Completed Research Projects

  • Project

    STDs in General Practice

    Funding: None

    STIRC has collaborated with Family Medicine Research Centre, Sydney School of Public Health, University of Sydney to conduct secondary analyses of the Bettering of Evaluation and Care of Health (BEACH) database. BEACH is a national encounter based database commenced in 1998 to record general practice activity in Australia.

    Three studies have been completed. The first looked at the management of STIs in general practice, the second looked at ‘sexual health problems’ in general practice and the final study looked at chlamydia testing in general practice.

    Dr Shailendra Sawleshwarkar
    Herpes Simplex Virus (HSV) Vaccine Trials

    Funding:  Glaxo SmithKline International

    These studies evaluated the efficacy of a vaccine for prevention of HSV-2 infection.

    Professor Adrian Mindel

    The Epidemiology of Herpes Simplex Virus in Pregnancy

    Funding: Ramaciotti Foundation and PHRDC

    A study that established the prevalence and risk factors for the presence of HSV-2 and HSV-1 infections in pregnant women in Western Sydney.

    Professor Adrian Mindel

    HSV Vaccine

    A multi-centre international trial of a new GSK vaccine against genital Herpes.

    This vaccine has proven safe and effective in adult women who are sero-negative for HSV-1. It has no efficacy in men or in women who have been exposed to HSV-1. The study included adolescent girls (between the ages of 12-17). This study is being carried out in conjunction with the Westmead Millennium Institute and the Westmead Children's Hospital. The participant visits and follow-up are now complete.

    Margaret Piper

    Prevalence of Chlamydia in Adolescents in NSW

    Funding: None

    A study to evaluate the prevalence and risk factors of Chlamydia trachomatis infection among ‘high risk’ young people in New South Wales.

    Professor Adrian Mindel

    A Retrospective Review of Sex Worker Attendees at the Parramatta Sexual Health Clinic and its Outreach Facilities at Mount Druitt

    Funding: None

    Sex workers (SWs) are globally recognised to be at high risk for the acquisition and transmission of sexually transmissible infections (STIs) and this study determined the demographics, sexual practices and health care needs of SWs attending Sexual Health Clinics in the region Western Sydney.

    Dr Shailendra Sawleshwarkar

    Evaluation of Sexual Health Services within Australia and New Zealand

    Funding: None

    This study examined and compared specialised services for patients with sexually transmitted diseases (STDs) in Australia and New Zealand.

    Professor Adrian Mindel

    Management of Sexually Transmitted Diseases Comparing Specialists and General Practitioners in Australia

    Funding: None

    The study documents the range of diagnostic techniques, treatments and partner notification policies used by Sexual Health Physicians (SHP) and General Practitioners (GPs).

    Professor Adrian Mindel

    Cervical Pre-cancer in Female Sex Workers in Sydney

    Funding: Sydney Foundation for Medical Research

    We have investigated the prevalence of, and risk factors for, cervical human papillomavirus (HPV) infection in commercial sex workers (CSWs) and controls attending the same sexual health clinics in Sydney.

    Professor Adrian Mindel

    Imiquimod 5% Cream Treatment for the Treatment of Genital Warts

    Funding: 3M Pharmaceuticals

    This study determined the optimal duration of treatment with imiquimod for external genital warts.

    Professor Adrian Mindel

    An Evaluation of the After-Hours Clinical Service at Sydney Sexual Health Centre

    Funding: None

    This study analysed patterns of patient utilisation of the after hours service at Sydney Sexual Health Centre (SSHC).

    Professor Adrian Mindel

    Demographic and Sexual Characteristics of Patients Presenting with Genital Warts to Sydney Sexual Health Centre

    Funding: None

    This study characterises risk factors for the acquisition of genital warts and specifically to determine whether condoms confer protection from infection.

    Professor Adrian Mindel

    The Management of Women with Recurrent Genital Herpes in Pregnancy in Australia

    Funding: None

    This study documents clinical practice for the management of recurrent genital herpes in pregnant women in Australia.

    Professor Adrian Mindel

    HIV p24 Vaccine Trial

    Funding: SmithKline Beecham Pharmaceuticals

    In a randomized placebo controlled trial 304 HIV infected patients with CD4 cell counts below 350 cells/mL received therapeutic vaccination with: alum placebo (Group I, n = 102), p24-VLP 500 mg (Group II, n = 101) or p24-VLP 1000 mg (Group III, n = 101) p24-VLP monthly for six months.

    Professor Adrian Mindel

    Evaluation of Sexual Health Teaching at Medical Schools in Australia and New Zealand

    • This is a questionnaire-based study to evaluate the quality and quantity of sexual health medicine being taught to medical students in Australia and New Zealand, conducted in collaboration with the RACP, Chapter of Sexual Health Medicine.
    • Data collection for this study commenced in September 2008.

    Evaluation of the Social and Demographic Characteristics, Sexual Practises and Health Care Needs of the Sex Workers Attending the Parramatta Sexual Health Clinic

    • A prospective study on the sex worker population attending the Parramatta Sexual Health Clinic and its outreach clinic at Mount Druitt.
    • The protocol development for this study has commenced.

    HPV Vaccine - PATRICIA Study

    • This is a multi-centre international trial of a new GSK vaccine against HPV types 16 and 18. The aim is to reduce the persistence of HPV infection and the incidence of high grade CIN and Cervical cancer. Follow-up is via liquid cytology, colposcopy and HPV typing, and is for four years. Most of the participants are up to their last follow-up visit (Year 4).

    NPEP Study

    • This is the study of awareness, knowledge and practice of non-occupational post-exposure prophylaxis (NPEP) for HIV among health care personnel (HCP) working in the sexual health clinics, general practice and emergency departments in New South Wales, Australia.
    • HREC approval has been received. Awaiting SSA clearance.

    Presence of Helicobacter Pylori in Sexual Health Clinic Attendees

    • Helicobacter pylori is responsible for chronic gastritis and peptic ulcer disease and is associated with an increased risk of developing stomach cancer. The exact mode of transmission of Helicobacter pylori infection remains unknown and it has been suggested that sexual transmission may be important. This study is a preliminary investigation into a possible association between sexual risk factors and Helicobacter pylori infection.
    • All patients aged 18 and above, presenting to the Parramatta Sexual Health Clinic who were having blood taken for any other purpose, were included in the study. Blood samples were collected for Helicobacter pylori serology using and enzyme-linked immunosorbent assay to detect Helcicobacter pylori IgG.
    • Preliminary results of the study were presented at the Australasian Sexual Health Conference held at the Gold Coast in October 2007. The abstract is available at:
    • The enrolment for this study is now complete and the data is being analysed.