Seminar - Quantification of cardiorespiratory synchronisation

20 November 2012

Full title: Quantification of cardiorespiratory synchronisation in healthy infants and infants with chronic neonatal lung disease during sleep

Presenter:Mr Chinh D. Nguyen, University of Queensland


Cardiorespiratory interaction (coupling) is a vital phenomenon in human life, for providing gas exchange within a narrow range, in a manner responsive to varying physiological and metabolic demands. Analysis of the cardiorespiratory coupling, hence, might provide useful information of maturational process and cardiorespiratory control in infants. However, detection and quantification of the cardiorespiratory coupling in infants are difficult, due to noise and nonstationarity of the signals.
In this talk, I will present a semi-automated technique to characterise the cardiorespiratory coupling in the context of phase synchronisation. The technique has been validated by mathematical models and applied on two cohort of healthy infants and infants with chronic neonatal lung disease (CNLD). The results showed that cardiorespiratory synchronisation (CRS) increased with maturation in both groups; sighs followed by a central apnea were associated with lower CRS compared to sighs followed by a pause in healthy infants; and supplemental oxygen normalises CRS in infants with CNLD towards the normal value of healthy infants. The quantification of CRS might be useful to characterise cardiorespiratory control and maturation of infants during sleep.

About the speaker

Chinh D. Nguyen received the B.Eng. (Hons.) degree in Electrical and Electronics Engineering from the University Technology PETRONAS, Malaysia, in 2008. He has just submitted the Ph.D. thesis in biomedical engineering at the University of Queensland, Brisbane, QLD, Australia.
His research interests include mathematical analysis of physiological signals, cardiorespiratory synchronisation, and the signal-processing technique applied to sleep medicine.

Hosted by Woolcock Institute of Medical Research

Time: 8.45am

Location: Woolcock Institute of Medical Research, Level 5, Theatre 1

Contact: Andrew Vakulin

Email: 1b001d262c436602331301293f0628161b575b2952012b3504011044