Dr Aaron Schindeler

Senior Lecturer
Paediatrics & Child Health, Children's Hospital, Westmead

C29 - Children's Hospital Westmead
The University of Sydney
NSW 2006 Australia

T: 02 98451451
F: 02 98453078

Current national competitive grants*


Pre-clinical validation of a novel implant for bone tissue engineering
Little D, Cooper-White J, Ruys A, Schindeler A
NHMRC Project Grants ($421,175 over 3 years)

* Grants administered through the University of Sydney


2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008


  • El-Hoss, J., Kolind, M., Jackson, M., Deo, N., Mikulec, K., McDonald, M., Little, C., Little, D., Schindeler, A. (2014), Modulation of endochondral ossification by MEK inhibitors PD0325901 and AZD6244 (Selumetinib). Bone. 59C, 151-161. [Abstract]
  • Sullivan, K., El-Hoss, J., Quinlan, K., Deo, N., Garton, F., Seto, J., Gdalevitch, M., Turner, N., Cooney, G., Kolanczyk, M., North, K., Little, D., Schindeler, A. (2014), NF1 is a critical regulator of muscle development and metabolism. Human Molecular Genetics. 23(5), 1250-1259. [Abstract]
  • Bobyn, J., Rasch, A., Kathy, M., Little, D., Schindeler, A. (2014), Maximizing bone formation in posterior spine fusion using rhBMP-2 and zoledronic acid in wild type and NF1 deficient mice. Journal of Orthopaedic Research. 32(8), 1090-1094. [Abstract]
  • Murphy, C., Schindeler, A., Gleeson, J., Yu, N., Cantrill, L., Mikulec, K., Peacock, L., O'Brien, F., Little, D. (2014), A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates. Acta Biomaterialia. 10, 2250-2258. [Abstract]
  • Yu, N., Gdalevitch, M., Murphy, C., Mikulec, K., Peacock, L., Fitzpatrick, J., Cantrill, L., Ruys, A., Cooper-White, J., Little, D., Schindeler, A. (2014), Spatial control of bone formation using a porous polymer scaffold co-delivering anabolic rhBMP-2 and anti-resorptive agents. European Cells & Materials. 27, 98-111. [Abstract]


  • Ravarian, R., Zhong, X., Barbeck, M., Ghanaati, S., Kirkpatrick, C., Murphy, C., Schindeler, A., Chrzanowski, W., Dehghani, F. (2013), Nanoscale Chemical Interaction Enhances the Physical Properties of Bioglass Composites. ACS Nano. 7(10), 8469-8483. [Abstract]
  • Stevenson, D., Little, D., Armstrong, L., Crawford, A., Eastwood, D., Friedman, J., Greggi, T., Gutierrez, G., Hunter-Schaedle, K., Kendler, D., Kolanczyk, M., Monsell, F., Oetgen, M., Richards, B., Schindeler, A., Schorry, E., Wilkes, D., Viskochil, D., Yang, F., Elefteriou, F. (2013), Approaches to Treating NF1 Tibial Pseudarthrosis: Consensus From the Children's Tumor Foundation NF1 Bone Abnormalities Consortium. Journal of Pediatric Orthopedics. 33(3), 269-275. [Abstract]
  • Schindeler, A., Kolind, M., Little, D. (2013), Cellular transitions and tissue engineering. Cellular Reprogramming. 15(2), 101-106. [Abstract]
  • Bobyn, J., Rasch, A., Little, D., Schindeler, A. (2013), Posterolateral inter-transverse lumbar fusion in a mouse model. Journal of Orthopaedic Surgery and Research. 8(1), 2. [Abstract]
  • Yu, N., Schindeler, A., Peacock, L., Mikulec, K., Fitzpatrick, J., Ruys, A., Cooper-White, J., Little, D. (2013), Modulation of anabolic and catabolic responses via a porous polymer scaffold manufactured using thermally induced phase separation. European Cells & Materials. 25, 190-203. [Abstract]
  • Murphy, C., O'Brien, F., Little, D., Schindeler, A. (2013), Cell-scaffold interactions in the bone tissue engineering triad. European Cells & Materials. 26, 120-132. [Abstract]
  • Cheng, T., Valtchev, P., Murphy, C., Cantrill, L., Dehghani, F., Little, D., Schindeler, A. (2013), A sugar-based phase-transitioning delivery system for bone tissue engineering. European Cells & Materials. 26, 208-221. [Abstract]


  • Yu, N., Schindeler, A., Tagil, M., Ruys, A., Little, D. (2012), Use of BMPs and bisphosphonates to improve bone fracture healing. Frontiers in Bioscience. 4, 2647-2653. [Abstract]
  • Cairns, D., Liu, R., Sen, M., Canner, J., Schindeler, A., Little, D., Zeng, L. (2012), Interplay of Nkx3.2, Sox9 and Pax3 regulates chondrogenic differentiation of muscle progenitor cells. PLoS one. 7(7), e39642. [Abstract]


  • Sullivan, K., El-Hoss, J., Little, D., Schindeler, A. (2011), JNK inhibitors increase osteogenesis in Nf1-deficient cells. Bone. 49(6), 1311-6. [Abstract]
  • Yang, N., Schindeler, A., McDonald, M., Seto, J., Houweling, P., Lek, M., Hogarth, M., Morse, A., Raftery, J., Balasuriya, D., Macarthur, D., Berman, Y., Quinlan, K., Eisman, J., Nguyen, T., Center, J., Prince, R., Wilson, S., Zhu, K., Little, D., North, K. (2011), α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse. Bone. 49(4), 790-798. [Abstract]
  • El-Hoss, J., Sullivan, K., Cheng, T., Yu, N., Bobyn, J., Peacock, L., Mikulec, K., Baldock, P., Alexander, I., Schindeler, A., Little, D. (2011), A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells. Journal of Bone and Mineral Research. 27(1), 68-78. [Abstract]
  • Schindeler, A., Birke, O., Yu, N., Morse, A., Ruys, A., Baldock, P., Little, D. (2011), Distal tibial fracture repair in a neurofibromatosis type 1-deficient mouse treated with recombinant bone morphogenetic protein and a bisphosphonate. The Journal of Bone and Joint Surgery. British Volume. 93(8), 1134-1139. [Abstract]
  • Liu, R., Birke, O., Morse, A., Peacock, L., Mikulec, K., Little, D., Schindeler, A. (2011), Myogenic progenitors contribute to open but not closed fracture repair. BMC Musculoskeletal Disorders. 12, 288. [Abstract]
  • El-Hoss, J., Micallef, A., Fairfull-Smith, K., Bottle, S., Little, D., Schindeler, A. (2011), Assessment of Tumor Prevention in Type 1 Neurofibromatosis using a Nitroxide Compound. Free Radicals and Antioxidants. 1(3), 13-18.


  • McDonald, M., Morse, A., Peacock, L., Mikulec, K., Schindeler, A., Little, D. (2010), Characterization of the bone phenotype and fracture repair in osteopetrotic Incisors absent rats. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. (5). [Abstract]
  • Yu, N., Schindeler, A., Little, D., Ruys, A. (2010), Biodegradable poly(alpha-hydroxy acid) polymer scaffolds for bone tissue engineering. Journal of Biomedical Materials Research. Part B: Applied Biomaterials. 93(1), 285-295. [Abstract]
  • Liu, R., Schindeler, A., Little, D. (2010), The potential role of muscle in bone repair. Journal of Musculoskeletal and Neuronal Interactions. 10(1), 71-76. [Abstract]
  • Yu, N., Schindeler, A., Peacock, L., Mikulec, K., Baldock, P., Ruys, A., Little, D. (2010), In vivo local co-delivery of recombinant human bone morphogenetic protein-7 and pamidronate via poly-D, L-lactic acid. European Cells & Materials. 20, 431-442. [Abstract]
  • Birke, O., Schindeler, A., Ramachandran, M., Cowell, C., Munns, C., Bellemore, M., Little, D. (2010), Preliminary experience with the combined use of recombinant bone morphogenetic protein and bisphosphonates in the treatment of congenital pseudarthrosis of the tibia. Journal of Children's Orthopaedics. 4(6), 507–517.
  • Schindeler, A., Morse, A., Peacock, L., Mikulec, K., Yu, N., Liu, R., Kijumnuayporn, S., McDonald, M., Baldock, P., Ruys, A., Little, D. (2010), Rapid cell culture and pre-clinical screening of a transforming growth factor-beta (TGF-beta) inhibitor for orthopaedics. BMC Musculoskeletal Disorders. 11, 105. [Abstract]


  • Liu, R., Ginn, S., Lek, M., North, K., Alexander, I., Little, D., Schindeler, A. (2009), Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1a. BMC musculoskeletal disorders. 10(0), 51. [Abstract]
  • Schindeler, A., Liu, R., Little, D. (2009), The contribution of different cell lineages to bone repair: exploring a role for muscle stem cells. Differentiation. 77(1), 12-18. [Abstract]
  • Elefteriou, F., Kolanczyk, M., Schindeler, A., Viskochil, D., Hock, J., Schorry, E., Crawford, A., Friedman, J., Little, D., Peltonen, J., Carey, J., Feldman, D., Yu, X., Armstrong, L., Birch, P., Kendler, D., Mundlos, S., Yang, F., Agiostratidou, G., Hunter-Schaedle, K., Stevenson, D. (2009), Skeletal Abnormalities in Neurofibromatosis Type 1: Approaches to Therapeutic Options. American Journal of Medical Genetics Part A. 149A(10), 2327-2338. [Abstract]


  • Yu, N., Ruys, A., Zenios, M., Godfrey, C., McDonald, M., Kiely, P., Mikulec, K., Little, D., Schindeler, A. (2008), Bisphosphonate-laden acrylic bone cement: Mechanical properties, elution performance, and in vivo activity. Journal of biomedical materials research. Part B, Applied biomaterials. 87(2), 482-91. [Abstract]
  • Schindeler, A., McDonald, M., Bokko, P., Little, D. (2008), Bone remodeling during fracture repair: The cellular picture. Seminars in cell & developmental biology. 19(5), 459-66. [Abstract]
  • Schindeler, A., Morse, A., Harry, L., Godfrey, C., Mikulec, K., McDonald, M., Gasser, J., Little, D. (2008), Models of tibial fracture healing in normal and Nf1-deficient mice. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 26(8), 1053-60. [Abstract]
  • Schindeler, A., Little, D. (2008), Recent insights into bone development, homeostasis, and repair in type 1 neurofibromatosis (NF1). Bone. 42(4), 616-622. [Abstract]
  • Schindeler, A., Ramachandran, M., Godfrey, C., Morse, A., McDonald, M., Mikulec, K., Little, D. (2008), Modeling bone morphogenetic protein and bisphosphonate combination therapy in wild-type and Nf1 haploinsufficient mice. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 26(1), 65-74. [Abstract]