People_

Associate Professor Aaron Schindeler

Head, Bioengineering & Molecular Medicine (BAMM) Laboratory, Children's Hospital at Westmead (CHW) and Westmead Institute for Medical Research (WIMR)

Associate Professor, Faculty of Engineering
Conjoint Associate Professor, Faculty of Medicine &
Health

Phone

02 98451451

Fax

02 98453078

aaron.schindeler@sydney.edu.au

Details

Member of The Centre for Drug Discovery Innovation

Websites

Research Supervisor Profile

Biographical details

A/Prof Schindeler heads the Bioengineering & Molecular Medicine laboratory at The Children’s Hospital at Westmead and the Westmead Institute for Medical Research. He holds an academic position in the School of Chemical and Biomolecular Engineering (Faculty of Engineering).

Research interests

A/Prof Schindeler has a diverse range of research interests across the fields of medicine, health, and engineering. Key focus areas include the development of novel tools for functional genomics and gene therapy for bone fragility disorders; pharmaceutical modulation of bone healing; bone tissue engineering using novel biomaterials and 3D printing; and treating the musculoskeletal complications associated with Neurofibromatosis type 1.

“My research aims to target major problems affecting children’s health. To accomplish this, I am working to create new tools for understanding the mechanisms of disease and subsequent disease treatment. In some cases we are repurposing old drugs, in other cases we are designing new drugs as well as new gene editing strategies using technologies such as CRISPR.

“One example of the timeline of such research can be seen in the treatment of the genetic disease neurofibromatosis type I or NF1. Children with this condition have a broad range of complications, but my work has focused on those affecting muscle and bone. Together with my colleagues we found that other drugs used for treatment of non-unions combined with adult osteoporosis drugs could reduce the number of amputations seen in children with crippling bone non-unions. More recently, we found that specific over-the-counter dietary supplements were able to effectively treat muscle weakness in a preclinical model, and this work has now moved into clinical trials.

“Another exciting advance is how we are using CRISPR gene editing to develop functional genomics methods to identify causes of bone disease in hospital patients. However the real challenge will be to then find ways to repair these mutations. Recently we had a major advance, developing an adeno-associated viral vector system that specifically targets the bone and that can affect gene editing throughout the skeleton with a single injection. While there is a lot of work to be done before we can cure genetic bone diseases, this is a critical first step.”

Teaching and supervision

A/Prof has supervised over 50 resesarch students from the faculties of Medicine & Health (including MDs pursuing research doctrates) and Engineering.

Current projects

https://www.sydney.edu.au/research/opportunities/3415.html

https://www.sydney.edu.au/research/opportunities/3416.html

https://www.sydney.edu.au/research/opportunities/3417.html

Themes

Reproductive, Maternal and Child Health, Biomedical engineering and technology

Keywords

Musculoskeletal diseases, Orthopaedics

Approaches

Animal Models, Cellular/Molecular

PhD and master's project opportunities

GENE THERAPY FOR BRITTLE BONE DISEASE

DEVELOPING GENE THERAPY APPROACHES FOR TYPE 1 AND TYPE 2 DIABETES

TARGETING SENESCENT CELLS IN BONE TO PREVENT AGE-RELATED BONE LOSS

Current research students

Project title	Research student
Development of CRISPR-based gene therapy for dominant negative Osteogenesis Imperfecta	Christal AU-YEUNG
Development of tissue-targeted vectors for musculoskeletal gene therapy	Julian CHU
Gene Therapy for Neurofibromatosis types 1 and 2	Hsien KAO
Exploring Vitamin D's Effects on Muscle Regeneration and Mitochondrial Function	Johnson LI
Engineering a Targeted Delivery System	Timothy SCHOFIELD
Microfluidic Analysis of Protein Condensate Interactions for Drug Discovery	Jiaxin, Caramel XIE

Publications

By Type

Expand all

Book Chapters

Wu, J., Blackshaw, K., Cho, J., Koolaji, N., Yun, J., Schindeler, A., Valtchev, P., Dehghani, F. (2021). Recovery of high-value compounds from food by-products. In Not known (Eds.), Food Engineering Innovations Across the Food Supply Chain, (pp. 61-88). TBC. [More Information]

Journals

Schindeler, A., Ludwig, K., Munns, C. (2024). Enzyme replacement therapy for hypophosphatasia—The current paradigm. Clinical Endocrinology. [More Information]
Julovi, S., Dao, A., Trinh, K., O'Donohue, A., Shu, C., Smith, S., Shingde, M., Schindeler, A., Rogers, N., Little, C. (2023). Disease-modifying interactions between chronic kidney disease and osteoarthritis: A new comorbid mouse model. RMD Open, 9(3). [More Information]
O'Donohue, A., Dao, A., Bobyn, J., Munns, C., Little, D., Schindeler, A. (2023). Modeling anabolic and antiresorptive therapies for fracture healing in a mouse model of osteogenesis imperfecta. Journal of Orthopaedic Research, 41(4), 808-814. [More Information]
Dao, A., O'Donohue, A., Vasiljevski, E., Bobyn, J., Little, D., Schindeler, A. (2023). Murine models of orthopedic infection featuring Staphylococcus aureus biofilm. Journal of Bone and Joint Infection, 8(2), 81-89. [More Information]
Shahen, V., Schindeler, A., Rybchyn, M., Girgis, C., Mulholland, B., Mason, R., Levinger, I., Brennan-Speranza, T. (2023). Rescue of High Glucose Impairment of Cultured Human Osteoblasts Using Cinacalcet and Parathyroid Hormone. Calcified Tissue International, 112(4), 452-462. [More Information]
Power, H., Valtchev, P., Dehghani, F., Schindeler, A. (2023). Strategies for senolytic drug discovery. Aging Cell, 22(10), e13948. [More Information]
O'Donohue, A., Xiao, Y., Lee, L., schofield, T., Cheng, T., Munns, C., Baldock, P., Schindeler, A. (2023). Targeted postnatal knockout of Sclerostin using a bone-targeted adeno-associated viral vector increases bone anabolism and decreases canalicular density. Bone, 167. [More Information]
Talebian, S., schofield, T., Valtchev, P., Schindeler, A., Kavanagh, J., Adil, Q., Dehghani, F. (2022). Biopolymer-Based Multilayer Microparticles for Probiotic Delivery to Colon. Advanced Healthcare Materials, 11(11). [More Information]
Lee, L., Holman, A., Li, X., Vasiljevski, E., O'Donohue, A., Cheng, T., Little, D., Schindeler, A., Biggin, A., Munns, C. (2022). Combination treatment with growth hormone and zoledronic acid in a mouse model of Osteogenesis imperfecta. Bone, 159, 116378-1-116378-12. [More Information]
Schindeler, A., Lee, L., O'Donohue, A., Ginn, S., Munns, C. (2022). Curative Cell and Gene Therapy for Osteogenesis Imperfecta. Journal of Bone and Mineral Research, 37(5), 826-836. [More Information]
Wu, J., Power, H., Miranda-Saksena, M., Valtchev, P., Schindeler, A., Cunningham, A., Dehghani, F. (2022). Identifying HSV-1 Inhibitors from Natural Compounds via Virtual Screening Targeting Surface Glycoprotein D. Pharmaceuticals, 15(3), 361. [More Information]
Dao, A., Mcdonald, M., Savage, P., Little, D., Schindeler, A. (2022). Preventing osteolytic lesions and osteomyelitis in multiple myeloma. Journal of Bone Oncology, 37. [More Information]
Blackshaw, K., Wu, J., Proschogo, N., Davies, J., Oldfield, D., Schindeler, A., Banati, R., Dehghani, F., Valtchev, P. (2022). The effect of thermal pasteurization, freeze-drying, and gamma irradiation on donor human milk. Food Chemistry, 373, 131402. [More Information]
Power, H., Wu, J., Turville, S., Aggarwal, A., Valtchev, P., Schindeler, A., Dehghani, F. (2022). Virtual screening and in vitro validation of natural compound inhibitors against SARS-CoV-2 spike protein. Bioorganic Chemistry, 119, 105574. [More Information]
Casanova, M., Schindeler, A., Peacock, L., Lee, L., Schneider, P., Little, D., Müller, R. (2021). Characterization of the Developing Lacunocanalicular Network During Fracture Repair. JBMR Plus, 5(9), e10525. [More Information]
Fois, C., Schindeler, A., Valtchev, P., Dehghani, F. (2021). Dynamic flow and shear stress as key parameters for intestinal cells morphology and polarization in an organ-on-a-chip model. Biomedical Microdevices, 23(4), 55. [More Information]
Mirkhalaf Valashani, M., Goldsmith, J., Ren, J., Dao, A., Newman, P., Schindeler, A., Woodruff, M., Dunstan, C., Zreiqat, H. (2021). Highly substituted calcium silicates 3D printed with complex architectures to produce stiff, strong and bioactive scaffolds for bone regeneration. Applied Materials Today, 25, 101230. [More Information]
Vasiljevski, E., Burns, J., Bray, P., Donlevy, G., Mudge, A., Jones, K., Summers, M., Biggin, A., Munns, C., McKay, M., Little, D., Schindeler, A., et al (2021). L-carnitine supplementation for muscle weakness and fatigue in children with neurofibromatosis type 1: A Phase 2a clinical trial. American Journal of Medical Genetics, Part A, 185(10), 2976-2985. [More Information]
Bobyn, J., Deo, N., Little, D., Schindeler, A. (2021). Modulation of spine fusion with BMP-2, MEK inhibitor (PD0325901), and zoledronic acid in a murine model of NF1 double inactivation. Journal of Orthopaedic Science, 26(4), 684-689. [More Information]
Mirkhalaf Valashani, M., Dao, A., Schindeler, A., Little, D., Dunstan, C., Zreiqat, H. (2021). Personalized Baghdadite scaffolds: stereolithography, mechanics and in vivo testing. Acta Biomaterialia, 132, 217-226. [More Information]
Mohammadpour, H., Zarei, M., Cullen, P., Valtchev, P., Schindeler, A., Dehghani, F. (2021). Potential application of non-thermal atmospheric plasma in reducing the activity of Pseudomonas-secreted proteases in milk. International Dairy Journal, 120, 105078. [More Information]
Kamble, S., Valtchev, P., Dao, A., Pelras, T., Rogers, M., Savage, P., Dehghani, F., Schindeler, A. (2021). Synthesis and Characterization of Bone Binding Antibiotic-1 (BBA-1), a Novel Antimicrobial for Orthopedic Applications. Molecules, 26(6). [More Information]
Blackshaw, K., Wu, J., Valtchev, P., Lau, E., Banati, R., Dehghani, F., Schindeler, A. (2021). The effects of thermal pasteurisation, freeze-drying, and gamma-irradiation on the antibacterial properties of donor human milk. Foods, 10(9), 2077. [More Information]
Blackshaw, K., Valtchev, P., Koolaji, N., Berry, N., Schindeler, A., Dehghani, F., Banati, R. (2021). The risk of infectious pathogens in breast-feeding, donated human milk and breast milk substitutes. Public Health Nutrition, 24(7), 1725-1740. [More Information]
Koolaji, N., Shammugasamy, B., Schindeler, A., Dong, Q., Dehghani, F., Valtchev, P. (2020). Citrus Peel Flavonoids as Potential Cancer Prevention Agents. Current Developments in Nutrition, 4(5), 1-20. [More Information]
Schindeler, A., Biggin, A., Munns, C. (2020). Clinical Evidence for the Benefits of Burosumab Therapy for X-Linked Hypophosphatemia (XLH) and Other Conditions in Adults and Children. Frontiers in Endocrinology, 11, 338. [More Information]
Mills, R., Boyling, A., Cheng, T., Peacock, L., Savage, P., Tägil, M., Little, D., Schindeler, A. (2020). CSA-90 reduces periprosthetic joint infection in a novel rat model challenged with local and systemic Staphylococcus aureus. Journal of Orthopaedic Research, 38(9), 2065-2073. [More Information]
Vasiljevski, E., Houweling, P., Rupasinghe, T., Kaur, T., Summers, M., Roessner, U., Little, D., Schindeler, A. (2020). Evaluating modified diets and dietary supplement therapies for reducing muscle lipid accumulation and improving muscle function in neurofibromatosis type 1 (NF1). PloS One, 15(8), e0237097. [More Information]
Morse, A., Ko, F., McDonald, M., Lee, L., Schindeler, A., Van Der Meulen, M., Little, D. (2020). Increased anabolic bone response in Dkk1 KO mice following tibial compressive loading. Bone, 131, 115054. [More Information]
Morse, A., McDonald, M., Mikulec, K., Schindeler, A., Munns, C., Little, D. (2020). Pretreatment with Pamidronate Decreases Bone Formation but Increases Callus Bone Volume in a Rat Closed Fracture Model. Calcified Tissue International, 106(2), 172-179. [More Information]
Lu, Z., Chiu, J., Lee, L., Schindeler, A., Jackson, M., Ramaswamy, Y., Dunstan, C., Hogg, P., Zreiqat, H. (2020). Reprogramming of human fibroblasts into osteoblasts by insulin-like growth factor-binding protein 7. Stem Cells Translational Medicine, 9(3), 403-415. [More Information]
Dao, A., Mills, R., Kamble, S., Savage, P., Little, D., Schindeler, A. (2020). The application of ceragenins to orthopedic surgery and medicine. Journal of Orthopaedic Research, 38(9), 1883-1894. [More Information]
Arab, M., Bahramian, B., Schindeler, A., Fathi, A., Valtchev, P., McConchie, R., Dehghani, F. (2019). A benign process for the recovery of solanesol from tomato leaf waste. Heliyon, 5(4), 1-17. [More Information]
Cheng, T., Leblanc, E., Kalinina, A., Cantrill, L., Valtchev, P., Dehghani, F., Little, D., Schindeler, A. (2019). A Bioactive Coating Enhances Bone Allografts in Rat Models of Bone Formation and Critical Defect Repair. Journal of Orthopaedic Research, 37(11), 2278-2286. [More Information]
Lee, L., Peacock, L., Ginn, S., Cantrill, L., Cheng, T., Little, D., Munns, C., Schindeler, A. (2019). Bone Marrow Transplantation for Treatment of the Col1a2+/G610C Osteogenesis Imperfecta Mouse Model. Calcified Tissue International, 104(4), 426-436. [More Information]
Manavitehrani, I., Ebrahimi, P., Yang, I., Daly, S., Schindeler, A., Saxena, A., Little, D., Fletcher, D., Dehghani, F., Winlaw, D. (2019). Current Challenges and Emergent Technologies for Manufacturing Artificial Right Ventricle to Pulmonary Artery (RV-PA) Cardiac Conduits. Cardiovascular Engineering and Technology, 10(2), 205-215. [More Information]
Bateman, J., Sampurno, L., Maurizi, A., Lamande, S., Sims, N., Cheng, T., Schindeler, A., Little, D. (2019). Effect of rapamycin on bone mass and strength in the Î±2(I)-G610C mouse model of osteogenesis imperfecta. Journal of Cellular and Molecular Medicine, 23(3), 1735-1745. [More Information]
Arab, M., Bahramian, B., Schindeler, A., Valtchev, P., Dehghani, F., McConchie, R. (2019). Extraction of phytochemicals from tomato leaf waste using subcritical carbon dioxide. Innovative Food Science and Emerging Technologies, 57, 1-9. [More Information]
Imel, E., Biggin, A., Schindeler, A., Munns, C. (2019). FGF23, Hypophosphatemia, and Emerging Treatments. JBMR Plus, 3(8), 1-9. [More Information]
Manavitehrani, I., Le, T., Daly, S., Wang, Y., Maitz, P., Schindeler, A., Dehghani, F. (2019). Formation of porous biodegradable scaffolds based on poly(propylene carbonate) using gas foaming technology. Materials Science and Engineering C, 96, 824-830. [More Information]
Ferner, R., Bakker, A., Elgersma, Y., Evans, D., Giovannini, M., Legius, E., Lloyd, A., Messiaen, L., Plotkin, S., Reilly, K., et al (2019). From process to progress-2017 International Conference on Neurofibromatosis 1, Neurofibromatosis 2 and Schwannomatosis. American Journal of Medical Genetics, Part A, 179(6), 1098-1106. [More Information]
Cheng, T., Cantrill, L., Schindeler, A., Little, D. (2019). Induction of periosteal bone formation by intraosseous BMP-2 injection in a mouse model of osteogenesis imperfecta. Journal of Children's Orthopaedics, 13(5), 543-550. [More Information]
Mumford, J., Kohn, M., Briody, J., Miskovic-Wheatley, J., Madden, S., Clarke, S., Biggin, A., Schindeler, A., Munns, C. (2019). Long-term Outcomes of Adolescent Anorexia Nervosa on Bone. Journal of Adolescent Health, 64(3), 305-310. [More Information]
Girgis, C., Cha, K., So, B., Tsang, M., Chen, J., Houweling, P., Schindeler, A., Stokes, R., Swarbrick, M., Evesson, F., Cooper, S., Gunton, J. (2019). Mice with myocyte deletion of vitamin D receptor have sarcopenia and impaired muscle function. Journal of Cachexia, Sarcopenia and Muscle, 10(6), 1228-1240. [More Information]
Fois, C., Le, T., Schindeler, A., Naficy, S., McClure, D., Read, M., Valtchev, P., Khademhosseini, A., Dehghani, F. (2019). Models of the Gut for Analyzing the Impact of Food and Drugs. Advanced Healthcare Materials, 8(21), 1-23. [More Information]
Mirmohseni, F., Cheng, T., Oveissi, F., Behi, M., Schindeler, A., Little, D., Naficy, S., Dehghani, F., Valtchev, P. (2019). Optimized Synthesis of Poly(deoxyribose) Isobutyrate, a Viscous Biomaterial for Bone Morphogenetic Protein-2 Delivery. ACS Applied Materials and Interfaces, 11(3), 2870-2879. [More Information]
Biglari, S., Le, T., Tan, R., Wise, S., Zambon, A., Codolo, G., De Bernard, M., Warkiani, M., Schindeler, A., Naficy, S., Valtchev, P., Dehghani, F., et al (2019). Simulating Inflammation in a Wound Microenvironment Using a Dermal Wound-on-a-Chip Model. Advanced Healthcare Materials, 8(1), 1-12. [More Information]
Lee, L., Peacock, L., Lisowski, L., Little, D., Munns, C., Schindeler, A. (2019). Targeting Adeno-Associated Virus Vectors for Local Delivery to Fractures and Systemic Delivery to the Skeleton. Molecular Therapy - Methods & Clinical Development, 15, 101-111. [More Information]
Daly, S., Fathi, A., Bahramian, B., Manavi Tehrani, I., McClure, D., Valtchev, P., Schindeler, A., Dehghani, F., Kavanagh, J. (2018). A green process for the purification of biodegradable poly(B-hydroxybutyrate). The Journal of Supercritical Fluids, 135, 84-90. [More Information]
Torabian, G., Bahramian, B., Zambon, A., Spilimbergo, S., Adil, Q., Schindeler, A., Valtchev, P., Dehghani, F. (2018). A hybrid process for increasing the shelf life of elderberry juice. The Journal of Supercritical Fluids, 140, 406-414. [More Information]
Mills, R., Cheng, T., Mikulec, K., Peacock, L., Isaacs, D., Genberg, C., Savage, P., Little, D., Schindeler, A. (2018). CSA-90 Promotes Bone Formation and Mitigates Methicillin-resistant Staphylococcus aureus Infection in a Rat Open Fracture Model. Clinical Orthopaedics and Related Research, 476(6), 1311-1323. [More Information]
Summers, M., Vasiljevski, E., Mikulec, K., Peacock, L., Little, D., Schindeler, A. (2018). Developmental dosing with a MEK inhibitor (PD0325901) rescues myopathic features of the muscle-specific but not limb-specific Nf1 knockout mouse. Molecular Genetics and Metabolism, 123(4), 518-525. [More Information]
Fiscaletti, M., Coorey, C., Biggin, A., Briody, J., Little, D., Schindeler, A., Munns, C. (2018). Diagnosis of Recurrent Fracture in a Pediatric Cohort. Calcified Tissue International, 103(5), 529-539. [More Information]
Summers, M., Rupasinghe, T., Vasiljevski, E., Evesson, F., Mikulec, K., Peacock, L., Quinlan, K., Cooper, S., Roessner, U., Stevenson, D., Little, D., Schindeler, A. (2018). Dietary intervention rescues myopathy associated with neurofibromatosis type 1. Human Molecular Genetics, 27(4), 577-588. [More Information]
Morse, A., Cheng, T., Schindeler, A., McDonald, M., Mohanty, S., Kneissel, M., Kramer, I., Little, D. (2018). Dkk1 KO Mice Treated with Sclerostin Antibody Have Additional Increases in Bone Volume. Calcified Tissue International, 103(3), 298-310. [More Information]
McDonald, M., Morse, A., Schindeler, A., Mikulec, K., Peacock, L., Cheng, T., Bobyn, J., Lee, L., Baldock, P., Croucher, P., Tam, P., Little, D. (2018). Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation. Calcified Tissue International, 102(1), 105-116. [More Information]
Deo, N., Cheng, T., Mikulec, K., Peacock, L., Little, D., Schindeler, A. (2018). Improved union and bone strength in a mouse model of NF1 pseudarthrosis treated with recombinant human bone morphogenetic protein-2 and zoledronic acid. Journal of Orthopaedic Research, 36(3), 930-936. [More Information]
Deo, N., El-Hoss, J., Kolind, M., Mikulec, K., Peacock, L., Little, D., Schindeler, A. (2018). JNK inhibitor CC-930 reduces fibrosis in a murine model of Nf1-deficient fracture repair. Journal of Applied Biomedicine, 16(4), 350-357. [More Information]
Vasiljevski, E., Summers, M., Little, D., Schindeler, A. (2018). Lipid storage myopathies: Current treatments and future directions. Progress In Lipid Research, 72, 1-17. [More Information]
Manavitehrani, I., Schindeler, A., Parviz, M. (2018). Mesoporous Silica Nanoparticles: Synthesis, Modification and Applications. Nanomedicine & Nanotechnology Open Access, 3(2), 1-10.
Tarento, T., McClure, D., Vasiljevski, E., Schindeler, A., Dehghani, F., Kavanagh, J. (2018). Microalgae as a source of vitamin K1. Algal Research, 36, 77-87. [More Information]
Schindeler, A., Mills, R., Bobyn, J., Little, D. (2018). Preclinical Models for Orthopedic Research and Bone Tissue Engineering. Journal of Orthopaedic Research, 36(3), 832-840. [More Information]
Naficy, S., Oveissi, F., Patrick, B., Schindeler, A., Dehghani, F. (2018). Printed, Flexible pH Sensor Hydrogels for Wet Environments. Advanced Materials Technologies, 3(11), 1-10. [More Information]
Morse, A., Schindeler, A., McDonald, M., Kneissel, M., Kramer, I., Little, D. (2018). Sclerostin antibody augments the anabolic bone formation response in a mouse model of mechanical tibial loading. Journal of Bone and Mineral Research, 33(3), 486-498. [More Information]
McDonald, M., Morse, A., Birke, O., Yu, N., Mikulec, K., Peacock, L., Schindeler, A., Liu, M., Ke, H., Little, D. (2018). Sclerostin antibody enhances bone formation in a rat model of distraction osteogenesis. Journal of Orthopaedic Research, 36(4), 1106-1113. [More Information]
Manavi Tehrani, I., Fathi, A., Schindeler, A., Dehghani, F. (2018). Sustained Protein Release from a Core-Shell Drug Carrier System Comprised of Mesoporous Nanoparticles and an Injectable Hydrogel. Macromolecular Bioscience, 18(12), 1-9. [More Information]
Little, D., Peacock, L., Mikulec, K., Kneissel, M., Kramer, I., Cheng, T., Schindeler, A., Munns, C. (2017). Combination sclerostin antibody and zoledronic acid treatment outperforms either treatment alone in a mouse model of osteogenesis imperfecta. Bone, 101, 96-103. [More Information]
Manavi Tehrani, I., Fathi, A., Wang, Y., Maitz, P., Mirmohseni, F., Cheng, T., Peacock, L., Little, D., Schindeler, A., Dehghani, F. (2017). Fabrication of a Biodegradable Implant with Tunable Characteristics for Bone Implant Applications. Biomacromolecules, 18(6), 1736-1746. [More Information]
Yang, I., Gottliebsen, M., Martinkevich, P., Schindeler, A., Little, D. (2017). Guided Growth: Current Perspectives and Future Challenges. JBJS Reviews, 5(11), 1-12. [More Information]
Summers, M., Mikulec, K., Peacock, L., Little, D., Schindeler, A. (2017). Limitations of the Pax7-creER(T2) transgene for driving deletion of Nf1 in adult mouse muscle. International Journal of Developmental Biology, 61(8-Sep), 531-536. [More Information]
Yu, N., Fathi, A., Murphy, C., Mikulec, K., Peacock, L., Cantrill, L., Dehghani, F., Little, D., Schindeler, A. (2017). Local co-delivery of rhBMP-2 and cathepsin K inhibitor L006235 in poly(D,L-lactide-co-glycolide) nanospheres. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 105B (1), 136-144. [More Information]
Morse, A., McDonald, M., Schindeler, A., Peacock, L., Mikulec, K., Cheng, T., Liu, M., Ke, H., Little, D. (2017). Sclerostin Antibody Increases Callus Size and Strength but does not Improve Fracture Union in a Challenged Open Rat Fracture Model. Calcified Tissue International, 101(2), 217-228. [More Information]
Cheng, T., Schindeler, A., Little, D. (2016). BMP-2 delivered via sucrose acetate isobutyrate (SAIB) improves bone repair in a rat open fracture model. Journal of Orthopaedic Research, 34(7), 1168-1176. [More Information]
Murphy, C., Duffy, G., Schindeler, A., O'Brien, F. (2016). Effect of Collagen-Glycosaminoglycan Scaffold Pore Size on Matrix Mineralisation and Cellular Behaviour in Different Cell Types. Journal of Biomedical Materials Research A, 104(1), 291-304. [More Information]
Casanova, M., Herelle, J., Thomas, M., Softley, R., Schindeler, A., Little, D., Schneider, P., Muller, R. (2016). Effect of combined treatment with zoledronic acid and parathyroid hormone on mouse bone callus structure and composition. Bone, 92, 70-78. [More Information]
Morse, A., Cheng, T., Peacock, L., Mikulec, K., Little, D., Schindeler, A. (2016). RAP-011 augments callus formation in closed fractures in rats. Journal of Orthopaedic Research, 34(2), 320-330. [More Information]
Bobyn, J., Little, D., Gray, R., Schindeler, A. (2015). Animal Models of Scoliosis. Journal of Orthopaedic Research, 33(4), 458-467. [More Information]
Ravarian, R., Murphy, C., Schindeler, A., Rawal, A., Hook, J., Dehghani, F. (2015). Bioactive poly(methyl methacrylate) for bone fixation. RSC Advances, 5(75), 60681-60690. [More Information]
Cheng, T., Murphy, C., Ravarian, R., Dehghani, F., Little, D., Schindeler, A. (2015). Bisphosphonate-adsorbed ceramic nanoparticles increase bone formation in an injectable carrier for bone tissue engineering. Journal of Tissue Engineering, 6, 1-9. [More Information]
Seime, T., Kolind, M., Mikulec, K., Summers, M., Cantrill, L., Little, D., Schindeler, A. (2015). Inducible cell labeling and lineage tracking during fracture repair. Development, Growth and Differentiation, 57(1), 10-23. [More Information]
Kolind, M., Bobyn, J., Matthews, B., Mikulec, K., Aiken, A., Little, D., Kalajzici, I., Schindeler, A. (2015). Lineage tracking of mesenchymal and endothelial progenitors in BMP-induced bone formation. Bone, 81, 53-59. [More Information]
Schindeler, A., Yu, N., Cheng, T., Sullivan, K., Mikulec, K., Peacock, L., Matthews, R., Little, D. (2015). Local delivery of the cationic steroid antibiotic CSA-90 enables osseous union in a rat open fracture model of Staphylococcus aureus infection. Journal of Bone and Joint Surgery: American Volume, 97(4), 302-309. [More Information]
Murphy, C., Schindeler, A., Cantrill, L., Mikulec, K., Peacock, L., Little, D. (2015). PTH(1-34) Treatment Increases Bisphosphonate Turnover in Fracture Repair in Rats. Journal of Bone and Mineral Research, 30(6), 1022-1029. [More Information]
Summers, M., Quinlan (nee Edwards), K., Payne, J., Little, D., North, K., Schindeler, A. (2015). Skeletal muscle and motor deficits in Neurofibromatosis Type 1. Journal of Musculoskeletal and Neuronal Interactions, 15(2), 161-170.
Murphy, C., Schindeler, A., Gleeson, J., Yu, N., Cantrill, L., Mikulec, K., Peacock, L., O'Brien, F., Little, D. (2014). A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates. Acta Biomaterialia, 10, 2250-2258. [More Information]
El-Hoss, J., Cheng, T., Carpenter, E., Sullivan, K., Deo, N., Mikulec, K., Little, D., Schindeler, A. (2014). A combination of rhBMP-2 (recombinant human Bone Morphogenetic Protein-2) and MEK (MAP kinase/ERK kinase) inhibitor PD0325901 increases bone formation in a murine model of neurofibromatosis type I pseudarthrosis. Journal of Bone and Joint Surgery: American Volume, 96(14), 1-11. [More Information]
Shen, K., Murphy, C., Chan, B., Kolind, M., Cheng, T., Cheng, T., Mikulec, K., Peacock, L., Xue, M., Park, S., Little, D., Jackson, C., Schindeler, A. (2014). Activated Protein C (APC) can Increase Bone Anabolism via a Protease Activated Receptor (PAR)1/2 Dependent Mechanism. Journal of Orthopaedic Research, 32(12), 1549-1556. [More Information]
Tu, J., Henneicke, H., Zhang, Y., Stoner, S., Cheng, T., Schindeler, A., Chen, D., Tuckermann, J., Cooper, M., Seibel, M., Zhou, H. (2014). Disruption of glucocorticoid signaling in chondrocytes delays metaphyseal fracture healing but does not affect normal cartilage and bone development. Bone, 69, 12-22. [More Information]
Cheng, T., Murphy, C., Cantrill, L., Mikulec, K., Carpenter, C., Schindeler, A., Little, D. (2014). Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs. International Orthopaedics, 38(7), 1527-1533. [More Information]
Bobyn, J., Rasch, A., Kathy, M., Little, D., Schindeler, A. (2014). Maximizing bone formation in posterior spine fusion using rhBMP-2 and zoledronic acid in wild type and NF1 deficient mice. Journal of Orthopaedic Research, 32(8), 1090-1094. [More Information]
Morse, A., McDonald, M., Kelly, N., Melville, K., Schindeler, A., Kramer, I., Kneissel, M., Van Der Meulen, M., Little, D. (2014). Mechanical Load Increases in Bone Formation Via a Sclerostin-Independent Pathway. Journal of Bone and Mineral Research, 29(11), 2456-2467. [More Information]
El-Hoss, J., Kolind, M., Jackson, M., Deo, N., Mikulec, K., McDonald, M., Little, C., Little, D., Schindeler, A. (2014). Modulation of endochondral ossification by MEK inhibitors PD0325901 and AZD6244 (Selumetinib). Bone, 59, 151-161. [More Information]
Sullivan, K., El-Hoss, J., Quinlan (nee Edwards), K., Deo, N., Garton, F., Seto, J., Gdalevitch, M., Turner, N., Cooney, G., Kolanczyk, M., North, K., Little, D., Schindeler, A. (2014). NF1 is a critical regulator of muscle development and metabolism. Human Molecular Genetics, 23(5), 1250-1259. [More Information]
Casanova, M., Schindeler, A., Little, D., Muller, R., Schneider, P. (2014). Quantitative phenotyping of bone fracture repair: a review. BoneKEy Reports, 3, 1-8. [More Information]
Schindeler, A., Deo, N. (2014). Ras-ERK signalling in endochondral ossification: insights from neurofibromin. IBMS BoneKEy, 11(488), 1-3. [More Information]
Yu, N., Gdalevitch, M., Murphy, C., Mikulec, K., Peacock, L., Fitzpatrick, J., Cantrill, L., Ruys, A., Cooper-White, J., Little, D., Schindeler, A. (2014). Spatial control of bone formation using a porous polymer scaffold co-delivering anabolic rhbmp-2 and anti-resorptive agents. European Cells and Materials, 27, 98-111. [More Information]
Plotkin, S., Albers, A., Babovic-Vuksanovic, D., Blakeley, J., Breakefield, X., Dunn, C., Evans, D., Fisher, M., Friedman, J., Giovannini, M., Schindeler, A., et al (2014). Update from the 2013 International Neurofibromatosis Conference. American Journal of Medical Genetics, Part A, 164A (12), 2969-2978. [More Information]
Cheng, T., Valtchev, P., Murphy, C., Cantrill, L., Dehghani, F., Little, D., Schindeler, A. (2013). A sugar-based phase-transitioning delivery system for bone tissue-engineering. European Cells and Materials, 26, 208-221. [More Information]
Stevenson, D., Little, D., Armstrong, L., Crawford, A., Eastwood, D., Friedman, J., Greggi, T., Gutierrez, G., Hunter-Schaedle, K., Kendler, D., Schindeler, A., et al (2013). Approaches to Treating NF1 Tibial Pseudarthrosis: Consensus From the Children's Tumor Foundation NF1 Bone Abnormalities Consortium. Journal of Pediatric Orthopaedics, 33(3), 269-275. [More Information]
Murphy, C., O'Brien, F., Little, D., Schindeler, A. (2013). Cell-scaffold interactions in the bone tissue engineering triad. European Cells and Materials, 26, 120-132. [More Information]
Schindeler, A., Kolind, M., Little, D. (2013). Cellular Transitions and Tissue Engineering. Cellular Reprogramming, 15(2), 101-106. [More Information]
Yu, N., Schindeler, A., Peacock, L., Mikulec, K., Fitzpatrick, J., Ruys, A., Cooper-White, J., Little, D. (2013). Modulation of anabolic and catabolic responses via a porous polymer scaffold manufactured using thermally induced phase separation. European Cells and Materials, 25, 190-203. [More Information]
Ravarian, R., Zhong, X., Barbeck, M., Ghanaati, S., Kirkpatrick, C., Murphy, C., Schindeler, A., Chrzanowski, W., Dehghani, F. (2013). Nanoscale Chemical Interaction Enhances the Physical Properties of Bioglass Composites. ACS Nano, 7(10), 8469-8483. [More Information]
Bobyn, J., Rasch, A., Little, D., Schindeler, A. (2013). Posterolateral inter-transverse lumbar fusion in a mouse model. Journal of Orthopaedic Surgery and Research, 8(1), 1-9. [More Information]
El-Hoss, J., Sullivan, K., Cheng, T., Yu, N., Bobyn, J., Peacock, L., Mikulec, K., Baldock, P., Alexander, I., Schindeler, A., Little, D. (2012). A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells. Journal of Bone and Mineral Research, 27(1), 68-78. [More Information]
Cairns, D., Liu, R., Sen, M., Canner, J., Schindeler, A., Little, D., Zeng, L. (2012). Interplay of Nkx3.2, Sox9 and Pax3 Regulates Chondrogenic Differentiation of Muscle Progenitor Cells. PloS One, 7(7), 1-17. [More Information]
Carr, D., Yu, N., Fitzpatrick, J., Peacock, L., Mikulec, K., Ruys, A., Cooper-White, J., Little, D., Schindeler, A. (2012). Synergy between rhBMP-2 and IKK-Inhibitor PS-1145 Delivered via a Porous Biodegradable Polymer Implant. Journal of Tissue Science and Engineering, S1, 1-7. [More Information]
Yu, N., Schindeler, A., Tagil, M., Ruys, A., Little, D. (2012). Use of BMPs and bisphosphonates to improve bone fracture healing. Frontiers in Bioscience, 4E(7), 2647-2653. [More Information]
El-Hoss, J., Micallef, A., Fairfull-Smith, K., Bottle, S., Little, D., Schindeler, A. (2011). Assessment of Tumor Prevention in Type 1 Neurofibromatosis using a Nitroxide Compound. Free Radicals and Antioxidants, 1(3), 13-18. [More Information]
McDonald, M., Morse, A., Peacock, L., Mikulec, K., Schindeler, A., Little, D. (2011). Characterization of the Bone Phenotype and Fracture Repair in Osteopetrotic Incisors Absent Rats. Journal of Orthopaedic Research, 29(5), 726-733. [More Information]
Schindeler, A., Birke, O., Yu, N., Morse, A., Ruys, A., Baldock, P., Little, D. (2011). Distal tibial fracture repair in a neurofibromatosis type 1-deficient mouse treated with recombinant bone morphogenetic protein and a bisphosphonate. Journal of Bone and Joint Surgery: British Volume, 93 B (8), 1134-1139. [More Information]
Sullivan, K., El-Hoss, J., Little, D., Schindeler, A. (2011). JNK inhibitors increase osteogenesis in Nf1-deficient cells. Bone, 49(6), 1311-1316. [More Information]
Liu, R., Birke, O., Morse, A., Peacock, L., Mikulec, K., Little, D., Schindeler, A. (2011). Myogenic progenitors contribute to open but not closed fracture repair. BMC Musculoskeletal Disorders, 12, 288 - 1-288 - 9. [More Information]
Yang, N., Schindeler, A., McDonald, M., Seto, J., Houweling, P., Lek, M., Hogarth, M., Morse, A., Raftery, J., Balasuriya, D., Berman, Y., Quinlan (nee Edwards), K., Little, D., North, K., et al (2011). Î±-Actinin-3 deficiency is associated with reduced bone mass in human and mouse. Bone, 49(4), 790-798. [More Information]
Yu, N., Schindeler, A., Little, D., Ruys, A. (2010). Biodegradable poly(alpha-hydroxy acid) polymer scaffolds for bone tissue engineering. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 93B(1), 285-295. [More Information]
Yu, N., Schindeler, A., Peacock, L., Mikulec, K., Baldock, P., Ruys, A., Little, D. (2010). In vivo local co-delivery of recombinant human bone morphogenetic protein-7 and pamidronate via poly-D, L-lactic acid. European Cells and Materials, 20, 431-442. [More Information]
Birke, O., Schindeler, A., Ramachandran, M., Cowell, C., Munns, C., Bellemore, M., Little, D. (2010). Preliminary experience with the combined use of recombinant bone morphogenetic protein and bisphosphonates in the treatment of congenital pseudarthrosis of the tibia. Journal of Children's Orthopaedics, 4(6), 507-517. [More Information]
Schindeler, A., Morse, A., Peacock, L., Mikulec, K., Yu, N., Liu, R., Kijumnuayporn, S., McDonald, M., Baldock, P., Ruys, A., Little, D. (2010). Rapid cell culture and pre-clinical screening of a transforming growth factor-beta (TGF-beta) inhibitor for orthopaedics. BMC Musculoskeletal Disorders, 11(105), 105-1-105-9. [More Information]
Liu, R., Schindeler, A., Little, D. (2010). The potential role of muscle in bone repair. Journal of Musculoskeletal and Neuronal Interactions, 10(1), 71-76. [More Information]
Liu, R., Ginn, S., Lek, M., North, K., Alexander, I., Little, D., Schindeler, A. (2009). Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1 a. BMC Musculoskeletal Disorders, 10, 51-1-51-12. [More Information]
Elefterious, F., Kolanczyk, M., Schindeler, A., Viskochil, D., Hock, J., Schorry, E., Crawford, A., Friedman, J., Little, D., Peltonen, J., et al (2009). Skeletal Abnormalities in Neurofibromatosis Type 1: Approaches to Therapeutic Options. American Journal of Medical Genetics, Part A, 149(10), 2327-2338. [More Information]
Schindeler, A., Liu, R., Little, D. (2009). The contribution of different cell lineages to bone repair: exploring a role for muscle stem cells. Differentiation, 77(1), 12-18. [More Information]
Yu, N., Ruys, A., Zenios, M., Godfrey, C., McDonald, M., Kiely, P., Mikulec, K., Little, D., Schindeler, A. (2008). Bisphosphonate-Laden Acrylic Bone Cement: Mechanical Properties, Elution Performance, and In Vivo Activity. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 87B(2), 482-491. [More Information]
Schindeler, A., McDonald, M., Little, D., Bokka, P. (2008). Bone remodeling during fracture repair: The cellular picture. Seminars in Cell and Developmental Biology, 19(5), 459-466. [More Information]
Schindeler, A., Ramachandran, M., Godfrey, C., Morse, A., McDonald, M., Mikulec, K., Little, D. (2008). Modeling Bone Morphogenetic Protein and Bisphosphonate Combination Therapy in Wild-Type and Nf1 Haploinsufficient Mice. Journal of Orthopaedic Research, 26(1), 65-74. [More Information]
Schindeler, A., Morse, A., Harry, L., Godfrey, C., Mikulec, K., McDonald, M., Gasser, J., Little, D. (2008). Models of Tibial Fracture Healing in Normal and Nf1-Deficient Mice. Journal of Orthopaedic Research, 26(8), 1053-1060. [More Information]
Schindeler, A., Little, D. (2008). Recent insights into bone development, homeostasis, and repair in type 1 neurofibromatosis (NF1). Bone, 42(4), 616-622. [More Information]
Schindeler, A., Little, D. (2007). Bisphosphonate action: Revelations and deceptions from in vitro studies. Journal of Pharmaceutical Sciences, 96(8), 1872-1878. [More Information]
Dulai, S., Briody, J., Schindeler, A., North, K., Cowell, C., Little, D. (2007). Decreased bone mineral density in neurofibromatosis type 1: results from a pediatric cohort. Journal of Pediatric Orthopaedics, 27(4), 472-475. [More Information]
Little, D., Ramachandran, M., Schindeler, A. (2007). The anabolic and catabolic responses in bone repair. Journal of Bone and Joint Surgery: British Volume, 89(4), 425-433. [More Information]
Schindeler, A., Little, D. (2006). Ras-MAPK signaling in osteogenic differentiation: friend or foe? Journal of Bone and Mineral Research, 21(9), 1331-1338. [More Information]
Schindeler, A., Little, D. (2005). Osteoclasts but not osteoblasts are affected by a calcified surface treated with zoledronic acid in vitro. Biochemical and Biophysical Research Communications, 338(2), 710-716. [More Information]

show 129 more

Conferences

Schindeler, A., Ramachandran, M., Little, D. (2006). BMP-2 treatment produces an attenuated response in a mouse model of type 1 neurofibromatosis.
Schindeler, A., Little, D. (2006). Osteoclasts but not osteoblasts are affected by bispbospbonate bound to a calcified substrate.

By Year

Expand all

2024

Schindeler, A., Ludwig, K., Munns, C. (2024). Enzyme replacement therapy for hypophosphatasia—The current paradigm. Clinical Endocrinology. [More Information]

2023

Julovi, S., Dao, A., Trinh, K., O'Donohue, A., Shu, C., Smith, S., Shingde, M., Schindeler, A., Rogers, N., Little, C. (2023). Disease-modifying interactions between chronic kidney disease and osteoarthritis: A new comorbid mouse model. RMD Open, 9(3). [More Information]
O'Donohue, A., Dao, A., Bobyn, J., Munns, C., Little, D., Schindeler, A. (2023). Modeling anabolic and antiresorptive therapies for fracture healing in a mouse model of osteogenesis imperfecta. Journal of Orthopaedic Research, 41(4), 808-814. [More Information]
Dao, A., O'Donohue, A., Vasiljevski, E., Bobyn, J., Little, D., Schindeler, A. (2023). Murine models of orthopedic infection featuring Staphylococcus aureus biofilm. Journal of Bone and Joint Infection, 8(2), 81-89. [More Information]
Shahen, V., Schindeler, A., Rybchyn, M., Girgis, C., Mulholland, B., Mason, R., Levinger, I., Brennan-Speranza, T. (2023). Rescue of High Glucose Impairment of Cultured Human Osteoblasts Using Cinacalcet and Parathyroid Hormone. Calcified Tissue International, 112(4), 452-462. [More Information]
Power, H., Valtchev, P., Dehghani, F., Schindeler, A. (2023). Strategies for senolytic drug discovery. Aging Cell, 22(10), e13948. [More Information]
O'Donohue, A., Xiao, Y., Lee, L., schofield, T., Cheng, T., Munns, C., Baldock, P., Schindeler, A. (2023). Targeted postnatal knockout of Sclerostin using a bone-targeted adeno-associated viral vector increases bone anabolism and decreases canalicular density. Bone, 167. [More Information]

show 3 more

2022

Talebian, S., schofield, T., Valtchev, P., Schindeler, A., Kavanagh, J., Adil, Q., Dehghani, F. (2022). Biopolymer-Based Multilayer Microparticles for Probiotic Delivery to Colon. Advanced Healthcare Materials, 11(11). [More Information]
Lee, L., Holman, A., Li, X., Vasiljevski, E., O'Donohue, A., Cheng, T., Little, D., Schindeler, A., Biggin, A., Munns, C. (2022). Combination treatment with growth hormone and zoledronic acid in a mouse model of Osteogenesis imperfecta. Bone, 159, 116378-1-116378-12. [More Information]
Schindeler, A., Lee, L., O'Donohue, A., Ginn, S., Munns, C. (2022). Curative Cell and Gene Therapy for Osteogenesis Imperfecta. Journal of Bone and Mineral Research, 37(5), 826-836. [More Information]
Wu, J., Power, H., Miranda-Saksena, M., Valtchev, P., Schindeler, A., Cunningham, A., Dehghani, F. (2022). Identifying HSV-1 Inhibitors from Natural Compounds via Virtual Screening Targeting Surface Glycoprotein D. Pharmaceuticals, 15(3), 361. [More Information]
Dao, A., Mcdonald, M., Savage, P., Little, D., Schindeler, A. (2022). Preventing osteolytic lesions and osteomyelitis in multiple myeloma. Journal of Bone Oncology, 37. [More Information]
Blackshaw, K., Wu, J., Proschogo, N., Davies, J., Oldfield, D., Schindeler, A., Banati, R., Dehghani, F., Valtchev, P. (2022). The effect of thermal pasteurization, freeze-drying, and gamma irradiation on donor human milk. Food Chemistry, 373, 131402. [More Information]
Power, H., Wu, J., Turville, S., Aggarwal, A., Valtchev, P., Schindeler, A., Dehghani, F. (2022). Virtual screening and in vitro validation of natural compound inhibitors against SARS-CoV-2 spike protein. Bioorganic Chemistry, 119, 105574. [More Information]

show 4 more

2021

Casanova, M., Schindeler, A., Peacock, L., Lee, L., Schneider, P., Little, D., Müller, R. (2021). Characterization of the Developing Lacunocanalicular Network During Fracture Repair. JBMR Plus, 5(9), e10525. [More Information]
Fois, C., Schindeler, A., Valtchev, P., Dehghani, F. (2021). Dynamic flow and shear stress as key parameters for intestinal cells morphology and polarization in an organ-on-a-chip model. Biomedical Microdevices, 23(4), 55. [More Information]
Mirkhalaf Valashani, M., Goldsmith, J., Ren, J., Dao, A., Newman, P., Schindeler, A., Woodruff, M., Dunstan, C., Zreiqat, H. (2021). Highly substituted calcium silicates 3D printed with complex architectures to produce stiff, strong and bioactive scaffolds for bone regeneration. Applied Materials Today, 25, 101230. [More Information]
Vasiljevski, E., Burns, J., Bray, P., Donlevy, G., Mudge, A., Jones, K., Summers, M., Biggin, A., Munns, C., McKay, M., Little, D., Schindeler, A., et al (2021). L-carnitine supplementation for muscle weakness and fatigue in children with neurofibromatosis type 1: A Phase 2a clinical trial. American Journal of Medical Genetics, Part A, 185(10), 2976-2985. [More Information]
Bobyn, J., Deo, N., Little, D., Schindeler, A. (2021). Modulation of spine fusion with BMP-2, MEK inhibitor (PD0325901), and zoledronic acid in a murine model of NF1 double inactivation. Journal of Orthopaedic Science, 26(4), 684-689. [More Information]
Mirkhalaf Valashani, M., Dao, A., Schindeler, A., Little, D., Dunstan, C., Zreiqat, H. (2021). Personalized Baghdadite scaffolds: stereolithography, mechanics and in vivo testing. Acta Biomaterialia, 132, 217-226. [More Information]
Mohammadpour, H., Zarei, M., Cullen, P., Valtchev, P., Schindeler, A., Dehghani, F. (2021). Potential application of non-thermal atmospheric plasma in reducing the activity of Pseudomonas-secreted proteases in milk. International Dairy Journal, 120, 105078. [More Information]
Wu, J., Blackshaw, K., Cho, J., Koolaji, N., Yun, J., Schindeler, A., Valtchev, P., Dehghani, F. (2021). Recovery of high-value compounds from food by-products. In Not known (Eds.), Food Engineering Innovations Across the Food Supply Chain, (pp. 61-88). TBC. [More Information]
Kamble, S., Valtchev, P., Dao, A., Pelras, T., Rogers, M., Savage, P., Dehghani, F., Schindeler, A. (2021). Synthesis and Characterization of Bone Binding Antibiotic-1 (BBA-1), a Novel Antimicrobial for Orthopedic Applications. Molecules, 26(6). [More Information]
Blackshaw, K., Wu, J., Valtchev, P., Lau, E., Banati, R., Dehghani, F., Schindeler, A. (2021). The effects of thermal pasteurisation, freeze-drying, and gamma-irradiation on the antibacterial properties of donor human milk. Foods, 10(9), 2077. [More Information]
Blackshaw, K., Valtchev, P., Koolaji, N., Berry, N., Schindeler, A., Dehghani, F., Banati, R. (2021). The risk of infectious pathogens in breast-feeding, donated human milk and breast milk substitutes. Public Health Nutrition, 24(7), 1725-1740. [More Information]

show 8 more

2020

Koolaji, N., Shammugasamy, B., Schindeler, A., Dong, Q., Dehghani, F., Valtchev, P. (2020). Citrus Peel Flavonoids as Potential Cancer Prevention Agents. Current Developments in Nutrition, 4(5), 1-20. [More Information]
Schindeler, A., Biggin, A., Munns, C. (2020). Clinical Evidence for the Benefits of Burosumab Therapy for X-Linked Hypophosphatemia (XLH) and Other Conditions in Adults and Children. Frontiers in Endocrinology, 11, 338. [More Information]
Mills, R., Boyling, A., Cheng, T., Peacock, L., Savage, P., Tägil, M., Little, D., Schindeler, A. (2020). CSA-90 reduces periprosthetic joint infection in a novel rat model challenged with local and systemic Staphylococcus aureus. Journal of Orthopaedic Research, 38(9), 2065-2073. [More Information]
Vasiljevski, E., Houweling, P., Rupasinghe, T., Kaur, T., Summers, M., Roessner, U., Little, D., Schindeler, A. (2020). Evaluating modified diets and dietary supplement therapies for reducing muscle lipid accumulation and improving muscle function in neurofibromatosis type 1 (NF1). PloS One, 15(8), e0237097. [More Information]
Morse, A., Ko, F., McDonald, M., Lee, L., Schindeler, A., Van Der Meulen, M., Little, D. (2020). Increased anabolic bone response in Dkk1 KO mice following tibial compressive loading. Bone, 131, 115054. [More Information]
Morse, A., McDonald, M., Mikulec, K., Schindeler, A., Munns, C., Little, D. (2020). Pretreatment with Pamidronate Decreases Bone Formation but Increases Callus Bone Volume in a Rat Closed Fracture Model. Calcified Tissue International, 106(2), 172-179. [More Information]
Lu, Z., Chiu, J., Lee, L., Schindeler, A., Jackson, M., Ramaswamy, Y., Dunstan, C., Hogg, P., Zreiqat, H. (2020). Reprogramming of human fibroblasts into osteoblasts by insulin-like growth factor-binding protein 7. Stem Cells Translational Medicine, 9(3), 403-415. [More Information]
Dao, A., Mills, R., Kamble, S., Savage, P., Little, D., Schindeler, A. (2020). The application of ceragenins to orthopedic surgery and medicine. Journal of Orthopaedic Research, 38(9), 1883-1894. [More Information]

show 5 more

2019

Arab, M., Bahramian, B., Schindeler, A., Fathi, A., Valtchev, P., McConchie, R., Dehghani, F. (2019). A benign process for the recovery of solanesol from tomato leaf waste. Heliyon, 5(4), 1-17. [More Information]
Cheng, T., Leblanc, E., Kalinina, A., Cantrill, L., Valtchev, P., Dehghani, F., Little, D., Schindeler, A. (2019). A Bioactive Coating Enhances Bone Allografts in Rat Models of Bone Formation and Critical Defect Repair. Journal of Orthopaedic Research, 37(11), 2278-2286. [More Information]
Lee, L., Peacock, L., Ginn, S., Cantrill, L., Cheng, T., Little, D., Munns, C., Schindeler, A. (2019). Bone Marrow Transplantation for Treatment of the Col1a2+/G610C Osteogenesis Imperfecta Mouse Model. Calcified Tissue International, 104(4), 426-436. [More Information]
Manavitehrani, I., Ebrahimi, P., Yang, I., Daly, S., Schindeler, A., Saxena, A., Little, D., Fletcher, D., Dehghani, F., Winlaw, D. (2019). Current Challenges and Emergent Technologies for Manufacturing Artificial Right Ventricle to Pulmonary Artery (RV-PA) Cardiac Conduits. Cardiovascular Engineering and Technology, 10(2), 205-215. [More Information]
Bateman, J., Sampurno, L., Maurizi, A., Lamande, S., Sims, N., Cheng, T., Schindeler, A., Little, D. (2019). Effect of rapamycin on bone mass and strength in the Î±2(I)-G610C mouse model of osteogenesis imperfecta. Journal of Cellular and Molecular Medicine, 23(3), 1735-1745. [More Information]
Arab, M., Bahramian, B., Schindeler, A., Valtchev, P., Dehghani, F., McConchie, R. (2019). Extraction of phytochemicals from tomato leaf waste using subcritical carbon dioxide. Innovative Food Science and Emerging Technologies, 57, 1-9. [More Information]
Imel, E., Biggin, A., Schindeler, A., Munns, C. (2019). FGF23, Hypophosphatemia, and Emerging Treatments. JBMR Plus, 3(8), 1-9. [More Information]
Manavitehrani, I., Le, T., Daly, S., Wang, Y., Maitz, P., Schindeler, A., Dehghani, F. (2019). Formation of porous biodegradable scaffolds based on poly(propylene carbonate) using gas foaming technology. Materials Science and Engineering C, 96, 824-830. [More Information]
Ferner, R., Bakker, A., Elgersma, Y., Evans, D., Giovannini, M., Legius, E., Lloyd, A., Messiaen, L., Plotkin, S., Reilly, K., et al (2019). From process to progress-2017 International Conference on Neurofibromatosis 1, Neurofibromatosis 2 and Schwannomatosis. American Journal of Medical Genetics, Part A, 179(6), 1098-1106. [More Information]
Cheng, T., Cantrill, L., Schindeler, A., Little, D. (2019). Induction of periosteal bone formation by intraosseous BMP-2 injection in a mouse model of osteogenesis imperfecta. Journal of Children's Orthopaedics, 13(5), 543-550. [More Information]
Mumford, J., Kohn, M., Briody, J., Miskovic-Wheatley, J., Madden, S., Clarke, S., Biggin, A., Schindeler, A., Munns, C. (2019). Long-term Outcomes of Adolescent Anorexia Nervosa on Bone. Journal of Adolescent Health, 64(3), 305-310. [More Information]
Girgis, C., Cha, K., So, B., Tsang, M., Chen, J., Houweling, P., Schindeler, A., Stokes, R., Swarbrick, M., Evesson, F., Cooper, S., Gunton, J. (2019). Mice with myocyte deletion of vitamin D receptor have sarcopenia and impaired muscle function. Journal of Cachexia, Sarcopenia and Muscle, 10(6), 1228-1240. [More Information]
Fois, C., Le, T., Schindeler, A., Naficy, S., McClure, D., Read, M., Valtchev, P., Khademhosseini, A., Dehghani, F. (2019). Models of the Gut for Analyzing the Impact of Food and Drugs. Advanced Healthcare Materials, 8(21), 1-23. [More Information]
Mirmohseni, F., Cheng, T., Oveissi, F., Behi, M., Schindeler, A., Little, D., Naficy, S., Dehghani, F., Valtchev, P. (2019). Optimized Synthesis of Poly(deoxyribose) Isobutyrate, a Viscous Biomaterial for Bone Morphogenetic Protein-2 Delivery. ACS Applied Materials and Interfaces, 11(3), 2870-2879. [More Information]
Biglari, S., Le, T., Tan, R., Wise, S., Zambon, A., Codolo, G., De Bernard, M., Warkiani, M., Schindeler, A., Naficy, S., Valtchev, P., Dehghani, F., et al (2019). Simulating Inflammation in a Wound Microenvironment Using a Dermal Wound-on-a-Chip Model. Advanced Healthcare Materials, 8(1), 1-12. [More Information]
Lee, L., Peacock, L., Lisowski, L., Little, D., Munns, C., Schindeler, A. (2019). Targeting Adeno-Associated Virus Vectors for Local Delivery to Fractures and Systemic Delivery to the Skeleton. Molecular Therapy - Methods & Clinical Development, 15, 101-111. [More Information]

show 13 more

2018

Daly, S., Fathi, A., Bahramian, B., Manavi Tehrani, I., McClure, D., Valtchev, P., Schindeler, A., Dehghani, F., Kavanagh, J. (2018). A green process for the purification of biodegradable poly(B-hydroxybutyrate). The Journal of Supercritical Fluids, 135, 84-90. [More Information]
Torabian, G., Bahramian, B., Zambon, A., Spilimbergo, S., Adil, Q., Schindeler, A., Valtchev, P., Dehghani, F. (2018). A hybrid process for increasing the shelf life of elderberry juice. The Journal of Supercritical Fluids, 140, 406-414. [More Information]
Mills, R., Cheng, T., Mikulec, K., Peacock, L., Isaacs, D., Genberg, C., Savage, P., Little, D., Schindeler, A. (2018). CSA-90 Promotes Bone Formation and Mitigates Methicillin-resistant Staphylococcus aureus Infection in a Rat Open Fracture Model. Clinical Orthopaedics and Related Research, 476(6), 1311-1323. [More Information]
Summers, M., Vasiljevski, E., Mikulec, K., Peacock, L., Little, D., Schindeler, A. (2018). Developmental dosing with a MEK inhibitor (PD0325901) rescues myopathic features of the muscle-specific but not limb-specific Nf1 knockout mouse. Molecular Genetics and Metabolism, 123(4), 518-525. [More Information]
Fiscaletti, M., Coorey, C., Biggin, A., Briody, J., Little, D., Schindeler, A., Munns, C. (2018). Diagnosis of Recurrent Fracture in a Pediatric Cohort. Calcified Tissue International, 103(5), 529-539. [More Information]
Summers, M., Rupasinghe, T., Vasiljevski, E., Evesson, F., Mikulec, K., Peacock, L., Quinlan, K., Cooper, S., Roessner, U., Stevenson, D., Little, D., Schindeler, A. (2018). Dietary intervention rescues myopathy associated with neurofibromatosis type 1. Human Molecular Genetics, 27(4), 577-588. [More Information]
Morse, A., Cheng, T., Schindeler, A., McDonald, M., Mohanty, S., Kneissel, M., Kramer, I., Little, D. (2018). Dkk1 KO Mice Treated with Sclerostin Antibody Have Additional Increases in Bone Volume. Calcified Tissue International, 103(3), 298-310. [More Information]
McDonald, M., Morse, A., Schindeler, A., Mikulec, K., Peacock, L., Cheng, T., Bobyn, J., Lee, L., Baldock, P., Croucher, P., Tam, P., Little, D. (2018). Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation. Calcified Tissue International, 102(1), 105-116. [More Information]
Deo, N., Cheng, T., Mikulec, K., Peacock, L., Little, D., Schindeler, A. (2018). Improved union and bone strength in a mouse model of NF1 pseudarthrosis treated with recombinant human bone morphogenetic protein-2 and zoledronic acid. Journal of Orthopaedic Research, 36(3), 930-936. [More Information]
Deo, N., El-Hoss, J., Kolind, M., Mikulec, K., Peacock, L., Little, D., Schindeler, A. (2018). JNK inhibitor CC-930 reduces fibrosis in a murine model of Nf1-deficient fracture repair. Journal of Applied Biomedicine, 16(4), 350-357. [More Information]
Vasiljevski, E., Summers, M., Little, D., Schindeler, A. (2018). Lipid storage myopathies: Current treatments and future directions. Progress In Lipid Research, 72, 1-17. [More Information]
Manavitehrani, I., Schindeler, A., Parviz, M. (2018). Mesoporous Silica Nanoparticles: Synthesis, Modification and Applications. Nanomedicine & Nanotechnology Open Access, 3(2), 1-10.
Tarento, T., McClure, D., Vasiljevski, E., Schindeler, A., Dehghani, F., Kavanagh, J. (2018). Microalgae as a source of vitamin K1. Algal Research, 36, 77-87. [More Information]
Schindeler, A., Mills, R., Bobyn, J., Little, D. (2018). Preclinical Models for Orthopedic Research and Bone Tissue Engineering. Journal of Orthopaedic Research, 36(3), 832-840. [More Information]
Naficy, S., Oveissi, F., Patrick, B., Schindeler, A., Dehghani, F. (2018). Printed, Flexible pH Sensor Hydrogels for Wet Environments. Advanced Materials Technologies, 3(11), 1-10. [More Information]
Morse, A., Schindeler, A., McDonald, M., Kneissel, M., Kramer, I., Little, D. (2018). Sclerostin antibody augments the anabolic bone formation response in a mouse model of mechanical tibial loading. Journal of Bone and Mineral Research, 33(3), 486-498. [More Information]
McDonald, M., Morse, A., Birke, O., Yu, N., Mikulec, K., Peacock, L., Schindeler, A., Liu, M., Ke, H., Little, D. (2018). Sclerostin antibody enhances bone formation in a rat model of distraction osteogenesis. Journal of Orthopaedic Research, 36(4), 1106-1113. [More Information]
Manavi Tehrani, I., Fathi, A., Schindeler, A., Dehghani, F. (2018). Sustained Protein Release from a Core-Shell Drug Carrier System Comprised of Mesoporous Nanoparticles and an Injectable Hydrogel. Macromolecular Bioscience, 18(12), 1-9. [More Information]

show 15 more

2017

Little, D., Peacock, L., Mikulec, K., Kneissel, M., Kramer, I., Cheng, T., Schindeler, A., Munns, C. (2017). Combination sclerostin antibody and zoledronic acid treatment outperforms either treatment alone in a mouse model of osteogenesis imperfecta. Bone, 101, 96-103. [More Information]
Manavi Tehrani, I., Fathi, A., Wang, Y., Maitz, P., Mirmohseni, F., Cheng, T., Peacock, L., Little, D., Schindeler, A., Dehghani, F. (2017). Fabrication of a Biodegradable Implant with Tunable Characteristics for Bone Implant Applications. Biomacromolecules, 18(6), 1736-1746. [More Information]
Yang, I., Gottliebsen, M., Martinkevich, P., Schindeler, A., Little, D. (2017). Guided Growth: Current Perspectives and Future Challenges. JBJS Reviews, 5(11), 1-12. [More Information]
Summers, M., Mikulec, K., Peacock, L., Little, D., Schindeler, A. (2017). Limitations of the Pax7-creER(T2) transgene for driving deletion of Nf1 in adult mouse muscle. International Journal of Developmental Biology, 61(8-Sep), 531-536. [More Information]
Yu, N., Fathi, A., Murphy, C., Mikulec, K., Peacock, L., Cantrill, L., Dehghani, F., Little, D., Schindeler, A. (2017). Local co-delivery of rhBMP-2 and cathepsin K inhibitor L006235 in poly(D,L-lactide-co-glycolide) nanospheres. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 105B (1), 136-144. [More Information]
Morse, A., McDonald, M., Schindeler, A., Peacock, L., Mikulec, K., Cheng, T., Liu, M., Ke, H., Little, D. (2017). Sclerostin Antibody Increases Callus Size and Strength but does not Improve Fracture Union in a Challenged Open Rat Fracture Model. Calcified Tissue International, 101(2), 217-228. [More Information]

show 3 more

2016

Cheng, T., Schindeler, A., Little, D. (2016). BMP-2 delivered via sucrose acetate isobutyrate (SAIB) improves bone repair in a rat open fracture model. Journal of Orthopaedic Research, 34(7), 1168-1176. [More Information]
Murphy, C., Duffy, G., Schindeler, A., O'Brien, F. (2016). Effect of Collagen-Glycosaminoglycan Scaffold Pore Size on Matrix Mineralisation and Cellular Behaviour in Different Cell Types. Journal of Biomedical Materials Research A, 104(1), 291-304. [More Information]
Casanova, M., Herelle, J., Thomas, M., Softley, R., Schindeler, A., Little, D., Schneider, P., Muller, R. (2016). Effect of combined treatment with zoledronic acid and parathyroid hormone on mouse bone callus structure and composition. Bone, 92, 70-78. [More Information]
Morse, A., Cheng, T., Peacock, L., Mikulec, K., Little, D., Schindeler, A. (2016). RAP-011 augments callus formation in closed fractures in rats. Journal of Orthopaedic Research, 34(2), 320-330. [More Information]

show 1 more

2015

Bobyn, J., Little, D., Gray, R., Schindeler, A. (2015). Animal Models of Scoliosis. Journal of Orthopaedic Research, 33(4), 458-467. [More Information]
Ravarian, R., Murphy, C., Schindeler, A., Rawal, A., Hook, J., Dehghani, F. (2015). Bioactive poly(methyl methacrylate) for bone fixation. RSC Advances, 5(75), 60681-60690. [More Information]
Cheng, T., Murphy, C., Ravarian, R., Dehghani, F., Little, D., Schindeler, A. (2015). Bisphosphonate-adsorbed ceramic nanoparticles increase bone formation in an injectable carrier for bone tissue engineering. Journal of Tissue Engineering, 6, 1-9. [More Information]
Seime, T., Kolind, M., Mikulec, K., Summers, M., Cantrill, L., Little, D., Schindeler, A. (2015). Inducible cell labeling and lineage tracking during fracture repair. Development, Growth and Differentiation, 57(1), 10-23. [More Information]
Kolind, M., Bobyn, J., Matthews, B., Mikulec, K., Aiken, A., Little, D., Kalajzici, I., Schindeler, A. (2015). Lineage tracking of mesenchymal and endothelial progenitors in BMP-induced bone formation. Bone, 81, 53-59. [More Information]
Schindeler, A., Yu, N., Cheng, T., Sullivan, K., Mikulec, K., Peacock, L., Matthews, R., Little, D. (2015). Local delivery of the cationic steroid antibiotic CSA-90 enables osseous union in a rat open fracture model of Staphylococcus aureus infection. Journal of Bone and Joint Surgery: American Volume, 97(4), 302-309. [More Information]
Murphy, C., Schindeler, A., Cantrill, L., Mikulec, K., Peacock, L., Little, D. (2015). PTH(1-34) Treatment Increases Bisphosphonate Turnover in Fracture Repair in Rats. Journal of Bone and Mineral Research, 30(6), 1022-1029. [More Information]
Summers, M., Quinlan (nee Edwards), K., Payne, J., Little, D., North, K., Schindeler, A. (2015). Skeletal muscle and motor deficits in Neurofibromatosis Type 1. Journal of Musculoskeletal and Neuronal Interactions, 15(2), 161-170.

show 5 more

2014

Murphy, C., Schindeler, A., Gleeson, J., Yu, N., Cantrill, L., Mikulec, K., Peacock, L., O'Brien, F., Little, D. (2014). A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates. Acta Biomaterialia, 10, 2250-2258. [More Information]
El-Hoss, J., Cheng, T., Carpenter, E., Sullivan, K., Deo, N., Mikulec, K., Little, D., Schindeler, A. (2014). A combination of rhBMP-2 (recombinant human Bone Morphogenetic Protein-2) and MEK (MAP kinase/ERK kinase) inhibitor PD0325901 increases bone formation in a murine model of neurofibromatosis type I pseudarthrosis. Journal of Bone and Joint Surgery: American Volume, 96(14), 1-11. [More Information]
Shen, K., Murphy, C., Chan, B., Kolind, M., Cheng, T., Cheng, T., Mikulec, K., Peacock, L., Xue, M., Park, S., Little, D., Jackson, C., Schindeler, A. (2014). Activated Protein C (APC) can Increase Bone Anabolism via a Protease Activated Receptor (PAR)1/2 Dependent Mechanism. Journal of Orthopaedic Research, 32(12), 1549-1556. [More Information]
Tu, J., Henneicke, H., Zhang, Y., Stoner, S., Cheng, T., Schindeler, A., Chen, D., Tuckermann, J., Cooper, M., Seibel, M., Zhou, H. (2014). Disruption of glucocorticoid signaling in chondrocytes delays metaphyseal fracture healing but does not affect normal cartilage and bone development. Bone, 69, 12-22. [More Information]
Cheng, T., Murphy, C., Cantrill, L., Mikulec, K., Carpenter, C., Schindeler, A., Little, D. (2014). Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs. International Orthopaedics, 38(7), 1527-1533. [More Information]
Bobyn, J., Rasch, A., Kathy, M., Little, D., Schindeler, A. (2014). Maximizing bone formation in posterior spine fusion using rhBMP-2 and zoledronic acid in wild type and NF1 deficient mice. Journal of Orthopaedic Research, 32(8), 1090-1094. [More Information]
Morse, A., McDonald, M., Kelly, N., Melville, K., Schindeler, A., Kramer, I., Kneissel, M., Van Der Meulen, M., Little, D. (2014). Mechanical Load Increases in Bone Formation Via a Sclerostin-Independent Pathway. Journal of Bone and Mineral Research, 29(11), 2456-2467. [More Information]
El-Hoss, J., Kolind, M., Jackson, M., Deo, N., Mikulec, K., McDonald, M., Little, C., Little, D., Schindeler, A. (2014). Modulation of endochondral ossification by MEK inhibitors PD0325901 and AZD6244 (Selumetinib). Bone, 59, 151-161. [More Information]
Sullivan, K., El-Hoss, J., Quinlan (nee Edwards), K., Deo, N., Garton, F., Seto, J., Gdalevitch, M., Turner, N., Cooney, G., Kolanczyk, M., North, K., Little, D., Schindeler, A. (2014). NF1 is a critical regulator of muscle development and metabolism. Human Molecular Genetics, 23(5), 1250-1259. [More Information]
Casanova, M., Schindeler, A., Little, D., Muller, R., Schneider, P. (2014). Quantitative phenotyping of bone fracture repair: a review. BoneKEy Reports, 3, 1-8. [More Information]
Schindeler, A., Deo, N. (2014). Ras-ERK signalling in endochondral ossification: insights from neurofibromin. IBMS BoneKEy, 11(488), 1-3. [More Information]
Yu, N., Gdalevitch, M., Murphy, C., Mikulec, K., Peacock, L., Fitzpatrick, J., Cantrill, L., Ruys, A., Cooper-White, J., Little, D., Schindeler, A. (2014). Spatial control of bone formation using a porous polymer scaffold co-delivering anabolic rhbmp-2 and anti-resorptive agents. European Cells and Materials, 27, 98-111. [More Information]
Plotkin, S., Albers, A., Babovic-Vuksanovic, D., Blakeley, J., Breakefield, X., Dunn, C., Evans, D., Fisher, M., Friedman, J., Giovannini, M., Schindeler, A., et al (2014). Update from the 2013 International Neurofibromatosis Conference. American Journal of Medical Genetics, Part A, 164A (12), 2969-2978. [More Information]

show 10 more

2013

Cheng, T., Valtchev, P., Murphy, C., Cantrill, L., Dehghani, F., Little, D., Schindeler, A. (2013). A sugar-based phase-transitioning delivery system for bone tissue-engineering. European Cells and Materials, 26, 208-221. [More Information]
Stevenson, D., Little, D., Armstrong, L., Crawford, A., Eastwood, D., Friedman, J., Greggi, T., Gutierrez, G., Hunter-Schaedle, K., Kendler, D., Schindeler, A., et al (2013). Approaches to Treating NF1 Tibial Pseudarthrosis: Consensus From the Children's Tumor Foundation NF1 Bone Abnormalities Consortium. Journal of Pediatric Orthopaedics, 33(3), 269-275. [More Information]
Murphy, C., O'Brien, F., Little, D., Schindeler, A. (2013). Cell-scaffold interactions in the bone tissue engineering triad. European Cells and Materials, 26, 120-132. [More Information]
Schindeler, A., Kolind, M., Little, D. (2013). Cellular Transitions and Tissue Engineering. Cellular Reprogramming, 15(2), 101-106. [More Information]
Yu, N., Schindeler, A., Peacock, L., Mikulec, K., Fitzpatrick, J., Ruys, A., Cooper-White, J., Little, D. (2013). Modulation of anabolic and catabolic responses via a porous polymer scaffold manufactured using thermally induced phase separation. European Cells and Materials, 25, 190-203. [More Information]
Ravarian, R., Zhong, X., Barbeck, M., Ghanaati, S., Kirkpatrick, C., Murphy, C., Schindeler, A., Chrzanowski, W., Dehghani, F. (2013). Nanoscale Chemical Interaction Enhances the Physical Properties of Bioglass Composites. ACS Nano, 7(10), 8469-8483. [More Information]
Bobyn, J., Rasch, A., Little, D., Schindeler, A. (2013). Posterolateral inter-transverse lumbar fusion in a mouse model. Journal of Orthopaedic Surgery and Research, 8(1), 1-9. [More Information]

show 4 more

2012

El-Hoss, J., Sullivan, K., Cheng, T., Yu, N., Bobyn, J., Peacock, L., Mikulec, K., Baldock, P., Alexander, I., Schindeler, A., Little, D. (2012). A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells. Journal of Bone and Mineral Research, 27(1), 68-78. [More Information]
Cairns, D., Liu, R., Sen, M., Canner, J., Schindeler, A., Little, D., Zeng, L. (2012). Interplay of Nkx3.2, Sox9 and Pax3 Regulates Chondrogenic Differentiation of Muscle Progenitor Cells. PloS One, 7(7), 1-17. [More Information]
Carr, D., Yu, N., Fitzpatrick, J., Peacock, L., Mikulec, K., Ruys, A., Cooper-White, J., Little, D., Schindeler, A. (2012). Synergy between rhBMP-2 and IKK-Inhibitor PS-1145 Delivered via a Porous Biodegradable Polymer Implant. Journal of Tissue Science and Engineering, S1, 1-7. [More Information]
Yu, N., Schindeler, A., Tagil, M., Ruys, A., Little, D. (2012). Use of BMPs and bisphosphonates to improve bone fracture healing. Frontiers in Bioscience, 4E(7), 2647-2653. [More Information]

show 1 more

2011

El-Hoss, J., Micallef, A., Fairfull-Smith, K., Bottle, S., Little, D., Schindeler, A. (2011). Assessment of Tumor Prevention in Type 1 Neurofibromatosis using a Nitroxide Compound. Free Radicals and Antioxidants, 1(3), 13-18. [More Information]
McDonald, M., Morse, A., Peacock, L., Mikulec, K., Schindeler, A., Little, D. (2011). Characterization of the Bone Phenotype and Fracture Repair in Osteopetrotic Incisors Absent Rats. Journal of Orthopaedic Research, 29(5), 726-733. [More Information]
Schindeler, A., Birke, O., Yu, N., Morse, A., Ruys, A., Baldock, P., Little, D. (2011). Distal tibial fracture repair in a neurofibromatosis type 1-deficient mouse treated with recombinant bone morphogenetic protein and a bisphosphonate. Journal of Bone and Joint Surgery: British Volume, 93 B (8), 1134-1139. [More Information]
Sullivan, K., El-Hoss, J., Little, D., Schindeler, A. (2011). JNK inhibitors increase osteogenesis in Nf1-deficient cells. Bone, 49(6), 1311-1316. [More Information]
Liu, R., Birke, O., Morse, A., Peacock, L., Mikulec, K., Little, D., Schindeler, A. (2011). Myogenic progenitors contribute to open but not closed fracture repair. BMC Musculoskeletal Disorders, 12, 288 - 1-288 - 9. [More Information]
Yang, N., Schindeler, A., McDonald, M., Seto, J., Houweling, P., Lek, M., Hogarth, M., Morse, A., Raftery, J., Balasuriya, D., Berman, Y., Quinlan (nee Edwards), K., Little, D., North, K., et al (2011). Î±-Actinin-3 deficiency is associated with reduced bone mass in human and mouse. Bone, 49(4), 790-798. [More Information]

show 3 more

2010

Yu, N., Schindeler, A., Little, D., Ruys, A. (2010). Biodegradable poly(alpha-hydroxy acid) polymer scaffolds for bone tissue engineering. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 93B(1), 285-295. [More Information]
Yu, N., Schindeler, A., Peacock, L., Mikulec, K., Baldock, P., Ruys, A., Little, D. (2010). In vivo local co-delivery of recombinant human bone morphogenetic protein-7 and pamidronate via poly-D, L-lactic acid. European Cells and Materials, 20, 431-442. [More Information]
Birke, O., Schindeler, A., Ramachandran, M., Cowell, C., Munns, C., Bellemore, M., Little, D. (2010). Preliminary experience with the combined use of recombinant bone morphogenetic protein and bisphosphonates in the treatment of congenital pseudarthrosis of the tibia. Journal of Children's Orthopaedics, 4(6), 507-517. [More Information]
Schindeler, A., Morse, A., Peacock, L., Mikulec, K., Yu, N., Liu, R., Kijumnuayporn, S., McDonald, M., Baldock, P., Ruys, A., Little, D. (2010). Rapid cell culture and pre-clinical screening of a transforming growth factor-beta (TGF-beta) inhibitor for orthopaedics. BMC Musculoskeletal Disorders, 11(105), 105-1-105-9. [More Information]
Liu, R., Schindeler, A., Little, D. (2010). The potential role of muscle in bone repair. Journal of Musculoskeletal and Neuronal Interactions, 10(1), 71-76. [More Information]

show 2 more

2009

Liu, R., Ginn, S., Lek, M., North, K., Alexander, I., Little, D., Schindeler, A. (2009). Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1 a. BMC Musculoskeletal Disorders, 10, 51-1-51-12. [More Information]
Elefterious, F., Kolanczyk, M., Schindeler, A., Viskochil, D., Hock, J., Schorry, E., Crawford, A., Friedman, J., Little, D., Peltonen, J., et al (2009). Skeletal Abnormalities in Neurofibromatosis Type 1: Approaches to Therapeutic Options. American Journal of Medical Genetics, Part A, 149(10), 2327-2338. [More Information]
Schindeler, A., Liu, R., Little, D. (2009). The contribution of different cell lineages to bone repair: exploring a role for muscle stem cells. Differentiation, 77(1), 12-18. [More Information]

2008

Yu, N., Ruys, A., Zenios, M., Godfrey, C., McDonald, M., Kiely, P., Mikulec, K., Little, D., Schindeler, A. (2008). Bisphosphonate-Laden Acrylic Bone Cement: Mechanical Properties, Elution Performance, and In Vivo Activity. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 87B(2), 482-491. [More Information]
Schindeler, A., McDonald, M., Little, D., Bokka, P. (2008). Bone remodeling during fracture repair: The cellular picture. Seminars in Cell and Developmental Biology, 19(5), 459-466. [More Information]
Schindeler, A., Ramachandran, M., Godfrey, C., Morse, A., McDonald, M., Mikulec, K., Little, D. (2008). Modeling Bone Morphogenetic Protein and Bisphosphonate Combination Therapy in Wild-Type and Nf1 Haploinsufficient Mice. Journal of Orthopaedic Research, 26(1), 65-74. [More Information]
Schindeler, A., Morse, A., Harry, L., Godfrey, C., Mikulec, K., McDonald, M., Gasser, J., Little, D. (2008). Models of Tibial Fracture Healing in Normal and Nf1-Deficient Mice. Journal of Orthopaedic Research, 26(8), 1053-1060. [More Information]
Schindeler, A., Little, D. (2008). Recent insights into bone development, homeostasis, and repair in type 1 neurofibromatosis (NF1). Bone, 42(4), 616-622. [More Information]

show 2 more

2007

Schindeler, A., Little, D. (2007). Bisphosphonate action: Revelations and deceptions from in vitro studies. Journal of Pharmaceutical Sciences, 96(8), 1872-1878. [More Information]
Dulai, S., Briody, J., Schindeler, A., North, K., Cowell, C., Little, D. (2007). Decreased bone mineral density in neurofibromatosis type 1: results from a pediatric cohort. Journal of Pediatric Orthopaedics, 27(4), 472-475. [More Information]
Little, D., Ramachandran, M., Schindeler, A. (2007). The anabolic and catabolic responses in bone repair. Journal of Bone and Joint Surgery: British Volume, 89(4), 425-433. [More Information]

2006

Schindeler, A., Ramachandran, M., Little, D. (2006). BMP-2 treatment produces an attenuated response in a mouse model of type 1 neurofibromatosis.
Schindeler, A., Little, D. (2006). Osteoclasts but not osteoblasts are affected by bispbospbonate bound to a calcified substrate.
Schindeler, A., Little, D. (2006). Ras-MAPK signaling in osteogenic differentiation: friend or foe? Journal of Bone and Mineral Research, 21(9), 1331-1338. [More Information]

2005

Schindeler, A., Little, D. (2005). Osteoclasts but not osteoblasts are affected by a calcified surface treated with zoledronic acid in vitro. Biochemical and Biophysical Research Communications, 338(2), 710-716. [More Information]

Selected Grants

2023

Gene Therapy for Neurofibromatosis types 1 and 2, Schindeler A, Burgio G, National Health and Medical Research Council (NHMRC)/Ideas Grant

2020

Design a Targeted Delivery System for Probiotics, Dehghani F, Kavanagh J, Valtchev P, Schindeler A, Australian Research Council (ARC)/Linkage Projects (LP)

2017

Optimising bone regeneration using advanced design and fabrication technologies, Zreiqat H, Little D, Li Q, Roohaniesfahani S, Schindeler A, Woodruff M, National Health and Medical Research Council (NHMRC)/Project Grants

2015

Prevention and treatment of bone infection with CSA-90, Little D, Schindeler A, Isaacs D, Tagil M, National Health and Medical Research Council (NHMRC)/Project Grants

2014

Leica CM1950 Freestanding Cryostat , Cooper S, Schindeler A, Wang Y, Brilot-Turville F, National Health and Medical Research Council (NHMRC)/Equipment Grant

2011

Pre-clinical validation of a novel implant for bone tissue engineering, Little D, Cooper-White J, Ruys A, Schindeler A, National Health and Medical Research Council (NHMRC)/Project Grants

2010

Novel therapeutic interventions for the orthopaedic complications of Neurofibromatosis type 1 (NF1), Little D, Alexander I, Schindeler A, National Health and Medical Research Council (NHMRC)/Project Grants
The role of muscle and the application of muscle-cell therapies in bone repair, Little D, Schindeler A, Hamrick M, National Health and Medical Research Council (NHMRC)/Project Grants

2007

Modelling the loss of NF1 heterozygosity in congenital pseudarthrosis of the tibia (CPT), Alexander I, Baldock P, Little D, Schindeler A, National Health and Medical Research Council (NHMRC)/Project Grants

2006

The role of muscle cells in bone repair, Little D, Schindeler A, National Health and Medical Research Council (NHMRC)/Project Grants

Faculty of Engineering

Page not found

Associate Professor Aaron Schindeler

Publications

By Type

By Year

Selected Grants

2023

2020

2017

2015

2014

2011

2010

2007

2006

Related research articles

ARC grant aims to improve viability of probiotics