundation for students wishing to continue in molecular biology or apply molecular techniques to other fields.
MBLG2072 Genetics and Genomics

Credit points: 6 Teacher/Coordinator: A/Prof Penny Smith Session: Semester 2 Classes: Two 1-hour lectures per week, one 2-3 hour practical per week, one tutorial every second week. Prerequisites: 6 credit points of BIOL1XXX and (MBLG1001 or MBLG1901 or MBLG1991) and 6 credit points of CHEM1XXX Prohibitions: MBLG2002 or MBLG2972 or MBLG2102 or MBLG2902 Assessment: One 2 hour exam (50%), laboratory reports and quizzes (50%). Practical field work: 3 hours per week Mode of delivery: Normal (lecture/lab/tutorial) day
Note: For students planning a Molecular Biology and Genetics major, 12 credit points of CHEM1XXX is required.
This unit of study brings together traditional genetic analysis and modern molecular biology to study genetics of all life forms from humans and other complex multicellular organisms through to single celled organisms such as bacteria. Students will be introduced to complex modes of Mendelian inheritance, including those involved in human diseases. The molecular basis for different patterns of inheritance will be discussed. The interaction of genes and gene products will be illustrated by the examination of the molecular genetics of development. The application of genomics to the study of genetic variation, molecular evolution and gene function in humans and model organisms will also be described. In the practical sessions students will investigate the genetics of a variety of prokaryotic and eukaryotic organisms in order to illustrate concepts covered in the lecture material. Students will develop familiarity and competence with equipment used in molecular genetic analysis, bioinformatics, microscopy and statistical tests. This unit of study provides a suitable foundation for senior biology units of study, which can lead to a major in Biology, and successful completion of this unit of study is required in order to progress in the Molecular Biology and Genetics major.
MBLG2972 Genetics and Genomics (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Penny Smith Session: Semester 2 Classes: Two 1-hour lectures per week, one 2-3 hour practical per week, one tutorial every second week. Prerequisites: [An average mark of 75 in (6 credit points of BIOL1XXX) and (MBLG1001 or MBLG1901 or MBLG1991)] and (6 credit points of CHEM1XXX). Prohibitions: MBLG2002 or MBLG2072 or MBLG2102 or MBLG2902 Assessment: One 2-hour exam (50%), laboratory reports and quizzes (50%). Mode of delivery: Normal (lecture/lab/tutorial) day
Note: For students planning a Molecular Biology and Genetics major, 12 credit points of CHEM1XXX is required.
The content of MBLG2972 will be based on MBLG2072 but qualified students will participate in alternative components at a more advanced level. The content and nature of these components may vary from year to year but includes a practical project in the laboratory to improve molecular biology skills
BCHM3071 Molecular Biology and Biochemistry-Genes

Credit points: 6 Teacher/Coordinator: Jill Johnston, Prof Iain Campbell. Session: Semester 1 Classes: Two 1-hour lectures per week; two 3-hours practicals per fortnight Prerequisites: [12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [(BMED2401, BMED2405 and 6 additional credit points of BMED240X) and (MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)] Prohibitions: BCHM3001 or BCHM3901 or BCHM3971 Assessment: One 2.5-hour exam (theory and theory of prac 70%), in-semester (practical work and assignments 30%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study is designed to provide a comprehensive coverage of the activity of genes in living organisms, with a focus on eukaryotic and particularly human systems. The lecture component covers the arrangement and structure of genes, how genes are expressed, promoter activity and enhancer action. This leads into discussions on the biochemical basis of differentiation of eukaryotic cells, the molecular basis of imprinting, epigenetics, and the role of RNA in gene expression. Additionally, the course discusses the effects of damage to the genome and mechanisms of DNA repair. The modern techniques for manipulating and analysing macromolecules such as DNA and proteins and their relevance to medical and biotechnological applications are discussed. Techniques such as the generation of gene knockout and transgenic mice are discussed as well as genomic methods of analysing gene expression patterns. Particular emphasis is placed on how modern molecular biology and biochemical methods have led to our current understanding of the structure and functions of genes within the human genome. The practical course is designed to complement the lecture course and will provide students with experience in a wide range of techniques used in molecular biology laboratories.
Textbooks
Lewin, B. Genes XI. 11th edition. Jones & Bartlett. 2011.
BCHM3971 Molecular Biology and Biochem-Genes (Adv)

Credit points: 6 Teacher/Coordinator: Jill Johnston, Prof Iain Campbell. Session: Semester 1 Classes: Two 1-hour lectures per week; two 3-hours practicals per fortnight Prerequisites: [An average mark of 75 in 12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [BMED2401 and (a mark of 75 in BMED2405) and (6 additional credit points from BMED240X) and (a mark of 75 in MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)] Prohibitions: BCHM3901 or BCHM3001 or BCHM3071 Assessment: One 2.5-hour exam (theory and theory of prac 70%), in-semester (practical work and assignments 30%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study is designed to provide a comprehensive coverage of the activity of genes in living organisms, with a focus on eukaryotic and particularly human systems. The lecture component covers the arrangement and structure of genes, how genes are expressed, promoter activity and enhancer action. This leads into discussions on the biochemical basis of differentiation of eukaryotic cells, the molecular basis of imprinting, epigenetics, and the role of RNA in gene expression. Additionally, the course discusses the effects of damage to the genome and mechanisms of DNA repair. The modern techniques for manipulating and analysing macromolecules such as DNA and proteins and their relevance to medical and biotechnological applications are discussed. Techniques such as the generation of gene knockout and transgenic mice are discussed as well as genomic methods of analysing gene expression patterns. Particular emphasis is placed on how modern molecular biology and biochemical methods have led to our current understanding of the structure and functions of genes within the human genome. The practical course is designed to complement the lecture course and will provide students with experience in a wide range of techniques used in molecular biology laboratories.
The lecture component of this unit of study is the same as BCHM3071. Qualified students will attend seminars/practical classes in which more sophisticated topics in gene expression and manipulation will be covered.
Textbooks
Lewin, B. Genes XI. 11th edition. Jones & Bartlett. 2011.
BCHM3081 Mol Biology and Biochemistry-Proteins

Credit points: 6 Teacher/Coordinator: Jill Johnston, Prof Joel Mackay Session: Semester 1 Classes: Two 1-hour lectures per week; two 3-hours practicals per fortnight Prerequisites: [12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [(BMED2401, BMED2405 and 6 additional credit points of BMED240X) and (MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)] Prohibitions: BCHM3981 or BCHM3001 or BCHM3901 Assessment: One 2.5-hour exam (theory and theory of prac 70%), in-semester (practical work and assignments 30%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study is designed to provide a comprehensive coverage of the functions of proteins in living organisms, with a focus on eukaryotic and particularly human systems. Its lecture component deals with how proteins adopt their biologically active forms, including discussions of protein structure, protein folding and how recombinant DNA technology can be used to design novel proteins with potential medical or biotechnology applications. Particular emphasis is placed on how modern molecular biology and biochemical methods have led to our current understanding of the structure and functions of proteins. It also covers physiologically and medically important aspects of proteins in living systems, including the roles of chaperones in protein folding inside cells, the pathological consequences of misfolding of proteins, how proteins are sorted to different cellular compartments and how the biological activities of proteins can be controlled by regulated protein degradation. The practical course is designed to complement the lecture course and will provide students with experience in a wide range of techniques used in molecular biology and protein biochemistry laboratories.
Textbooks
Williamson M. How Proteins Work. Garland. 2011.
BCHM3981 Mol Biology and Biochem-Proteins (Adv)

Credit points: 6 Teacher/Coordinator: Jill Johnston, Prof Joel Mackay Session: Semester 1 Classes: Two 1-hour lectures per week; two 3-hours practicals per fortnight Prerequisites: [An average mark of 75 in 12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [BMED2401 and (a mark of 75 in BMED2405) and (6 additional credit points of BMED240X) and (an average mark of 75 in MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)] Prohibitions: BCHM3901 or BCHM3001 or BCHM3081 Assessment: One 2.5-hour exam (theory and theory of prac 70%), in-semester (practical work and assignments 30%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study is designed to provide a comprehensive coverage of the functions of proteins in living organisms, with a focus on eukaryotic and particularly human systems. Its lecture component deals with how proteins adopt their biologically active forms, including discussions of protein structure, protein folding and how recombinant DNA technology can be used to design novel proteins with potential medical or biotechnology applications. Particular emphasis is placed on how modern molecular biology and biochemical methods have led to our current understanding of the structure and functions of proteins. It also covers physiologically and medically important aspects of proteins in living systems, including the roles of chaperones in protein folding inside cells, the pathological consequences of misfolding of proteins, how proteins are sorted to different cellular compartments and how the biological activities of proteins can be controlled by regulated protein degradation. The practical course is designed to complement the lecture course and will provide students with experience in a wide range of techniques used in molecular biology and protein biochemistry laboratories.
The lecture component of this unit of study is the same as BCHM3081. Qualified students will attend seminars/practical classes in which more sophisticated topics in protein biochemistry will be covered.
Textbooks
Williamson M. How Proteins Work. Garland. 2011.
BCHM3072 Human Molecular Cell Biology

Credit points: 6 Teacher/Coordinator: Jill Johnston, Prof Iain Campbell Session: Semester 2 Classes: Two 1-hour lectures per week; two 3-hours practicals per fortnight Prerequisites: [12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [(BMED2401, BMED2405 and 6 additional credit points of BMED240X) and (MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)] Prohibitions: BCHM3972 or BCHM3004 or BCHM3002 or BCHM3902 or BCHM3904 Assessment: One 2.5-hour exam (theory and theory of prac 70%), in-semester (practical work and assignments 30%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study will explore the responses of cells to changes in their environment in both health and disease. The lecture course consists of four integrated modules. The first will provide an overview of the role of signalling mechanisms in the control of human cell biology and then focus on cell surface receptors and the downstream signal transduction events that they initiate. The second will examine how cells detect and respond to pathogenic molecular patterns displayed by infectious agents and injured cells by discussing the roles of relevant cell surface receptors, cytokines and signal transduction pathways. The third and fourth will focus on the life, death and differentiation of human cells in response to intra-cellular and extra-cellular signals by discussing the eukaryotic cell cycle under normal and pathological circumstances and programmed cell death in response to abnormal extra-cellular and intra-cellular signals. In all modules emphasis will be placed on the molecular processes involved in human cell biology, how modern molecular and cell biology methods have led to our current understanding of them and the implications of them for pathologies such as cancer. The practical component is designed to complement the lecture course, providing students with experience in a wide range of techniques used in modern molecular cell biology.
Textbooks
Alberts, B. et al. Molecular Biology of the Cell. 6th edition. Garland Science. 2014.
BCHM3972 Human Molecular Cell Biology (Advanced)

Credit points: 6 Teacher/Coordinator: Jill Johnston, Prof Iain Campbell Session: Semester 2 Classes: Two 1-hour lectures per week; two 3-hours practicals per fortnight Prerequisites: [An average mark of 75 in 12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [BMED2401 and (a mark of 75 in BMED2405) and (6 additional credit points of BMED240X) and (a mark of 75 in MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)] Prohibitions: BCHM3072 or BCHM3004 or BCHM3902 or BCHM3904 or BCHM3002 Assessment: One 2.5-hour exam (theory and theory of prac 70%), in-semester (practical work and assignments 30%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study will explore the responses of cells to changes in their environment in both health and disease. The lecture course consists of four integrated modules. The first will provide an overview of the role of signalling mechanisms in the control of human cell biology and then focus on cell surface receptors and the downstream signal transduction events that they initiate. The second will examine how cells detect and respond to pathogenic molecular patterns displayed by infectious agents and injured cells by discussing the roles of relevant cell surface receptors, cytokines and signal transduction pathways. The third and fourth will focus on the life, death and differentiation of human cells in response to intra-cellular and extra-cellular signals by discussing the eukaryotic cell cycle under normal and pathological circumstances and programmed cell death in response to abnormal extra-cellular and intra-cellular signals. In all modules emphasis will be placed on the molecular processes involved in human cell biology, how modern molecular and cell biology methods have led to our current understanding of them and the implications of them for pathologies such as cancer. The practical component is designed to complement the lecture course, providing students with experience in a wide range of techniques used in modern molecular cell biology.
The lecture component of this unit of study is the same as BCHM3072. Qualified students will attend seminars/practical classes in which more sophisticated topics in modern molecular cell biology will be covered.
Textbooks
Alberts, B. et al. Molecular Biology of the Cell. 6th edition. Garland Science. 2014.
BCHM3082 Medical and Metabolic Biochemistry

Credit points: 6 Teacher/Coordinator: Jill Johnston, A/Prof Gareth Denyer Session: Semester 2 Classes: Two 1-hour lectures per week; two 3-hours practicals per fortnight Prerequisites: [12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [(BMED2401, BMED2405 and 6 additional credit points of BMED240X) and (MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)] Prohibitions: BCHM3002 or BCHM3982 or BCHM3004 or BCHM3902 or BCHM3904 Assessment: One 2.5-hour exam (theory and theory of prac 70%), in-semester (practical work and assignments 30%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study will explore the biochemical processes involved in the operation of cells and how they are integrated in tissues and in the whole human body in normal and diseased states. These concepts will be illustrated by considering whole-body aspects of energy utilisation, fat and glycogen storage and their regulation under normal conditions compared to obesity and diabetes. Key concepts that will be discussed include energy balance, regulation of metabolic rate, control of food intake, tissue interactions in fuel selection, the role of adipose tissue and transport of fuel molecules from storage organs and into cells. Particular emphasis will be placed on how the modern concepts of metabolomics, coupled with molecular biology methods and studies of the structure and function of enzymes, have led to our current understanding of how metabolic processes are normally integrated and how they become deranged in disease states. The practical component is designed to complement the lecture course and will provide students with experience in a wide range of techniques used in modern medical and metabolic biochemistry.
BCHM3982 Medical and Metabolic Biochemistry (Adv)

Credit points: 6 Teacher/Coordinator: Jill Johnston, A/Prof Gareth Denyer Session: Semester 2 Classes: Two 1-hour lectures per week; two 3-hours practicals per fortnight Prerequisites: [An average mark of 75 in 12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [BMED2401 and (a mark of 75 in BMED2405) and (6 additional credit points of BMED240X) and (an average mark of 75 in MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)] Prohibitions: BCHM3082 or BCHM3902 or BCHM3004 or BCHM3904 or BCHM3002 Assessment: One 2.5-hour exam (theory and theory of prac 70%), in-semester (practical work and assignments 30%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study will explore the biochemical processes involved in the operation of cells and how they are integrated in tissues and in the whole human body in normal and diseased states. These concepts will be illustrated by considering whole-body aspects of energy utilisation, fat and glycogen storage and their regulation under normal conditions compared to obesity and diabetes. Key concepts that will be discussed include energy balance, regulation of metabolic rate, control of food intake, tissue interactions in fuel selection, the role of adipose tissue and transport of fuel molecules from storage organs and into cells. Particular emphasis will be placed on how the modern concepts of metabolomics, coupled with new methods, including magnetic resonance techniques and molecular biology methods, as well as studies of the structure and function of enzymes, have led to our current understanding of how metabolic processes are normally integrated and how they become deranged in disease states. The practical component is designed to complement the lecture course and will provide students with experience in a wide range of techniques used in modern medical and metabolic biochemistry. Qualified students will attend some lectures/practical classes in common with BCHM3082 and some separate lectures/ practical classes in which more sophisticated topics in metabolic biochemistry will be covered.
BCHM3092 Proteomics and Functional Genomics

Credit points: 6 Teacher/Coordinator: A/Prof Stuart Cordwell, Jill Johnston Session: Semester 2 Classes: Two 1-hour lectures per week and one 3-hour practical per week. Prerequisites: [12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [(BMED2401, BMED2405 and 6 additional credit points of BMED240X) and (MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)] Prohibitions: BCHM3992 or BCHM3098 Assessment: One 2.5-hour exam (theory and theory of prac 70%), in-semester (practical work and assignments 30%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study will focus on the high throughput methods for the analysis of gene structure and function (genomics) and the analysis of proteins (proteomics), which are at the forefront of discovery in the biomedical sciences. The course will concentrate on the hierarchy of gene-protein-structure-function through an examination of modern technologies built on the concepts of genomics versus molecular biology, and proteomics versus biochemistry. Technologies to be examined include DNA sequencing, nucleic acid and protein microarrays, two-dimensional gel electrophoresis of proteins, uses of mass spectrometry for high throughput protein identification, isotope tagging for quantitative proteomics, high-performance liquid chromatography, high-throughput functional assays, affinity chromatography and modern methods for database analysis. Particular emphasis will be placed on how these technologies can provide insight into the molecular basis of changes in cellular function under both physiological and pathological conditions as well as how they can be applied to biotechnology for the discovery of biomarkers, diagnostics, and therapeutics. The practical component is designed to complement the lecture course and will provide students with experience in a wide range of techniques used in proteomics and genomics.
Textbooks
Kraj A and Silberring J Proteomics Introduction to Methods and Applications Wiley 2008
BCHM3992 Proteomics and Functional Genomics (Adv)

Credit points: 6 Teacher/Coordinator: A/Prof Stuart Cordwell, Jill Johnston Session: Semester 2 Classes: Two 1-hour lectures per week and one 3-hour practical per fortnight. Prerequisites: [An average mark of 75 in 12 credit points of (MBLG2071, MBLG2971, BCHM2071, BCHM2971, BCHM2072, BCHM2972)] OR [BMED2401 and (a mark of 75 in BMED2405) and (6 additional credit points of BMED240X) and (an average mark of 75 in MBLG2071 or MBLG2971 or BCHM2071 or BCHM2971)] Prohibitions: BCHM3092 or BCHM3098 Assessment: One 2.5-hour exam (theory and theory of prac 70%), in-semester (practical work and assignments 30%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study will focus on the high throughput methods for the analysis of gene structure and function (genomics) and the analysis of proteins (proteomics) which are at the forefront of discovery in the biomedical sciences. The course will concentrate on the hierarchy of gene-protein-structure-function through an examination of modern technologies built on the concepts of genomics versus molecular biology, and proteomics versus biochemistry. Technologies to be examined include DNA sequencing, nucleic acid and protein microarrays, two-dimensional gel electrophoresis of proteins, uses of mass spectrometry for high throughput protein identification, isotope tagging for quantitative proteomics, high-performance liquid chromatography, high-throughput functional assays, affinity chromatography and modern methods for database analysis. Particular emphasis will be placed on how these technologies can provide insight into the molecular basis of changes in cellular function under both physiological and pathological conditions as well as how they can be applied to biotechnology for the discovery of biomarkers, diagnostics, and therapeutics. The practical component is designed to complement the lecture course and will provide students with experience in a wide range of techniques used in proteomics and genomics.
The lecture component of this unit of study is the same as BCHM3092. Qualified students will attend seminars/practical classes in which more sophisticated topics in proteomics and genomics will be covered.
Textbooks
Kraj A and Silberring J Proteomics Introduction to Methods and Applications Wiley 2008