Winner, Best Literature Review - 2010 National Institute of Forensic Science (NIFS) Australia Award
26 October 2011
The review paper by Dr Reza Alaeddini and Dr Ali Abbas from the School of Chemical and Biomolecular Engineering in collaboration with Dr Simon Walsh from the AFP has won the NIFS Best Review Paper Award for 2010. The award was presented by NIFS Director Mr Alastair Ross, during a ceremony held at University of Technology (UTS) in Sydney.
The review paper published in the journal 'Forensic Science International: Genetics' reviews the pathways involved in cell death and DNA decomposition and the subsequent difficulties these present in DNA analysis of degraded forensic samples. Understanding the pathways of DNA degradation has implications for forensic DNA profiling. DNA decomposes during biological decay in a process that leaves the DNA highly fragmented or chemically modified, therefore reducing the yield of intact DNA fragments. This consequently leads to failure or poor DNA PCR amplification or to mistyping. Awareness of DNA degradation pathways and mechanisms assists in choosing the most appropriate target samples and in designing improved techniques for sampling, storage, purification and probable DNA repair. Moreover consideration of the original phenomena that drive DNA degradation could assist in better interpretation of the results.
Full reference to the article: Reza Alaeddini, Simon Walsh and Ali Abbas. Forensic implications of genetic analyses from degraded DNA - A review. Forensic Science International: Genetics, 2010, 4, 148-157.
Click here to go to review article.