Examining microRNA function in plants
11 May 2012
Dr Tony Millar (Research School of Biology, Australian National University) hosted by Mary Byrne Of the many classes of recently discovered non-coding RNAs, microRNAs (miRNAs) have been the most extensively studied, where they have been functionally implicated in controlling a multitude of critical processes in both plants and animals. Many of the principles and claims underlying the specificity, mechanism and function of plant miRNAs have been derived from bioinformatics predictions, global studies and gain-of-function approaches. To assess the validity of these principles, we have extensively examined the miR159 system in [[i||Arabidopsis]], one of the most highly conserved and abundant miRNA in plants. Using a loss-of-function and transgenic approaches we have examined its specificity, mode of action and function. I will discuss our findings in context of the general principles of miRNA regulation in plants and approaches that have been used to define them.
Location: DT Anderson Lecture Theatre, A08