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From the molecular study of receptor-ligand interactions to novel biomarkers of disease and non-invasive brain imaging - opportunities in basic and clinically oriented research

Methodologically broad but thematically focused on the role of receptors in glial (non-neuronal) cells in brain disease, the available basic science projects are concerned with the more...

Supervisor(s): Banati, Richard (Professor)

Refining cell-based therapies to cure diabetes

The most promising route for a cure for type 1 diabetes is the use of insulin-secreting cells to replace those that have died. more...

Supervisor(s): Thorn, Peter (Professor)

Unravelling mechanisms determining the balance between tolerance and immunity in the liver

Role of primary T cell activation in the liver in CD8 T cell tolerance more...

Supervisor(s): Bertolino, Patrick (Dr)

Biology of Dipeptidyl Peptidase IV and related proteins

Research projects centre on mouse models of liver disease and obesity and on the delineation of inhibitors, substrates, biochemistry and in vivo expression and function of the Dipep more...

Supervisor(s): Gorrell, Mark (Associate Professor)

Dysregulation of the inflammatory response in diabetes: Its role in poor wound healing

Diabetes is known to alter inflammatroy response but how this contributes to poor wound healing and other complications of diabetes is not known and will be investigated in this wor more...

Supervisor(s): McLennan, Susan (Dr), Shackel, Nicholas (Dr)

Elucidating the neural mechanisms of stress: a 13C-NMR study of glutamate and neuronal-glial interactions

13C-Magnetic Resonance Spectroscopy (13C-MRS) is an emerging imaging modality that allows the measurement of concentrations and synthesis rates of glutamate, glutamine and GABA with more...

Supervisor(s): Lagopoulos, Jim (Associate Professor)

Molecular investigations of receptors involved in neurological disorders

The Laboratory of Molecular Neuroscience investigates molecular regulation and drug interactions that occur in receptors associated with neurological diseases. more...

Supervisor(s): Holsinger, Damian (Dr)

An investigation into the mechanisms of immune evasion in metastatic melanoma patients treated with molecular or immune checkpoint inhibitors.

The aim of this project is to characterise the immune reaction and prevalence of immune inhibitory mechanisms present in metastatic melanoma patient tumours whilst on immune checkpo more...

Supervisor(s): Scolyer, Richard (Professor), Long, Georgina (Professor)

Understanding ageing of the endothelium

The investigations are focussed on identifying the biological and molecular changes that occur when endothelial cells undergo senescence (ageing) and the impact on disease such as d more...

Supervisor(s): Gamble, Jennifer (Professor)

The role of dendritic cells in co-infection with HIV and herpes simplex virus

The role of dendritic cells in co-infection with HIV and herpes simplex virus. more...

Supervisor(s): Cunningham, Tony (Professor)